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T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3/FoxO3α/MnSOD signaling pathway-mediated oxidative stress

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Journal of Environmental sciences 2025年第4期150卷 532-544页

作者： Lichun Qiao Xue Lin Haobiao Liu Rongqi Xiang Jingming Zhan Feidan Deng Miaoye Bao Huifang He Xinyue Wen Huan Deng Xining Wang Yujie He Zhihao Yang Jing Han Department of Occupational and Environmental health School of Public HealthHealth Science CenterXi’an Jiaotong UniversityXi’an 710061China Global health institute Health Science CenterXi’an Jiaotong UniversityXi’an 712000China Key Laboratory for Disease Prevention and Control and health Promotion of Shaanxi Province Xi’an 710061China Department of Radiological Medicine and Environmental Medicine China Institute of Radiation ProtectionTaiyuan 030006China Key Laboratory of Environment and Genes Related to Diseases School of Public HealthHealth Science CenterXi’an Jiaotong UniversityXi’an 710061China

T-2 toxin,an omnipresent environmental contaminant,poses a serious risk to the health of humans and animals due to its pronounced *** study aimed to elucidate the molecular mechanism of cardiac tissue damage by T-2 ***-four male Sprague-Dawley rats were orally administered T-2 toxin through gavage for 12 weeks at the dose of 0,10,and 100 nanograms per gram body weight per day(ng/(g·day)),***,pathological,and ultrastructural alterations in cardiac tissue were meticulously ***-targeted metabolomics analysis was employed to analyze alterations in cardiac *** expression of the Sirt3/FoxO3α/MnSOD signaling pathway and the level of oxidative stress markers were *** results showed that exposure to T-2 toxin elicited myocardial tissue disorders,interstitial hemorrhage,capillary dilation,and fibrotic *** were markedly impaired,including swelling,fusion,matrix degradation,and membrane *** analysis unveiled that T-2 toxin could cause alterations in cardiacmetabolic profiles as well as in the Sirt3/FoxO3α/MnSOD signaling pathway.T-2 toxin could inhibit the expressions of the signaling pathway and elevate the level of oxidative *** conclusion,the T-2 toxin probably induces cardiac fibrotic impairment by affecting amino acid and choline metabolism as well as up-regulating oxidative stress mediated by the Sirt3/FoxO3α/MnSOD signaling *** study is expected to provide targets for preventing and treating T-2 toxin-induced cardiac fibrotic injury.

关键词： Environmental contaminant T-2 toxin Cardiac fibrosis Oxidative stress Metabolic disorder Sirt3/FoxO3α/MnSOD signaling pathway

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A fully mesh-independent non-linear topology optimization framework based on neural representations:Quasi-static problem

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science China(Physics,Mechanics & Astronomy) 2025年第4期Mechanics & Astronomy) .卷 123-147页

作者： Zeyu Zhang Yu Li Weien Zhou Wen Yao College of Aerospace science and Engineering National University of Defense Technology Defense Innovation institute Chinese Academy of Military Science Intelligent Game and Decision Laboratory

In artificial intelligence(AI) for science, the AI-empowered topology optimization methods have garnered sustained attention from researchers and achieved significant development. In this paper, we introduce the implicit neural representation(INR) from AI and the material point method(MPM) from the field of computational mechanics into topology optimization, resulting in a novel differentiable and fully mesh-independent topology optimization framework named MI-TONR, and it is then applied to nonlinear topology optimization(NTO) design. Within MI-TONR, the INR is combined with the topology description function to construct the design model, while implicit MPM is employed for physical response analysis. A skillful integration is achieved between the design model based on the continuous implicit representation field and the analysis model based on the Lagrangian particles. Along with updating parameters of the neural network(i.e., design variables), the structural topologies iteratively evolve according to the responses analysis results and optimization functions. The computational differentiability is ensured at every step of MI-TONR, enabling sensitivity analysis using automatic differentiation. In addition, we introduce the augmented Lagrangian Method to handle multiple constraints in topology optimization and adopt a learning rate adaptive adjustment scheme to enhance the robustness of the optimization process. Numerical examples demonstrate that MI-TONR can effectively conduct NTO design under large loads without any numerical techniques to mitigate numerical instabilities. Meanwhile, its natural satisfaction with the no-penetration condition facilitates the NTO design of considering contact. The infinite spatial resolution characteristic facilitates the generation of structural topology at multiple resolutions with clear and continuous boundaries.

关键词： topology optimization implicit neural representation material point method automatic differentiation nonlinearity

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Exposure of individuals aged 18-44 years to personal care products in Beijing,China:Exposure profiles,possible influencing factors,and risk assessment

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Journal of Environmental sciences 2025年第2期148卷 691-701页

作者： Xu Zhang Linxue Han Qi Sun Xiaochen Wang Xiaojian Hu Xiao Lin Ying Zhu China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China The Bureau for health Inspection and Supervision of Haidian District Beijing 100037China

Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the *** data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health *** gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs,we determined six parabens,six benzophenone-type ultraviolet filters,and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing,*** urinary levels of benzophenone-3(BP-3)and 4-hydroxybenzophenone(4-OHBP)were significantly higher in summer compared to winter,suggesting these compounds have different seasonal usage ***,the total concentration of 15 PCPs in female was 430 ng/mL,approximately two times higher than that in male.P-chloro-m-xylenol(PCMX),as a new type of antibacterial agent,has the greatest level among all target analytes,indicating the increasingly use of this antibacterial alternative *** potential influencing factors that lead to the elevated exposure level of PCPs were *** 19%of the target population had a high hazard index value(greater than 1)which was attributed to exposure to propyl paraben(PrP),benzophenone-1(BP-1),BP-3 and PCMX,indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.

关键词： Personal care products Hazard quotient Risk assessment Exposure patterns Urine

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A review on multi-scale structure engineering of carbon-based electrode materials towards dense energy storage for supercapacitors

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Journal of Energy Chemistry 2025年第03期102卷 768-799页

作者： Dongyang Wu Fei Sun Min Xie Hua Wang Wei Fan Jihui Gao Guangbo Zhao Shaoqin Liu School of Energy science and Engineering Harbin Institute of Technology national Innovation Platform for Industry-Education Integration of Energy Storage Technology Harbin Electric science and Technology Co. Ltd Micro- and Nanotechnology Research Center School of Materials science and Engineering Harbin Institute of Technology

Improving the volumetric energy density of supercapacitors is essential for practical applications,which highly relies on the dense storage of ions in carbon-based *** functional units of carbon-based electrode exhibit multi-scale structural characteristics including macroscopic electrode morphologies,mesoscopic microcrystals and pores,and microscopic defects and dopants in the carbon basal ***,the ordered combination of multi-scale structures of carbon electrode is crucial for achieving dense energy storage and high volumetric performance by leveraging the functions of various scale structu *** that previous reviews have focused more on the discussion of specific scale structu re of carbon electrodes,this review takes a multi-scale perspective in which recent progresses regarding the structureperformance relationship,underlying mechanism and directional design of carbon-based multi-scale structures including carbon morphology,pore structure,carbon basal plane micro-environment and electrode technology on dense energy storage and volumetric property of supercapacitors are systematically *** analyzed in detail the effects of the morphology,pore,and micro-environment of carbon electrode materials on ion dense storage,summarized the specific effects of different scale structures on volumetric property and recent research progress,and proposed the mutual influence and trade-off relationship between various scale *** addition,the challenges and outlooks for improving the dense storage and volumetric performance of carbon-based supercapacitors are analyzed,which can provide feasible technical reference and guidance for the design and manufacture of dense carbon-based electrode materials.

关键词： Carbon-based electrodes Dense energy storage Multi-scale structure Supercapacitors Volumetric performances

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A Review of Terahertz Solid-State Electronic/Optoelectronic Devices and Communication Systems

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Chinese Journal of Electronics 2025年第1期34卷 26-48页

作者： Wenbo Li Hongxin Zeng Lin Huang Sen Gong Haoyi Cao Weipeng Wang Zheng Wang Hongji Zhou Shixiong Liang Ziqiang Yang Yaxin Zhang University of Electronic science and Technology of China Huzhou Key Laboratory of Terahertz Integrated Circuits and Systems Yangtze Delta Region Institute (Huzhou)University of Electronic Science and Technology of China Terahertz institute Zhangjiang national Laboratory national Key Laboratory of Application Specific Integrated Circuit Hebei Semiconductor Research Institute

With the rapid development of modern communication technology, spectrum resources have become non-renewable and precious resources, and the terahertz frequency band has entered people's vision. Nowadays, terahertz communication technology has become one of the core technologies for future high-capacity and high-rate communication. This paper discusses and analyzes the core technologies related to the field of terahertz *** introduce the characteristics, domestic and international comparisons and development trends of the core devices for terahertz communication, and also introduce and discuss the terahertz solid-state frequency mixing communication system, terahertz direct modulation communication system, and terahertz optoelectronic communication ***, we summarize the development of terahertz communication technology and the outlook of future applications.

关键词： Frequency modulation Reviews Solids Market research Terahertz communications

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Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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science China Chemistry 2025年第3期68卷 1199-1206页

作者： Cong Xie Zedong Xiong Xinlu Liu Wen Wang Yang Liu Xueshi Jiang Xin Lu Lulu Sun Yinhua Zhou Wuhan national Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Kunming institute of Physics Kunming 650221China

Large-area flexible organic photovoltaic(OPV)modules are challenging to achieve high power conversion efficiency(PCE).Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin(100-200 nm)and soft active *** the surface smoothness of bottom transparent electrode will be able to suppress the shunts and *** this work,we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film,and further to fabricate efficient large-area flexible OPV *** fabricated thin silver transparent electrodes simultaneously have high conductivity,high optical transmittance,good mechanical flexibility and low surface *** exposure(h.e.)treatment on MoO_(3)effectively facilitates the continuous growth of the thin transparent silver electrode.6 nm silver film on MoO_(3)(h.e.)on plastic substrate shows a transmittance up to 89%,a sheet resistance of 15Ω/sq,and a low surface roughness with a rootmean-square value of 0.276 ***,52-cm^(2)flexible organic solar modules(15 subcells)showed a certified PCE of 12.66%.Furthermore,a 1350 cm^(2)flexible component assembled by 25 pieces of 52-55 cm^(2)modules showed certified PCE of 12.10%with an open-circuit voltage of 62.85 V.

关键词： flexible organic photovoltaic modules flexible transparent electrode silver transparent electrode growth template low surface roughness

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A Biomimetic Alveoli-in-Lung-Structured Electrode:Robustly Anchored Tungsten Oxide Quantum Dot on Ti3C2 MXene for Multifunctional Sodium-Ion-Based Electrochromic Devices

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Energy & Environmental Materials 2025年第01期8卷 137-145页

作者： Qi Zhao Jinkai Wang Jianguo Sun Changyuan Bao Xue Chen Junhui Wang Yu Liu Usha Bhat Chin Ho Kirk Yanfeng Gao John Wang Department of Materials science and Engineering National University of Singapore School of Materials science and Engineering Shanghai University School of Chemical and Environmental Engineering Anhui Polytechnic University national University of Singapore (Chongqing) Research institute Chongqing Liang Jiang New Area

Sodium-ion-based electrochromic device(SECD) has been identified as an appealing cost-effective alternative of lithium-based counterparts,only if it can address the challenges in association with the inadequate electrochromic *** this regard,the quantized strategy is a particularly promising approach owing to the large surface-to-volume ratio and high reaction ***,quantum dots inevitably suffer from volume changes and undesired aggregation during electrochemical cycling.

关键词： biomimetic electrochromic multifunctional quantum dots sodium ion

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High strength-ductility synergy in refractory multi-principal element alloys via special deformation mechanisms and dislocation behaviors

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稀有金属（英文版） 2025年第1期44卷 608-622页

作者： Zhi-Wen Li Bao-Xian Su Liang Wang Chen Liu Zhe Li Qing-Da Zhang Bin-Bin Wang Xiang Xue Rui-Run Chen Yan-Qing Su national Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China national Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Zhengzhou Research institute Harbin Institute of TechnologyZhengzhou 450000China Laboratory for Space Environment and Physical sciences Harbin Institute of TechnologyHarbin 150001China

Ti-Zr-Nb refractory multi-principal element alloys(RMPEAs)have attracted increased attention due to their excellent mechanical *** this study,(TiZr)80-xNb20Mox(x=0,5 and 10)alloys were designed,and the intrinsic conflicts between strength and ductility were overcome via composition optimization and *** causes of the superior strength-ductility synergy were investigated in terms of their deformation mechanism and dislocation *** results show that the strength improvement can be attributed to the defor-mation mechanism transition caused by local chemical fluctuations and lattice ***,the slip band widths decrease after Mo addition,and the measured slip traces in the fracture samples are associated with high-order {112} and { 123} slip ***,the grain refinement achieved via recrystallization promotes multi-slip system activation and shortens the slip-band spacing,which reduces the stress concentration and inhibits crack source formation,thereby allowing the alloy to ensure sufficient ***,the Ti35Zr35Nb20Mo10 alloy annealed at 900 ℃ exhibits high yield strength and *** findings provide a new strategy for designing high-strength RMPEAs and addressing room-temperature brittleness.

关键词： Refractory multi-principal element alloy Mechanical property Strengthening mechanism Deformation substructure Dislocation behavior

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Real-Time Detection of Sub-ppm Aromatic Compounds in Alcohol by Surface Plasmon Resonance Using Label-Free Graphene

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Energy & Environmental Materials 2025年第01期8卷 146-154页

作者： Sung Hwan Cho Jun Min Suh Wontaek Kim Jaehyun Kim Yeong Jae Kim Tae Hyung Lee Jae Young Kim Jaegun Sim Seung Won Choi Byung Hee Hong So Young Kim Ho Won Jang Department of Materials science and Engineering Research Institute of Advanced Materials Seoul National University Department of Mechanical Engineering Massachusetts Institute of Technology Infra Analysis Team Global Manufacturing & Infra Technology Samsung Electronics Department of Chemistry Seoul National University

The increasing importance of high-purity isopropyl alcohol(IPA) in semiconductor processing technology has led to a higher demand for technologies capable of detecting impurities in I *** accurate and various impurity detection technologies have been developed,most of them have limitations in real-time and repeatable detection of ***,for the first time,surface plasmon resonance(SPR) sensor was developed utilizing graphene transferred Au film(Au/graphene) to detect sub-ppm levels of 2,4-dinitrophenol(2,4-DNP) dissolved in IPA and this sensor demonstrates the ability to detect 2,4-DNP in real-time with great reversibility.

关键词： density functional theory graphene liquid sensor surface plasmon resonance π–π stacking interaction

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A Practical Zinc Metal Anode Coating Strategy Utilizing Bulk h-BN and Improved Hydrogen Redox Kinetics

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Energy & Environmental Materials 2025年第2期8卷 63-71页

作者： Dong Il Kim Hee Bin Jeong Jungmoon Lim Hyeong Seop Jeong Min Kyeong Kim Sangyeon Pak Sanghyo Lee Geon-Hyoung An Sang-Soo Chee Jin Pyo Hong Seung Nam Cha John Hong Department of Physics Research Institute for Natural Science Hanyang University School of Materials science and Engineering Kookmin University Department of Physics Sungkyunkwan University (SKKU) School of Electronic and Electrical Engineering Hongik University Materials science and Engineering Kumoh National Institute of Technology Department of Energy Engineering Gyeongsang National University Nano Convergence Materials Center Korea Institute of Ceramic Engineering and Technology (KICET) Division of Nano-Scale Semiconductor Engineering Hanyang University

Achieving high-performance aqueous zinc-ion batteries requires addressing the challenges associated with the stability of zinc metal anodes,particularly the formation of inhomogeneous zinc dendrites during cycling and unstable surface *** study introduces a practical method for scattering untreated bulk hexagonal boron nitride（h-BN） particles onto the zinc anode *** cycling,stabilized zinc fills the interstices of scattered h-BN,resulting in a more favorable（002） ***,zinc dendrite formation is effectively suppressed,leading to improved electrochemical *** zinc with scattered h-BN in a symmetric cell configuration maintains stability 10 times longer than the bare zinc symmetric cell,lasting 500 ***,in a full cell configuration with α-MnO2cathode,increased H+ion activity can effectively alter the major redox kinetics of cycling due to the presence of scattered h-BN on the zinc *** shift in H+ion activity lowers the overall redox potential,resulting in a discharge capacity retention of 96.1% for 300 cycles at a charge/discharge rate of 0.5 *** study highlights the crucial role of surface modification,and the innovative use of bulk h-BN provides a practical and effective solution for improving the performance and stability.

关键词： aqueous zinc ion batteries H+ ion insertion hexagonal boron nitride scattering Zn metal anode

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