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Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance

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World Journal of Gastroenterology 2022年第26期28卷 3027-3046页

作者： María Belén Novoa Díaz María Julia Martín Claudia Gentili departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Argentina departamento de química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Argentina

Colorectal cancer(CRC)continues to be one of the main causes of death from cancer because patients progress unfavorably due to resistance to current *** of the Wnt/β-catenin pathway plays a fundamental role in the genesis and progression of several types of cancer,including *** many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli ***,it can also be associated with other *** recent years,studies of the tumor microenvironment(TME)have demonstrated its importance in the development and progression of *** this tumor nest,several cell types,structures,and biomolecules interact with neoplastic cells to pave the way for the spread of the ***-communications between tumor cells and the TME are then established primarily through paracrine factors,which trigger the activation of numerous signaling *** advances in the field of oncology have been made in the last *** Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressiveness,focusing on crosscommunication between CRC cells and the *** this analysis,our main objective was to increase the understanding of this complex disease considering a more global *** many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies.

关键词： Colorectal cancer β-catenin pathway Tumor stroma Tumor microenvironment factors Cancer progression Drug resistance

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Stable and efficient metal-biochar supported catalyst:degradation of model pollutants through sulfate radical-based advanced oxidation processes

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Biochar 2020年第3期2卷 319-328页

作者： Fermín delgado Victoria S.Gutierrez Mariana dennehy Mariana Alvarez inquisur Departamento de QuímicaUniversidad Nacional del SurAv.Alem 12538000 Bahía BlancaArgentina Planta Piloto de Ingeniería química PLAPIQUI(CONICET-UNS)Camino La Carrindanga Km 78000 Bahía BlancaArgentina

This study focuses on the synthesis of metal-based biochar catalysts and their catalytic activation of peroxymonosulfate(PMS,HSO5−)for the degradation of three different wastewater model pollutants employing advanced oxidation processes(AOP).Iron,copper,and two different cobalt-based catalysts were prepared and *** catalysts were supported on a biochar obtained from the pyrolysis of woody pruning *** were characterized by C,H,and N elemental analysis,X-Ray diffraction(XRD),Fourier-transform infrared spectroscopy(FTIR),and scanning electron microscope(SEM).The metal content in each catalyst was determined by means of atomic absorption spectroscopy(AAS).The degradation reac-tions of benzoic acid(BA),catechol(C),and cinnamic acid(CA)were carried out in a lab scale batch glass reactor and were followed by UV-Visible spectroscopy(UV-Vis).A colorimetric technique was employed to verify the presence of oxidant during the reaction *** catalyst/oxidant optimal ratio was determined for the cobalt *** mineralization degree of the pollutants after the degradations was verified by means of total organic carbon(TOC)content in the residual *** 4 h of reaction,the maximum mineralization was reached when C was treated with a cobalt-based catalyst(>80%),and its stability was evaluated through successive cycles of use.

关键词： Biochar Organic pollutants Advanced oxidation processes Sulfate radicals Cobalt catalysts

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Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： María Belén Novoa Díaz Pedro Matías Carriere María Julia Martín Natalia Calvo Claudia Gentili departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina departamento de química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases *** general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC *** on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein Colorectal cancer Tumor biomarkers Neoplastic processes Drug resistance Tumor microenvironment

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The Transfer of Cu, Zn, Mn and Fe between Soils and <i>Allium</i>Plants (Garlic and Onion), and Tomato in the Southwest of the Buenos Aires Province, Argentina

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American Journal of Plant Sciences 2014年第4期5卷 480-487页

作者： María del Pilar Moralejo Silvia Graciela Acebal inquisur-departamento de química Universidad Nacional del Sur Bahía Blanca Argentina

Chemical extraction methods are generally used to evaluate trace element concentrations in soils. The adequacy of these soil tests is commonly assessed by comparing the extraction results with the metal contents in the plants. In this study, soil and leaf samples were collected in the southwest area of the Buenos Aires Province, Argentina. Garlic (Allium sativum L.), onion (Allium cepa L.) and tomato (Solanum lycopersicum L.) are species of great regional economic importance. These crops need good mineral nutrition for optimum growth and sustainable production. Cu, Zn, Mn and Fe micronutrient uptake by plants was analyzed together with the trace element contents in the soil in which those plants were grown. A single EDTA-extraction procedure was performed to determine soil micronutrients. The amount of extractable-trace elements increased as the concentration of the chelating agent EDTA increased. The range of total element content in soil was: 15.68-31.5 mg·kg-1 for Cu, 75.0-386.3 mg·kg-1 for Zn, 542.5 -1686 mg·kg-1 for Mn and 28,325-32,675 mg·kg-1 for Fe. Micronutrient contents in mature leaf tissue were determined by the acid digestion method. Total and available micronutrient content in soil as well as total content in leaves were measured by flame atomic absorption spectrometry (FAAS). Total micronutrient content and the available extractable-fraction in soils were below the critical values for plant growth. This was in agreement with the amount of micronutrients present in the leaf tissue. A strong relationship between the extraction data and the soil-plant transfer coefficients suggested an appropriate exchange of trace elements from soils to garlic, onion and tomato plants.

关键词： Micronutrients Soil-Plant Transfer Garlic (Allium sativum L.) Onion (Allium cepa L.) Tomato (Solanum lycopersicum L.) Extractions

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pH值、阴离子和阳离子对腐植酸颗粒分解动力学的影响

pH值、阴离子和阳离子对腐植酸颗粒分解动力学的影响

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第八届全国绿色环保肥料（农药）新技术、新产品交流会

作者： Maximiliano Brigante Graciela Zanini Marcelo Avena 裴玉贺 inquisur Departamento de Quimica Universidad Nacional del Sur Argentina CERZOS(CONICET-UNS) Departamento de Agronomia Universidad Nacional del Sur Argentina 青岛农业大学

本文报道分析了固体腐植酸颗粒在不同条件下的分解动力学。在pH值为4和5时,分解速率非常小,达到平衡需要若干年的时间。这一速率非常明显地随pH的增加而增大,在pH=11时,在30min内就能完全分解。在单羧酸和阴离子除草剂如草甘膦和2,4-D... 详细信息

本文报道分析了固体腐植酸颗粒在不同条件下的分解动力学。在pH值为4和5时,分解速率非常小,达到平衡需要若干年的时间。这一速率非常明显地随pH的增加而增大,在pH=11时,在30min内就能完全分解。在单羧酸和阴离子除草剂如草甘膦和2,4-D存在时,分解速率显著增加。相反,在无机二价阳离子(Mg,Ca,Sr,Ba)存在时,速率减小。而二价阳离子百草枯具有双重效应,在pH>7时减小分解速率,在pH<7时增加分解速率。一个假定表面控制的分解动力学的简单模型可以合理再现阴阳离子的效应。不同离子通过调节位于颗粒表面的HA分子之间的相互作用力来影响分解速率。

关键词：固态腐植酸腐植酸-水分界面疏水结合静电作用金属复合物分解速率

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