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Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma

四川生理科学杂志 2021年第10期43卷 1699-1699页

作者： HervéTilly From the Department of Hematology and INSERM Unité 1245 Centre Henri-Becquerel and University of Rouen Rouen (H.T.) Université de Lille Centre Hospitalier Universitaire (CHU) Lille ULR 7365 - GRITA - Groupe de Recherche sur les Formes Injectables et les Technologies Associées Lille (F.M.) CHU de Montpellier Montpellier (C.H.) the Department of Hematology Institut Universitaire du Cancer Toulouse-Oncopole Toulouse (L.O.) and the Department of Hematology Centre Hospitalier Régional Universitaire - Besançon Besançon (A.C.) - all in France the Centre for Lymphoid Cancer at BC Cancer and the University of British Columbia Vancouver (L.H.S.) the Odette Cancer Centre Sunnybrook Health Sciences Centre University of Toronto Toronto (M.C.C.) and F. Hoffmann-La Roche Mississauga ON (M.Y.) - all in Canada the Wilmot Cancer Institute University of Rochester Rochester (J.W.F.) and Memorial Sloan Kettering Cancer Center New York (M.M. G.S.) - both in New York the First Faculty of Medicine Charles University and the General University Hospital Prague Czech Republic (M.T.) the Willamette Valley Cancer Institute and Research Center the US Oncology Network Eugene OR (J.P.S.) Rocky Mountain Cancer Centers Aurora CO (J.M.B.) Memorial Sloan Kettering Cancer Center Montvale NJ (M.M.) the Department of Hematology and Rheumatology Kindai University Faculty of Medicine Osaka-Sayama City (S.R.) and the National Cancer Center Hospital Tokyo (K.I.) - both in Japan Washington University in St. Louis St. Louis (N.M.-S.) the Maria Sklodowska-Curie National Research Institute of Oncology Krakow Poland (W.J.) Peking University Cancer Hospital Beijing (Y.S.) the 3rd Medical Department Paracelsus Medical University Salzburg Cancer Research Institute-Center for Clinical Cancer and Immunology Trials and Cancer Cluster Salzburg Salzburg Austria (R.G.) the Feofaniya Clinical Hospital Kyiv Ukraine (L.M.) Hospital San Pedro de Alcántara Cáceres (J.M.B.-B.) and the Department of Hematology Vall d'He

Background:Diffuse large B-cell lymphoma(DLBCL)is typically treated with rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP).However,only 60%of patients are cured with *** vedotin is an antibody-drug conjugate targeting CD79b,which is ubiquitously expressed on the surface of malignant B ***:We conducted a double-blind,placebo-controlled,international phase 3 trial to evaluate a modified regimen of RCHOP(pola-R-CHP),in which vincristine was replaced with polatuzumab vedotin,as compared with standard R-CHOP,in patients with previously untreated intermediate-risk or high-risk *** 18 to 80 years of age were randomly assigned in a 1:1 ratio to receive six cycles of either pola-R-CHP or R-CHOP,plus two cycles of rituximab *** primary end point was investigator-assessed progression-free *** end points included overall survival and safety.

关键词： CHOP assessed alone

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胰腺微创手术迈阿密国际循证指南(2020)

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肝胆外科杂志 2020年第6期28卷 478-480页

作者： Asbun HJ 崔笑(译) 耿小平(审校) Division of Hepatobiliary and Pancreas Surgery Miami Cancer Institute Miami FL. Department of Surgery University Hospital Southampton NHS Foundation Trust Southampton UK. Department of Surgery Amsterdam UMC University of Amsterdam Amsterdam the Netherlands. Department of Surgery San Raffaele Hospital Milan Italy. Division of Hepatopancreatobiliary and Endocrine Surgery Virginia Mason Medical Center Seattle VA. Department of Surgery Memorial Sloan Kettering Cancer Center New York City NY. Division of Pancreatic Surgery University Hospital of Verona Verona Italy. Department of Surgery and Department of Clinical and Experimental Medicine Linköping University Linköping Sweden. Division of General and Transplant Surgery University of Pisa Pisa Italy. Department of General and Gastrointestinal Surgery Beth Israel Deaconess Medical Center Boston MA. Department of Surgery Division of Surgical Oncology University of Colorado Denver CO. Department of Abdominal Surgery AC Camargo Cancer Center São Paulo Brazil. Department of Surgery St. Elizabeth's Medical Center Boston MA. Wessex Institute University of Southampton UK. General Surgery and Liver Transplant Unit Department of General Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy. Department of Surgery Medical School University of Cyprus Cyprus. Department of Surgery Beaujon Hospital Paris France. Department of Surgery University of Oklahoma Oklahoma City OK. The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Institute of Clinical Medicine Faculty of Medicine University of Oslo Oslo Norway. Division of Minimally Invasive General Surgery & Robotic Surgery University of Illinois Chicago IL. Department of Surgery Seoul National University Hospital Seoul South Korea. Department of Surgery Portland Providence Medical Center Portland OR. Department of Surgery University of Texas Southwestern Medical Center Dallas TX. Department of Surgery Nor

国际微创胰腺外科研究组(I-MIPS)基于2019年迈阿密国际微创胰腺手术会议专家共识及既往研究的基础上制定了微创胰腺手术国际性循证指南,对微创胰腺手术规范、技术、开展条件和手术效果等6大议题26个临床热点问题进行了系统评价。对有明... 详细信息

国际微创胰腺外科研究组(I-MIPS)基于2019年迈阿密国际微创胰腺手术会议专家共识及既往研究的基础上制定了微创胰腺手术国际性循证指南,对微创胰腺手术规范、技术、开展条件和手术效果等6大议题26个临床热点问题进行了系统评价。对有明确推荐意见的热点问题予以摘译如下:问题1不考虑适应症,在条件合适时|微创远端胰腺切除术相对开放手术应当优先使用吗?

关键词：胰腺手术循证指南胰腺外科推荐意见开放手术优先使用专家共识迈阿密

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Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

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四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer

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