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Neural Regeneration Research 2011年第29期6卷 2295-2297页

作者： Rosa Morabito Annalisa Baglieri Rosella Ciurleo Francesco Corallo Rosaria De Luca Simona De Salvo Silvia Guerrera Francesca Timpano Maria Adele Marino Placido Bramanti Silvia Marino Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo"MessinaItaly

The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

关键词： Creutzfeldt-Jacob disease fluid-attenuated inversion recovery diffusion-weighted imaging magnetic resonance imaging

Magnetic resonance imaging markers for early diagnosis of Parkinson's disease

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Neural Regeneration Research 2012年第8期7卷 611-619页

作者： Silvia Marino Rosella Ciurleo Giuseppe Di Lorenzo Marina Barresi Simona De Salvo Sabrina Giacoppo Alessia Bramanti Pietro Lanzafame Placido Bramanti Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo" Messina 98124 Italy

Parkinson＇s disease （PD） is a neurodegenerative disorder characterized by selective and progressive degeneration, as well as loss of dopaminergic neurons in the substantia nigra. In PD, approximately 60-70% of nigrostriatal neurons are degenerated and 80% of content of the striatal dopamine is reduced before the diagnosis can be established according to widely accepted clinical diagnostic criteria. This condition describes a stage of disease called ＂prodromal＂, where non-motor symptoms, such as olfactory dysfunction, constipation, rapid eye movement behaviour disorder, depression, precede motor sign of PD. Detection of prodromal phase of PD is becoming an important goal for determining the prognosis and choosing a suitable treatment strategy. In this review, we present some non-invasive instrumental approaches that could be useful to identify patients in the prodromal phase of PD or in an early clinical phase, when the first motor symptoms begin to be apparent. Conventional magnetic resonance imaging （MRI） and advanced MRI techniques, such as magnetic resonance spectroscopy imaging, diffusion-weighted and diffusion tensor imaging and functional MRI, are useful to differentiate early PD with initial motor symptoms from atypical parkinsonian disorders, thus, making easier early diagnosis. Functional MRI and diffusion tensor imaging techniques can show abnormalities in the olfactory system in prodromal PD.

关键词： Parkinson’s disease early diagnosis conventional magnetic resonance imaging magnetic resonance spectroscopy diffusion-weighted imaging diffusion tensor imaging functional magnetic resonance imaging olfactory dysfunction

Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment

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Neural Regeneration Research 2021年第3期16卷 587-590页

作者： Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno Department of Neurobioimaging Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Centro Neurolesi Bonino-PulejoMessinaItaly

Anxiety and depression in Parkinson's disease(PD)reduce well-being of the *** alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment *** investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative *** self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December ***,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive *** multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech ***-motor symptoms may worsen severe disability and reduce quality of *** are often poorly recognized and inadequately ***,multidisciplinary rehabilitative training represents an optimal strategy to improve disease *** study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(irccs)centro neurolesi"bonino-pulejo"Ethical Committee(approval No.6/2016)in June 2016.

关键词： anxiety depression multidisciplinary rehabilitation Parkinson's disease

Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis？

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Neural Regeneration Research 2016年第12期11卷 1896-1899页

作者： Sabrina Giacoppo Emanuela Mazzon irccs centro neurolesi"bonino-pulejo" Via Provinciale PalermoContrada CasazzaMessinaItaly

Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.

关键词： amyotrophic lateral sclerosis cannabinoids symptomatic ALS treatment experimental ALS model clinical trials mechanisms of neuroprotection

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Neural Regeneration Research 2013年第17期8卷 1615-1622页

作者： Letteria Spadaro Lilla Bonanno Giuseppe Di Lorenzo Placido Bramanti Silvia Marino Istituto di Ricovero e Cura a Carattere Scientifico centro neurolesi "bonino pulejo" Via Provinciale Palermo

Parkinson＇s disease has a negative impact on health-related quality of life in Parkinson＇s disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopaminergic drugs are the variables that most affect health-related quality of life. The ecological model of human development focuses attention on both individual and social environmental factors as targets for health interventions. From this perspective, the aim of this cross-sectional survey was to evaluate the influence of gender, family size and perceived autonomy on health-related quality of life in Parkinson＇s disease patients in nOrtheastern Sicily, Italy. Ninety Parkinson＇s disease patients, attending the Movement Disorders Clinic at irccs centro neurolesi ＂bonino-pulejo＂（Messina）, were consecutively enrolled. The Unified Parkinson Disease Rating Scale motor subscale （UPDRS-Ⅲ） scores, the Parkinson Disease Questionnaire-39 Item scores （as a disease-specific measure of health-related quality of life）, scores on the Short Form （36） Health Survey Questionnaire （as a generic measure）, and answers to a brief checklist were recorded. A total of 85 Parkinson＇s disease patients （49% males and 51% females; mean age 70.8 ± 8.6 years mean UPDRS-Ⅲ 24.15 ± 6.55; mean disease duration 5.52 ± 4.65 years） completed the booklet of questionnaires. In the multivariate regression analysis, we included clinical and social variables as independent predictors of health-related quality of life. Our results suggest a potential compounding effect of ecological intrapersonal and interpersonal levels on health-related quality of life outcomes. Gender, self-evaluated autonomy and family size significantly impacted health-related quality of life. If quality of life is used as an indicator of treatment outcomes, an ecological perspective of the case history will be important to disclose relevant prognostic information and trigger personalized health care interventions.

关键词： neural regeneration neurodegenerative disease health-related quality of life Parkinson's disease ecological model Parkinson's Disease Questionnaire-39 Items social variables the UnifiedParkinson Disease Rating Scale motor subscales caregiver grants-supported paper

Deficit of pursuit ocular movements in early Alzheimer's disease

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Neural Regeneration Research 2010年第20期5卷 1583-1586页

作者： Francesco Cordici Pietro Lanzafame Silvia Marino Alessandro Celona Lilla Bonanno Annalisa Baglieri Alessia Bramanti Placido Bramanti irccs centro neurolesi "bonino-pulejo" S.S. Via Palermo C.da Casazza 98124 Messina Italy

Previous studies have demonstrated that advanced Alzheimer＇s disease（AD）patients have deficiency of eye ***,there have been no reports on eye movement in the early stages of *** aim of this study was to evaluate pursuit ocular movements（POM）provided by a vision-based non-intrusive eye tracker in patients with early *** values were significantly lower in AD patients than in normal controls（P 〈 0.01）.In AD patients,POM values were not closely correlated with the Mini-Mental State Examination scores（P = 0.3）.There was no significant difference in POM values among patients treated with or without anticholinesterase *** used a vision-based method,for non-intrusive eye tracking,which can be proposed as a possible tool for supporting the diagnosis of early AD.

关键词： Alzheimer's disease early diagnosis pursuit ocular movements smooth pursuit dysfunctions vision-based eye tracking system

Role of genomics in cardiovascular medicine

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World Journal of Cardiology 2010年第12期2卷 428-436页

作者： Giuseppe Novelli Irene M Predazzi Ruggiero Mango Francesco Romeo Jawahar L Mehta Department of Biopathology and Diagnostic Imaging Section of Medical Genetics School of MedicineTor Vergata University Department of Internal Medicine University of Arkansas for Medical Sciences centro neurolesi"bonino pulejo" 98100 Messina Italy Department of Internal Medicine University of Rome Tor Vergata

As all branches of science grow and new experimental techniques become readily accessible,our knowledge of medicine is likely to increase exponentially in the coming *** developed technologies have revolutionized our analytical capacities,leading to vast knowledge of many genes or genomic regions involved in the pathogenesis of congenital heart diseases,which are often associated with other genetic syndromes,coronary artery disease and non-ischemic cardiomyopathies and *** knowledge-base of the genesis of cardiovascular diseases is likely going to be further revolutionized in this new era of genomic ***,we review the advances that have been made over the last several years in this field and discuss different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases.

关键词： Genomics Polymorphisms Mutations Complex diseases Atherosclerosis

Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications

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World Journal of Stem Cells 2022年第1期14卷 54-75页

作者： Carla Vicinanza Elisabetta Lombardi Francesco Da Ros Miriam Marangon Cristina Durante Mario Mazzucato Francesco Agostini Stem Cell Unit Centro di Riferimento Oncologico di AvianoIRCCSAviano 33081Italy

Mesenchymal stem stromal cells(MSC)are characterized by the intriguing capacity to home toward cancer cells after systemic ***,MSC can be harnessed as targeted delivery vehicles of cytotoxic agents against *** cancer patients,MSC based advanced cellular therapies were shown to be safe but their clinical efficacy was ***,the amount of systemically infused MSC actually homing to human cancer masses is insufficient to reduce tumor ***,induction of an unequivocal anticancer cytotoxic phenotype in expanded MSC is necessary to achieve significant therapeutic *** vivo cell modifications are,thus,required to improve anti-cancer properties of *** based cellular therapy products must be handled in compliance with good manufacturing practice(GMP)*** the present review we include MSCimproving manipulation approaches that,even though actually tested at preclinical level,could be compatible with GMP *** particular,we describe possible approaches to improve MSC homing on cancer,including genetic engineering,membrane modification and cytokine ***,we discuss appropriate modalities aimed at inducing a marked cytotoxic phenotype in expanded MSC by direct chemotherapeutic drug loading or by genetic *** conclusion,we suggest that,to configure MSC as a powerful weapon against cancer,combinations of clinical grade compatible modification protocols that are currently selected,should be introduced in the final *** standardized cancer clinical trials are required to test the efficacy of ameliorated MSC based cell therapies.

关键词： Cancer Mesenchymal stem stromal cells Good manufacturing practice Homing Targeted therapy Ex vivo cell modification

Difficult case of a trans-septal puncture: Use of a “SafeSept” guidewire

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World Journal of Cardiology 2015年第8期7卷 499-503页

作者： Martina Zucchetti Michela Casella Antonio Dello Russo Gaetano Fassini Corrado Carbucicchio Eleonora Russo Vittoria Marino Valentina Catto Claudio Tondo Cardiac Arrhythmia Research Centre Centro Cardiologico Monzino IRCCS 20138 Milan Italy

A 69-year-old man was admitted to our center to undergo catheter ablation of paroxysmal atrial fibrillation refractory to antiarrhythmic drug therapy. This procedure required access to the left atrium through the interatrial septum. During hospitalization, the patient performed routinely pre-procedure transthoracic echocardiography and gadolinium-enhanced cardiac magnetic resonance showing a normal anatomy of both the fossa ovalis and the interatrial septum. Access to the left atrium proved difficult and several unsuccessful attempts to perform the trans-septal puncture were made under both fluoroscopy and intracardiac echocardiography guidance, even with radiofrequency energy delivery. Finally, trans-septal puncture was successfully carried out using a novel nitinol J-shaped "Safe Sept" trans-septal guidewire, designed to cross the interatrial septum through the trans-septal needle thanks to a special sharp tip. Moreover, thanks to its rounded J shape that reduces the risk of atrial perforation, the "Safe Sept" guidewire, when advanced into the left atrium, becomes atraumatic.

关键词： Trans-septal puncture "Safe Sept" guide-wire Atrial fibrillation Interatrial septum Intracardiac echocardiography

Clinical significance of erectile dysfunction developing after acute coronary event： exception to the rule or confirmation of the artery size hypothesis？

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Asian Journal of Andrology 2015年第1期17卷 21-25,I0006页

作者： Piero Montorsi Paolo M Ravagnani Charalambos Vlachopoulos Department of Clinical Sciences and Community Health Cardiovascular Section University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Department of Cardiology Athens Medical School Greece.

Erectile dysfunction （ED） has been found to frequently precedes the onset of coronary artery disease （CAD）, representing an early marker of subclinical vascular disease, included CAD. Its recognition is, therefore, a ＂window opportunity＂ to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis （ASH） has been proposed as a putative mechanism to explain the relationship between ED and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels （i.e. the penile artery） being able to less well tolerate the same amount of plaque when compared with larger ones （i.e. the coronary artery）. If true, ED will develop before CAD. We present a case in which ED developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.

关键词： artery size hypothesis coronary artery disease erectile dysfunction