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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de recherche en santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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Anthelmintic activity of Saba senegalensis(***.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 945-949页

作者： Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou Laboratoire de Développement du Médicament Centre de recherche sur le médicament Ecole Doctorale de la SantéUniversité de Ouagadougou Ecole Doctorale de Santé Département Médecine Pharmacopée Traditionnelles–Pharmacie (MEPHATRA-Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) Département Productions Animales Institut de l’Environnement et de Recherches Agricoles(INERA/CNRST)

Objective: To evaluate the anthelmintic property of Saba senegalensis(***) Pichon(Apocynaceae)(S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites ***: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/m L was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ***: The LC_(50) on adult worms was 6.79 mg/m L and 3.25 mg/m L for the leaves of S. senegalensis and the levamisole(reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/m L of S. ***: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.

关键词： Saba senegalensis Anthelmintic properties Haemonchus contortus In vitro Burkina Faso

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Prevalence of intestinal opportunistic parasites infections in the University hospital of Bobo-Dioulasso, Burkina Faso

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Infectious Diseases of Poverty 2015年第1期4卷 512-517页

作者： Ibrahim Sangaré Sanata Bamba Mamoudou Cissé Adama Zida Rabila Bamogo Constant Sirima Bienvenue KYaméogo Roger Sanou François Drabo Roch KDabiré Robert TGuiguemdé institut Supérieur des Sciences de la santé UniversitéPolytechnique de Bobo-Dioulasso01 BP 1091 Bobo-DioulassoBurkina Faso Centre MURAZ Unitéde Recherche en Paludisme et Maladies Tropicales NégligéesBobo-DioulassoBurkina Faso Centre Hospitalier Universitaire Souro Sanou Bobo-DioulassoBurkina Faso Centre Hospitalier Universitaire Yalgado Ouédraogo OuagadougouBurkina Faso institut de recherche en Sciences de la santé Direction Régionale de l’ouestOuagadougouBurkina Faso Ministère de la santé Direction de la Lutte contre la MaladieCoordination de la lutte contre les Maladies tropicales NégligéesOuagadougouBurkina Faso

Background:Gastrointestinal parasites infections are widespread in Africa and their prevalence infections vary from country to *** study aimed at assessing the prevalence of opportunistic intestinal parasites infection and other gastrointestinal parasites infection among patients attending the laboratory of Parasitology and Mycology of the University Hospital Souro Sanou of ***:A hospital cross-sectional based study was conducted from April to August,*** were persons whom parasitological examination of stools has been prescribed by a *** stools examination methods included direct wet saline examination,lugol’s iodine staining technique,formol-ether concentration and modified Ziehl-Neelsen *** recorded age and sex information for each ***:The overall prevalence of intestinal parasite infections was 65.3%(190/291).Majority of the parasitic infections was waterborne(64.3%)consisting of high prevalence of Cryptosporidium sp.(26.5%)and entamoeba histolytica/dispar(23.4%).The prevalence of opportunistic parasites was 28.9%and Cryptosporidium *** the most prevalent species followed by Blastocystis sp.(1.0%),Cyclospora sp.(0.7%)and Isospora belli(0.7%).The prevalence of intestinal helminthes was 1.7%.Conclusions:The prevalence of intestinal parasitism in general remains high in Bobo-Dioulasso requiring the establishment of adequate diagnostic techniques,treatment and prevention.

关键词： Intestinal opportunistic parasite Prevalence Bobo-Dioulasso Burkina Faso

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Liver transplantation for perihilar cholangiocarcinoma is not a provocative idea

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 232-234页

作者： Alexandre Chebaro Heithem Jeddou Service de Chirurgie Hépatobiliaire et Digestive CHU RennesUniv RennesRennesFrance Inserm EHESPIrset(Institut de recherche en santéenvironnement et travail)-UMR_S 1085Univ RennesRennesFrance

This is a multicenter benchmarking study on liver transplantation(LT)for perihilar cholangiocarcinoma(PHC)after neoadjuvant chemoradiotherapy(1).The study comprises of 134 patients from 2014 to 2018 among whom the majority had underlying primary sclerosing cholangitis(PSC).Dropout rate was available from 4 out of 17 centers and was 28%,primarily for oncological reasons(tumor progression and lymph node invasion).All patients followed neo-adjuvant chemoradiotherapy according to the Mayo(88%)or Mayo-like *** grafts originated from brain-dead donors in 61.3%of cases and from living donors in 29.7%of cases.

关键词： Liver invasion patients

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Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu Miguel santos-santos Ignacio lllán-Gala Victor Montal Teresa Estellés Isabel Barroeta Miren Altuna Javier Arranz Laia Muñoz Olivia Belbin Isabel Sala Maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles Rafael Blesa Jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea sant Pau Memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas(CIBERNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(GFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma GFAP(pGFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pGFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single Molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pGFAP was increased in FTD but lower than in AD(all Pder the curve[AUC]:combination 0.78;pGFAP 0.7;pNfL 0.61,all Pen the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： Glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

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Effect of a Nutrition Education Intervention on Mothers’ Infant and Young Child Feeding Knowledge and Practices in the Peri-Urban Areas of Bobo-Dioulasso: Before and after Study

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Food and Nutrition Sciences 2023年第3期14卷 175-199页

作者： Alain Hien Jérome W. Somé Roland Nâg-Tiero Meda Augustin N. Zeba Isidore Traoré Georges Anicet Ouedraogo institut Supérieur des Sciences de la santé Université Nazi Boni Bobo-Dioulasso Burkina Faso Centre Muraz/institut National de santé Publique Bobo-Dioulasso Burkina Faso Laboratoire de recherche et d’enseignement en santé et Biotechnologies Animales Université Nazi Boni Bobo-Dioulasso Burkina Faso Centre National de recherche Scientifique et Technologique/institut de recherche en Sciences de la santé Ouagadougou Burkina Faso Centre National de recherche Scientifique et Technologique/institut de recherche en Sciences de la santé/Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso

Background: This study assessed the effect of a nutrition education intervention aiming to improve the knowledge and practices of under 5 years children’s mothers on infant and young child feeding in peri urban areas of Bobo-Dioulasso in Burkina Faso. Methods: A total of 243 mothers of children under 5 years in the peri-urban of Bobo-Dioulasso were surveyed before and after the intervention using the FAO questionnaire for infant and young child feeding (IYCF) knowledge and practices assessment in January and October 2017. The intervention included two components consisting of a theoretical phase (counselling and discussion) and cooking demonstrations implemented for ten months. To account for the before-and-after design of the study, the McNemar’s test was used to assess the effect of the intervention on mothers’ infant and young child feeding knowledge and practices. Results: The mean age of mothers was 29 ± 6.2 years and 50.6% of the mothers were between 20 and 29 years old. All indicators used to assess the mothers’ knowledge of breastfeeding and complementary feeding significantly improved after the intervention (all p-values entary feeding initiation, and minimum meal frequency) significantly increased (all p = 0.001) while two indicators (minimum dietary diversity, and minimum acceptable diet) did not change (p = 0.06 and 0.67) after the intervention. Finally, continued breastfeeding, significantly declined after the intervention (73.3% vs 86.0% p = 0.001). Conclusion: The intervention improved the mothers’ knowledge on breastfeeding and complementary feeding and some child feeding practices. This study provided some evidence of an effective nutrition education intervention to increase maternal knowledge and practices.

关键词： Nutrition Intervention Mothers’ Nutrition Knowledge Child Feeding Practices

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Strategies and governance to reduce health inequalities:evidences from a cross-European survey

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Global Health Research and Policy 2017年第1期2卷 182-192页

作者： Sara Barsanti Louis-Rachid Salmi Yann Bourgueil Antonio Daponte Ewelina Pinzal Solange Ménival Laboratorio Management e Sanità Institute of ManagementScuola Superiore Sant’AnnaPisaItaly institut de santéPublique Épidémiologie et de DéveloppementINSERM U-1219 Bordeaux Population Health Research CenterUniversitéde Bordeaux et CHU de BordeauxPôle de SantépubliqueBordeauxFrance institut de recherche et de Documentation en Economie de la santé ParisFrance Observatorio de Salud y Medio Ambiente de Andalucía(OSMAN) Escuela Andaluza de Salud PúblicaGranadaSpain Conseil Régional d’Aquitaine BordeauxFrance

Background:The main objective of the paper is to identify the governance system related to policies to reduce health inequalities in the European *** the Action Spectrum of inequalities and the check list of health equity governance,we developed a survey in the framework of the AIR Project-Addressing Inequalities Intervention in Regions-was an European project funded by the Executive Agency of Health and ***:A web-based qualitative questionnaire was developed that collected information about practiced strategies to reduce health *** total 28 questionnaires from 28 different regions,related to 13countries,were suitable for the ***:Progress in health equity strategies at the national and regional levels has been made by countries such as France,Portugal,Poland,and *** the other hand,Spain,Italy,and Belgium have a variable situation depending on the ***,the results of the survey indicate that the governance system for health equity different in terms of commitment,resources and ***:The survey highlights a weakness of governance system for the majority of countries in terms of evaluation actions and of impact of interventions in reducing inequalities,and the difficulties in having a clear and integrated vision between the national and regional levels.

关键词： inequalities system qualitative

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From Research Data to Intervention Models: Intervening with All Stakeholders

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Psycho-Oncologie 2023年第3期17卷 109-112页

作者： Louise Potvin Grégory Ninot Sabine Dutheil Anne-Fleur Guillemin Jérôme Foucaud department de Médecine sociale et préventive Ecole de santépublique de l’Universitéde MontréalMontréalQuébecQCH3N 1X7Canada institut desbrest d’Epidémiologie et de santéPublique(Universitéde Montpellier-INSERM) Montpellier34093France institut du Cancer de Montpellier Montpellier34298France institut du Sein d’Aquitaine Clinique TivoliBordeaux33000France department recherche en sciences humaines et sociales Épidémiologie et santépubliqueInstitut national du cancer(INCa)Boulogne-Billancourt92513France

[French version]en tant que dispositif de recherche innovant pour développer et mettre en oeuvre les préventions,la recherche interventionnelle en santédes populations(RISP)occupe une place particulière dans le d... 详细信息

关键词： les dis des

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Cytokine production in patients with cirrhosis and TLR4 polymorphisms

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World Journal of Gastroenterology 2014年第46期20卷 17516-17524页

作者： Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano department of Immunology Institut de Recerca-IIB Sant PauUniversitat Autònoma de Barcelona08025 BarcelonaSpain department of Gastroenterology Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain department of Gastroenterology Instituto de Salud Carlos Ⅲ Institut de Recerca-IIB Sant PauUniversitat Autònoma de Barcelona08025 BarcelonaSpain department of Gastroenterology Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas08025 BarcelonaSpain instituto de Salud Carlos Ⅲ Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas08025 BarcelonaSpain department of Gastroenterology Escola Universitària d’Infermeria Sant Pau08025 BarcelonaSpain department of Gastroenterology Universitat Autònoma de Barcelona08025 BarcelonaSpain

AIM: To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.

关键词： Inflammatory response Hepatic encephalopathy Genetic factors Infections

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Cholinesterase Activity as an Indicator of Health Risks among Kou Valley Farmers

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Journal of Biosciences and Medicines 2024年第7期12卷 71-86页

作者： Thiombiano Cherileila Hien S. Aristide Koevi Nadège Bayili Bazoma Ouattara Abdoulaye Traore Patrice Traore T. Isidore Hien Herve Centre Muraz Institut National de Sant Publique (INSP) Bobo-Dioulasso Burkina Faso institut Suprieur des Science de la sant (INSSA) University of Nazi Boni Bobo-Dioulasso Burkina Faso institut de recherche en Science de la sant (IRSS) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso

Introduction: Pesticides are currently an essential component of agricultural production techniques for controlling pests and weeds. In Burkina Faso, non-compliance with good practice in the use of pesticides poses a real health problem for the population. This study examines the health risks associated with pesticide management in rice-growing areas. Material and Methods: A field survey was conducted in Bama, involving farmers, focusing on their socio-demographic characteristics, pesticide usage, and health effects. Cholinesterase levels were measured in subsample of farmers using a portable device. Data were analysed using Microsoft Excel, calculating means and percentages for various practices. Health consultations, protection methods, and pesticide management were studied. Erythrocyte acetylcholinesterase activity was compared before and after treatment. Data were categorised into classes based on inhibition levels, and correlation analyses determined relationships between variables such as age, years of experience, and cholinesterase activity. Results: The results indicate that rice cultivation is mainly carried out by a fairly young population, with nearly 63% being under the age of 50. Common poor practices in pesticide use include improper storage and reuse of leftover pesticides. Seven types of pesticides were identified, including organophosphates such as glyphosate, which was used in 26.7% of cases. This organophosphate has resulted in class B poisoning, causing a 30% - 50% reduction in erythrocyte cholinesterase activity. The health effects of pesticide use are felt by agricultural farmers through various symptoms of poisoning. Conclusion: To reduce the occurrence of pesticide poisoning, it is essential to launch information and awareness campaigns among the population and farmers to promote safe practices in pesticide use in Bama, Burkina Faso.

关键词： Pesticides environmental Sanitary Risk Acetylcholinesterase Farmers Bama Burkina Faso

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