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Determining the hospital cost of anterior epistaxis treatment modalities at a Canadian tertiary care centre

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 193-199页

作者： Harrish Nithianandan Kednapa Thavorn Fatmahalzahra Banaz Kristian Macdonald Andrea Lasso Shaun J.Kilty Faculty of Medicine University of OttawaOttawaOntarioCanada Ottawa Hospital Research Institute(OHRI) OttawaOntarioCanada School of Epidemiology and Public Health University of OttawaOttawaOntarioCanada Institute for Clinical and Evaluative Sciences ICES uOttawaOttawaOntarioCanada Department of Otolaryngology-Head and Neck Surgery The University of OttawaOttawaOntarioCanada Dr.S.Kilty Medicine Prof.Corp. OttawaONCanada

Objective:To estimate the hospital costs of managing anterior epistaxis in the Emergency Department at a Tertiary Care centre in *** and methods:A cost analysis was conducted based on a retrospective review of Emergency Department visits from January 2012 to May 2014.A consecutive sample of adult patients with a diagnosis of anterior epistaxis was *** epistaxis was managed via one of:Nasal clip,Merocel(R),Silver Nitrate cautery,Vaseline packing,other treatment or no *** the direct and indirect hospital costs(SCDN)for anterior epistaxis treatment were calculated from the hospital's *** linear models were used to assess the association between treatment modalities and total hospital costs while controlling for potential confounding ***:Three hundred and fifty-three patients(49%female)with a mean age of(69.9±18.5)years were included in the *** median(interquartile ranges)costs of treatment ranged from CS227.83(CS167.96,CS328.69)for observation to CS763.98(CS632.25,CS830.23)for Merocel(R).The overall median total hospital costs incurred across all modalities was CS566.24(CS459.61,CS753.46)for the management of anterior *** Nitrate,nasal clip,and observation were statistically associated with a lower cost when compared to Merocel(R)(P<0.001)even after potential confounding factors were ***:Our results show wide difference in the hospital cost of epistaxis across treatment *** cost estimates can help inform future economic evaluation studies aiming to guide the allocation of health care resources for patients with epistaxis.

关键词： Anterior epistaxis Nasal packing Cautery Silver nitrate Hospital costs

Epoxy resin nanocomposites reinforced with ionized liquid stabilized carbon nanotubes

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International Journal of Smart and Nano Materials 2011年第3期2卷 176-193页

作者： Zhe Wang Xiongtao Yang Qiang Wang H.Thomas Hahn Sang-gi Lee Kun-Hong Lee Zhanhu Guo Mechanical&Aerospace Engineering Department University of California Los AngelesLos AngelesCA 90095USA Integrated Composites Lab Dan F.Smith Department of Chemical EngineeringLamar UniversityBeaumontTX 77710USA Institute of Chemical and Engineering Sciences(ices) A-STARApplied Catalysis1Pesek RoadJurong Island627833 Singapore Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 120-750Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 790-784Korea

Epoxy resin nanocomposites reinforced with three different ionic liquid functionalized carbon nanotubes(f-CNTs)were fabricated by an in situ polymerization *** influence of the anions on the curing process was studied through differential scanning calorimetry(DSC)and normalized Fourier transform infrared(FTIR)*** composition of the nanocomposites was analyzed by X-ray photoelectron *** different mechanisms are proposed to explain the curing process of the neat epoxy and its *** electric conductivity and mechanical properties of the nanocomposites are also *** tensile strength was increased dramatically due to the insertion of *** electron microsopy fracture surface analysis indicates a strong interfacial bonding between the carbon nanotubes and the polymer matrix.

关键词： epoxy resin nanocomposite carbon nanotube ionic liquid functionalization

冠状动脉搭桥术后长期无症状存活者的生活质量与普通人群相当

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 28-29页

作者： Bradshaw P.J. Jamrozik K.D. Gilfillan I.S. Thompson P.L. 黎一兵 Institute for Clinical Evaluative Sciences(ices) 2075 Bayview Avenue Toronto Ont. M4N 3M5 Canada Dr.

Background: Health- related quality of life(HRQOL) among long- term survivors of coronary artery bypass surgery is an important outcome that has been little studied at the population level. Methods: A postal survey was conducted in 1999 to 2000 in patients 6 to 20 years after coronary artery bypass graft(CABG) surgery in Western Australia. A random stratified sample of 2500 was drawn from 8910 patients who had their first CABG surgery in 1980 to 1993. Health- related quality of life was measured with Short Form 36 and EuroQol visual analogue scale. Results: Response was 82% (n=2061). Health- related quality of life declined with age and was similar for men and women, although scores for women were worse for physical functioning. Compared with Australian population norms, the age- and sex- standardized scores of survivors of CABG were generally worse, mainly in the physical domain. Reported angina at the time of follow- up(33% ), symptoms of heart failure equivalent to New York Heart Association(NYHA) classes II to IV(34% ), and comorbidities such as diabetes and hypertension were associated with poorer HRQOL. For both men and women without angina or heart failure at follow- up,HRQOL was no different from that of the general population. Conclusion: Overall, the quality of life among long- term survivors of CABG is worse than that of the general population, the difference being mainly attributable to recurrent symptoms and comorbidities. Quality of life for those without angina or heart failure at follow- up was equivalent to the population norms, providing an incentive to maximize efforts to abolish angina and ameliorate heart failure symptoms.

关键词：健康相关生活质量 CABG术后冠状动脉搭桥术长期存活者普通人群无症状 HRQOL 视觉模拟评分年龄增长澳大利亚

冰盖减少将降低波罗的海灰海豹(Halichoerus grypus)雌兽的繁殖成功率

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AMBIO－人类环境杂志 2008年第2期37卷 76-81页

作者： Mart Jüssi Tero Hrknen Eero Helle Ivar Jüssi 王胜芬兰狩猎和渔业研究所瑞典自然历史博物馆 HELCOM和ices海洋哺乳动物工作组

根据冰的条件,波罗的海灰海豹(Halichoerus grypus)在陆地和冰面上交替繁殖。我们指出,与冰面相比,灰海豹雌兽在陆地上繁殖的状况以幼仔死亡率和质量衡量均有下降。陆地上断奶前的平均死亡率是21.1%(范围0%～31.6%),与出生密度相关(范围... 详细信息

根据冰的条件,波罗的海灰海豹(Halichoerus grypus)在陆地和冰面上交替繁殖。我们指出,与冰面相比,灰海豹雌兽在陆地上繁殖的状况以幼仔死亡率和质量衡量均有下降。陆地上断奶前的平均死亡率是21.1%(范围0%～31.6%),与出生密度相关(范围0.5～5.2头幼仔/100m^2)。冰面上的平均死亡率为1.5%,在特别密集的繁殖群体中,最高密度为0.2头幼仔/100m^2。在开始换毛时,冰上出生的幼仔平均体重(48.3±8.1kg)明显高于陆地出生的幼仔(37.4±7.8kg)。与陆地相比,冰上终生净繁殖率(幼仔存活)和幼仔质量(断奶体重和健康)的指标更为有利,所以冰面逐渐缩小,会降低波罗的海灰海豹雌兽的健康,并显著增加准灭绝的危险性。

关键词：繁殖成功率波罗的海灰海豹冰盖平均体重死亡率密度相关繁殖群体

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渔业资源开发改变了对海底生物的捕食水平

AMBIO－人类环境杂志 1999年第7期28卷 578-582页

作者： Chris L. J. Frid Sture Hansson Stefan A. Ragnarsson Adriaan Rijnsdorp Sigmar A. Steingrimsson 苗泽伟国际海洋开发联合会(ices)捕鱼对生态系统影响工作组中国科学院生态环境中心

在许多沿海地区,捕鱼构成了人类对海洋生态系统的主要影响。毋庸置疑,捕鱼改变了鱼群落的丰度和鱼种群的大小组成。我们用北海8个海底鱼种丰度及其食物消耗速率的时间序列数据来构建海底捕食压力的时间序列。主要由捕鱼压力所产生的鱼... 详细信息

在许多沿海地区,捕鱼构成了人类对海洋生态系统的主要影响。毋庸置疑,捕鱼改变了鱼群落的丰度和鱼种群的大小组成。我们用北海8个海底鱼种丰度及其食物消耗速率的时间序列数据来构建海底捕食压力的时间序列。主要由捕鱼压力所产生的鱼类生物量的变化导致了鱼类捕食者所消耗的海底生物数量和种类组成的变化。由于捕鱼的间接影响,在生态系统各部分之间物质流的这种变化可能进一步改变生态系统功能。

关键词：渔业资源海底生物捕食水平海洋鱼类生态系统

Design,synthesis and bioevaluation of N-hydroxyquinolinones as potential anti-plasmodial,anti-bacterial and iron(Ⅱ)-chelating agents

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中国药理学与毒理学杂志 2015年第S1期29卷 101-101页

作者： Yan-boTENG Alicesoh-MeoyONG LaurentRNIA ChristinaLi-LinCHAI Department of Pharmacy National University of Singapore 18 Science Drive 4 117543 Laboratory of Malaria Immunobiology Singapore Immunology Network (SIgN) Agency for Science Technology and Research (A*STAR) 8ABiomedical Grove Immunos Building 138648 Singapore Institute of Chemical and Engineering Sciences (ices) Agency for Science Technology and Research (A*STAR) 8 Biomedical Grove 138665 Singapore

OBJECTIVE To establish a small compound library via a versatile synthetic route for the investigation of natural-inspiring compounds containing N-hydroxypyridones motif as potential anti-plasmodial,anti-bacterial and iron(Ⅱ)-chelating *** An amidation/cyclization approach was adopted to synthesize a library of *** anti-plasmodial susceptibility of lab clone 3D7 *** was measured using aprotocol modified from the WHO *** minimum bactericidal concentration(MBC)values were determined against Escherichia coli and Staphylococcus *** compounds were selected to test their iron(Ⅱ)-chelating *** iron(Ⅱ)-chelating ability was determined by measuring the absorbance of ferrozine-iron complex at 562 *** A new route for the facile synthesis of a library of N-hydroxyquinolinones based on one-pot palladium catalyzed C-N amidation/dehydrocyclizationsequence was *** compounds show anti-plasmodial activities with the range of 1.1-1.4μmol·L-1,50% chelation abilities of the nine selected compounds were shown to be 0.24-0.29mmol·*** Alibrary of N-hydroxyquinolinones was synthesized via a novel synthetic *** anti-plasmodial and anti-bacterial activities of these compounds were *** compounds show potent anti-plasmodial activities Nine compounds were examined for their propensities to undergo iron chelation and these compounds were shown to be promising iron(Ⅱ)chelators as compared to EDTA.

关键词： N-hydroxyquinolinones anti-plasmodial anti-bacteri

Inflammatory bowel disease among first generation immigrants in Israel:A nationwide epi-Israeli Inflammatory Bowel Disease Research Nucleus study

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World Journal of Methodology 2023年第5期13卷 475-483页

作者： Mira Stulman Gili Focht Yiska Loewenberg Weisband Shira Greenfeld Amir Ben Tov Natan Ledderman Eran Matz Ora Paltiel Shmuel Odes Iris Dotan Eric Ian Benchimol Dan Turner The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical CenterFaculty of MedicineThe Hebrew University of JerusalemJerusalem 9103102Israel Braun School of Public Health and Community Medicine Hadassah Medical OrganizationFaculty of MedicineHebrew University of JerusalemJerusalem 9574869Israel Clalit Research Institute Tel Aviv 6209804Israel Maccabi Health Services and the Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6801296Israel Meuhedet Health Services Tel Aviv 6203854Israel Leumit Health Services Tel Aviv 6473704Israel Faculty of Health Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Gastroenterology Rabin Medical CenterPetah Tikva 49100Israel Department of Paediatrics and Institute of Health Policy Management and EvaluationThe Hospital for Sick ChildrenUniversity of TorontoToronto M5G 1X8ONCanada SickKids Inflammatory Bowel Disease Centre Division of GastroenterologyHepatology and NutritionChild Health Evaluative SciencesThe Hospital for Sick Children and the SickKids Research InstituteToronto M5G 1X8Canada ices Toronto M4N 3M5Canada

BACKGROUND Israel has a high rate of Jewish immigration and a high prevalence of inflammatory bowel disease(IBD).AIM To compare IBD prevalence in first-generation immigrants vs Israel-born *** Patients with a diagnosis of IBD as of June 2020 were included from the validated epi-IIRN(Israeli IBD Research Nucleus)cohort that includes 98%of the Israeli *** stratified the immigration cohort by IBD risk according to country of origin,time period of immigration,and age group as of June *** A total of 33544 patients were ascertained,of whom 18524(55%)had Crohn’s disease(CD)and 15020(45%)had ulcerative colitis(UC);28394(85%)were Israel-born and 5150(15%)were *** was more prevalent in immigrants(2717;53%)than in non-immigrants(12303,43%,P<0.001),especially in the<1990 immigration *** adjusting for age,longer duration in Israel was associated with a higher point prevalence rate in June 2020(high-risk origin:Immigration<1990:645.9/100000,≥1990:613.2/100000,P=0.043;intermediate/low-risk origin:<1990:540.5/100000,≥1990:192.0/100000,P<0.001).The prevalence was higher in patients immigrating from countries with high risk for IBD(561.4/100000)than those originating from intermediate-/low-risk countries(514.3/100000;P<0.001);non-immigrant prevalence was 528.9/*** Lending support to the environmental effect on IBD etiology,we found that among immigrants to Israel,the prevalence of IBD increased with longer time since immigration,and was related to the risk of IBD in the country of *** UC rate was higher than that of CD only in those immigrating in earlier time periods.

关键词： Epidemiology Inflammatory bowel disease Immigration Environment

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微生物海洋学——一个新兴交叉学科

大自然 2016年第3期37卷 1-1页

作者：焦念志中国科学院发展中国家科学院厦门大学海洋微型生物与地球圈层研究所北太平洋海洋科学组织(Pices)与国际海洋考察理事会(ices)联合工作组中国未来海洋联盟中国微生物学会

海洋是生命的摇篮，微生物足生命的起点，从诞生之日就影响着整个地球系统。微生物在地球圈层中的作用超乎人们的想象。二十多亿年前的微生物产氧作用从根本上改变了地球环境，并促进了后续生命形式的诞生和演化，直至形成今天的世间万物。

关键词：微生物海洋学交叉学科生命形式地球系统地球圈层地球环境