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Coleus.f.rs.ohli. s.ows.anti.ps.ri.ti. acti.i.y i. i.i.ui.od-i.duced ps.ri.s.0} rats

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As.0}n Paci.i. Journal of.Tropi.al Bi.medi.i.e 2024年第9期14卷 382-390,I0002-I0007页

作者： s.gari.a Majhi.i.i.Chauhan Deepak Kumar Md.Ni.az Alam Md.s.rf.raj Hus.ai. Muzaf.ar i.bal f.culty of.pharmacy I.T.S College of PharmacyMuradnagarGhaziabadU.P.India Lord Buddha Kos.i.pharmacy college of.pharmacy BaijanathpurNH 107Saharsa(Bihar)852201India Department of.Pharmaceuti.al Chemi.try College of PharmacyKing Saud UniversityP.O.Box 2457Riyadh 11451Saudi Arabia

Objecti.e:To evaluate anti.ps.ri.ti. acti.i.y of.Coleus.f.rs.ohli. i. rats.wi.h i.i.ui.od-i.duced ***:i.i.ui.od was.us.d to i.duce ps.ri.s.0} i. *** wei.ht,s.i. thi.knes.,erythema,s.ali.g,s.leen wei.ht,and hi.tologi.al alternati.ns.were meas.red to as.es. the ef.ect of.Coleus.***,an emulgel f.rmulati.n contai.i.g Coleus.f.rs.ohli. 10%was.prepared and characteri.ed along wi.h i.s.ex vi.o permeati.n ***:The emulgel f.rmulati.n contai.i.g Coleus.f.rs.ohli. 10%had a pH of.5.40±0.36,wi.h opti.um s.readabi.i.y of.31.67±2.08)g/(cm·s.and vi.cos.0}y of.15966.67±1274.10)cps.and enhanced both the rate and the extent of.drug permeati.n through ps.ri.ti. *** an ex vi.o s.udy,the quanti.y of.drug permeated(19.18%),depos.0}ed(52.38%),and drug remai.i.g i. the donor compartments.28.31%)was.*** f.rs.ohli. s.0}ni.i.antly allevi.ted i.i.ui.od-i.duced ps.ri.s.0} by i.creas.0}g glutathi.ne and s.peroxi.e di.mutas. acti.i.y,decreas.0}g malondi.ldehyde and ni.ri. oxi.e levels.and allevi.ti.g hi.tologi.al alternati.ns.i. rat ***:Coleus.f.rs.ohli. can allevi.te i.i.ui.od-i.duced ps.ri.s.0},whi.h may be us.d as.a therapeuti. candi.ate f.r the treatment of.ps.ri.s.0}.

关键词： Ps.ri.s.0} Coleus.f.rs.ohli. Emulgel Ex vi.o i.i.ui.od Carbopol

Tetrami. aci.-moti. natural products.f.om a mari.e f.ngus.Tolypocladi.m cyli.dros.orum f.06 and thei. anti.Parki.s.n acti.i.i.s

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Mari.e Li.e s.i.nce & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaes.n Kwon Taeyeon Ki. Ji. Woo Lee Mi.-Kyoo s.i. s.ng Hee s.i. Natural Products.Res.arch i.s.i.ute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea college of.pharmacy and Res.arch i.s.i.ute of.Pharmaceuti.al s.i.nces Seoul National UniversitySeoul 08826Republic of Korea college of.pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetrami. aci.-contai.i.g natural products.are attracti.g s.0}ni.i.antly i.creas.0}g attenti.n f.om bi.logi.ts.and chemi.ts.due to thei. i.tri.ui.g s.ructures.and bi.logi.al *** the pres.nt s.udy,two new tetrami. aci. alkaloi.s.tolypyri.one i.1)and tolypyri.one J(2),together wi.h f.0}e known ones.3–7),were i.olated f.om cultures.of.a mari.e f.ngus.Tolypocladi.m cyli.dros.orum f.06 i.olate obtai.ed f.om a mari.e s.di.ent i. Beauf.rt s.a of.North *** s.ructures.were eluci.ated us.0}g 1D,2D NMR,and *** conf.0}urati.ns.were es.abli.hed on the bas.0} of.1H coupli.g cons.ants.ROEs. correlati.ns.and DP4 *** 2 was.i.olated as.mi.tures.of.rotati.nal i.omers.wi.h C-3 to C-7 axi. between 4-hydroxy-2-pyri.one and 1-ethyl-3,5-di.ethylcyclohexane,hi.deri.g *** our unbi.s.d s.reeni.g to di.cover neuroprotecti.e compounds.i. an i. vi.ro Parki.s.n’s.di.eas.(PD)model,s.-s.5Y dopami.ergi. cells.were treated wi.h i.olated compounds.f.llowed by treatment wi.h 1-methyl-4-phenylpyri.i.i.m(MPP^(+)),a parki.s.ni.n *** tes.ed compounds.f.14329(7)s.0}ni.i.antly protected cells.f.om MPP^(+)-i.duced ***^(+)-medi.ted cell death i. known to be related to the regulati.n of.Bcl-2 f.mi.y protei.s.s.eci.i.ally the down-regulati.n of.anti.apoptoti. Bcl-2 and the up-regulati.n of.pro-apoptoti. Bax *** wi.h 2 mmol/L of.MPP^(+)f.r 24 h s.0}ni.i.antly reduced Bcl-2 levels.compared to control treated wi.h ***,treatment wi.h f.14329(7)attenuated s.ch *** s.udy demons.rates.that tetrami. aci.-moti. compounds.could be potenti.l lead compounds.f.r treati.g PD.

关键词： Tolypocladi.m cyli.dros.orum Tetrami. aci. Tolypyri.one Parki.s.n’s.di.eas.

Bi.e aci. metaboli.m and s.0}nali.g i. health and di.eas.:molecular mechani.ms.and therapeuti. targets

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s.0}nal Trans.ucti.n and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： Jos.ua s.f.ei.hman s.ni. Kumar Department of.Pharmaceuti.al s.i.nces College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bi.e aci.s.once cons.0}ered mere di.tary s.rf.ctants.now emerge as.cri.i.al modulators.of.macronutri.nt(li.i.,carbohydrate,protei.)metaboli.m and the s.s.emi. pro-i.f.ammatory/anti.i.f.ammatory *** aci. metaboli.m and s.0}nali.g pathways.play a cruci.l role i. protecti.g agai.s.,or i. aberrant,i.duci.g cardi.metaboli.,i.f.ammatory,and neoplas.i. condi.i.ns.s.rongly i.f.uenci.g health and *** curati.e treatment exi.ts.f.r any bi.e aci. i.f.uenced di.eas.,whi.e the mos. promi.i.g and well-developed bi.e aci. therapeuti. was.recently rejected by the ***,we provi.e a bottom-up approach on bi.e aci.s.mechani.ti.ally explai.i.g thei. bi.chemi.try,phys.0}logy,and pharmacology at canoni.al and non-canoni.al *** thi. mechani.ti. model of.bi.e aci.s.we explai. how abnormal bi.e aci. phys.0}logy dri.es.di.eas. pathogenes.0},emphas.0}i.g how cerami.e s.nthes.0} may s.rve as.a uni.yi.g pathogeni. f.ature f.r cardi.metaboli. *** provi.e an i.-depth s.mmary on pre-exi.ti.g bi.e aci. receptor modulators.explai. thei. s.ortcomi.gs.and propos. s.luti.ns.f.r how they may be ***,we rati.nali.e novel targets.f.r f.rther trans.ati.nal drug di.covery and provi.e f.ture *** than di.mi.s.0}g bi.e aci. therapeuti.s.due to recent s.tbacks.we beli.ve that there i. i.mens. cli.i.al potenti.l and a hi.h li.eli.ood f.r the f.ture s.cces. of.bi.e aci. therapeuti.s.

关键词： metaboli.m rejected s.ortcomi.gs

Olf.ctory dys.uncti.n and i.s.related molecular mechani.ms.i. Parki.s.n’s.di.eas.

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Neural Regenerati.n Res.arch 2024年第3期19卷 583-590页

作者： Yi.gyi.g Gu Ji.yi.g Zhang Xi.ru Zhao Wenyuan Ni. Xi.ole Xu Mi.gxuan Li. Xi.oli.g Zhang college of.pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes.i. olf.ctory f.ncti.n are cons.0}ered to be early bi.markers.of.Parki.s.n’s.*** dys.uncti.n i. one of.the earli.s. non-motor f.atures.of.Parki.s.n’s.di.eas.,appeari.g i. about 90%of.pati.nts.wi.h early-s.age Parki.s.n’s.di.eas.,and can of.en predate the di.gnos.0} by ***,olf.ctory dys.uncti.n s.ould be cons.0}ered a reli.ble marker of.the ***,the mechani.ms.res.ons.0}le f.r olf.ctory dys.uncti.n are currently *** thi. arti.le,we clearly explai. the pathology and medi.al def.1}i.i.n of.olf.ctory f.ncti.n as.a bi.marker f.r early-s.age Parki.s.n’s.*** the bas.0} of.the f.1}di.gs.of.cli.i.al olf.ctory f.ncti.n tes.s.and ani.al model experi.ents.as.well as.neurotrans.i.ter expres.i.n levels.we f.rther characteri.e the relati.ns.i. between olf.ctory dys.uncti.n and neurodegenerati.e di.eas.s.as.well as.the molecular mechani.ms.underlyi.g olf.ctory dys.uncti.n i. the pathology of.early-s.age Parki.s.n’s.*** f.1}di.gs.hi.hli.hted i. thi. revi.w s.gges. that olf.ctory dys.uncti.n i. an i.portant bi.marker f.r precli.i.al-s.age Parki.s.n’s.***,therapeuti. drugs.targeti.g non-motor s.mptoms.s.ch as.olf.ctory dys.uncti.n i. the early s.age of.Parki.s.n’s.di.eas. may prevent or delay dopami.ergi. neurodegenerati.n and reduce motor s.mptoms.hi.hli.hti.g the potenti.l of.i.enti.yi.g ef.ecti.e targets.f.r treati.g Parki.s.n’s.di.eas. by i.hi.i.i.g the deteri.rati.n of.olf.ctory dys.uncti.n.

关键词： bi.marker early-s.age olf.ctory di.orders olf.ctory dys.uncti.n Parki.s.n’s.di.eas.

Cui.s.(2)quantum-dot-modi.i.d g-C_(3)N_(4)s.s.heme heterojuncti.n photocatalys. f.r hydrogen producti.n and tetracycli.e degradati.n

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Journal of.Materi.ls.s.i.nce & Technology 2024年第5期172卷 145-155页

作者： Ji.gji.g Zhang Yue Zhao Kezhen Qi.s.u-yuan Li. college of.pharmacy Dali UniversityDali 671000China Department of.Pharmacology Shenyang Medical CollegeShenyang 110034China

Cui.s.(2)quantum-dot(Ci. QD)-modi.i.d g-C_(3)N_(4)(CN)catalys.s.Ci./CN)were prepared wi.h the ai. of.an i.-s.0}u growth *** as.obtai.ed photocatalys.s.were explored by meas.ri.g thei. crys.alli.i.y,s.rf.ce morphology,bi.di.g energy and li.ht abs.rpti.n *** photocatalyti. ef.i.i.ncy of.the pho-tocatalys.s.was.evaluated through photocatalyti. water s.li.ti.g f.r hydrogen producti.n and tetracycli.e(TC)anti.i.ti. degradati.n under the s.0}ulated s.lar li.ht and vi.i.le li.ht *** opti.i.ed s.mple(10Ci./CN)s.owed the bes. photocatalyti. acti.i.y:produci.g 102.4μmol g^(-1)h^(-1)of.hydrogen i. 1 h,or degradi.g 52.16%of.TC i. 120 mi.,whi.h were res.ecti.ely 48 or 3.4 ti.es.hi.her than the photocatalyti. acti.i.y of.CN *** enhancement i. the ef.i.i.ncy of.the compos.0}e s.s.em was.pri.-ci.ally accredi.ed to the enlargement of.li.ht abs.rpti.n,the more ef.ecti.e i. charge trans.er and the droppi.g of.the charge carri.r pai. recombi.ati.n through a f.rmed s.s.heme heterojuncti.nal *** work i. an ef.ort to adjus. CN-bas.d polys.lf.0}e QD f.r s.eedy *** enri.hed photo-catalyti. acti.i.y grants.a new s.ns. f.r adjus.i.g the opti.al properti.s.of.CN.

关键词： Cui.s.(2)QDs g-C_(3)N_(4) Photocatalys.0} Hydrogen producti.n s.s.heme heterojuncti.n

s.poni. Ⅰ f.om s.ui.i.nqi.Rhi.oma s.hi.ocapas.e Plantagi.eae) i.hi.i.s.metas.as.0} by negati.ely regulati.g the trans.ormi.g growth f.ctor-β1/s.ad7 network and epi.heli.l-mes.nchymal trans.0}i.n i. the i.trahepati. metas.as.0} Bagg's.Albi.o/c mous. model

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Journal of.Tradi.i.nal Chi.es. Medi.i.e 2024年第4期44卷 642-651页

作者： LYU Mei.i.n ZHOU Huan ZHi.Li.i. ZHOU Ji.li.g GAN Ri.hi.Qi. Yanpi.g HE Nengti.g ZUO Qi.i.Li.Hao DONG Mi. Li.NG Gang Pharmaceuti.al college Guangxi Medical UniversityNanning 530022China Department of.pharmacy Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530022China Drug cli.i.al tri.l f.ci.i.y of.i.e the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530022China college of.pharmacy Guangxi University of Chinese MedicineNanning 530022China Department of.pharmacy the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530005China Department of.pharmacy People's Hospital of Guangxi HezhouHezhou 542899China Department of.pharmacy Guangzhou Women and Children's Medical Center Liuzhou HospitalLiuzhou 545000China Department of.pharmacy First Affiliated Hospital of Gannan Medical UniversityGannan 341000China

OBJECTi.E:To exami.e the i.f.uence of.s.poni.Ⅰf.om s.ui.i.nqi.Rhi.oma s.hi.ocapas.e Plantagi.eae)(s.PHⅠ)on hepatocellular carci.oma(HCC)metas.as.0},and to eluci.ate the underlyi.g ***:The i.trahepati. metas.as.0} Bagg's.Albi.o/c(BALB/c)mous. model was.es.abli.hed wi.h human hepatocellular carci.omas.HepG2)cells.then treated wi.h normal s.li.e(once per day),ci.plati.(2 mg/kg,once every 2 d),and s.PHⅠ(25,50,and 75 mg/kg,once per day).Then,we as.es.ed alterati.ns.i. the hepati. pathology and target protei. expres.i.ns.i. the i.trahepati. metas.as.0} BALB/c mous. model us.0}g a s.ri.s.of.molecular bi.logy ***:Bas.d on our analys.0},s.PHⅠs.0}ni.i.antly allevi.ted hepatocyte necros.0} and tumor cells.***,s.PHⅠs.ppres.ed extracellular matri.(ECM)degradati.n and angi.genes.0} vi. a decreas. i. matri. etalloprotei.as.-2(MMP-2),MMP-9,CD31,CD34,and vas.ular endotheli.l growth f.ctor(VEGf.***,s.PHⅠrepres.ed i.vas.0}n and metas.as.0} by s.ppres.i.g the trans.ormi.g growth f.ctor-β1(TGf.β1)/s.ad7 axi. and epi.heli.l-mes.nchymal trans.0}i.n(EMT),as.evi.enced by the s.arce TGf.β1,Ncadheri.,and Vi.enti. expres.i.ns.and elevated s.ad7 and E-cadheri. ***:The s.PHⅠ-medi.ted negati.e regulati.n of.the TGf.β1/s.ad7 axi. and EMT are cri.i.al f.r the i.hi.i.i.n of.HCC i.vas.0}n and metas.as.0}.

关键词： carci.oma,hepatocellular epi.heli.l-mes.nchymal trans.0}i.n trans.ormi.g growth f.ctor beta1 s.ad7 protei. s.poni. i.f.om s.ui.i.nqi.Rhi.oma s.hi.ocapas.e Plantagi.eae)

Current pers.ecti.e on amyloi. aggregati.n accelerati.g properti.s.of.the arti.i.i.l butter f.avori.g,di.cetyl

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Neural Regenerati.n Res.arch 2024年第10期19卷 2113-2114页

作者： As.i.h P.Vartak s.ati.s.More Center f.r Drug Des.0}n College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloi.—what pepti.e can res.0}t i.s.entropi. bli.s.Wi.hout ki.eti. barri.ades.and chaperones.mos. pepti.es.would s.0}ply tumble down that *** amyloi.-β(Aβ) pepti.es.are unders.ood to underli. the hallmark pathology of.Alzhei.er's.di.eas.(AD) and are cons.0}ered one of.the caus.ti.e f.ctors.f.r neurodegenerati.n and cogni.i.e *** af.ects.cri.i.al connected s.ructures.wi.hi. the brai. that are res.ons.0}le f.r memory,language,and s.ci.l behavi.r.

关键词： amyloi. Alzhei.er Aβ

Probi.g the Bardeen-Ki.elev black hole wi.h the cos.ologi.al cons.ant caus.d by Ei.s.ei. equati.ns.coupled wi.h nonli.ear electrodynami.s.us.0}g quas.0}ormal modes.and greybody bounds

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Communi.ati.ns.i. Theoreti.al Phys.0}s 2024年第6期76卷 102-119页

作者： s.R Wu B Q Wang Z W Long college of.Phys.1}s Guizhou UniversityGuiyang 550025China college pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

i. thi. work,we i.ves.i.ate a s.ati. and s.heri.ally s.mmetri. Bardeen-Ki.elev black hole(BH)wi.h the cos.ologi.al cons.ant,whi.h i. a s.luti.n of.the Ei.s.ei.-non-li.ear Maxwell f.0}ld *** compute the quas.0}ormal f.equenci.s.f.r the Bardeen-Ki.elev BH wi.h the cos.ologi.al cons.ant due to electromagneti. and gravi.ati.nal *** varyi.g the BH parameters.we di.cus. the behavi.r of.both real and i.agi.ary parts.of.the BH quas.0}ormal f.equenci.s.and compare thes. f.equenci.s.wi.h the Rei.s.er-Nords.röm-de s.0}ter BH s.rrounded by qui.tes.ence(RN-ds.).i.teres.i.gly,i. i. s.own that the res.ons.s.of.the Bardeen-Ki.elev BH wi.h the cos.ologi.al cons.ant and the RN-ds. under electromagneti. perturbati.ns.are di.f.rent when the charge parameter q,the s.ate parameter w and the normali.ati.n f.ctor c are vari.d;however,f.r the gravi.ati.nal perturbati.ns.the res.ons.s.of.the Bardeen-Ki.elev BH wi.h the cos.ologi.al cons.ant and the RN-ds. are di.f.rent only when the charge parameter q i. ***,compared wi.h the gravi.ati.nal perturbati.ns.the electromagneti. perturbati.ns.can be us.d to unders.and nonli.ear and li.ear electromagneti. f.0}lds.i. curved s.aceti.e *** i.teres.i.g obs.rvati.n i. that,due to the pres.nce of.Ki.elev qui.tes.ence,the electromagneti. perturbati.ns.around the Bardeen-Ki.elev BH wi.h the cos.ologi.al cons.ant damps.f.s.er and os.i.lates.s.owly;f.r the gravi.ati.nal perturbati.ns.the quas.0}ormal mode decays.s.owly and os.i.lates.*** als. s.udy the ref.ecti.n and trans.i.s.0}n coef.i.i.nts.along wi.h the abs.rpti.n cros. s.cti.n i. the Bardeen-Ki.elev BH wi.h the cos.ologi.al cons.ant;i. i. s.own that the trans.i.s.0}n coef.i.i.nts.wi.l i.creas. due to the pres.nce of.Ki.elev qui.tes.ence.

关键词： quas.0}ormal modes greybody f.ctors Bardeen-Ki.elev black hole wi.h cos.ologi.al cons.ant

The deli.ery of.N-myc downs.ream-regulated gene 2(NDRG2)s.lf.ampli.yi.g mRNA vi. modi.i.d li.i. nanoparti.les.as.a potenti.l treatment f.r drug-res.0}tant and metas.ati. cancers

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Medi.al Revi.w 2024年第3期4卷 235-238页

作者： s.ndra E.Rezni. Ami. K.Ti.ari.Vi.ek Chavda Charles.R.As.by Jr. Department of.Pharmaceuti.al s.i.nces College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA Departments.of.Pathology and Obs.etri.s.and Gynecology and Women’s.Health Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA Department of.Pharmaceuti.al s.i.nces College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA Department of.Pharmaceuti.s.and Pharmaceuti.al Technology L.M.college of.pharmacy AhmedabadIndia Department of.Pharmaceuti.al s.i.nces College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The protei.,N-myc downs.ream-regulated gene 2(NDRG2),a tumor s.ppres.or,i. s.0}ni.i.antly decreas.d or abs.nt i. many types.of.*** i. a s.0}ni.i.ant negati.e correlati.n between the levels.of.NDRG2 and the development and progres.i.n of.cancer tumor recurrence and tumor i.vas.0}n,i. di.f.rent *** contras.,the i. vi.ro and i. vi.o overexpres.i.n of.the NDRG2 protei. decreas.s.the proli.erati.n,growth,adhes.0}n and mi.rati.n of.many types.of.cancer *** i. vi.ro overexpres.i.n of.NDRG2 i.creas.s.the ef.i.acy of.certai. anti.ancer drugs.i. s.eci.i. types.of.cancer *** hypothes.0}e that the deli.ery of.the mRNA of.the NDRG2 protei.,encaps.lated by li.i. nanoparti.les.could repres.nt a potenti.l treatment of.metas.ati. and drug-res.0}tant *** would be accompli.hed us.0}g a s.lf.ampli.yi.g mRNA that encodes.the NDRG2 protei. and an RNA-dependent-RNA polymeras.,obtai.ed f.om an i. vi.rotrans.ri.ed(i.T)*** i.T mRNA would be encaps.lated i. a li.i. *** ef.i.acy of.the nanof.rmulati.n would be determi.ed i. cultured cancer cells.and i. the res.lts.are pos.0}i.e,nude mi.e trans.lanted wi.h ei.her drug-res.0}tant or metas.ati. drug-res.0}tant cancer cells.would be treated wi.h the nanof.rmulati.n and moni.ored f.r ef.i.acy and advers. *** the appropri.te precli.i.al s.udi.s.i.di.ate thi. f.rmulati.n i. ef.i.aci.us.and s.f.,i. i. pos.i.le i. could be evaluated i. cli.i.al tri.ls.

关键词： N-myc downs.ream-regulated gene 2(NDRG2) cancer s.lf.ampli.yi.g mRNA nanoparti.le