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Cardiovascular risk factor cluster in hypertensive patients with obstructive sleep apnea syndrome

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Cardiovascular risk factor cluster in hypertensive patients ...

Systemic Vasculitis:An Important and Underestimated Cause of Malignant hypertension

中华医学会第十五次全国心血管病学大会

作者： Nanfang Li Juhong Zhang hypertension center of peoples hospital in Xinjiang

Objective Obstructive sleep apnoea (OSAS) is a common disorder in which repetitive apnoeas expose the cardiovascular system to cycles of hypoxia, exaggerated negative intrathoracic pressure, and arousalsSeveral studie...

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Cardiovascular Innovations and Applications 2019年第B07期4卷 99-108页

作者： Qing Zhu Shasha Liu Mulalibieke Heizhati Xiaoguang Yao Menghui Wang Qin Luo Lei Wang Delian Zhang Guijuan Chang Nanfang Li The center for hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region Hypertension Institute of Xinjiang Uygur Autonomous RegionUrumqiChina

Objectives:Malignant hypertension(MHT)is defi ned as severe hypertension accompanied by ischemic failure of one or more *** aims of this study were to evaluate the current clinical and etiologic profi les of ***:As a retrospective study,we selected all patients admitted to our center from January 2013 to December *** patients with MHT were ***:The average age of the patients was 40 years,and more than half of the patients were male(78.57%).There were 24 patients with essential hypertension,accounting for 34.29%of the patients,and 46 with secondary hypertension,accounting for 65.71%of the *** secondary MHT,systemic vasculitis(25.57%)was the most common cause,followed by severe obstructive sleep apnea syndrome(15.71%),primary renal parenchymal hypertension(11.43%),primary aldosteronism(7.14%),and Cushing syndrome(1.43%)and nutcracker phenomenon(1.43%).Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing *** levels of white blood cells,hypersensitive C-reactive protein,serum creatinine,and 24-hour urinary protein were above their normal ***:Systemic vasculitis may be one of the main causes of MHT,and has been underestimated in the *** future clinical work,clinicians need to pay more attention to patients with systemic vasculitis.

关键词： malignant hypertension cause systemic vasculitis

Molecular regulation of calcium-sensing receptor(CaSR)-mediated signaling

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Chronic Diseases and Translational Medicine 2024年第3期10卷 167-194页

作者： Li Tian Corey Andrews Qiuyun Yan Jenny J.Yang Department of Chemistry Center for Diagnostics and TherapeuticsAdvanced Translational Imaging FacilityGeorgia State UniversityAtlantaGeorgiaUSA

Calcium-sensing receptor(CaSR),a family C G-protein-coupled receptor,plays a crucial role in regulating calcium homeostasis by sensing small concentration changes of extracellular Ca^(2+),Mg^(2+),amino acids(e.g.,L-Trp and L-Phe),small peptides,anions(e.g.,HCO_(3)^(-)and PO_(4)^(3-)),and ***-mediated intracellular Ca^(2+)signaling regulates a diverse set of cellular processes including gene transcription,cell proliferation,differentiation,apoptosis,muscle contraction,and neuronal *** of CaSR with mutations results in diseases such as autosomal dominant hypocalcemia,familial hypocalciuric hypercalcemia,and neonatal severe *** also influences calciotropic disorders,such as osteoporosis,and noncalciotropic disorders,such as cancer,Alzheimer's disease,and pulmonary arterial *** study first reviews recent advances in biochemical and structural determination of the framework of CaSR and its interaction sites with natural ligands,as well as exogenous positive allosteric modulators and negative allosteric *** establishment of the first CaSR protein-protein interactome network revealed 94 novel players involved in protein processing in endoplasmic reticulum,trafficking,cell surface expression,endocytosis,degradation,and signaling *** roles of these proteins in Ca^(2+)-dependent cellular physiological processes and in CaSR-dependent cellular signaling provide new insights into the molecular basis of diseases caused by CaSR mutations and dysregulated CaSR activity caused by its protein interactors and facilitate the design of therapeutic agents that target CaSR and other family C G-protein-coupled receptors.

关键词： calcium signaling calcium-sensing receptor G-protein-coupled receptors structure trafficking

CILP-2 is a novel secreted protein and associated with insulin resistance

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Journal of Molecular Cell Biology 2019年第12期11卷 1083-1094页

作者： Tong Wu Qin Zhang Shaobo Wu Wenjing Hu Tingting Zhou Ke Li Dongfang Liu Harvest FGu Hongting Zheng Zhiming Zhu Ling Li and Gangyi Yang Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing Clinical Research Center for GeriatricsChongqingChina Key Laboratory of Diagnostic Medicine(Ministry of Education)and Department of Clinical Biochemistry College of Laboratory MedicineChongqing Medical UniversityChongqingChina center for Pathophysiology School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingChina Department of Endocrinology Xinqiao HospitalThird Military Medical UniversityChongqingChina Department of hypertension and Endocrinology Daping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqingChina

Genetic association studies have implicated that cartilage intermediate layer protein 2 (CILP-2) confers the risk susceptibility for type 2 diabetes (T2DM). However, it is still unknown whether CILP-2 is involved in the regulation of glucose homeostasis and insulin resistance (IR). In the current study, we initially observed that CILP-2 as a secreted protein was detected in both conditioned medium and lysates of cells transfected with an overexpressed vector. We then found that circulating CILP-2 levels had a progressive increase from normal to impaired glucose tolerance (a pre-diabetic status) and then to diabetes, which was correlated positively with waist-to-hip ratio, triglyceride, fasting blood glucose, 2-h blood glucose after glucose overload, HbA1c, fasting insulin, 2-h plasma insulin after glucose overload, and homeostasis model assessment of insulin resistance but negatively with HDL-C. CILP-2 expression was increased in the liver and muscle but decreased in adipose tissues of obese mice or T2DM patients. Furthermore, we demonstrated that CILP-2 circulating levels were affected by OGTT and Exenatide. CILP-2 overexpression resulted in impaired glucose tolerance and hepatic IR in vivo and increased PEPCK expression whereas suppressed phosphorylation of insulin receptor and Akt kinase in vitro. Based on these findings, we have identified a direct interaction between CILP-2 and PEPCK and suggested that CILP-2 plays an important role in the regulation of hepatic glucose production.

关键词： CILP-2 secreted protein insulin resistance type 2 diabetes

The emerging role of tubulin posttranslational modifications in cilia and ciliopathies

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Biophysics Reports 2020年第4期6卷 89-104页

作者： Kai He Kun Ling Jinghua Hu Department of Biochemistry and Molecular Biology Mayo Clinic Division of Nephrology and hypertension Mayo Clinic Mayo Translational Polycystic Kidney Diseases center Mayo Clinic

Tubulin posttranslational modifications(PTMs) add ‘ tubulin code”” to generate functional diversities of microtubules. Several types of tubulin PTMs accumulate on axonemes and basal bodies of cilia,including acetylation, glutamylation, glycylation and detyrosination. Among them, glutamylation, glycylation and detyrosination are mostly enriched in the B-tubules, whereas acetylation occurs on both Aand B-tubule of the microtubule doublets in a similar level. Recent studies indicate that tubulin PTMs are critical for the fine tuning of assembly/disassembly, maintenance, motility, and signaling of *** tubulin PTMs are strongly implicated in human disorders including ciliopathies and neuron degeneration. Here, we review the current understanding how tubulin PTMs regulate cilia formation and function, and their relevance to human health.

关键词： Tubulin posttranslational modifications (PTMs) Cilia Ciliopathies Acetylation Glutamylation Glycylation

The association between orthostatic blood pressure changes and subclinical target organ damage in subjects over 60 years old

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Journal of Geriatric Cardiology 2019年第5期16卷 387-394页

作者： Hong-Jie CHI Hai-Jun FENG Xiao-Jiao CHEN Xiao-Tao ZHAO En-Xiang ZHANG Yi-Fan FAN Xian-Chen MENG Jiu-Chang ZHONG Shou-Ling WU Jun CAI Heart center&Beijing Key Laboratory of hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Respiratory Department Beijing First Hospital of Integrated Chinese and Western MedicineBeijingChina Cardiology Department Beijing Liangxiang HospitalCapital Medical UniversityBeijingChina Department of Statistics Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Cardiology Kailuan General HospitalHebei United UniversityTangshanChina hypertension center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Although recent studies have indicated that both orthostatic hypotension and orthostatic hypertension independently predict cardiovascular events,the underlying mechanisms are still *** aim of the study was to investigate the relationships between orthostatic changes and organ damage in subjects over 60 years *** This is a prospective observational cohort *** thousand nine hundred and ninety-seven subjects over 60 years old were *** were grouped according to whether they had a drop>20 mmHg in systolic or>10 mmHg in diastolic BP(orthostatic hypotension),an increase in mean orthostatic systolic blood pressure>20 mm Hg(orthostatic hypertension),or normal changes within 3 min of *** regression modeling was used to investigate the relationship between orthostatic hypotension,orthostatic hypertension and subclinical organ damage with adjustment for *** Orthostatic hypotension and orthostatic hypertension were found in 461(23.1%)and 189(9.5%)participants,*** of carotid intima-media thickness(IMT),brachial-ankle pulse wave velocity(baPWV),clearance of creatinine,and microalbuminuria were associated with orthostatic hypotension;measurement of IMT and baPWV were associated with orthostatic hypertension in a cruse *** adjustment,IMT[odds ratio(OR),95%confidence interval(CI)per one-SD increment:1.385,1.052-1.823;P=0.02],baPWV(OR=1.627,95%CI:1.041-2.544;P=0.033)and microalbuminuria(OR=1.401,95%CI:1.002-1.958;P=0.049)were still associated with orthostatic hypotension,while orthostatic hypertension was only associated with IMT(OR=1.730,95%CI:1.143-2.618;P=0.009).Conclusions Orthostatic hypotension seems to be independently correlated with increased carotid atherosclerosis,arterial stiffness and renal damage in subjects over 60 years *** hypertension correlates with carotid atherosclerosis only.

关键词： Atherosclerosis Blood pressure Orthostatic Organ damage

How to identify early complications in patients undergoing distal gastrectomy?

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 974-981页

作者： Giuseppe Tropeano Maria Michela Chiarello Valeria Fico Giuseppe Brisinda Emergency Surgery and Trauma center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Department of Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy

In this editorial we comment on the article by Zhang et al published in a recent issue of the World Journal of Gastrointestinal *** with appropriate lymph node dissection is still standard curative treatment in locally advanced gastric *** studies point out that gastric cancer surgery is a complex procedure that leads to a high risk of morbidity and *** factors can contribute to the onset of complications with consequent effects on prognosis and increased *** complications can be divided in complications related to anastomosis,to motility and to surgical site *** study presented by Zhang B et al represent an interesting analysis on the possibility to prevent postoperative *** study was performed on 131 patients with distal gastric cancer who underwent gastrectomy with D2 lymph node *** these patients,16%developed early postoperative *** univariate analysis showed that prealbumin level,hypertension,diabetes,history of abdominal surgery,R0 resection,and blood transfusion were factors influencing early postoperative complications after distal ***,the inclusion of the above significant variables in the logistic regression analysis revealed that hypertension,diabetes,a history of abdominal surgery,and blood transfusion were independent predictors of postoperative *** conclusion,preoperative and intraoperative factors can be used to establish an early postoperative nomogram *** results of the study presented by Zhang et al suggest that the prediction model can be used to guide the detection of postoperative complications and has clinical reference value.

关键词： Gastric cancer Gastrectomy Lymph node dissection Morbidity Mortality Surgical site infections

Growth differentiation factor 15 predicts cardiovascular events in stable coronary artery disease

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Journal of Geriatric Cardiology 2023年第7期20卷 527-537页

作者： Juan WANG Li-Na HAN Dao-Sheng AI Xin-Yu WANG Wan-Jing ZHANG Xiao-Rong XU Hong-Bin LIU Jing ZHANG Pan WANG Xu LI Mu-Lei CHEN Heart center of Beijing Chao-Yang Hospital Capital Medical UniversityBeijing Key Laboratory of HypertensionBeijingChina Department of Cardiology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Academy for Advanced Interdisciplinary Studies Peking University National Institute of Biological SciencesZhongguancun Life Science ParkTsinghua UniversityBeijingChina

BACKGROUND Growth differentiation factor 15(GDF-15)has been explored as a potential biomarker for various inflammatory diseases and cardiovascular *** study aimed to assess the predictive role of GDF-15 levels in cardiovascular events and all-cause mortality,considering traditional risk factors and other *** A prospective study was conducted and 3699 patients with stable coronary artery disease(CAD)were enrolled into the *** GDF-15 levels were *** follow-up was 3.1 years during the *** analyzed clinical variables and several *** Cox regression analysis was performed to evaluate prognostic performance of GDF-15 levels in predicting myocardial infarction(MI),heart failure,stroke,cardiovascular death,and non-cardiovascular *** Baseline GDF-15 levels for 3699 patients were grouped by quartile(≤1153,1153-1888,1888-3043,>3043 ng/L).Higher GDF-15 levels were associated with older age,male gender,history of hypertension,and elevated levels of N-terminal pro Btype natriuretic peptide(NT-pro BNP),soluble suppression of tumorigenesis-2(sST2),and creatine(each with P<0.001).Adjusting for established risk factors and biomarkers in Cox proportional hazards models,a 1 standard deviation(SD)increase in GDF-15 was associated with elevated risk of clinical events[hazard ratio(HR)=2.18,95%confidence interval(CI):(1.52-3.11)],including:MI[HR=2.8395%CI:(1.03-7.74)],heart failure[HR=2.7195%CI:(1.18-6.23)],cardiovascular and non-cardiovascular death[HR=2.48,95%CI(1.49-4.11)]during the median follow up of 3.1 *** Higher levels of GDF-15 consistently provides prognostic information for cardiovascular events and all cause death,independent of clinical risk factors and other ***-15 could be considered as a valuable addition to future risk prediction model in secondary prevention for predicting clinical events in patient with stable CAD.

关键词： cardiovascular elevated coronary

Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population

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Biomedical and Environmental Sciences 2018年第11期31卷 787-796页

作者： XU Jing Jing JIANG Lin XU Lian Jun GAO Zhan ZHAO Xue Yan ZHANG Yin SONG Ying LIU Ru SUN Kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing Department of cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College Department of hypertension Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College

Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P < 0.001), and rs3217986 G(P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders.

关键词： Premature triple-vessel disease Single-nucleotide polymorphism Risk