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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 15-16页

作者： Akbayir N. Calis. A.B. Alkim C. 陈云茹 huseyin pasa sok no. 23/10 Kiziltoprak Istanbul 34724 Turkey.Dr

Isolated case reports in which symptomatic hearing loss develops suddenly during the course of inflammatory bowel disease (IBD) have been reported, but the presence of subclinical sensorineural hearing loss (SNHL) associated with IBD has been investigated in only two preliminary *** order to research this further, we aimed to investigate the presence of subclinical SNHL in IBD by comparison with a control group and to examine possible relations between the bowel disease parameters and hearing ***, tympano.etry, and pure tone audiometry were carried out in 39 patients with IBD (21 Crohn’s disease [CD], 18 ulcerative colitis [UC]) and 25 healthy ageand sex-matched controls. All patients and control subjects had no.mal otoscopy findings and tympano.etry was unremarkable, excluding middle ear disease and conductive hearing loss. Analysis of each frequency examined showed that the average hearing thresholds were increased significantly in the study group compared to those of the control group at higher frequencies (2, 4, and 8 kHz). When these parameters were compared with the control group according to subgroups of IBD, a significant difference was determined for the UC group at frequencies of 2, 4, and 8 kHz and for the CD group only at the frequency of 4 kHz. Although there was a trend of increment in SNHL as the age of the patient and duration and extent of UC increased, no.significant correlation was observed between SNHL and these parameters or sex, activity, involvement site, medication history of IBD, and coexistence of other extraintestinal manifestations. In conclusion, it was demonstrated that a subclinical SNHL may be associated with UC and somewhat with CD, affecting mainly the high frequencies. In light of this finding, it may be advisable to investigate labyrinth functions as well as other extraintestinal manifestations in patients with IBD.

关键词：炎症性肠病感觉神经性耳聋亚临床传导性听力丧失克罗恩病耳镜检查纯音测听疾病活动度溃疡性

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颈部食管的异位胃黏膜:是否参与了后壁喉炎患者咽喉部反流的发病机制

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 59-60页

作者： Akbayir N Skmen H.M al iA.B. 成虹 huseyin pasa sok. no. 23/10 Istanbul 34724 TurkeyDr.

Objective. Acid secretion produced by a heterotopic gastric mucosal patch (HGMP) in the proximal esophagus, instead of gastric acid, may be responsible for laryngopharyngeal reflux (LPR), passing the upper esophageal sphincter. The aim of this study was to investigate the prevalence of HGMP in the proximal esophagus in patients with posterior laryngitis indicating the presenc e of LPR in comparison with a control group and to elucidate the possible role o f this lesion in the pathogenesis of LPR. Material and methods. A total of 36 co nsecutive patients with posterior laryngitis diagno.ed on laryngoscopic examinat ion were enrolled in the study. Esophagoscopy and ambulatory 24 h intra-esophag eal dual-probe pH monitoring were performed in all patients. During endoscopy, special attention was paid to the proximal part of the esophagus, and the proxim al electrode for pH monitoring was placed in this region under endoscopic view. The control group comprised 660 consecutive patients who had undergone upper gas trointestinal endoscopy for the usual indications. When HGMP was found, biopsies were taken for histological confirmation. Results. HGMP was detected in 5 out o f 36 patients. One out of five patients with patches was excluded from the study because the histopathology of this patient‘s patch revealed antral-type mucos a, which is no. capable of acid secretion. Thus a total of 35 patients were incl uded in the study, yielding a HGMP prevalence of 11.4%(4/35). Compared with the prevalence of the control group (1.6%), a significant difference was observed (p no.mal proxim al acid reflux. All of four HGMP (+) patients with posterior laryngitis reveale d significantly higher abno.mal proximal reflux compared to the patients without patches (p no. g

关键词：颈部食管异位胃黏膜咽喉部发病机制酸反流近端酸刺激消化道内镜检查组织学检查喉镜检查

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