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Journal of Innovative Optical Health sciences 2024年第2期17卷 59-66页

作者： Dongmin Zhang Guang Yang Yao Tan Chong Chen Jie Zhang Hui Li School of biomedical Engineering(Suzhou)Division of Life sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou institute of biomedical Engineering and Technology Chinese A cademy of sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3D)structures and functions of various millimeter-size bio-specimen such as ***,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3D image of thick ***,we report a continuous-rotational light-sheet microscope(CR-LSM)that enables simultaneous 3D bright-field and fluorescence *** a high-accuracy rotational stage,CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation ***,3D morphology and fluorescent structure were reconstructed with a developed *** CR-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA

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National Science Review 2024年第3期11卷 72-91页

作者： Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Department of biomedical sciences City University of Hong Kong institute of Systems and Physical Biology Shenzhen Bay Laboratory

Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer（CRC） cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione（GSH） via the upregulation of RRM2B——a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3 UTR of RRM2B increased its m RNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence（CDS） of OPA1——an essential GTPase protein for mitochondrial inner membrane fusion——also increased m RNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.

关键词： m6A mitochondrial fusion glutathione OPA1 colorectal cancer

Preparation of water-soluble tantalum nanoparticles and their radiosensitization application

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Tungsten 2024年第4期6卷 748-758页

作者： Wang Zhang Shuang-Long Du Zhi-Guo Zhang Tao Wang Chun-Jian Su Xing-Hua Dong Shuang Zhu Zhan-Jun Gu College of Mechanical and Electronic Engineering Shandong University of Science and Technology CAS Key Laboratory for biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Science GBA Research Innovation institute for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Chinese Academy of Sciences

Radiation therapy(RT) that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment ***,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the *** high atom number(Z) element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma *** nanoparticles(Ta NPs) exhibit good radiotherapy sensitization ***,achieving the water solubility of Ta NPs is *** study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP) for radiotherapy sensitization *** results showed that the water solubility of Ta NPs modified with SHMP was significantly *** biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.

关键词： Mechanochemical method Radiotherapy sensitization Sodium hexametaphosphate Tantalum nanoparticles

Trend of Developing Aqueous Liquid and Gel Electrolytes for Sustainable,Safe,and High‑Performance Li‑Ion Batteries

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Nano-Micro Letters 2024年第1期16卷 17-34页

作者： Donghwan Ji Jaeyun Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Health sciences and Technology Samsung Advanced Institute for Health Sciences&Technology(SAIHST)Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea biomedical institute for Convergence at SKKU(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea institute of Quantum Biophysics(IQB) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Present Address:Department of NanoEngineering University of California San DiegoLa JollaSan DiegoCA 92093USA

Current lithium-ion batteries(LIBs)rely on organic liquid electrolytes that pose significant risks due to their flammability and *** potential for environmental pollution and explosions resulting from battery damage or fracture is a critical ***-based(aqueous)electrolytes have been receiving attention as an alternative to organic ***,a narrow electrochemicalstability window,water decomposition,and the consequent low battery operating voltage and energy density hinder the practical use of aqueous ***,developing novel aqueous electrolytes for sustainable,safe,high-performance LIBs remains *** Review first commences by summarizing the roles and requirements of electrolytes–separators and then delineates the progression of aqueous electrolytes for LIBs,encompassing aqueous liquid and gel electrolyte development trends along with detailed principles of the *** aqueous electrolytes are progressed based on strategies using superconcentrated salts,concentrated diluents,polymer additives,polymer networks,and artificial passivation layers,which are used for suppressing water decomposition and widening the electrochemical stability window of water of the *** addition,this Review discusses potential strategies for the implementation of aqueous Li-metal batteries with improved electrolyte–electrode interfaces.A comprehensive understanding of each strategy in the aqueous system will assist in the design of an aqueous electrolyte and the development of sustainable and safe high-performance batteries.

关键词： Lithium-ion battery(LIB) Aqueous electrolyte Gel electrolyte Electrochemical stability window Li dendrite

Improved Integrated Deep Model for Pap-Smear Cell Analysis

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Journal of Systems Science and Information 2024年第1期12卷 113-124页

作者： Somasundaram DEVARAJ Nirmala MADIAN Gnanasaravanan SUBRAMANIAM Rithaniya CHELLAMUTHU Muralitharan KRISHANAN School of Electronics Engineering Vellore Institute of TechnologyVellore 632014India Department of biomedical Engineering Dr.N.G.P Institute of TechnologyCoimbatore 641045India Karunya institute of Technology and sciences Coimbatore 641114India Department of Computer Science Institute of Mathematical ScienceSungkyunkwan UniversitySuwon 16419South Korea

Cervical cancer is the fourth most common malignancy to strike a woman *** discovered early enough,it can be effectively *** there is a chance of error owing to human error,the Pap smear is a good tool for first screening for cervical *** also takes a lot of time and effort to *** aim of this study was to reduce the possibility of error by automating the process of classifying cervical cancer using Pap smear *** the purpose of this study,dual convolution neural networks with LSTM were employed to classify images due to deep learning approaches inspire distinct features and powerful classifiers for many computer vision *** proposed deep learning model based on convolution neural networks(CNN)with the long short-term memory(LSTM)network is to learn features which give better recognition *** overall model is known as *** which‘smear’indicates‘pap-smear cancer cells’and‘net’refers to neural *** parameters such as,Accuracy,Precision,Recall,Accuracy,Sensitivity,and Specificity are used to validate the *** proposed method provides the improved accuracy of 99.57 percentage for classification of the pap-smear *** proposed approaches demonstrate the effectiveness of our contributions by testing and comparing with the state-of-the-art techniques.

关键词： pap-smear deep learning convolution neural network smear-net

Structural changes in the obese brain

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Neural Regeneration Research 2024年第12期19卷 2561-2562页

作者： Anna R.R.Da Conceicao Marcelo N.N.Vieira Fernanda G.De Felice D’Or institute for Research and Education Rio de JaneiroBrazil institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for Neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

Non-linear dynamic state-space network modeling for decoding neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 1879-1880页

作者： Venkata C.Chirumamilla Chi Wang Ip Martin Reich Robert Peach Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatrics institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity of WürzburgWürzburgGermany Academic Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously *** disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

A new ChatGPT-empowered,easy-to-use machine learning paradigm for environmental science

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Eco-Environment & Health 2024年第2期3卷 131-136页

作者： Haoyuan An Xiangyu Li Yuming Huang Weichao Wang Yuehan Wu Lin Liu Weibo Ling Wei Li Hanzhu Zhao Dawei Lu Qian Liu Guibin Jiang State Key Laboratory of Environmental Chemistry and Toxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China biomedical Engineering institute School of Control Science and EngineeringShandong UniversityJinan 250061China

The quantity and complexity of environmental data show exponential growth in recent ***-quality big data analysis is critical for performing a sophisticated characterization of the complex network of environmental *** learning(ML)has been employed as a powerful tool for decoupling the complexities of environmental big data based on its remarkable fitting ***,due to the knowledge gap across different subjects,ML concepts and algorithms have not been well-popularized among researchers in environmental *** this context,we introduce a new research paradigm—“ChatGPT t ML t Environment”,providing an unprecedented chance for environmental researchers to reduce the difficulty of using ML *** instance,each step involved in applying ML models to environmental sustainability,including data preparation,model selection and construction,model training and evaluation,and hyper-parameter optimization,can be easily performed with guidance from *** also discuss the challenges and limitations of using this research paradigm in the field of environmental ***,we highlight the importance of“secondary training”for future application of“ChatGPT t ML t Environment”.

关键词： Machine learning Environmental application ChatGPT Secondary training

Inflammatory bowel disease(ulcerative colitis type)severity shows inverse correlation with semen parameters and testosterone levels

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Asian Journal of Andrology 2024年第2期26卷 155-159页

作者： Darmadi Darmadi Cennikon Pakpahan Rajender Singh Ankur Saharan Wanly Syahrizal Pasaribu Hermansyah Hermansyah Andri Rezano Department of Internal Medicine Faculty of MedicineUniversitas Sumatera UtaraMedan 20155Indonesia Andrology Study Program Faculty of MedicineUniversitas AirlanggaSurabaya 60132Indonesia Department of biomedical sciences Faculty of MedicineUniversitas AirlanggaSurabaya 60132Indonesia Division of Endocrinology Central Drug Research InstituteLucknowUtar Pradesh 226031India Amity University LucknowUttar Pradesh 226010India Department of biomedical sciences Faculty of MedicineUniversitas PadjadjaranSumedang 45363Indonesia

Individuals with inflammatory bowel disease(IBD)have been reported to be at an increased risk of infertility and sexual *** the relationship between them remains unclear,IBD severity is suspected to affect hormone levels and *** analyze the impact of IBD severity on semen parameters and sex hormone levels in ulcerative colitis-type IBD(UC-IBD),we conducted a cross-sectional study involving 120 patients with UC-IBD in Adam Malik General Hospital,Medan,*** patients were classified into three groups based on the Mayo score for Uc,followed by a comparison of various semen and hormone parameters among these *** addition to the cross-sectional analysis,a simple correlation test was conducted irrespective of the patient *** concentration,motility,and morphology were found to decline significantly with an increase in IBD *** classifying patients with IBD into subgroups,the Mayo score showed negative correlations with sperm concentration(r=-0.375,P<0.0001),rapid progressive motility(r=-0.660,P<0.0001),free testosterone(r=-0.732,P<0.0001),and total testosterone(r=-0.721,P<0.0001),and positivecorrelations with immotile sperm(r=0.660,P<0.0001),abnormal morphology(r=0.657,P<0.0001),and sex hormone-binding globulin(SHBG;r=0.278,P=0.002).Sperm concentration,motility,and morphology declined significantly with the severity of *** study suggests a significant negative impact of IBD severityonsemenqualityand sexhormones.

关键词： inflammatory bowel disease reproductive health sexual health sperm parameter testosterone

Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice

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Zoological Research 2024年第5期45卷 1073-1087页

作者： Jing-Wei Ye Tanveer Abbas Jian-Teng Zhou Jing Chen Meng-Lei Yang Xiong-Heng Huang Huan Zhang Hui Ma Ao Ma Bo Xu Ghulam Murtaza Qing-Hua Shi Bao-Lu Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230026China institute of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

Infertility represents a significant health concern,with sperm quantity and quality being crucial determinants of male ***(OAT)is characterized by reduced sperm motility,lower sperm concentration,and morphological abnormalities in sperm heads and *** variants in several genes have been implicated in OAT,its genetic etiologies and pathogenetic mechanisms remain inadequately *** this study,we identified a homozygous nonsense mutation(c.916C>T,***306*)in the coiled-coil domain containing 146(CCDC146)gene in an infertile male patient with *** mutation resulted in the production of a truncated CCDC146 protein(amino acids 1-305),retaining only two out of five coiled-coil *** validate the pathogenicity of the CCDC146 mutation,we generated a mouse model(Ccdc146^(mut/mut))with a similar mutation to that of the ***,the Ccdc146mut/mut mice exhibited infertility,characterized by significantly reduced sperm counts,diminished motility,and multiple defects in sperm heads and ***,the levels of axonemal proteins,including DNAH17,DNAH1,and SPAG6,were significantly reduced in the sperm of Ccdc146^(mut/mut) ***,both human and mouse CCDC146 interacted with intraflagellar transport protein 20(IFT20),but this interaction was lost in the mutated versions,leading to the degradation of *** study identified a novel deleterious homozygous nonsense mutation in CCDC146 that causes male infertility,potentially by disrupting axonemal protein *** findings offer valuable insights for genetic counseling and understanding the mechanisms underlying CCDC146 mutant-associated infertility in human males.

关键词： Oligoasthenoteratozoospermia Human infertility Sperm flagellum CCDC146 Intraflagellar transport IFT20