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对顺铂和紫杉醇耐药的卵巢上皮癌患者采用Adp53(INGN201;AdVEXIN)治疗的Ⅰ期研究

世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 52-53页

作者： Wolf J.K. Bodurka d.C. Gano J.B. 罗勇 Thedept. of Gynecologic On cology Univ. TexasM. D. Anderson Cancer C. Houston TX United States

Purpose. Adenoviral p53 (Adp53) is a replication-deficient adenovirus contain ing human p53 cdNA. This phase I study was designed as a toxicity study of multi ple dosing of Adp53 administered by intraperitoneal (ip) delivery to patients wi th ovarian cancer. Experimental design. Eligibility criteria included patients w ith platinum-and paclitaxel-resistant metastatic epithelial ovarian cancer; a Zubrod performance status of 0, 1, or 2; and adequate bone marrow, liver, and re nal function. Patients underwent laparoscopy, washings, biopsies, and placement of an ip catheter within 10 days of Adp53 administration. Adp53 was given daily for 5 days every 3 weeks at one of the following four dose levels: 3 ×1010, 3 ×1011, 1 ×1012, or 3 ×1012 viral particles (vp). Results. Seventeen patients were enrolled in the trial. Fifteen (88%) patients are evaluable for toxicity. The mean age of the study group was 51 years (range 32-67). All but one patient received two or more chemotherapy regimens before study entry. No doselimiting toxicities (dLT) were observed. Grade 3 toxicities included fatigue (six patient s), fever (two patients), chills (one patient), abdominal pain (three patients), nausea (two patients), and sinus congestion (one patient). One patient had Grad e 3 edema and headache. There were no hematologic toxicities. Eleven patients (6 5%) are evaluable for response. Two of 17 patients (12%) had a mixed response. Four patients (24%) had stable disease for up to four courses. Five patients ( 29%) had progressive disease after one to two courses. Conclusions. Multiple do sing of ip Adp53 was well tolerated in this group of heavily pretreated patients ; however, the dosing schedule and the amount cannot be concluded from this stud y. With a negative randomized trial of ovarian cancer in front-line treatment t hat included an adenovirus p53 plus chemotherapy, we feel that further refinemen t of gene therapy is required before additional trials are undertaken. Overview sum

关键词：卵巢上皮癌 Adp53 复发性卵巢癌卵巢转移腔内注射一线治疗方案基因突变毒性反应腺病毒病毒颗粒

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Thermodynamic re-assessment of Fe-Ti binary system

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Transactions of Nonferrous Metals Society of China 2012年第9期22卷 2204-2211页

作者：薄宏王江 Liliana dUARTE Christian LEINENBACH 刘立斌刘华山金展鹏中南大学材料科学与工程学院长沙410083 Laboratory for Joining and Interface Technology Swiss Federal Laboratories for Materials Science and Technology überlandstrasse 129 CH-8600 Dübendorf Switzerland 中南大学有色金属材料科学与工程教育部重点实验室长沙410083

The Fe-Ti binary system was re-assessed using the CALPHAd method in order to improve the capability of being extrapolated to a ternary or higher-order system. Compared with previous assessments, the main focus was put on the thermodynamic description of the two intermetallic compounds Fe2Ti and FeTi. The C14_Laves phase Fe2Ti was described by the two-sublattice model, which is widely used at present. By checking the homogeneity range on the boundary of the ternary systems involving the binary, the phase boundary of this compound was further confirmed. The FeTi phase with a BCC_B2 crystal structure was treated as the ordered phase of the BCC_A2 phase and a unified Gibbs energy function was used to describe both the ordered and disordered phases. Reproduction of the specific heat capacities of these compounds was another aspect paid particular attention to. Comprehensive comparisons of the calculated and experimental results regarding the phase diagram and thermodynamic properties show a good agreement between them and prove the validity of the present thermodynamic description.

关键词： Fe-Ti system order-disorder transition thermodynamic assessment phase diagram CALPHAd

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Seasonal variations and bioavailability of inorganic phosphorus in soils of Yeyahu Wetland in Beijing,China

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International Journal of Sediment Research 2011年第2期26卷 181-192页

作者： ZHANG Jing,LI Min,LIU Shuang,LIU Yujin,ZHANG Liqiang,CAO Qi,and SUN dezhi 1 Ph.d.student,~ 2 Assoc,Prof,~(3,6) Master,~7 Prof,College of Environmental Science and Engineering,Beijing Forestry University,Beijing,P.R.China,100083 ~(4,5) Senior Engineer,Beijing Yanqing Yeyahu Wetland Nature Reserve,Beijing,P.R.China,102101 Ph.d. student College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 Assoc. Prof. College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 Master College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083 Senior Engineer Beijing Yanqing Yeyahu Wetland Nature Reserve Beijing P.R. China 102101 Prof. College of Environmental Science and Engineering Beijing Forestry University Beijing P.R. China 100083

Phosphorus(P) in soils has an important influence on the development and productivity of wetland. The objective of this study was to investigate the distribution,bioavailability and seasonal variations of inorganic phosphorus(ip) in soils of Yeyahu *** results showed that the concentration of Ca-bound P(Ca-P) remained the main occurrence in all ip fractions despite the season,at the same time the Al-bound P(Al-P) was always the lowest ip fraction despite the ***-P and Fe-bound P (Fe-P) concentration were all reached the highest value in May and the lowest in November,which was opposite to the occluded P(Oc-P) *** notable higher Oc-P concentration in November observed in this study was probably due to the decomposition of plants and the subsequently releasing of oxides to ***-P didn’t change much with season *** P(Ex-P) and Oc-P were all positively correlated with soil moisture content and organic matter content,but Al-P was negatively correlated with these two soil *** a stable form,Ca-P was not associated with soil ***-P,Fe-P and Ca-P might contribute to the storage of P in studied wetland with the principle component analysis *** concentration rank order of the bio-available P in soils was generally as follows:Olsen-P > Algal available P(AAP) > Water soluble P(WSP) > Readily desorbed P(RdP).Olsen-P was positively correlated with Ex-P and Oc-P,and it was thought to be a more suitable indicator for bio-available P in soils.

关键词： Inorganic phosphorus fractions distribution Bioavailability Seasonal variations

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Observation and modelling of stimulated Raman scattering driven by an optically smoothed laser beam in experimental conditions relevant for shock ignition

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High Power Laser Science and Engineering 2021年第4期9卷 160-178页

作者： G.Cristoforetti S.Hüller P.Koester L.Antonelli S.Atzeni F.Baffigi d.Batani C.Baird N.Booth M.Galimberti K.Glize A.Héron M.Khan P.Loiseau d.Mancelli M.Notley P.Oliveira O.Renner M.Smid A.Schiavi G.Tran N.C.Woolsey L.A.Gizzi Intense Laser Irradiation Laboratory INO-CNRINO-CNR56124 PisaItaly Centre de Physique Théorique CPHT CNRSIP ParisEcole Polytechnique91128 PalaiseauFrance York Plasma Institute Department of PhysicsUniversity of YorkYork YO105DDUK dipartimento SBAI Universitàdi Roma'La Sapienza'00161 RomaItaly Universitéde Bordeaux CNRSCEACELIA33405 TalenceFrance STFC Rutherford Appleton Lab Central Laser FacilityDidcot SN21SZUK Key Laboratory for Laser Plasmas(MOE) Shanghai Jiao Tong UniversityShanghai 200240China CEA DAMDIF91297 ArpajonFrance UniversitéParis-Saclay CEALMCE91680 Bruyeres-le-ChatelFrance Institute of Physics ELI BeamlinesInstitute of Plasma PhysicsCzech Academy of Sciences18221 PragueCzech Republic Helmholtz-Zentrum dresden-Rossendorf 01328 DresdenGermany

We report results and modelling of an experiment performed at the Target Area West Vulcan laser facility,aimed at investigating laser±plasma interaction in conditions that are of interest for the shock ignition scheme in inertial confinement fusion(ICF),that is,laser intensity higher than 10^(16) W/cm^(2) impinging on a hot(T>1 keV),inhomogeneous and long scalelength pre-formed *** show a significant stimulated Raman scattering(SRS)backscattering(;%-20%of laser energy)driven at low plasma densities and no signatures of two-plasmon decay(TPd)/SRS driven at the quarter critical density *** are satisfactorily reproduced by an analytical model accounting for the convective SRS growth in independent laser speckles,in conditions where the reflectivity is dominated by the contribution from the most intense speckles,where SRS becomes *** and kinetic simulations well reproduce the onset of SRS at low plasma densities in a regime strongly affected by non-linear Landau damping and by filamentation of the most intense laser *** absence of TPd/SRS at higher densities is explained by pump depletion and plasma smoothing driven by *** prevalence of laser coupling in the low-density profile justifies the low temperature measured for hot electrons(7-12 keV),which is well reproduced by numerical simulations.

关键词： plasma simulations shock ignition stimulated Raman scattering inertial confinement fusion laser-plasma interaction

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卵巢浆液性癌的组织学分级与发病机制研究新进展

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中华病理学杂志 2011年第8期40卷 507-510页

作者：申彦杨帆刘劲松天津市中心妇产科医院病理科 300100 四川大学华西第二医院病理科 department of Pathology the University of Texas M. D. Anderson Cancer Center Houston TX 77030USA

根据美国癌症数据库的统计，2009年全美卵巢癌的发病人数为21550人，而死亡人数为14600人，因此卵巢癌已成为最致命的妇科恶性肿瘤…。长期以来，人们对上皮性卵巢癌的认识停留在：（1）它起源于卵巢表面上皮（ovarian surface epithel... 详细信息

根据美国癌症数据库的统计，2009年全美卵巢癌的发病人数为21550人，而死亡人数为14600人，因此卵巢癌已成为最致命的妇科恶性肿瘤…。长期以来，人们对上皮性卵巢癌的认识停留在：（1）它起源于卵巢表面上皮（ovarian surface epithelial，OSE），即间皮，向下内陷形成皮质包涵囊肿，此后再经过一系列的变化发展为肿瘤；（2）尽管卵巢癌的组织学类型有多种，但浆液性癌占绝大多数，故常将它们视为一类疾病；（

关键词：卵巢浆液性癌组织学分级发病机制上皮性卵巢癌妇科恶性肿瘤卵巢表面上皮 2009年组织学类型

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Geolocation and Verification of ip-Addresses with Specific Focus on ipv6

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通讯和计算机（中英文版） 2013年第11期10卷 1381-1395页

作者： Robert Koch Mario Golling Gabi dreo Rodosek Faculty of Computer Science University of the Federal Armed Forces Munich Neubiberg D-85577 Germany

Geolocation, the mapping of a network entity with its geographical position is used frequently in today"s Internet. New location aware applications like e-commerce, web site content and advertisements are just some examples of what has appeared since the last couple of years. Regarding network security, geolocation also has a significant impact, since it offers possibilities for advanced network security (e. g., including sophisticated geo-based attack correlation/classification). However, determining the physical position of a network entity is challenging, as there is no inherent relationship between an ip address and its geographical location. In addition, with the introduction of ipv6, the address space is enhanced by a factor of296, making the process far more complex in comparison to ipv4. Although numerous techniques for geolocation are existing, each strategy is subject to certain restrictions. Therefore, this publication illustrates and evaluates different approaches of geolocation. Furthermore, strategies to obtain additional information related to the location of ip addresses are examined. After considering procedures how to verify the achieved data and following the ideas of Endo et al., we are designing an architecture for a combination of different methods for optimized geolocation. Finally we introduce and evaluate our proof of concept called geolabel, a tool capable of mapping ipv4 as well as ipv6 addresses to certain geographical locations on a country level.

关键词： ipv6地址地理位置 ip地址验证网络安全性地理定位网络实体位置感知

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大洋低成本解决方案

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世界广播电视 2006年第5期20卷 38-41页

作者：白侗中科大洋科技发展股份有限公司产品中心d-PowerⅡ网络产品经理

国内电视台及视音频制作单位在视音频制作网络的投资方面逐渐成熟，越来越重视成本投入控制等问题，希望得到最大的投资回报。中科大洋科技发展有限公司的技术团队，积多年网络结构和软件功能设计的经验，将先进的网络技术和人性化的软... 详细信息

国内电视台及视音频制作单位在视音频制作网络的投资方面逐渐成熟，越来越重视成本投入控制等问题，希望得到最大的投资回报。中科大洋科技发展有限公司的技术团队，积多年网络结构和软件功能设计的经验，将先进的网络技术和人性化的软件功能融入大洋低成本解决方案，充分考虑了网络项目的总体拥有成本，让广大用户进行有效的成本控制，以获得最大的投资回报。

关键词： TCO 低成本解决方案 ip-SAN d-PowerⅡ

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Systemic humoral responses of non-muscle-invasive bladder cancer during BCG treatment: less is more

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Journal of Cancer Metastasis and Treatment 2017年第1期3卷 116-126页

作者： Fernando M.Calais da Silva Paula A.Videira dário Ligeiro Maria Guadalupe Cabral Richard Sylvester Fernando E.Calais da Silva Hélder Trindade Grupo Português Génito-Urinário Hospital São José1050-059 LisboaPortugal UCIBIO Departamento Ciências da VidaFaculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Centro de Estudos de doenças Crónicas CEDOCNOVA Medical School/Faculdade de Ciências MédicasUniversidade Nova de Lisboa1169-056 LisbonPortugal CdG&Allies Professionals and Patient Associations International Network(CDG&Allies-PPAIN)Faculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Centro de Sangue e Transplantação de Lisboa IPSTIP.1749-005 LisboaPortugal EAU Guidelines Office 241040 BrusselsBelgium

Aim:Intravesical Bacille Calmette-Guérin(BCG)is the mainstay adjuvant treatment of non-muscle-invasive bladder ***,one third of the patients on BCG regimen relapse within the first year of *** study aimed at identifying biomarkers to predict response to BCG ***:Gene expression was analyzed in blood cells of 58 patients treated with BCG through six consecutive weekly instillations and then at month 3,6,9,and *** tumor necrosis factor(TNF)-α,interleukin(IL)-10,interferon(IFN)-γ,IL-1β,IL-2,IL-4,and IL-6;chemokines CCL2,CCL3,CCL8,CXCL9,and ip-10;and mediators of cytotoxicity CTLA4,Fas-L,Perf,GNLY,NOS2A,and HMOX-1 were analyzed before the 1st and the 6th week instillation and 24 h after to assess fast(within 24 h)and prolonged changes resulting from ***:BCG instillation led to fast-increased expression of IL-1β,TNF-α,and IL-10 *** compared to relapsing patients,patients with no relapses within one year showed significantly lower expression of IL-1βat 1st week and less IFN-γ,HMOX-1,and GNLY at week ***-1 and GNLY were independent predictive biomarkers,and values above the cut-off≥110 and≥13.0‰mRNA,respectively,were considered prejudicial *** with two HMOX-1 and GNLY factors had highest(66.7%)relapsing ***:Assessing immunomodulators’expression in blood allows the establishment of predictive cut-off values and identification of probabilities for patients’relapses after BCG treatment.

关键词： Bladder cancer Bacille Calmette-Guérin immunomodulatory molecules multivariate analysis

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Effect of Cytokinins on the Micropropagation of Carob(Ceratonia siliqua L.)through Shoot Tip Culture

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American Journal of Plant Sciences 2019年第9期10卷 1469-1481页

作者： Rabah Saidi Safaa Rahmouni Zineb Nejjar El Ansari Abdelfettah Maouni Alain Badoc Ahmed Lamarti department of Matter and Life Sciences High Normal SchoolMartilMorocco Laboratory of Plant Biotechnology Biology DepartmentFaculty of SciencesAbdelmalek Essaadi UniversityTetouanMorocco Axe MIB(Molecules d’Interet Biologique) Unite de Recherche(Enologie EA 4577USC 1366 INRA)UFR des Sciences PharmaceutiquesUniversite de BordeauxISVV(Institut des Sciences de la Vigne et du Vin)BordeauxFrance

In order to determine the most suitable cytokinin for the micropropagation of carob (Ceratonia siliqua L.), the effect of four cytokinins: BAP, zeatin, kinetin and 2-ip, was tested on explants derived from young seedlings of seven days. Organogenesis is better in the presence of BAP (0.5 mg/l), while buds growth is favored by zeatin (0.5 mg/l). The combination of the most suitable cytokinin (BAP at 0.5 mg/l) with IBA improves the caulogenesis when the concentration of this latter is low (0.1 mg/l);high concentrations of IBA have an inhibitory effect on elongation and neoformation of shoots and leaves. The multiplication and growth of shoots are more favorable on WPM medium in the presence of BAP (0.5 and 1 mg/l) alone or combined with 0.5 mg/l with GA3, while rooting is mainly favored by IBA, especially at 2 mg/l.

关键词： Carob Ceratonia siliqua L. Cytokinins Shoot Tip Culture

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不同泌乳时间驼初乳的氨基酸组成和氨基酸评分

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新疆畜牧业 2020年第3期35卷 28-31页

作者：李惠陆范璟李景芳陆东林乌鲁木齐市畜牧水产草原技术推广中心新疆乌鲁木齐830063 加拿大约克大学舒立克商学院加拿大多伦多M3J IP3 新疆维吾尔自治区乳品质量监测中心新疆乌鲁木齐830063 乌鲁木齐市奶业协会新疆乌鲁木齐830063

本文介绍了母驼分娩后不同时间驼初乳和常乳中氨基酸含量和组成,对照FAO(2011)3类人群的氨基酸模式进行比较,并对驼初乳和常乳进行氨基酸评分和营养价值评价。结果表明:驼初乳和常乳必需氨基酸占总氨基酸比例均达40%以上,必需氨基酸占... 详细信息

本文介绍了母驼分娩后不同时间驼初乳和常乳中氨基酸含量和组成,对照FAO(2011)3类人群的氨基酸模式进行比较,并对驼初乳和常乳进行氨基酸评分和营养价值评价。结果表明:驼初乳和常乳必需氨基酸占总氨基酸比例均达40%以上,必需氨基酸占非必需氨基酸比例达70%以上,符合FAO理想蛋白质标准。对于0~0.5岁婴儿,驼初乳和常乳的第一限制氨基酸均为色氨酸,2h、1~7d驼初乳和常乳的氨基酸酸评分分别为65、59和53分;对于0.5~3岁幼儿和3岁以上人群,第一限制氨基酸为色氨酸或蛋氨酸+半胱氨酸,除2h驼初乳氨基酸评分为93分外,其他均在100分以上。

关键词：驼初乳氨基酸含量氨基酸组成氨基酸评分

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