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培美曲塞加铂类联合或不联合帕博利珠单抗对初治转移性非鳞状NSCLC患者的疗效与安全性分析：KEYNOTE-189研究方案指定的最终分析

中国肺癌杂志 2022年第6期25卷 443-456页

作者：周彩存 Delvys RODRíGUEZ-ABREU S.F.POWELL M.J.HOCHMAIR S.GAD GEEL E.ESTEBAN E.FELIP G.SPERANZA F.De ANGELIS M.DóMINE S.Y.CHENG H.G.BISCHOFF N.PELED M.RECK R.HUI E.B.GARON M.BOYER T.KURATA J.YANG M.C.PIETANZA F.SOUZA M.C.GARASSINO 同济大学附属上海市肺科医院肿瘤科 Medical Oncology Complejo Hospitalario Universitario Insular Materno-Infantil de Gran CanariaUniversidad de Las Palmas de Gran Canaria Oncology Sanford Health 4. Department of Respiratory and Critical Care MedicineKarl Landsteiner Institute of Lung Research and Pulmonary Oncology Thoracic Oncology Karmanos Cancer InstituteWayne State University Department of Medical Oncology Hospital Universitario Central de Asturias Medical Oncology Department Vall d'Hebron UniversityVall d'Hebron Institute of Oncology (VHIO) 8. Centre Integre de Cancerologie de la MontérégieH?pital Charles-Le Moyne 9. Medical Oncology DepartmentHospital Universitario Fundacidn Jiménez DiazIIS-FJD Sunnybrook Health Sciences Centre Thoraxklinik Heidelberg Department of Oncology Shaare Zedek Medical Center LungenClinic Airway Research Center NorthGerman Center for Lung Research Department of Medical Oncology Westmead Hospital and University of Sydney Department of Medicine David Geffen School of Medicine at UCLA Department of Medical Oncology Chris O'Brien Lifehouse Department of Thoracic Oncology Kansai Medical University Hospital Merck & Co. Inc. Fondazione irccs istituto Nazionale dei Tumori University of Chicago Medicine & Biological Sciences Knapp Center for Biomedical Discovery

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(over... 详细信息

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。本研究报告了研究方案指定的最终分析的疗效结局,包括从培美曲塞-铂类交叉至帕博利珠单抗治疗的患者,以及完成35个周期(约2年)帕博利珠单抗治疗组的疗效。方法符合条件的患者以2:1随机分配至帕博利珠单抗,每3周一次,200 mg (n=410)或安慰剂(n=206)(共35周期,约2年),加上4个周期的培美曲塞(500 mg/m~2)和由研究者选择的每3周顺铂(75 mg/m~2)或卡铂(曲线下面积5 mg/min/mL)治疗,随后使用培美曲塞直至疾病进展。若符合纳入标准,分配至安慰剂联合培美曲塞加铂类治疗的患者可在疾病进展时转向帕博利珠单抗治疗。主要研究终点为OS和PFS。结果中位随访31.0个月,无论PD-L1的表达水平如何,与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类治疗可使患者的OS[风险比(hazard ratio,HR)为0.56;95%可信区间(confidence interval,CI) 0.46-0.69]和PFS (HR=0.49;95%CI:0.41-0.59)显著获益。接受帕博利珠单抗联合培美曲塞-铂类治疗的患者客观缓解率(objective response rate,ORR)(48.3%vs 19.9%)和第二次/后续无进展生存期(PFS2;HR=0.50;95%CI:0.41-0.61)均得到改善。安慰剂联合培美曲塞-铂类组的84例患者(40.8%)交叉至帕博利珠单抗治疗组。72.1%的接受帕博利珠单抗联合培美曲塞-铂类的患者和66.8%的接受安慰剂联合培美曲塞-铂类的患者发生了3级-5级不良事件。56例患者完成了35个周期(约2年)的帕博利珠单抗治疗;ORR为85.7%,53例(94.6%)患者存活至数据截止时间。结论与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类可持续提高疗效,且安全性可控。该研究结果支持将帕博利珠单抗联合培美曲塞-铂类作为初治转移性非鳞状NSCLC患者的一线治疗方案。

关键词：帕博利珠单抗化疗非鳞状非小细胞肺癌

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Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study

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Cancer Communications 2022年第10期42卷 1041-1045页

作者： Reynalda Córdova Ana-Lucia Mayén Viktoria Knaze Elom Kouassivi Aglago Casper Schalkwijk Karl-Heinz Wagner Kim Overvad Anne Tjønneland Cecilie Kyrø Verena Andrea Katzke Charlotte Le Cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto Catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta Crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena Colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-Cornago Elisabete Weiderpass Mazda Jenab Heinz Freisling Nutrition and Metabolism Branch International Agency for Research on Cancer(IARC-WHO)Lyon 69008France Department of Nutritional Sciences University of ViennaVienna 1090Austria Department of Internal Medicine Maastricht University Medical CentreMaastricht 6229the Netherlands Department of Public Health Aarhus UniversityAarhus 8000Denmark Danish Cancer Society Research Center Copenhagen 2100Denmark Division of Cancer Epidemiology German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam-RehbrueckeNuthetal 14558Germany Institute of Nutritional Science University of PotsdamNuthetal 14558Germany Cancer Risk Factors and Lifestyle Epidemiology Unit Institute for Cancer ResearchPrevention and Clinical Network(ISPRO)Florence 2-50139Italy Epidemiology and Prevention Unit Fondazione irccs istituto Nazionale dei Tumori di Milano Milan 20133Italy Department of Clinical Medicine and Surgery University of Naples Federico IINaples 80138Italy Department of Clinical and Biological Sciences University of TurinTurin 1012Italy Department of Community Medicine UiT-the Arctic University of NorwayTromsø9037Norway Unit of Nutrition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelona 08908Spain Department of Epidemiology Harvard T.H.Chan School of Public HealthBoston 02115USA Department of Nutrition and Food Science Faculty of PharmacyUniversity of GranadaGranada 18071Spain Ministry of Health of the Basque Government Sub Directorate for Public Health and Addictions of GipuzkoaSan Sebastian 20013Spain Biodonostia Health Research Institute Epidemiology of Chronic and Communicable Diseases GroupSan Sebastián 2014Spain Spanish Consortium for Research on Epidemiology and Public Health(CIBERESP) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Epidemiology Murcia Regional Health CouncilIMIB-ArrixacaM

Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed *** of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing *** production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].

关键词： dietary intake hence

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miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子

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神经损伤与功能重建 2018年第12期13卷 662-662页

作者： van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 Department of (Neuro)Pathology Academic Medical Center University of Amsterdam Department of Neuroscience IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri" Department of Pediatric Neurology University Medical Center Utrecht Department of Pathology University Medical Center Utrecht Department of Neurosurgery Rudolf Magnus Institute for NeuroscienceUniversity Medical Center Utrecht Department of Neurosurgery VU University Medical Center Stichting Epilepsie Instellingen Nederland (SEIN)

星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞... 详细信息

星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。

关键词：星形胶质细胞炎症白细胞介素1-β 微小RNA 颞叶癫痫结节性硬化症

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Feasibility and safety of self-expandable metal stent in nonmalignant disease of the lower gastrointestinal tract

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World Journal of Gastrointestinal Endoscopy 2020年第2期12卷 60-71页

作者： Ludovica Venezia Andrea Michielan Giovanna Condino Emanuele Sinagra Elisa Stasi Marianna galeazzi Carlo Fabbri Andrea Anderloni Gastroenterology Unit AOU Cittàdella Salute e della Scienza TurinTurin 10100Italy Gastroenterology and Digestive Endoscopy Unit Ospedale Santa ChiaraTrento 38122Italy Gastroenterology Unit Azienda Ospedaliera S.S.Antonio e Biagio e Cesare ArrigoAlessandria 15121Italy Gastroenterology and Endoscopy Unit Fondazione Istituto Giuseppe GiglioContrada Pietra Pollastra PisciottoCefalù90015Italy Euro-Mediterranean Institute of Science and Technology(IEMEST) Palermo 90100Italy Gastroenterology Unit Department of Medicine“Vito Fazzi”HospitalLecce 73100Italy University of Milano-Bicocca School of Medicine and SurgeryMonza 20052Italy Gastroenterology and Digestive Endoscopy Unit Forlì-CesenaAzienda U.S.L.RomagnaOspedale G.Morgagni-L.PierantoniCesena 200868Italy Digestive Endoscopy Unit Humanitas Research HospitalMilan 20100Italy

In recent years,self-expandable metal stents(SEMSs)have been employed to treat benign gastrointestinal strictures secondary to several conditions:Acute diverticulitis,radiation colitis,inflammatory bowel disease(IBD),and postanastomotic leakages and *** applications include endometriosis and fistulas of the lower gastrointestinal *** it may be technically feasible to proceed to stenting in the aforementioned benign diseases of the lower gastrointestinal tract,the outcome has been reported to be *** fact,in some settings(such as complicated diverticulitis and postsurgical anastomotic strictures),stenting seems to have a limited evidence-based benefit as a bridge to surgery,while in other settings(such as endometriosis,IBD,radiation colitis,etc.),even society guidelines are not able to guide the endoscopist through decisional algorithms for SEMS *** aim of this narrative paper is to review the scientific evidence regarding the use of SEMSs in nonmalignant diseases of the lower gastrointestinal tract,both in adult and pediatric settings.

关键词： Self-expandable metal stents Lower gastrointestinal tract Benign strictures

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Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer

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四川生理科学杂志 2021年第1期43卷 158-158页

作者： Yi-Long Wu From the Guangdong Lung Cancer Institute Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences Guangzhou (Y.-L.W.) the Thoracic Surgery Department National Cancer Center–National Clinical Research Center for Cancer–Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing (J.H.) and the Lung Cancer Center Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai (S.L.) — all in China the Department of Thoracic Surgery and Oncology National Cancer Center Hospital East Kashiwa (M.T.) and the Department of Thoracic Oncology Kanagawa Cancer Center Yokohama (T.K.) — both in Japan the Department of Medical Oncology Austin Health Melbourne VIC Australia (T.J.) the Department of Respiratory Diseases Evangelische Lungenklinik Berlin (C.G.) the Department of Medical Oncology Hospital de la Santa Creu i Sant Pau Barcelona (M.M.) and the Department of Oncology Hospital Universitario Fundación Jiménez Díaz Madrid (M.D.) the David Geffen School of Medicine at the University of California Los Angeles Los Angeles (J.W.G.) the Center of Innovative Technologies and Oncology N.N. Blokhin Russian Cancer Center Russian Academy of Medical Sciences Moscow (K.L.) the Department of Oncology Asan Medical Center University of Ulsan College of Medicine (S.-W.K.) and the Precision Medicine Lung Cancer Center Konkuk University Medical Center (K.-Y.L.) — both in Seoul South Korea the Department of Thoracic Surgery Cho Ray Hospital Ho Chi Minh City Vietnam (H.-V.V.) the Division of Medical Oncology Faculty of Medicine Siriraj Hospital Bangkok Thailand (C.A.) the Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan (C.-J.Y.) the Division of Thoracic Oncology European Institute of Oncology IRCCS Milan (F.M.) and Medical Oncology 2 Istituto Oncologico Veneto IRCCS Padua (L.B.) — both in Italy the Department of Medical Oncology and Hematology Univers

Background:Osimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor(EGFR)mutation-positive advanced non-small-cell lung cancer(NSCLC).The efficacy and safety of osimertinib as adjuvant therapy are ***:In this double-blind,phase 3 trial,we randomly assigned patients with completely resected EGFR mutation-positive NSCLC in a 1:1 ratio to receive either osimertinib(80 mg once daily)or placebo for 3 *** primary end point was disease-free survival among patients with stage Ⅱ to ⅢA disease(according to investigator assessment).

关键词： Lung NSCLC lung

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Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

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2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng Taguchi,Ayumu Dhillon,Dilsher Kundnani,DeepaliL. Patel,NikulJ. Yan,Qingxiang Byrnes,Graham Moons,KarelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,KarlSmith Boeing,Heiner Steffen,Annika Kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete N?st,ThereseH. Tsilidis,Kostas Riboli,Elio Grankvist,Kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,Samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology Group International Agency for Research on Cancer Department of Biostatistics The University of Texas MD Anderson Cancer Center Department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer Department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center Department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-Style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of Nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat Department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia Research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de Granada/Universidad de Granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de Navarra (IdiSNA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford Department of Epidemi

IMPORTANCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of ***:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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小胶质细胞控制成年小鼠海马中的谷氨酸能突触

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神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano Maria T Golia Alfonso Grimaldi Maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini Maria C Marrone Maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo Marie-Kim St-Pierre Micael Carrier Massimiliano Renzi Francesca Pagani Brijesh Modi Marcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia Marinelli Marie-Ève Tremblay Daniele Caprioli Laura Maggi Cristina Limatola Silvia Di Angelantonio Davide Ragozzino Department of Physiology and Pharmacology Sapienza University of RomeRomeItaly. Neurophysiology and Neuropharmacology Inflammaging Unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. Center for Life Nano-and Neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartimento di Biologia e Biotecnologie“Charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(irccs Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-Montalcini’ RomeItaly. CrestOptics S.p.A RomeItaly. Centre de Recherche du CHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Département de Médecine Moléculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research Council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and Neurobiology Unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of Medical Sciences University of VictoriaVictoriaCanada.1 Department of Physiology and Pharmacology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触

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Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy

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四川生理科学杂志 2022年第5期44卷 897-897页

作者： Yao-Chung Liu From the Department of Pathology Brigham and Women's Hospital (Y.-C.L. C. Gao Jun Liu J.Y. L. Chai) Harvard Stem Cell Institute Harvard Medical School (A.I.J. M.A.B. D.G.T.) and the Department of Medical Oncology Dana-Farber Cancer Institute (R.P.) - all in Boston the Division of Hematology Department of Medicine Taipei Veterans General Hospital (Y.-C.L.) and the Faculty of Medicine and the Program in Molecular Medicine Institute of Biopharmaceutical Sciences School of Life Science National Yang Ming Chiao Tung University (Y.-C.L. J.-H.L.) - both in Taipei Taiwan the Cancer Science Institute of Singapore Singapore (J.K. Y.V.L. H.Y. M.A.B. D.G.T.) the Department of Biomedicine and Prevention University of Rome Tor Vergata (E.F. G.F. L.V. C. Gurnari M.T.V.) and UniCamillus-Saint Camillus International University of Health Sciences (E.F.) Rome and Cellular Signaling Laboratory Department of Biomedical and Neuromotor Sciences University of Bologna (M.Y.F. L. Cocco) and IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" (C.F.) Bologna - all in Italy the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China (Z.X. Jinqin Liu H.H.) and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T. J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U. J.E.P.) Faculty of Medicine University of New South Wales Sydney and the Department of Hematology Prince of Wales Hospital Randwick NSW (J.E.P.) - both in Australia.

Background:Although hypomethylating agents are currently used to treat patients with cancer,whether they can also reactivate and up-regulate oncogenes is not well ***:We examined the effect of hypomethylating agents on SALL4,a known oncogene that plays an important role in myelodysplastic syndrome and other *** bone marrow samples that were obtained from two cohorts of patients with myelodysplastic syndrome before and after treatment with a hypomethylating agent were used to explore the relationships among changes in SALL4 expression,treatment response,and clinical *** cell lines with low or undetectable SALL4 expression were used to study the relationship between SALL4 methylation and expression.A locus-specific demethylation technology,CRISPR-DNMT1-interacting RNA(CRISPR-DiR),was used to identify the CpG island that is critical for SALL4 expression.

关键词： SALL4 expression. patients

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神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐

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国际脑血管病杂志 2019年第2期27卷 84-97页

作者： Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) Department of Medic al-Surgical Intensive Care Medicine Faculty of Biology and Medicine Centre Hospitalier Universitaire VauDOIs (CHUV) Lhiversity of Lausanne Rue du Bugnon 46 B4 08.623 1011 Lausanne Switzerland Department of Intensive Care Medicine St James's Lhiversity Hospital James's St Ushers P.O. Box 580 Dublin & Ireland Service de Reanimation Medic o-chirurgic ale Hopital Pasteur 2 UniversiteCote d'Azur CHU de Nice 06000 Nice France Unite CNRS 7275 Sophia-Antipolis France Department of Intensive Care Erasme Hospital University Libre de Bruxelles Brussels Belgium Neurosciences Critical Care Departments of Anesthesiology and Critical Care Medicine Neurology and Neurosurgery Johns Hopkins Lhiversity Baltimore MD USA Department of Neurology University of California San Francisco San Francisco CA LKA Service de Reanimation Polyvalente Hopital Pasteur 2 CHU de Nice 30 Voie Romaine CS 51069 06001 Nice Cedex 1 France Division of Anaesthesia University of Cambridge Addenbrooke's Ffospital Box 93 Hfills Road Cambridge Cambridgeshire CB2 2QQ UK Department of Intensive Care 4131 Copenhagen University Hospital- Rigshospitalet Copenhagen Denmark Department of Neuroanesthesia and Neurocritic al Care The National Ffospital for Neurosurgery and Neurology Lhiversity College London Hospitals London UK Anesthesia and Intensive Care Operative th it S. Martino Hospital Belluno Italy Hospital Nacional Professor Alejandro Posadas Buenos Aires Argentina Department of Neurosciences IRCCS-Istituto di Ricerche Farmacotogiche Mario Negri Milan Italy School of Medicine and Surgery University of Milan-Bicocca Milan Italy Neurointensive Care San Gerardo Hospital ASST-Monza 20900 Monza Italy 南方医科大学南方医院神经内科广州510515 Neurological Intensive Care Lhit Department of Neurology Medical University of Innsbruck Innsbruck Austria Department of Intensive Care Medicine University Hospitals Leuven Louvain Belgium Neuroscience Intensive Care Unit Department of Anesthesia and C

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会... 详细信息

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。

关键词：循证医学指南液体治疗创伤性脑损伤蛛网膜下腔出血脑出血卒中甘露醇高渗神经重症监护

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小胶质细胞在光/暗周期过程中调节海马突触传递和睡眠持续时间

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神经损伤与功能重建 2022年第5期17卷 310-310页

作者：杜一星(编译) Department of Physiology and Pharmacology Sapienza University of Rome Axe Neurosciences Centre de Recherche du CHU de Québec Université Laval Quebec City Department of Neurology San Raffaele of Cassino 4. National Research Council Institute of Biochemistry and Cell Biology (EMMA/Infrafrontier/IMPC ) International Campus "A. Buzzati-Traverso" INRAE Bordeaux INP NutriNeuro UMR 1286 Bordeaux University Tecniplast S.P.A. Buguggiate Department of Molecular Medicine Sapienza University INSERM Neurocentre Magendie Physiopathologie de la Plasticité Neuronale Division of Medical Sciences University of Victoria The Department of Biochemistry and Molecular Biology The University of British Columbia Department of Physiology and Pharmacology Sapienza University Laboratory affiliated to Istituto Pasteur Italia Department of Neurophysiology Neuropharmacology Inflammaging IRCCS Neuromed

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研... 详细信息

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研究。以光作为授时提示,我们研究了用集落刺激因子-1受体拮抗剂PLX5622消除小胶质细胞对雄性小鼠睡眠/觉醒周期和海马突触传递的影响。我们的数据表明,小胶质细胞几乎完全的耗竭会增加NREM睡眠的持续时间并减少海马兴奋性神经传递。由于cx3cr1GFP/GFP小鼠显现与PLX5622处理的小鼠中发现的相同情况,趋化因子fractalkine受体CX3CR1在这些效应中起相关作用。此外,在光照阶段小胶质细胞表达较低水平的cx3cr1;当培养的小胶质细胞受到ATP(一种在睡眠期间释放的嘌呤能分子)的刺激时其cx3cr1表达降低。我们的研究结果表明,小胶质细胞参与调节睡眠,调整其cx3cr1表达以响应光/暗阶段,并以时相依赖性方式调节突触活动。

关键词： cx3cr1 脑电图长期增强小胶质细胞耗竭微型兴奋性突触后电流睡觉眠自发兴奋性突触后电流

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