检索结果-南通市图书馆

Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance

引用

World Journal of Gastroenterology 2022年第26期28卷 3027-3046页

作者： María Belén Novoa Díaz María Julia Martín Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Argentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Argentina

Colorectal cancer(CRC)continues to be one of the main causes of death from cancer because patients progress unfavorably due to resistance to current *** of the Wnt/β-catenin pathway plays a fundamental role in the genesis and progression of several types of cancer,including *** many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli ***,it can also be associated with other *** recent years,studies of the tumor microenvironment(TME)have demonstrated its importance in the development and progression of *** this tumor nest,several cell types,structures,and biomolecules interact with neoplastic cells to pave the way for the spread of the ***-communications between tumor cells and the TME are then established primarily through paracrine factors,which trigger the activation of numerous signaling *** advances in the field of oncology have been made in the last *** Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressiveness,focusing on crosscommunication between CRC cells and the *** this analysis,our main objective was to increase the understanding of this complex disease considering a more global *** many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies.

关键词： Colorectal cancer β-catenin pathway Tumor stroma Tumor microenvironment factors Cancer progression Drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of underground explosions on soil and structures

引用

Underground Space 2020年第4期5卷 324-338页

作者： Daniel Ambrosini Bibiana Luccioni National University of Cuyo CONICETArgentina National University of Tucuman CONICETArgentina

Much effort has been dedicated to the study of underground explosions because they pose a major threat to people and structures below or above the *** this regard,it is especially important to model the propagation of blast waves in soil and their effects on *** main phenomena caused by underground explosive detonation that must be addressed are crater or camouflet formation,shock wave and elastic–plastic wave propagation in soil,and soil-structure *** phenomena can be numerically simulated using hydrocodes,but much care must be taken to obtain reliable *** objective of this study is to analyze the ability of a hydrocode and simple soil models that do not require much calibration to approximately reproduce experimental and empirical results related to different buried blast events and to provide general guidelines for the simulation of this type of *** this regard,crater formation,soil ejecta,blast wave propagation in soil,and their effects on structures below and above the ground are numerically simulated using different soil models and parameters;the results are *** properties of soil have a significant effect on structures,the ejecta,and the propagation of shock waves in ***,the model of the soil to study these phenomena must be carefully *** their effect on the diameter of a crater is insignificant.

关键词： Shock waves Underground explosions Soils Hydrocodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phosphorus fractions and sorption dynamics in the sediments of two Ca-SO4 water reservoirs in the central Argentine Andes

引用

International Journal of Sediment Research 2017年第3期32卷 442-451页

作者： José Gabriel León Fernando Luis Pedrozo Pedro Félix Temporetti Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA)CCT Mendoza Departamento General de Irrigación Gobierno de Mendoza Espaa y Barcala Instituto de Investigaciones en Biodiversidad y Medio Ambiente (inibioma) CONICET-Universidad Nacional del Comahue

Phosphorus（P） fractionation and sorption behavior were studied in the sediments of two calcium-sulfate(Ca-SO4: Ca2+170 mg L-1; SO42-400 mg L-1) water reservoirs in the southern central Argentine Andes-El Carrizal Reservoir（ECR）,which stratifies in summer and El Nihuil Reservoir（ENR）,which is vertically mixed throughout the year. Sediment size classes reflected the lithology of both basins and the reservoirs relative location: ECR（downstream from a valley adjacent to a mountain environment） had higher clay proportions while the sand fraction was more important in ENR（just next to a mountain environment）.In both reservoirs, the chemical composition revealed low alteration and calcium enrichment. Total P content was relatively high(1.1-1.6 mg P kg-1dry weight) as expected from the contribution of marine formations. P fractionation was dominated by Ca-P（ECR, 69% and ENR, 63%） followed by organic-P（23%）in summer-anoxic ECR and by iron/aluminum（Fe/Al）-P（27%） in oxic ENR. Batch experiments showed that sorption behavior in ECR had a typical Langmuir isotherm plot while in ENR that model fitted only at low dissolved P values(<5 mg PL-1) and co-precipitation evidence was observed at higher P concentrations. It is proposed that lower Fe/Al-P content in anoxic（ECR） vs. oxic（ENR） sediments results from the P released from iron-bound phosphorus due to sulfate reduction-ferrous sulfide formation in an anoxic environment. This condition should enable ECR sediments to adsorb P into fresh oxidized iron,and ENR sediments to co-precipitate P with calcium due to Fe/Al-P saturation, as observed in batch experiments. This paper constitutes the first description of phosphorus content and dynamics in reservoir sediments in arid central western Argentina, where water sulfate concentrations are naturally high due to basin lithology.

关键词： Reservoir Internal load Phosphorus binding Calcareous watershed Southern Central Andes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transmission line protection challenges influenced by inverter-based resources:a review

引用

Protection and Control of Modern Power Systems 2022年第1期7卷 406-422页

作者： Juan Carlos Quispe Eduardo Orduña Institute of Electrical and Energy-conicet Universidad Nacional de San JuanSan JuanArgentina Universidad Tecnológica del Perú LimaPeru

High penetration of renewable energy sources(RES)leads to new challenges for protection *** schemes are typically designed according to the dynamic behavior of rotating machines as generation sources,while the RES dynamic response,mainly governed by inverters,is not ***,some relevant algorithms of transmission line protection are experiencing challenges because of the fact that magnitude and phase angle com-parison,amount of negative-sequence,and short-circuit current level are affected by the ***,an in-depth study of this issue is necessary,one which considers the main causes and new methodological criteria *** work presents an extensive literature review of the evaluation of electrical protection performance and the effects of RES connected to a power grid through *** data on many representative publications related to this topic are obtained to show the current research lines and their proposed *** addition,this work identi-fies the main protection functions affected and describes the new protection schemes that consider ***,an analysis and discussion of the selected bibliography are presented.

关键词： Inverter-based resources Inverter control system Photovoltaic plant Transmission line protection Wind farm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats

引用

Food Science and Human Wellness 2023年第6期12卷 2022-2028页

作者： Maria Rosana Ramirez Debora Manuale Juan Carlos Yori Instituto Universitario de Ciencias de la Salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina Consejo Nacional de Investigaciones Científi cas Técnicas(conicet) Buenos Aires C1033AAJArgentina Instituto de Investigaciones en Catálisis y Petroquímica(INCAPE)FIQ-UNL-conicet Parque Tecnológico Litoral Centro 3000Santa FeArgentina Facultad de Ingeniería Química Universidad nacional del Litoral 3000Santa FeArgentina

This present study was conducted to evaluate the metabolic effects of isolated fi ber of carrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,control group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were collected at the time of sacrifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respect to body weight were *** kits were used to determine serum glucose concentration,lipid profi le(cholesterol,HDL-cholesterol,triglycerides),and the two main aminotransferases glutamic-oxalacetic transaminase(GOT)/glutamate-pyruvate transaminase(GPT).A histopathological assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induces a decrease in glucose levels in the supplemented *** the exception of total high-density lipoprotein cholesterol,the other lipid fractions decrease signifi cantly in rats *** supplementation did not induce changes in the dissected organs of the supplemented *** conclusion supplementation of fiber,improves glucose control,lower plasma lipid concentrations and reduced body weight in normal rats.

关键词： Carrot fiber Oral supplementation Animal studies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain and spinal cord trauma:what we know about the therapeutic potential of insulin growth factor 1 gene therapy

引用

Neural Regeneration Research 2023年第2期18卷 253-257页

作者： María Jose Bellini Florencia Labombarda Lab de Bioquímica del Envejecimiento INIBIOLP-CONICETFacultad de Ciencias MedicinaUniversidad Nacional de La PlataLa PlataArgentina Laboratory of Neuroendocrine Biochemistry IBYME-CONICETBuenos AiresArgentina Department of Human Biochemistry Faculty of MedicineUniversidad de Buenos AiresBuenos AiresArgentina

Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal co rd injury,several reports have described impairments in cognitive *** group also has contributed significantly to the study of cognitive impairments in a rat model of spinal co rd *** findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes,drugs of abuse,and combined *** are related to changes in brain structures involved in cognition and emotion,such as the *** spinal cord injury decreases neurogenesis,enhances glial reactivity leading to hippocampal neuroinflammation,and trigge rs cognitive *** brain distal abnormalities are recently called te rtiary *** that there is no treatment for Tertiary Damage,insulin growth factor 1 gene therapy emerges as a good *** growth factor 1 gene thera py recove rs neurogenesis and induces the polarization from pro-inflammato ry towards anti-inflammatory microglial phenotypes,which represents a potential strategy to treat the neuroinflammation that supports te rtiary *** growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is *** growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.

关键词： cognitive impairments gene therapy hippocampus insulin growth factor 1 microglial cells neurodegeneration neurogenesis neuroinflammation spinal cord injury traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Time-frequency multiresolution of fault-generated transient signals in transmission lines using a morphological filter

引用

Protection and Control of Modern Power Systems 2023年第2期8卷 85-98页

作者： Juan Carlos Quispe John Morales Eduardo Orduna Carlo Liebermann Michael Bruhns Peter Schegner Universidad Nacional de San Juan-conicet San JuanArgentina Universidad Tecnológica del Perú LimaPerú Technical University of Dresden DresdenGermany

The ongoing transformation of electrical power systems highlights the weaknesses of the protection schemes of traditional devices because they are designed and configured according to traditional characteristics of the ***,this work proposes a new methodology to study the fault-generated high frequency transient signals in transmission lines through multiresolution *** high frequency components are determined by a new digital filtering technique based on mathematical morphology theory and a spectral energy ***,wide spectra of signals in the time–frequency domain are *** performance of this method is verified on an electrical power system modeled in ATP-Draw,where simulation and test signals are developed for different locations,fault resistances,inception angles,high frequency noises,sampling frequencies,types of faults,and shapes of the structuring *** results show the characteristics of the fault such as the traveling wave frequency,location,and starting time.

关键词： Digital filter High frequency Mathematical morphology Time–frequency Traveling waves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A cloud-based platform to predict wind pressure coefficients on buildings

引用

Building Simulation 2022年第8期15卷 1507-1525页

作者： Facundo Bre Juan M.Gimenez Centro de Investigacion de Metodos Computacionales(CIMEC) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and improve indoor air ***,accurate modeling of the NV effects is a basic requirement to include this technique during the building design ***,there is an important lack of wind pressure coefficients(CP)data,essential input parameters for NV *** this,there are no simple but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which means a significant limitation to NV modeling in real *** this reason,the present contribution proposes a novel cloud-based platform to predict wind pressure coefficients on *** platform comprises a set of tools for performing fully unattended computational fluid dynamics(CFD)simulations of the atmospheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are implemented to automatize the generation of the computational domain,the meshing procedure the solution stage,and the post-processing of the *** evaluate the performance of the platform,an exhaustive validation against wind tunnel experimental data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreement with experimental data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform introduced shows being a reliable and practical C_(P) data source for NV modeling in real building design scenarios.

关键词： natural ventilation building simulation airflow network model EnergyPlus wind pressure coefficient computational fluid dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Response of ants to grazing disturbance at the central Monte Desert of Argentina: community descriptors and functional group scheme

引用

Journal of Arid Land 2014年第1期6卷 117-127页

作者： Silvia CLAVER Susana L SILNIK Florencia F CAMPóN Entomology Lab IADIZA-CONICET

Livestock ranching is one of the main productive activities in arid regions of the *** produces changes in animal as well as plant communities(***,abundance and species dominance relationships).Ants are good biological indicators due to the environmental fidelity of some of their community *** described the functional structure of the ant community in the central Monte of Mendoza,Argentina,and examined the effect of grazing using richness,diversity and the functional group *** used pitfall traps to sample ants at a reserve with 30-year cattle exclusion and at an adjacent *** of the 27 recorded species showed significant differences in their abundance and two species were absent at the *** richness and diversity did not reflect these differences,functional groups *** Climate Specialists were more abundant at the ranch while Cryptic Species and Generalized Myrmicinae increased at the *** study supports the utility of the functional group scheme to study the effects of grazing disturbance in ant communities of arid regions.

关键词： ants cattle grazing functional groups richness diversity arid zones Monte Desert

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal biology and locomotor performance in Phymaturus calcogaster:are Patagonian lizards vulnerable to climate change?

引用

Integrative Zoology 2021年第1期16卷 53-66页

作者： Rosa L.OBREGÓN Jose A.SCOLARO Nora R.IBARGÜENGOYTÍA Marlin MEDINA Instituto de Diversidad y Evolución Austral (CENPAT-CONICET)Puerto MadrynArgentina Facultad de Ciencias Naturales Universidad Nacional de la Patagonia San Juan BoscoTrelewArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente Consejo Nacional de Investigaciones Científicas y Técnicas(INIBIOMA-CONICET)San Carlos de BarilocheArgentina Centro de Investigación Esquel de Montaña y Estepa Patagónica Consejo Nacional de Investigaciones Científicas y Técnicas(CIEMEP-CONICET)EsquelArgentina

Behavioral and physiological traits of ectotherms are especially sensitive to fluctuations of environmental *** particular,niche-specialist lizards are dependent on their physiological plasticity to adjust to changing environmental *** of the genus Phymaturus are viviparous,mainly herbivorous,and inhabit only rock promontories in the steppe environments of Patagonia and the ***,we examine the vulnerability of the southernmost Phymaturus species to global warming:the endemic Phymaturus calcogaster,which lives in a mesic environment in eastern *** studied body temperatures in the field(T_(b)),preferred body temperatures in a thermogradient(T_(pref)),the operative(T_(e))and environmental temperatures,and the dependence of running performance on body *** had a mean T_(b)(27.04℃)and a mean Te(31.15℃)both lower than their preferred temperature(T_(pref)=36.61℃)and the optimal temperature for running performance(T_(o)=37.13℃).Lizard activity seems to be restraint during the early afternoon due high environmental ***,both,the high safety margin and warming tolerance suggest that the expected increase in environmental temperatures due to global warming(IPCC report in 2018)would not threaten,but indeed enhance locomotor performance in this population.

关键词： climate change cold environment locomotor performance Patagonia Phymaturus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：