检索结果-南通市图书馆

Dietary Green Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

引用

Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： Galande Sheethal Ranjeet K. Tokala Pavan Pondugala Krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya Satyanarayana Singh Guduru Venkat Rao Duvvur Nageshwar Reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical Gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/J Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets Glucose Stimulated Insulin Secretion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cooperative Spectrum Sensing Deployment for Cognitive Radio Networks for Internet of Things 5G Wireless Communication

引用

Tsinghua Science and Technology 2024年第3期29卷 698-720页

作者： Thulasiraman Balachander Kadiyala Ramana Rasineni Madana Mohana Gautam Srivastava Thippa Reddy Gadekallu SRM Institute of Science and Technology Tamil Nadu 603203India Lebanese American University Beirut 1102Lebanonand also with Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Chaitanya Bharathi Institute of Technology Hyderabad 500075India Brandon University BrandonR7A 0A1CanadaChinaMedical UniversityTaichung 404327Chinaand Lebanese American UniversityBeirut 1102Lebanon Department of Electrical and Computer Engineering Lebanese American UniversityBeirut 1102Lebanon

Recently,Cooperative Spectrum Sensing(CSS)for Cognitive Radio Networks(CRN)plays a significant role in efficient 5G wireless *** sensing is a significant technology in CRN to identify underutilized *** CSS technique is highly applicable due to its fast and efficient performance.5G wireless communication is widely employed for the continuous development of efficient and accurate Internet of Things(IoT)networks.5G wireless communication will potentially lead the way for next generation IoT *** has established significant consideration as a feasible resource to improve identification performance by developing spatial diversity in receiving signal strength in *** this paper,an optimal CSS for CRN is performed using Offset Quadrature Amplitude Modulation Universal Filtered Multi-Carrier Non-Orthogonal Multiple Access(OQAM/UFMC/NOMA)*** of spectrum and bandwidth utilization is a key challenge in CRN for IoT 5G wireless *** optimal solution for CRN in IoT-based 5G communication should be able to provide optimal bandwidth and CSS,low latency,Signal Noise Ratio(SNR)improvement,maximum capacity,offset synchronization,and Peak Average Power Ratio(PAPR)*** Energy Efficient All-Pass Filter(EEAPF)algorithm is used to eliminate *** deployment approach improves Quality of Service(QoS)in terms of system reliability,throughput,and energy *** in-depth experimental results show that the proposed methodology provides an optimal solution when directly compares against current existing methodologies.

关键词： cooperative spectrum sensing cognitive radio network Internet of Things offset quadratureamplitude modulation universal filtered multi-carrier non-orthogonal multiple access

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease

引用

World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 44-54页

作者： Suprabhat Giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar Department of Gastroenterology and Hepatology Kalinga Institute of Medical SciencesBhubaneswar 751024OdishaIndia Department of Gastroenterology Kalinga Gastroenterology FoundationCuttack753001OdishaIndia Department of Gastroenterology Nizam’s Institute of Medical SciencesHyderabad 500082TelanganaIndia Department of Gastroenterology Seth GS Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sagar HospitalBengaluru 560041KarnatakaIndia

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced ***,characterized by decreased muscle strength and mass,shares common pathophysiological traits with *** association exists between sarcopenia and increased NAFLD ***,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain *** To analyze the prevalence and outcomes of sarcopenia in patients with *** We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June *** included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse *** also used the Newcastle-Ottawa scale for quality *** Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for *** was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such *** in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and *** This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD *** variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent *** review demonstrates the multidimension

关键词： Non-alcoholic fatty liver disease Sarcopenia Hepatic fibrosis Low muscle mass Hand grip strength Bioelectric impedance analysis Dual X-ray absorptiometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute paroxysmal cold hemoglobinuria upon dengue fever:A case report

引用

Journal of Acute Disease 2024年第3期13卷 121-124页

作者： Momin Majed Abdul Basit Aluri Anamika Syed Arfa Ashrafunnisa Rahul Dev Singh Rathore Department of Laboratory Medicine Yashoda HospitalHyderabadIndia Department of Pediatrics and Neonatology Yashoda HospitalHyderabadIndia

Rationale:Dengue fever is capable of inciting the formation of transient polyclonal antibodies directed at red blood cell antigens,resulting in complement-mediated hemolysis,leading to intravascular hemolysis and ***’s concern:A 12-year-old male patient who recovered from dengue fever a week ago had red blood cell agglutination,spherocytes,and engulfment of red blood cells(erythrophagocytosis)by monocytes and neutrophils on routine hematological peripheral blood *** unexpected blood smear results prompted the lab physicians to investigate autoimmune hemolytic anemia,which revealed a monospecific positive direct antiglobulin test for complement(C3d,C3b)and the presence of Donath-Landsteiner ***:Paroxysmal cold hemoglobinuria(PCH),secondary to dengue ***:Oxygen supplements,antibiotics,intravenous immunoglobulins,steroid therapy,and packed cell transfusions were ***:The patient’s condition was improved following the ***:Post-dengue PCH is a rare complication that requires a thorough peripheral smear examination for erythrophagocytosis,as advanced hematology analyzers fail to detect such findings.

关键词： Paroxysmal cold hemoglobinuria Dengue Erythrophagocytosis Donath-Landsteiner test Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Intelligent Big Data Security Framework Based on AEFS-KENN Algorithms for the Detection of Cyber-Attacks from Smart Grid Systems

引用

Big Data Mining and Analytics 2024年第2期7卷 399-418页

作者： Sankaramoorthy Muthubalaji Naresh Kumar Muniyaraj Sarvade Pedda Venkata Subba Rao Kavitha Thandapani Pasupuleti Rama Mohan Thangam Somasundaram Yousef Farhaoui Department of Electrical and Electronics Engineering CMR College of Engineering&TechnologyHyderabad 501401India Department of Electronics and Communication Engineering Vardhaman College of Engineering KacharamShamshabad 501218India Department of Electronics and Communication Engineering Sreenidhi Institute of Science and TechnologyHyderabad 501301India Department of Electronics and Communication Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Electrical and Electronics Engineering Bharat Institute of Engineering and TechnologyHyderabad 501510India Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidhyapeethamBengaluru 560035India T-IDMS Department of Computer ScienceFaculty of Sciences and TechniquesMoulay Ismail UniversityErrachidia 52000Morocco

Big data has the ability to open up innovative and ground-breaking prospects for the electrical grid,which also supports to obtain a variety of technological,social,and financial *** is an unprecedented amount of heterogeneous big data as a consequence of the growth of power grid technologies,along with data processing and advanced *** main obstacles in turning the heterogeneous large dataset into useful results are computational burden and information *** original contribution of this paper is to develop a new big data framework for detecting various intrusions from the smart grid systems with the use of AI ***,an AdaBelief Exponential Feature Selection(AEFS)technique is used to efficiently handle the input huge datasets from the smart grid for boosting ***,a Kernel based Extreme Neural Network(KENN)technique is used to anticipate security vulnerabilities more *** Polar Bear Optimization(PBO)algorithm is used to efficiently determine the parameters for the estimate of radial basis ***,several types of smart grid network datasets are employed during analysis in order to examine the outcomes and efficiency of the proposed AdaBelief Exponential Feature Selection-Kernel based Extreme Neural Network(AEFS-KENN)big data security *** results reveal that the accuracy of proposed AEFS-KENN is increased up to 99.5%with precision and AUC of 99%for all smart grid big datasets used in this study.

关键词： smart grid Machine Learning(ML) big data analytics AdaBelief Exponential Feature Selection(AEFS) Polar Bear Optimization(PBO) Kernel Extreme Neural Network(KENN)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

引用

Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh Kumar Saini Mahendra Singh Devendra Singh Prem Manohar Seervi Pera Jayavardhan Reddy Neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction of corrosion rate for friction stir processed WE43 alloy by combining PSO-based virtual sample generation and machine learning

引用

Journal of Magnesium and Alloys 2024年第4期12卷 1518-1528页

作者： Annayath Maqbool Abdul Khalad Noor Zaman Khan Department of Mechanical Engineering National Institute of Technology SrinagarJ&K 190006India Department of Mechanical Engineering Indian Institute of TechnologyHyderabadSangareddyTelangana 502284India School of Engineering Deakin UniversityVictoria 3216Australia

The corrosion rate is a crucial factor that impacts the longevity of materials in different *** undergoing friction stir processing(FSP),the refined grain structure leads to a notable decrease in corrosion ***,a better understanding of the correlation between the FSP process parameters and the corrosion rate is still *** current study used machine learning to establish the relationship between the corrosion rate and FSP process parameters(rotational speed,traverse speed,and shoulder diameter)for WE43 *** Taguchi L27 design of experiments was used for the experimental *** addition,synthetic data was generated using particle swarm optimization for virtual sample generation(VSG).The application of VSG has led to an increase in the prediction accuracy of machine learning models.A sensitivity analysis was performed using Shapley Additive Explanations to determine the key factors affecting the corrosion *** shoulder diameter had a significant impact in comparison to the traverse speed.A graphical user interface(GUI)has been created to predict the corrosion rate using the identified *** study focuses on the WE43 alloy,but its findings can also be used to predict the corrosion rate of other magnesium alloys.

关键词： Corrosion rate Friction stir processing Virtual sample generation Particle swarm optimization Machine learning Graphical user interface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Weighted Probability Density Estimator with Updated Bandwidths

引用

Journal of Systems Science & Complexity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKASA RAO B L S School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000China School of Big Data and Statistics Anhui UniversityHefei 230601China CR Rao Advanced Institute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this paper,the authors study a class of weighted version of probability density *** is shown that the weighted estimator contains some existing estimators of probability density,no matter they are recursive or *** statistical results including weak consistency,strong consistency,rate of strong consistency,and asymptotic normality are established under some mild ***,the random weighted estimator is also *** numerical simulations and a real data analysis are presented to study the numerical performances of the estimators.

关键词： Asymptotic normality consistency numerical simulation probability density real data analysis updated bandwidths weighted estimator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantification of Structurally Alert Mutagenic Impurities in Meropenem Trihydrate Drug Substance by Liquid Chromatography with High Resolution Mass Spectrometer (LC-HRMS)

引用

American Journal of Analytical Chemistry 2024年第3期15卷 119-133页

作者： Anwar Sulaiman K. Ramakrishna Reddy Vundavilli Jagadeesh Kumar Hemant Kumar Sharma REVA University Bangalore India Quality Division Aurobindo Pharma Limited Hyderabad India APL Research Centre-II Analytical Research Department Aurobindo Pharma Limited Hyderabad India

Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic method using High Resolution Mass Spectrometer (LC-HRMS) technique is proved to be suitable for simultaneous quantification of all ten identified impurities with required specificity, sensitivity, resolution, precision, accuracy, and other method characteristics as per ICH Guidelines. The acceptable limit of less than 2.9 μg/g was considered for evaluations, based on drug substance dosage and duration of treatment. The method stands most sensitive with a Limit of Detection of 0.35 μg/g, considering the challenge full acceptance criteria as per current regulatory standards.

关键词： Mutagenic Impurities LC-HRMS Meropenem Trihydrate Method Validation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Leveraging React Components in Business Process Management (BPM) Applications

引用

Journal of Computer and Communications 2024年第4期12卷 86-94页

作者： Ashok Reddy Annaram Department of ECM (Electronics and Computers Engineering) Jawaharlal Nehru Technological University Hyderabad India

As organizations increasingly embrace digital transformation, the integration of modern web technologies like *** with Business Process Management (BPM) applications has become essential. React components offer flexibility, reusability, and scalability, making them ideal for enhancing user interfaces and driving user engagement within BPM environments. This article explores the benefits, challenges, and best practices of leveraging React components in BPM applications, along with real-world examples of successful implementations.

关键词： React.js Digital Transformation User Interface (UI) Development Component-Based Architecture Declarative UI Development User Experience (UX) Reusability Modularity Integration Customization Developer Productivity Legacy System Integration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：