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Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

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BIOCELL 2024年第4期48卷 639-651页

作者： JIAN TANG CHENQIANG ZHU YUN CHEN YUNLONG WU MING HE YI ZHOU MINGHUA XIE Department of Intensive Care Unit The First People’s Hospital of Linping DistrictHangzhouChina Department of Pharmacy The First People’s Hospital of Linping DistrictHangzhouChina

Background:The speciﬁc impact of sphingolipid metabolism on developing hepatocellular Carcinoma(HCC)remains *** study aims to explore the relationship between sphingolipid metabolism and HCC prognosis,immune response,and drug ***:Data were obtained from The Cancer Genome Atlas(TCGA)-Hepatocellular Carcinoma(LIHC)and Gene Expression Omnibus(GEO,GsE14520 datasets).47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)*** classifying HCC samples using the Non-negative Matrix Factorization(NMF)clustering method,differentially expressed genes were ***,8 risk genes were obtained by univariate analysis,survival random forest reduction and lasso *** expression of 8 risk genes was veriﬁed in ***:8 risk genes were used to construct the sphingolipid score ***-sphingolipid score predicted poor prognosis of HCC *** score was associated with immune checkpoints(IL-1B,TLR4,TGFB1,and IL-10),immune cells(Th2,Treg,MDsC,Neutrophil,Fibroblasts and macrophage),and MAPK *** the High-sphingolipid score group,a signiﬁcantly higher proportion of patients with TP53(p53)mutations was signiﬁcantly higher(56%).Furthermore,patients with a high-sphingolipid score were predicted to have a higher sensitivity to chemotherapy *** vitro validation showed that compared with normal liver cells LX-2,TRIM47,and s100A9 signiﬁcantly increased in liver cancer cells Hep G2,MHCC-97H,and Hep3B2.1-7,while sLC1A7,LPCAT1,and CFHR4 signiﬁcantly *** TRIM47 reduced the proliferation and promoted *** levels of ceramide synthesis-related indexes(CERs1,CERs6,CERs5,and sPTLC2)increased,and the ACER3 related to catalytic hydrolysis ***:We constructed a sphingolipid metabolism-related prognostic signature(sphingolipid score)based on 8 risk ***47 may affect the development of liver cancer by regulating the relevant indicators of

关键词： Hepatocellular carcinoma sphingolipid metabolism TRIM47 Prognosis

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safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing CHEN Wei-qing CHEN Fei-hua GONG Mou-chun Department of General surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(sY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(Ps,which were extremely further enhanced by sY(Psed fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(PsY(Ps of sY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(Psion sY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

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superhydrophobic surface-Assisted Preparation of Microspheres and supraparticles and Their Applications

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Nano-Micro Letters 2024年第4期16卷 110-138页

作者： Mengyao Pan Huijuan shao Yue Fan Jinlong Yang Jiaxin Liu Zhongqian Deng Zhenda Liu Zhidi Chen Jun Zhang Kangfeng Yi Yucai su Dehui Wang Xu Deng Fei Deng Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China school of Materials science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China shenzhen Institute for Advanced study University of Electronic Science and Technology of ChinaShenzhen 518110People’s Republic of China Pharmaceutical Glass Co.Ltd Zibo 256100People’s Republic of China Department of Nephropathy School of MedicineSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China Department of Nephrology Sichuan Provincial People’s Hospital Jinniu HospitalChengdu Jinniu District People’s HospitalChengduPeople’s Republic of China

superhydrophobic surface(sHs) has been well developed, as sHs renders the property of minimizing the water/solid contact interface. Water droplets deposited onto sHs with contact angles exceeding 150°, allow them to retain spherical shapes, and the low adhesion of sHs facilitates easy droplet collection when tilting the substrate. These characteristics make sHs suitable for a wide range of applications. One particularly promising application is the fabrication of microsphere and supraparticle materials. sHs offers a distinct advantage as a universal platform capable of providing customized services for a variety of microspheres and supraparticles. In this review, an overview of the strategies for fabricating microspheres and supraparticles with the aid of sHs, including cross-linking process, polymer melting,and droplet template evaporation methods, is first presented. Then, the applications of microspheres and supraparticles formed onto sHs are discussed in detail, for example, fabricating photonic devices with controllable structures and tunable structural colors, acting as catalysts with emerging or synergetic properties, being integrated into the biomedical field to construct the devices with different medicinal purposes, being utilized for inducing protein crystallization and detecting trace amounts of analytes. Finally,the perspective on future developments involved with this research field is given, along with some obstacles and opportunities.

关键词： superhydrophobic surface Microspheres and supraparticles Photonic devices Catalysts Biomedical and trace detections

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Anesthesia,Anesthetics,and Postoperative Cognitive Dysfunction in Elderly Patients

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Current Medical science 2024年第2期44卷 291-297页

作者： Hong-yu ZHU Jian-li YAN Min ZHANG Tian-yun XU Chen CHEN Zhi-lin WU Department of Anesthesiology Linhe District People's HospitalBayannur 015000China Department of Neurosurgery Xinzhou District People's HospitalWuhan 430408China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Postoperative cognitive dysfunction(POCD)remains a major issue that worsens the prognosis of elderly surgery *** article reviews the current research on the effect of different anesthesia methods and commonly utilized anesthetics on the incidence of POCD in elderly patients,aiming to provide an understanding of the underlying mechanisms contributing to this condition and facilitate the development of more reasonable anesthesia protocols,ultimately reducing the incidence of POCD in elderly surgery patients.

关键词： anesthesia anesthetics postoperative cognitive dysfunction elderly patients

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Lung ultrasound score evaluation of the effect of pressure-controlled ventilation volume-guaranteed on patients undergoing laparoscopicassisted radical gastrectomy

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1717-1725页

作者： Jian Tan Cheng-Ming Bao Xiao-Yuan Chen Department of Critical Care Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina Department of Ultrasound Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND Laparoscopic-assisted radical gastrectomy(LARG)is the standard treatment for early-stage gastric carcinoma(GC).However,the negative impact of this proce-dure on respiratory function requires the optimized intraoperative management of patients in terms of *** To investigate the influence of pressure-controlled ventilation volume-guaranteed(PCV-VG)and volume-controlled ventilation(VCV)on blood gas analysis and pulmonary ventilation in patients undergoing LARG for GC based on the lung ultrasound score(LUs).METHODs The study included 103 patients with GC undergoing LARG from May 2020 to May 2023,with 52 cases undergoing PCV-VG(research group)and 51 cases undergoing VCV(control group).LUs were recorded at the time of entering the operating room(T0),20 minutes after anesthesia with endotracheal intubation(T1),30 minutes after artificial pneumoperitoneum(PP)establishment(T2),and 15 minutes after endotracheal tube removal(T5).For blood gas analysis,arterial partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide(PaCO_(2))were *** airway pressure(P_(peak)),plateau pressure(Pplat),mean airway pressure(P_(mean)),and dynamic pulmonary compliance(C_(dyn))were recorded at T1 and T2,1 hour after PP establishment(T3),and at the end of the operation(T4).Postoperative pulmonary complications(PPCs)were ***-and postoperative serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were measured by enzyme-linked immunosorbent *** Compared with those at T0,the whole,anterior,lateral,posterior,upper,lower,left,and right lung LUs of the research group were significantly reduced at T1,T2,and T5;in the control group,the LUs of the whole and partial lung regions(posterior,lower,and right lung)decreased significantly at T2,while at T5,the LUs of the whole and some regions(lateral,lower,and left lung)increased *** comparison with the control group,the whole and regional LUs of the research group were reduc

关键词： Lung ultrasound score Pressure-controlled ventilation volume-guaranteed Laparoscopic-assisted radical gastrectomy Blood gas analysis indexes Pulmonary ventilation

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Efficacy and safety of minimally invasive laparoscopic surgery under general anesthesia for ovarian cancer

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World Journal of Clinical Cases 2024年第9期12卷 1569-1577页

作者： Xian Qin Chen Chen Yang Liu Xian-Hong Hua Jia-Yi Li Meng-Jie Liang Fang Wu Department of Anesthesiology The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of Obstetrics and Gynecology The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Ovarian cancer is one of the most common malignant tumors in female reproductive system in the world,and the choice of its treatment is very important for the survival rate and prognosis of *** open surgery is the main treatment for ovarian cancer,but it has the disadvantages of big trauma and slow *** the continuous development of minimally invasive technology,minimally invasive laparoscopic surgery under general anesthesia has been gradually applied to the treatment of ovarian cancer because of its advantages of less trauma and quick ***,the efficacy and safety of minimally invasive laparoscopic surgery under general anesthesia in the treatment of ovarian cancer are still *** To explore the efficacy and safety of general anesthesia minimally invasive surgery in the treatment of ovarian *** The clinical data of 90 patients with early ovarian cancer in our hospital were analyzed *** to the different surgical treatment methods,patients were divided into study group and control group(45 cases in each group).The study group received minimally invasive laparoscopic surgery under general anesthesia for ovarian cancer,while the control group received traditional open surgery for ovarian *** European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30),clinical efficacy and safety of the two groups were *** The intraoperative blood loss,length of hospital stay,postoperative gas evacuation time,and postoperative EORTC QLQ-C30 score of the study group were significantly better than those of the control group(Pstoperative complications in the study group was significantly lower than in the control group(Ps had no significant differences in the preoperative adrenocorticotropic hormone(ACTH),androstenedione(AD),cortisol(Cor),cluster of differentiation 3 positive(CD3+),and clu

关键词： Early-stage ovarian cancer Efficacy Minimally invasive Laparoscopy safety surgery

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Predictive utility of the Rockall scoring system in patients suffering from acute nonvariceal upper gastrointestinal hemorrhage

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World Journal of Gastrointestinal surgery 2024年第8期16卷 2620-2629页

作者： De-Ping Han Cai-Qian Gou Xin-Mian Ren Department of Emergency Chengyang District People’s HospitalQingdao 266109Shandong ProvinceChina

BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)represents a sig-nificant clinical challenge due to its unpredictability and potentially severe *** Rockall risk score has emerged as a critical tool for prognostic asse-ssment in patients with ANVUGIB,aiding in the prediction of rebleeding and ***,its applicability and accuracy in the Chinese population remain *** To assess the prognostic value of the Rockall risk score in a Chinese cohort of patients with *** A retrospective analysis of 168 ANVUGIB patients’medical records was *** study employed statistical tests,including the t-test,χ2 test,spearman correlation,and receiver operating characteristic(ROC)analysis,to assess the re-lationship between the Rockall score and clinical outcomes,specifically focusing on rebleeding events within 3 months *** significant associations were found between the Rockall score and various clinical *** Rockall scores were significantly associated with rebleeding events(r=0.735,R2=0.541,Pstrongly positively correlated with adverse *** hemoglobin levels(t=2.843,P=0.005),high international normalized ratio(t=3.710,Pscopy(χ2=7.950,P=0.005),large ulcer size(t=6.348,Psfusion(χ2=6.381,P=0.012)were all significantly associated with rebleeding ***,differences in treatment and management strategies were identified between patients with and without rebleeding *** analysis indicated the excellent discriminative power(sensitivity:0.914;specificity:0.816;area under the curve:0.933;Youden index:0.730)of the Rockall score in predicting rebleeding events within 3 *** This study provides valuable insights into the prognostic value of the Rockall risk score for ANVUGIB in the Chinese *** results underscore the potential of the Rockall score as an effective tool

关键词： Acute non-variceal upper gastrointestinal bleeding Rockall risk score Clinical outcomes Risk stratification Prognosis

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Left atrial appendage occluder detachment treated with transthoracic ultrasound combined with digital subtraction angiography guided catcher:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1157-1162页

作者： Kai Yu Yun-Hua Mei Department of Ultrasound Wuhan Dongxihu District People's HospitaWuhan 430400Hubei ProvinceChina Department of Infectious Diseases Wuhan Dongxihu District People's HospitalWuhan 430400Hubei ProvinceChina

BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after *** case innovatively used ultrasound guidance combined with digital subtraction angiography(DsA)to completely remove the occluder,accumulating some *** sUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial *** the surgery,the occluder fell off and became free in the left ventricle,which is very *** innovatively used ultrasound guidance,combined with DsA,and interventional surgery to successfully capture the free occluder using a catcher,completely remove it,and then re implant a new left atrial appendage *** the surgery,the patient recovered very *** The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.

关键词： Left atrial appendage occluder Detachment Ultrasound combined with digital subtraction angiography Interventional operation successfully captured Case report

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Psychological intervention based on social cognitive theory: Treating pain, anxiety, and depression in perioperative patients

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World Journal of Psychiatry 2024年第8期14卷 1199-1207页

作者： Hai-Jian Mao Lin-Fei Wang Chun Lin Department of surgical Anesthesiology The First People’s Hospital of Lin’an DistrictHangzhouHangzhou 311300Zhejiang ProvinceChina Department of Gastrointestinal surgery Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Department of Comprehensive Intervention The First People’s Hospital of Lin’an DistrictHangzhouHangzhou 311300Zhejiang ProvinceChina

BACKGROUND surgery is an effective method for treating certain *** such as disease,preoperative fear and tension,surgical stress,postoperative pain,and related complications directly affect the smooth progression and outcome of *** may experience a series of psychological and physiological changes during the perioperative period,resulting in anxiety and depression,which may reduce the pain threshold and worsen their *** We enrolled 200 patients who underwent surgical care at The First people’s hospital of Lin’an district,Hangzhou between January and December *** were categorized into a routine intervention group(n=103)and a psychological intervention group(n=97),based on the intervention strategies *** assessment tools,including the self-rating anxiety scale(sAs),the self-rating depression scale(sDs),and the Connor–Davidson Resilience scale,were used to measure patients’negative states and *** pre-and post-intervention scores for these metrics in the two groups were then *** In the psychological intervention group,the sAs and sDs scores(31.56±5.18 and 31.46±4.57,respectively)were significantly reduced compared to the routine intervention group(Psual analog scale pain scores at 12 and 24 hours after intervention(6.85±1.21,4.24±0.72)were notably higher than those in the routine intervention group(Psychological intervention group also demonstrated superior scores in perseverance(36.08±3.29),self-reliance(22.63±2.91),optimism(11.42±1.98),and resilience(70.13±5.37),compared to the routine intervention group(Psychological intervention group’s confrontation score(23.16±4.29)was higher(Ps group also reported lower scores in avoidance(9.28±1.94)and yielding(6.19±1.92)(Pstly,the short Form 36 Health survey scores were significantly higher in the psychological intervention group,indicating a better quality of life(PsION

关键词： Perioperative period social cognitive theory Psychological intervention Pain Anxiety and depression

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Clinical risk factors for preterm birth and evaluating maternal psychology in the postpartum period

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World Journal of Psychiatry 2024年第5期14卷 661-669页

作者： Jia-Jun Chen Xue-Jin Chen Qiu-Min she Jie-Xi Li Qiu-Hong Luo Department of Clinical Laboratory Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Otolaryngology Head and Neck surgery Outpatient Shenzhen Children’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Prevention and Health Care Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Obstetrics Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Although the specific pathogenesis of preterm birth(PTB)has not been thoroughly clarified,it is known to be related to various factors,such as pregnancy complications,maternal socioeconomic factors,lifestyle habits,reproductive history,environmental and psychological factors,prenatal care,and nutritional *** has serious implications for newborns and families and is associated with high mortality and ***,the prediction of PTB risk can facilitate early intervention and reduce its resultant adverse *** To analyze the risk factors for PTB to establish a PTB risk prediction model and to assess postpartum anxiety and depression in *** A retrospective analysis of 648 consecutive parturients who delivered at shenzhen Bao’an district songgang people’s hospital between January 2019 and January 2022 was *** to the diagnostic criteria for premature infants,the parturients were divided into a PTB group(n=60)and a full-term(FT)group(n=588).Puerperae were assessed by the self-rating Anxiety scale(sAs)and self rating Depression scale(sDs),based on which the mothers with anxiety and depression symptoms were screened for further *** factors affecting PTB were analyzed by univariate analysis,and the related risk factors were identified by logistic *** According to univariate analysis,the PTB group was older than the FT group,with a smaller weight change and greater proportions of women who underwent artificial insemination and had gestational diabetes mellitus(Ps of women with reproductive tract infections and greater white blood cell(WBC)counts(Pshorter cervical lengths in the second trimester and lower neutrophil percentages(Pstpartum sAs and sDs scores than did the FT group(Ps experiencing anxiety and depress

关键词： Preterm birth Risk factors Postpartum psychological state Risk model Prediction

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