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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González Elena González-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation

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Molecular Plant 2021年第11期14卷 1779-1781页

作者： Miguel Daniel-Mozo Armando Albert Instituto de Quimica Ffsica Rocasolano Consejo Superior de Investigaciones Cientificas(IQFR-CSIC)Calle Serrano 11928006 MadridSpain

Protein kinases are a conserved superfamily of proteins that play an essential role in signal transduction by attaching a phosphoryl group to serine,threonine,or tyrosine residues of a protein,hence converting them to *** process,which can be reversed by protein phosphatases,regulates vital cellular processes in plants,including metabolism,proliferation,and *** is also key to trigger response mechanisms to drought,increased salinity,and other abiotic stresses(Zhu,2016).

关键词： hence reversed translational

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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： JoséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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An optical fiber network oracle for NP-complete problems

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Light(Science & Applications) 2014年第1期3卷 304-308页

作者： Kan Wu Javier Garcia de Abajo Cesare Soci Perry Ping Shum Nikolay I Zheludev Centre for Disruptive Photonic Technologies Nanyang Technological UniversitySingapore 637371Singapore Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK iqfr-csic 28006 MadridSpain

The modern information society is enabled by photonic fiber networks characterized by huge coverage and great complexity and ranging in size from transcontinental submarine telecommunication cables to fiber to the home and local *** world-wide network has yet to match the complexity of the human brain,which contains a hundred billion neurons,each with thousands of synaptic connections on ***,it already exceeds the complexity of brains from primitive organisms,i.e.,the honey bee,which has a brain containing approximately one million *** this study,we present a discussion of the computing potential of optical networks as information *** a simple fiber network,we provide a proof-of-principle demonstration that this network can be treated as an optical oracle for the Hamiltonian path problem,the famous mathematical complexity problem of finding whether a set of towns can be travelled via a path in which each town is visited only *** of a Hamiltonian path is achieved by monitoring the delay of an optical pulse that interrogates the network,and this delay will be equal to the sum of the travel times needed to visit all of the nodes(towns).We argue that the optical oracle could solve this NP-complete problem hundreds of times faster than brute-force ***,we discuss secure communication applications for the optical oracle and propose possible implementation in silicon photonics and plasmonic networks.

关键词： Hamiltonian path problem NP complete optical oracle

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The magnetic response of graphene split-ring metamaterials

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Light(Science & Applications) 2013年第1期2卷 124-127页

作者： Nikitas Papasimakis Sukosin Thongrattanasiri Nikolay I Zheludev FJ Garcıa de Abajo Optoelectronics Research Centre and Centre for Photonic Metamaterials University of SouthamptonSouthamptonUK iqfr–csic Serrano 11928006 MadridSpain Centre for Disruptive Photonic Technologies Nanyang Technological UniversitySingapore ICFO–Institut de Ciencies Fotoniques Mediterranean Technology Park08860 Castelldefels(Barcelona)Spain

Graphene has emerged as a promising platform for THz plasmonics,allowing high confinement,long lifetimes and fast electrical ***,we predict a strong magnetic dipole response by graphene split nanorings at THz frequencies,allowing the attainment of metamaterials with a high degree of field confinement(approximately one hundredth of the excitation wavelength)that is not reachable with conventional noble *** magnetic response of highly doped graphene split-rings in the far-infrared is much stronger than that displayed by gold structures of similar *** further explored stacked graphene layers as a practical way of producing high-frequency magnetism in thin,electrically tunable *** results support the great potential of using graphene to achieve electrically tunable magnetic metamaterials.

关键词： artificial magnetism graphene graphene plasmons metamaterials plasmonics

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MPC and TGFC for UAV Real-time Route Planning 36

MPC and TGFC for UAV Real-time Route Planning

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第36届中国控制会议

作者： Qiang Wang Jianjun Zhang csic 710

ISBN: (纸本)9781538629185

This paper proposed a method of real-time route planning for UAV based on model predictive control（MPC）and threat gain fuzzy controller（TGFC）.First the model of three-dimensional route planning of UAV was built by MPC,including complex *** the TGFC was designed based on fuzzy control theory,in order to make UAV escape from the sudden threat *** the route was calculated by differential evolution *** simulations showed that the method could make a good performance of real-time,and it could enable UAV achieve the goal of terrain following and threat avoidance（TF/TA2）.

关键词： unmanned aerial vehicle real-time route planning model predictive control threat gain fuzzy controller

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Neural functions of small heat shock proteins

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Neural Regeneration Research 2022年第3期17卷 512-515页

作者： Teresa de los Reyes Sergio Casas-Tintó Instituto Cajal CSICMadridSpain

Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular factors that converge in a defense reaction to protect the cell against *** many mechanisms described,heat shock proteins were proposed as universally conserved protective factors in the stress core proteome,coping with different stress stimuli through its canonical role in protein ***,emerging evidences reveal non-canonical roles of heat shock proteins relevant for physiological and pathological ***,we review the implications of inducible heat shock proteins in the central nervous system *** particular,we discuss the relevance of heat shock proteins in the maintenance of synapses,as a balanced protective mechanism in central nervous system development,pathological conditions and aging.

关键词： aging central nervous system chaperones environment neuroprotection pathology stress synapses

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Experimental study on fly ash capture mercury in flue gas

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Science China(Technological Sciences) 2010年第4期53卷 976-983页

作者： Mercedes DíAZ-SOMOANO Patricia ABAD-VALLE M.Rosa MARTíNEZ-TARAZONA Instituto Nacional del Carbón(csic)

Systematic experiments were conducted on a fixed-bed reactor to investigate the interaction between fly ash and mercury,the results implied that fly ash can capture mercury *** different fly ashes,the unburned carbon in the FA2 and FA3 fly ashes has the highest mercury capture capacity,up to 10.3 and 9.36 μg/g,respectively,which is close to that of commercial activated *** is no obvious relationship between mercury content and carbon content or BET surface area of fly *** classification standard was applied to distinguish fly ash carbon *** content is not the only variable that controls mercury capture on fly ash,there are likely significant differences in the mercury capture capacities of the various carbon *** capture capacity mainly depends on the content of anisotropy carbon particles with porous network structure.

关键词： mercury fly ash unburned carbon petrography adsorption

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Superficial Color Patches as a Visual Diagnostic Criterion for Agricultural Management

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Pedosphere 2013年第6期23卷 740-751页

作者： C.CASTANEDA D.MORET-FERNNDEZ Estacio'n Experimental de Aula Dei CSIC

Soil management matters in semiarid lands are key to have acceptable yields and to preserve diversity. After the major agricultural intensification underwent in the semiarid lands of Monegros, NE Spain, custom tailored tools are needed to reconcile agriculture with habitats conservation. The objectives of this study were to quantify the effect of soil properties of two distinctly colored soils, white patches （WP） and dark patches （DP）, dominant in the arid landscape of the central Ebro Basin, Spain on winter cereal grain yield and to prove that superficial soil color could be used as a visual diagnostic criterion for evaluation of agricultural practices in arid lands. Significant differences between WP and DP soils were found in gypsum, carbonate contents, available water holding capacity and infiltration rate. The grain yield ranged from 51 to 5 713 kg ha-1. Significantly lower yields （P 〈 0.01） and precipitation-use efficiency （P 〈 0.05） were attained in the WP soils for the three seasons studied. This difference increased with the average rainfall due to the significantly lower soil water infiltration （P 〈 0.01） and water holding capacity （P 〈 0.05） found in the gypseous soils. Our results show that mapping the soil surface color at farm scale can be a low=cost tool for optimizing agricultural practices and recovering the natural vegetation. This approach can be advantageous in similar arid or semiarid environments around the world.

关键词： arid zones dryland cropping gypsum hydraulic conductivity soil mapping

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Catastrophic climate change and the collapse of human societies

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National Science Review 2023年第6期10卷 52-54页

作者： Josep Pe?uelas Sandra Nogué CREAF Cerdanyola del Vallès csic Global Ecology Unit CREAF-CSIC-UAB Universitat Autònoma de Barcelona

The scientific community has focused the agenda of studies of climate change on lower-end warming and simple risk analyses,because more realistic complex assessments of risk are more difficult,the benchmark of the international targets is the Paris Agreement goal of limiting warming to <2℃,and the culture of climate science is to try to avoid alarmism[1].Current fires,prolonged droughts,floods and heat waves,together with the consequent food insecurity,civil unrest and migrations,however,are opening the eyes not only of most scientists but also of most people all over the world to the need for considering,at least,the potential catastrophic effects of the collapse of ecosystems and society due to the current emergency of climate change.

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