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Ipsilateral fractures of the acromion and coracoid processes of the scapula

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Chinese Journal of Traumatology 2024年第2期27卷 121-124页

作者： Yusuf Omar Qalib Srinivasa Reddy Medagam Sunil Dachepalli Department of Orthopaedics The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai519000GuangdongChina Department of Orthopaedics Yashoda HospitalsSomajigudaHyderabadTelangana500082India

A fracture of the acromion and coracoid processes of scapula is rarely seen in the outpatient clinic,due to the acromion's anatomical position and shape,as well as the strong ligaments and muscles that are attached to *** fractures are caused by either direct or indirect high-energy trauma injuries to the shoulder joint,leading to severe pain and a grossly restricted range of *** acromial classifications were reported,but this type of longitudinal plane fracture of the acromion process in our case is yet to be described in the current *** present a rare combination of the coracoid process and unstable acromion bony projection fractures that have not previously been noted for this type of *** closest to this is Kuhn's type III classification.A 51-year-old male presented to our emergency department complaining of the right shoulder pain and difficulty raising his arm following a 2-wheeler *** patient was managed by open reduction and internal fixation with 3 cannulated cancellous screws fixation and progressed well with no postoperative *** was asymptomatic postoperatively and regained full range of motion after 4 months.

关键词： Acromion Scapular fracture Coracoid process

CompactChain:an efficient stateless chain for UTXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： B Swaroopa REDDY T Uday Kiran REDDY Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UTXO(Unspent Transaction Output)based blockchain systems into two RSA *** first accumulator is called Transaction Output(TXO)commitment which represents the TXO *** second one is called Spent Transaction Output(STXO)commitment which represents the STXO *** this work,we discuss three algorithms:(i)To update the TXO and STXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)To prove the transaction’s validity by providing a membership witness in TXO commitment and non-membership witness against STXO commitment for a coin being spent by a user;(iii)To update the witness for the coin that is not yet spent;The experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(Transactions per second(TPS)).

关键词： stateless blockchain RSA Accumulator STXO commitment TXO commitment UTXO Non-interactive Proof of Exponentiation(NI-PoE) Transactions per second(TPS)

Wormhole solutions under the effect of dark matter in f(R,L_(m))gravity

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Communications in Theoretical Physics 2024年第5期76卷 102-113页

作者： Lakhan V Jaybhaye Moreshwar Tayde PK Sahoo Department of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India

In the background of f(R,L_(m))gravity,this work investigates three distinct dark matter halo profiles to test the possibility of generalised wormhole geometry within the galactic halo *** current study aims to accomplish these goals by examining various dark matter profiles including universal rotation curves(URC),Navarro-Frenk-White(NFW)model-Ⅰ,and NFW model-Ⅱinside two distinct f(R,L_(m))gravity *** to the f(R,L_(m))=R/2+L^(a)_(m)model,the dark matter(DM)halo density profiles produce suitable shape functions that meet all the necessary requirements for exhibiting the wormhole geometries with appropriate choice of free *** addition,to examine DM profiles under the f(R,L_(m))=R/2+(1+λR)L_(m) model,we consider a specific shape ***,we observed that the derived solution from both two models violates the null energy constraints,confirming that the DM supports wormholes to maintain in the galactic halo.

关键词： f(R L_(m))gravity wormhole dark matter(Some figures may appear in colour only in the online journal)

Geochemistry and mineral chemistry of the armoor granitoids,eastern dharwar craton: implications for the redox conditions and tectono-magmatic environment

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Acta Geochimica 2024年第1期43卷 110-133页

作者： A.Ajay Kumar Ch.Ashok Department of Geology Osmania UniversityHyderabad 500007India CSIR-National Geophysical Research Institute UppalHyderabad 500007India

The mineralogical and geochemical characteristics of the K-rich granites from the Armoor granitic rocks in the northeastern portion of the Eastern Dharwar Craton(EDC) are *** order to understand its physicochemical conditions,the petrogenesis of the granitoid was explained from biotite chemistry and geochemical *** of mineral chemistry expose that compositionally,K-feldspar and plagioclase in Armoor granite rocks range from An0,Ab_(3-5.9),Or_(94-96.9) and An_(5-29,-Ab71.9-94.9),Or_(0-1.5),*** mineral chemistry of biotite crystals exhibits composition that varies from primary to re-equilibrated primary *** biotites from the Armoor granites generally exhibit an I-type trend,with calc-alkaline parental magma in a subduction *** chemistry of granites displays magnetite(oxidized)series nature,which has oxygen fugacity(fO_(2))=-15.1 to-16.7(log_(10) bar),under high oxidizing *** and pressure estimates for the crystallization of Armoor granites based on biotite composition are T=612-716 ℃ and 1.0-0.4 kbar,***,these rocks are metaluminous to slightly peraluminous and magnesian,with calc-alkaline potassiumrich *** the chondrite normalized REE diagram,the granites have positive europium anomalies;rich Sr/Y,(Dy/Yb)_(N) ratios and reduced Mg#,Rb/Sr,Rb,Sr indicate that the melting of earlier rocks,crystal accumulation and residual garnet source formed at high *** examined granites show that they are produced from the melting of crustal ***,the extensive analyses of the described Armoor granite suggest that they were produced by crust sources and developed under oxidizing conditions in subduction setting.

关键词： Armoor granites Oxygen fugacity Crystal accumulation Remelting Subduction

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

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Genes & Diseases 2024年第1期11卷 148-175页

作者： Divya Ajmeera Rajanna Ajumeera Cell Biology Department ICMR-National Institute of Nutrition(NIN)HyderabadTelangana 500007India

Chemotherapy is an effortless and frequently used approach in cancer ***,in most cases,it can only prolong life expectancy and does not guarantee a complete ***,chemotherapy is associated with severe adverse effects,one of the major complications of effective cancer *** addition,newly published research outputs show that cancer stem cells are involved in cancer disease progression,drug resistance,metastasis,and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to *** strategies are therefore required for better management of cancer *** prime approach would be to synthesize and develop novel drugs that need extensive resources,time,and endurance to be brought into therapeutic *** subsequent approach would be to screen the anti-cancer activity of avail-able non-cancerous *** concept of repurposing non-cancer drugs as an alternative to current cancer therapy has become popular in recent years because using existing anticancer drugs has several adverse *** have also been investigated for cancer ther-apy due to their significant anti-cancer effects with negligible or no side effects and availabil-ity in food *** this paper,we discuss an ideal hypothesis for screening available non-cancerous drugs with anticancer activity,with a focus on cancer stem cells and their clinical application for cancer ***,drug repurposing and the combination of micronu-trients that can target both cancers and cancer stem cells may result in a better therapeutic approach leading to maximum tumor growth control.

关键词： Cancerstem cells Chemotherapy Combination therapy micronutrients Non-cancer drugs Novel strategies

High-temperature elemental segregation induced structure degradation in high-entropy fluorite oxide

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Journal of Advanced Ceramics 2024年第3期13卷 310-322页

作者： Yixuan Hu Mariappan Anandkumar Yumeng Zhang Joydip Joardar Atul Suresh Deshpande Xiaodong Wang Kolan Madhav Reddy School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Materials Science and Metallurgical Engineering Indian Institute of Technology HyderabadSangareddy 502285India International Advanced Research Centre for Powder Metallurgy and New Materials(ARCI) Hyderabad 500005India

Fluorite-structured oxides constitute an important category of oxides with a wide range of high-temperature *** the concept of high entropy,high-entropy fluorite oxides(HEFOs)have showcased intriguing high-temperature application ***,unlocking this potential necessitates an assessment of their long-term stability under high-temperature *** this study,we conducted a prolonged heat treatment at 1000℃on typical HEFO,specifically(CeHfZrGdLa)O_(x).After 100 h,high-intensity X-ray diffraction(XRD)revealed a transition from a single-phase fluorite to a multi-phase *** investigation by analytical electron microscoy(AEM)demonstrated that this degradation resulted from facilitated element diffusion and consequent escalating chemical fluctuation at high temperatures,leading to spontaneous segregation and separation of Ce and La elements,forming Ce-rich,La-poor,and La-rich ***,the La-rich phase spontaneously transformed from a fluorite structure(space group Fm3m)to a bixbyite structure(space group Ia3)at elevated temperatures,resulting in the appearance of superstructure reflection in XRD profiles and electron diffraction *** the intricate phase decomposition,the energy band gap showed minimal variation,suggesting potential property stability of(CeHfZrGdLa)O_(x)across a broad range of *** findings offer valuable insights into the future applications of HEFOs.

关键词： phase transition high-temperature stability elemental segregation high-entropy fluorite oxides(HEFOs)

Chiglitazar and Thiazolidinedione in patients with type 2 diabetes:Which is better?

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World Journal of Diabetes 2024年第3期15卷 565-567页

作者： Kotha Sugunakar Reddy Archana Gaur Sakthivadivel Varatharajan Arvind Kumar Morya Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

This published Meta-Analysis by Lin et al is an indirect comparison between two drugs Chiglitazar and Thiazolidinedione which are commonly used for glycemic control in type-Ⅱ diabetes *** terms of safety and efficacy... 详细信息

关键词： Type-Ⅱdiabetes mellitus Glucose intolerance Hyperglycemia Research methodology

Non-alcoholic fatty liver disease in type 2 diabetes:Emerging evidence of benefit of peroxisome proliferator-activated receptors agonists and incretin-based therapies

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World Journal of Methodology 2024年第2期14卷 38-50页

作者： Subhodip Pramanik Partha Pal Sayantan Ray Department of Endocrinology Neotia Getwel Multispecialty HospitalSiliguri 734010West BengalIndia Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Endocrinology All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia

Nonalcoholic fatty liver disease(NAFLD)is a global epidemic,affecting more than half of the people living with type 2 diabetes(T2D).The relationship between NAFLD and T2D is bidirectional and the presence of one perpetuates the other,which significantly increases the hepatic as well as extrahepatic *** recently,there was no approved pharmacological treatment for NAFLD/nonalcoholic steatohepatitits(NASH).However,there is evidence that drugs used for diabetes may have beneficial effects on *** sensitizers acting through peroxisome proliferator-activated receptor(PPAR)modulation act on multiple levels of NAFLD ***(PPARγ agonist)and saroglitazar(PPARα/γagonist)are particularly beneficial and recommended by several authoritative bodies for treating NAFLD in T2D,although data on biopsyproven NASH are lacking with the *** data on elafibanor(PPARα/δ agonist)and Lanifibranor(pan PPAR agonist)are *** the other hand,incretin therapies based on glucagon-like peptide-1(GLP-1)receptor agonists(GLP-1RA)and dual-and triple-hormone receptor co-agonists reported impressive weight loss and may have anti-inflammatory and antifibrotic ***-1 RAs have shown beneficial effects on NAFLD/NASH and more studies on potential direct effects on liver function by dual-and triple-agonists are ***,the long-term safety of these therapies in NAFLD needs to be *** efforts among healthcare providers such as primary care doctors,hepatologists,and endocrinologists are warranted for selecting patients for the best possible management of NAFLD in T2D.

关键词： Non-alcoholic fatty liver disease Type 2 diabetes Evidence PPAR agonists Incretin-based therapies

Serum tumor markers:Can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar Reddy Ilakkiya Priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(CA19-9,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(CA19-9),CA242,and carcinoembryonic antigen,in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： Cancer antigen 19-9 Cancer antigen 242 Carcinoembryonic antigen Tumor markers Type 2 diabetes mellitus