检索结果-南通市图书馆

Control of embryonic stem cell metastability by L-proline catabolism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2011年第2期3卷 108-122页

作者： Laura Casalino Stefania Comes Giuseppina Lambazzi Benedetta De Stefano Stefania Filosa Sandro De Falco Dario De Cesare Gabriella Minchiotti Eduardo Jorge Patriarca Stem Cell Fate Laboratory Institute of Genetics and Biophysics“A.Buzzati-Traverso”CNRNaplesItaly

The molecular mechanisms controlling mouse embryonic stem cell(ESC)metastability,*** capacity to fluctuate between different states of pluripotency,are not fully *** developed and used a novel automation platform,the Cellmaker,to screen a library of metabolites on two ESC-based phenotypic assays(*** and colony phenotype)and identified two metabolically related amino acids,namely L-proline(L-Pro)and L-ornithine(L-Orn),as key regulators of ESC *** compounds,but mainly L-Pro,force ESCs toward a novel epiblast stem cell(EpiSC)-like state,in a dose-and time-dependent *** EpiSCs,L-Pro-induced cells(PiCs)contribute to chimeric embryos and rely on leukemia inhibitor factor(LIF)to ***,PiCs revert to ESCs or differentiate randomly upon removal of either L-Pro or LIF,***,PiC generation depends on both L-Pro metabolism(uptake and oxidation)and Fgf5 induction,and is strongly counteracted by antioxidants,mainly L-ascorbic acid(vitamin C,Vc).ESCs↔PiCs phenotypic transition thus represents a previously undefined dynamic equilibrium between pluripotent states,which can be unbalanced either toward an EpiSC-like or an ESC phenotype by L-Pro/L-Orn or Vc treatments,*** together,our data provide evidence that ESC metastability can be regulated at a metabolic level.

关键词： embryonic stem cells L-proline vitamin C colony phenotype pluripotent states metastability

3D floor plan recovery from overlapping spherical images

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2018年第4期4卷 367-383页

作者： Giovanni Pintore Fabio Ganovelli Ruggero Pintus Roberto Scopigno Enrico Gobbetti CRS4 Visual Computing Group cnr-ISTI Visual Computing Group

We present a novel approach to automatically recover, from a small set of partially overlapping spherical images, an indoor structure representation in terms of a 3D floor plan registered with a set of 3D environment maps. We introduce several improvements over previous approaches based on color and spatial reasoning exploiting Manhattan world priors. In particular, we introduce a new method for geometric context extraction based on a 3D facet representation,which combines color distribution analysis of individual images with sparse multi-view clues. We also introduce an efficient method to combine the facets from different viewpoints in a single consistent model, taking into the reliability of the facet information. The resulting capture and reconstruction pipeline automatically generates 3D multi-room environments in cases where most previous approaches fail, e.g., in the presence of hidden corners and large clutter, without the need for additional dense 3D data or tools. We demonstrate the effectiveness and performance of our approach on different real-world indoor scenes. Our test data is available to allow further studies and comparisons.

关键词： indoor reconstruction spherical panoramic cameras 360 degree photography multi-room environments

Spatiotemporal oxygen dynamics in young leaves reveal cyclic hypoxia in plants

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2024年第3期17卷 377-394页

作者： Paolo M.Triozzi Luca Brunello Giacomo Novi Gianmarco Ferri Francesco Cardarelli Elena Loreti Mariano Perales Pierdomenico Perata PlantLab Center of Plant SciencesSant'Anna School of Advanced Studies56010 PisaItaly Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA-CSIC)Campus de Montegancedo UPMPozuelo de Alarcon28223 MadridSpain Fondazione Pisana per la Scienza 56017 PisaItaly Laboratorio NEST Scuola Normale SuperioreIstituto Nanoscienze-CNRPiazza S.Silvestro1256127 PisaItaly institute of Agricultural Biology and Biotechnology National Research Council56124 PisaItaly Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 Madrid.Spain

Oxygen is essential for plant growth and *** occurs in plants due to limited oxygen avail-abilityfollowing adverse environmental conditions as well inhypoxic niches in otherwisenormoxic ***,the existence and functional integration of spatiotemporal oxygen dynamics with plant development remains *** animal systems dynamic fluctuations in oxygen availability are known as cyclic *** this study,we demonstrate that cyclic fluctuations in internal oxygen levels occur in young emerging leaves of Arabidopsis *** hypoxia in plants is based on a mechanism requiring the ETHYLENE RESPONSE FACTORS type VII(ERFVII)that are central components of the oxygen-sensing machinery in *** ERFVll-dependent mechanism allows precise adjustment of leaf growth in response to carbon status and oxygen availability within plant *** study thus establishes a functional connection between internal spatiotemporal oxygen dynamics and developmental processes of plants.

关键词： Arabidopsis hypoxia cyclic hypoxia leaf development oxygen-sensing mechanism ERFVII

Metal Oxide Nanocrystals Multi-Parametric Gas Sensors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

稀有金属材料与工程 2006年第A3期35卷 17-20页

作者： E.Comini C.Baratto M.Ferroni G.Faglia G.Sberveglieri Sensor CNR-INFMBrescia UniversityVia Valotti 925133 BresciaItaly

Interest in nanowires of semiconducting oxides is exponentially grown in the last years,due to their attracting potential applications in electronic,optical and sensor *** have focused our attention on the sensing properties of indium and zinc oxide *** have studied the influence of the deposition conditions on the nanostructures morphology and sensing *** report on the growth of ZnO and In_2O_3 nanostructures on silicon and alumina substrates,using vapour phase *** have synthesized,depending on the growth conditions,different structures such as nano-wires, tetrapod,nano-comb,nano-necklace,nano-pencil ZnO/In_2O_3 without using any metal catalyst.

关键词： indium oxide zin oxide gas sensors photoluminescence nanowires

Comparison of 2D and 4D Flow MRI Measurements for Hemodynamic Evaluation of the Fontan Palliation

在线全文

学校读者我要写书评

暂无评论

Congenital Heart Disease 2023年第6期18卷 627-638页

作者： Elisa Listo Nicola Martini Stefano Salvadori Elisa Valenti Nicola Stagnaro Gianluca Trocchio Chiara Marrone Alberto Clemente Francesca Raimondi Pierluigi Festa Lamia Ait Ali Department of Radiology IRCCS Istituto Giannina GasliniGenovaItaly U.O.C.Bioingegneria Gabriele Monasterio CNR-Tuscany FoundationPisaItaly Institute of Clinical Physiology cnr PisaItaly Cardiology Unit IRCCS Istituto Giannina GasliniGenovaItaly Pediatric Cardiology and GUCH Unit Massa Gabriele Monasterio CNR-Tuscany FoundationMassaItaly Gabriele Monasterio cnr-Tuscany Foundation PisaItaly Department of Cardiology Azienda Ospedaliero-Universitaria MeyerFlorenceItaly Institute of Clinical Physiology cnr MassaItaly

Background:The assessment of Fontan circuit’sﬂow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2Dﬂow),while recently,a single volumetric 4D-ﬂow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart ***:To compare 2D and 4D-ﬂow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential ***:39 patients after Fontan palliation(23 males,age 22±11 years)who underwent cardiac MRI with 2D and 4D-ﬂow MRI acquisition were included in the *** all patients,bloodﬂow quantiﬁcation in the Fontan circuit and aorta by 2Dﬂow and by 4Dﬂow MRI acquisition blinding to the 2D results was *** agreement between 2D and 4D-ﬂow MRI was calculated as the intraclass correlation coefﬁcient(ICC).The mean absolute differences between 4D and 2Dﬂows were analyzed using linear regression ***:4D-ﬂow MRI acquisition time was slightly lower than 2D(7.6±1.8 min vs.9.4±3.3 min,p=0.03).Flow was slightly predominant in the right pulmonary artery(58%of total pulmonaryﬂow).Conduit/tunnel-pul-monary arteriesﬂow accounted for 60%of the Fontan *** between 2D and 4D was overall good-to-excellent from ICC:0.81795%CI:0.637–0.907 to 0.93295%CI:0.866–*** was no signiﬁcant inﬂu-ence of evaluated parameters on the agreement on 4D and 2Dﬂ***:4D-ﬂow MRI represents a valid tool in Fontan’sﬂow quantiﬁ*** larger studies are needed to conﬁrm our results and to evaluate the impact of advanced 4D-ﬂow MRI parameters on the prognostic stratiﬁcation in patients after Fontan palliation.

关键词： Fontan palliation fontanﬂows 4Dﬂow MRI 2Dﬂow MRI cardiac magnetic resonance

Spinterface:A new platform for spintronics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Materials Science 2019年第3期1卷 149-155页

作者： Ilaria Bergenti Valentin Dediu Institute of Nanostructured Materials ISMN National Research Council CNR40129BolognaItaly cnr-ISMN Bologna Via P.Gobetti 10140129BolognaItaly

Since its discovery in early 2000’s Molecular Spintronics has developed in an established and fructuous research field,achieving a number of outstanding results and unveiling unusual spintronic *** the most mysterious device element,the interface,in molecular spintronics has on contrary received and enormous attention and even gained a special nickname–the *** on significant efforts of many research groups worldwide it has been established its critical role in defining the main functionalities of molecular spintronic *** the spinterface was found to control the properties of the both components constituting the interface,not only those of the molecular layer but surprisingly also those of the magnetic *** paper aims to overview the most striking spinterface properties and to highlight the possibilities to promote new device paradigms based on interfacial modulation.

关键词： Molecular spintronics Ferromagnetism Spin polarization Hybridization organic semiconductors

Procoagulant activity of circulating microparticles is associated with the presence of moderate calcified plaque burden detected by multislice computed tomography

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2014年第1期11卷 13-19页

作者： Serena Del Turco Giuseppina Basta Alessandro Mazzarisi Debora Battaglia Teresa Navarra Michele Coceani Massimiliano Bianchi Mathis Schlueter Paolo Marraccini Institute of Clinical Physiology CNR San Cataldo Research Area Via Moruzzi 1 56124 Pisa Italy Fondazione G. Monasterio cnr-Regione Toscana Via Moruzzi 1 56124 Pisa Italy

Background Circulating microparticles （MPs） have been reported to be associated with coronary artery disease （CAD）. In this study, we explored the relationship between MPs procoagulant activity and characteristics of atherosclerotic plaque detected by 64-slice computed tomography angiography （CTA）. Methods In 127 consecutive patients with CAD but without acute coronary syndrome and who under went 64-slice CTA, MPs procoagulant activity in plasma Coy a thrombin generation test）, soluble form of lectin-like oxidized low-density lipoprotein receptor-1 （sLOX-1） and N（epsilon）-（carboxymethyl） lysine （CML） circulating levels （by ELISA） were measured. A quantitative volumetric analysis of the lumen and plaque burden of the vessel wall （soft and calcific components）, for the three major coronary vessels, was performed. The patients were classified in three groups according to the presence of calcium volume： non-calcified plaque （NCP） group （calcium volume （%） = 0）, moderate calcified plaque （MCP） group （0 〈 calcium volume （%）〈 1）, and calcified plaque （CP） group （calcium volume （%）〉 1）. Results MPs procoagulant activity and CML levels were higher in MCP group than in CP or NCP group （P = 0.009 and P = 0.027, respectively）. MPs procoagulant activity was positively associated with CML （r = 0.317, P 〈 0.0001） and sLOX-1 levels （r = 0.216, P = 0.0025）. Conclusions MPs procoagulant activity was higher in the MCP patient group and correlated positively with sLOX-1 and CML levels, suggesting that it may characterize a state of blood vulnerability that may locally precipitate plaque instability and increase the risk of subsequent major cardiovascular events.

关键词： Computed tomograpby Micropanicles Low density lipoprotein Lysine Coronary artery disease

THE MODIFIED MOMENT PROBLEM IN THE PRESENCE OF NOISE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis in Theory and Applications 1993年第2期9卷 50-70页

作者： U.Amato M.F.Carfora Istituto per Applicazioni della Matematica cnr. Italy Istituto per Applicazioni della Matematica cnr Italy and Istituto per le Metodologie Avanzate di Analisi Ambientale CNR Italy

The modified moment problem is little studied in the literature with respect to the classical moment prob- lem due to the lacking of experiments measuring modified momenls. The modified moment problem is ana- lyaed in this paper, when noise affects the modified moments themselves. A numerical method for solving the problem, based on regularization. is given. together with a full theoretical analysis, convergence results and an optimized algorithm. The modified moment problem rereals strongly superior to the classical moment problem in terms of the amplification of the error, conditioning of the matrices involved and ease of computation.

关键词： Regularization Parameter Legendre Polynomial Moment Problem Fredholm Integral Equation Reproduce Kernel Hilbert Space

The implementation of international geospatial standards for earth and space sciences

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2010年第S1期3卷 2-13页

作者： Stefano Nativi cnr-IMAA University of Florence at PratoPiazza Ciardi 2559100 PratoItaly

The Earth and Space Sciences Informatics division of European Geosciences Union(EGU)and the Open Geospatial Consortium jointly organised a special event entitled:‘Implementation of international geospatial standards for earth and space sciences event’at the EGU General Assembly meeting held in Vienna,April *** event objectives included:(a)to discuss the integration of information systems from different geosciences disciplines;(b)to promote and discuss the present process to scale from specific and monolithic systems towards independent and modular enabling infrastructuresforming an earth system science(ESS)infrastructure;and(c)to show some of the latest advances in implementing open *** manuscript introduces the event motivations and describes the abstract and holistic framework,which can be used to situate the topics and the developments presented by the event *** manuscript introduces important,and relatively new technologies to build a multi-disciplinary geosciences information system:the System of Systems approach and the Model Driven *** achieve that,three important information infrastructure categories are recognised:(a)ESS information infrastructure;(b)geospatial information infrastructure;and(c)distributed information *** Earth should support the discussed framework to accelerate information transfer from theoretical discussions to applications,in all fields related to global climate change,natural disaster prevention and response,new energy-source development,agricultural and food security,and urban planning and management.

关键词： digital earth infrastructures System of Systems multi-disciplinary interoperability interoperability standards information modelling approach