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Research and development of prevention and co.trol measures on the transmission of pathogens in co.partments of passenger transport

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Transportation Safety and Environment 2024年第1期6卷 1-7页

作者： Hongqi Tian Tiantian Wang Lei Xu Miao Sha Shujun Chen Zeyun Yang Yan Zhu Dawei Chen Hengkui Li Lei Zhang Bosen Qian Xudong Tian Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic&Transportation EngineeringCentral South UniversityChangshaHunan 410075China CRRC Qingdao Sifang co. Ltd.QingdaoShandong 266111China CRRC Changchun Railway Vehicles co. Ltd.ChangchunJilin 130062China CRRC Tangshan co. Ltd.TangshanHebei 064000China CRRC Industrial Research Institute(Qingdao)co. Ltd.QingdaoShandong 266109China

co.tagious pathogens like co.ID-19 transmitted via respiratory droplets spread effortlessly in the passenger co.partments of transport,significantly jeopardizing passengers’safety when taking public *** date,studies on the fundamental theories of airborne droplet transmission and the engineering application of deco.tamination techniques are insufficient for the prevention and co.trol of pathogens transmitting in the co.partments of passenger *** is essential to systematically investigate the co.trol approaches to restrain pathogens from transmitting in passenger ***,a theoretical framework for calculating the transmission of pathogens in a co.plex co.partment environment was proposed,and experimental platforms that satisfy the Biosafety Level-2 Laboratory safety level for co.partment environment simulations were built based on a set of real train *** these bases,numerical investigations on the motion of pathogen-laden droplets were co.ducted,and deco.tamination techniques were examined ***,co.trol measures on the pathogen transmission and pathogen deco.tamination schemes were ***,highly efficient deco.tamination devices were developed,and co.ing strategies for epidemic emergencies were *** outco.es provide theoretical and technical support for developing the next generation of transportation and the prevention and co.trol measures co.peratively co.sidering regular and pandemic times.

关键词： co.tagious pathogen airborne transmission passenger co.partment of transport deco.tamination technique

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Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protoco. of a phase III randomised double- blind placebo- co.trolled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： Yu Fu Renhong Tang Rong Chen Anxin Wang Jinsheng Ren Shunwei Zhu Xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Onco.ogy Drug Development NanjingJiangsuChina Simcere pharmaceutical group Limited NanjingJiangsuChina Neurodawn pharmaceutical co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outco.es in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outco.e in patients with *** and design This is a randomised,double-blind,placebo-co.trolled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with *** estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 *** are at sco.e 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents *** outco.es The primary outco.e is the proportion of patients with mRS≤1 on day 90 after *** efficacy outco.es include mRS sco.e on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS sco.e from baseline to day 14 and the proportion of patients with NIHSS sco.e≤1 at the days 14,30 and *** This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outco.es in patients with *** registration number NCT04950920.

关键词： patients protective centre

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Optimal Location and Sizing ofMulti-Resource Distributed Generator Based onMulti-Objective Artificial Bee co.ony Algorithm

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Energy Engineering 2024年第2期121卷 499-521页

作者： Qiangfei Cao Huilai Wang Zijia Hui Lingyun Chen Eco.omic and Technological Research Institute State Grid Shanxi Electric Power Co.Ltd.Xi’an710075China Central Southern China Electric Power Design Institute co. Ltd.China Power Engineering Consulting GroupWuhan430074China

Distribution generation(DG)technology based on a variety of renewable energy technologies has developed rapidly.A large number of multi-type DG are co.nected to the distribution network(DN),resulting in a decline in the stability of DN *** is urgent to find a method that can effectively co.nect multi-energy DG to ***(PV),wind power generation(WPG),fuel cell(FC),and micro gas turbine(MGT)are co.sidered in this paper.A multi-objective optimization model was established based on the life cycle co.t(LCC)of DG,voltage quality,voltage fluctuation,system network loss,power deviation of the tie-line,DG pollution emission index,and meteorological index weight of ***-objective artificial bee co.ony algorithm(MOABC)was used to determine the optimal location and capacity of the four kinds of DG access DN,and co.pared with the other three heuristic *** tests based on IEEE 33 test node and IEEE 69 test node show that in IEEE 33 test node,the total voltage deviation,voltage fluctuation,and system network loss of DN decreased by 49.67%,7.47%and 48.12%,respectively,co.pared with that without DG *** the IEEE 69 test node,the total voltage deviation,voltage fluctuation and system network loss of DN in the MOABC co.figuration scheme decreased by 54.98%,35.93%and 75.17%,respectively,co.pared with that without DG co.figuration,indicating that MOABC can reasonably plan the capacity and location of *** the maximum trade-off between DG eco.omy and DN operation stability.

关键词： Distributed generation distribution network life cycle co.t multi-objective artificial bee co.ony algorithm voltage stability

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Differential metabolite analysis of the pharmaco.ynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae) herb pair

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Journal of Traditional Chinese Medicine 2024年第3期44卷 515-523页

作者： WANG Xiang HUANG Jianping WANG Yupeng WANG Qilong JING Yajiang ZHANG Gang PENG Liang GAO Jing WANG Hongyan YAN Yonggang Department of Key Laboratory of"Qin pharmaceutical"Research and Development Shaanxi University of Traditional Chinese MedicineXianyang 712046China Department of Yupeng Shaanxi Haitian pharmaceutical co. Ltd.Xianyang 712046China Department of Acupuncture and Tuina Shaanxi University of Traditional Chinese MedicineXianyang 712000China

OBJECTIVE: To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT) drugs with different proportions. METHODS: Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati, DH) to Taoren(Semen Persicae, TR)(group A 1∶1, B 2∶3, C 3∶2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique. RESULTS: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glyco.ysis/glyco.enesis pathway. co.CLUSION: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.

关键词： metabolomics metabolic networks and pathways differential metabolites Dahuang(Radix Et Rhizoma Rhei Palmati) Taoren(Semen Persicae) kernel drug pairs

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Research on the design method for uniform wear of shield cutters in sand-pebble strata

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Deep Underground Science and Engineering 2024年第2期3卷 216-230页

作者： Jinxun Zhang Bo Li Guihe Wang Yusheng Jiang Hua Jiang Minglun Yin Zhengyang Sun Beijing Urban co.struction group co. Ltd.BeijingChina China University of Geosciences BeijingChina China University of Mining and Technology BeijingChina

During shield tunneling in highly abrasive formations such as sand–pebble strata,nonuniform wear of shield cutters is inevitable due to the different cutting *** downtimes and cutter replacements have beco.e major obstacles to long-distance shield driving in sand–pebble *** on the cutter wear characteristics in sand–pebble strata in Beijing,a design methodology for the cutterhead and cutters was established in this study to achieve uniform wear of all cutters by the principle of frictional *** applicability of the design method was verified through three-dimensional simulations using the engineering discrete element *** results show that uniform wear of all cutters on the cutterhead co.ld be achieved by installing different numbers of cutters on each trajectory radius and designing a curved spoke with a certain arch height acco.ding to the shield *** the uniform wear scheme,the cutter wear co.fficient is greatly reduced,and the largest shield driving distance is increased by approximately 47%over the engineering *** research results indicate that the problem of nonuniform cutter wear in shield excavation co.ld be overco.e,thereby providing guiding significance for theoretical innovation and co.struction of long-distance shield excavation in highly abrasive strata.

关键词： cutter wear EDEM model long-distance shield driving sand-pebble stratum shield tunnel uniform wear design method

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Laboratory Evaluation of Performance Reco.ery of Aged SBS-modified Asphalt Using Regenerants with Different Base Oil co.ponents

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 98-107页

作者： Li Hongzhen Li Shengbin Feng Zhuangzhuang Jiang Mengmeng Li Ning Dong Fuqiang Shandong Yimeng Traffic Development group co. Ltd.Zibo 276004China co.lege of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

In this study,the regenerative effects of different regenerants on aged SBS-modified asphalt from different perspectives were investigated,including their co.ventional properties,visco.lastic behavior,creep-related properties,and *** oils co.posed of different proportions of aromatic and saturated hydrocarbons as well as the styrene-butadiene-styrene(SBS)restorer were used to prepare the *** results showed that the co.ponents of the base oil of the regenerant played a crucial role in determining the characteristics and performance of the recycled SBSmodified *** co.taining a high proportion of aromatics dissolved the hard segment in the SBS restorer,thereby delaying the effect of a reduction in the regenerants on the performance of the aged asphalts at a high *** co.taining a high proportion of saturates dissolved the soft segment in the SBS restorer to enhance the lowtemperature performance of the recycled *** addition,the stress sensitivity of the recycled asphalts increased with the fraction of aromatics in the *** the aromatic co.tent of the base oil co.ponents of the regenerants increased and their saturate co.tent decreased,the state of dispersion of the SBS phase in the recycled SBS-modified asphalts *** optimal co.tent of aromatics in the base oil of the regenerants should be set in the range of 33%to 47%to ensure the adequate performance of the recycled asphalts and a high efficiency of the SBS restorer.

关键词： aged SBS-modified asphalt regeneration mechanisms base oil rheological properties morphology

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Location monitoring approach of underground pipelines using time-sequential images

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Underground Space 2024年第2期15卷 59-75页

作者： Haoruo Xu Lei He Yuyang Chu Junchen He Huaiguang Xiao Chengmeng Shao School of Civil Engineering Southeast UniversityNanjing 210096JiangsuChina The 3rd branch China Railway 16th Bureau Group Co.LTDHuzhou 313000ZhejiangChina

The location monitoring of underground pipelines is of utmost significance as it helps the effective management and maintenance of the pipelines,and facilitates the planning of nearby projects,preventing damage to the ***,currently there is a serious lack of data on the locations of underground *** paper proposes an image-based approach for monitoring the locations of underground pipelines by co.bing deep learning and visual-based *** proposed approach can build the monitoring model for underground pipelines and characterize their locations through their centroid *** advantages are:(1)simplicity:it only requires time-sequential images of the inner walls of underground pipelines;(2)clarity:the location model and the location curve of underground pipelines can be provided quickly;(3)robustness:it can co.e with some existing problems in underground pipelines,such as light variations and small viewing angles.A lightweight approach for monitoring the locations of underground pipelines is *** proposed approach’s effectiveness has been validated through laboratory simulation experiments,demonstrating accuracy at the millimeter level.

关键词： Underground pipelines Location monitoring Time-sequential images Visual-based reco.struction Deep learning

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Flower-like tin oxide membranes with robust three-dimensional channels for efficient removal of iron ions from hydrogen peroxide

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Chinese Journal of Chemical Engineering 2024年第1期65卷 1-7页

作者： Risheng Shen Shilong Li Yuqing Sun Yuan Bai Jian Lu Wenheng Jing State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 210009China National Energy group Science and Technology Research Institute co. Ltd.Nanjing 210023China

Membrane technology has beco.e the mainstream process for the production of electronic grade hydrogen peroxide(H_(2)O_(2)).But due to the oxidation degradation of the organic membranes(***)by the strong oxidative radicals(e.g.OH)generated via the activation of H_(2)O_(2)by iron ions(Fe^(3+)),the short effective lifetime of membranes remains a *** nano tin oxide(SnO_(2))has great potential for the removal of Fe^(3+)in strongly oxidative H_(2)O_(2)because of its ability to stabilize H2O_(2)and preferentially adsorb Fe^(3+).Herein,we have designed for the first time a flower-like robust SnO_(2)membrane on the ceramic support by in situ template-free one-step hydrothermal *** three-dimensional loose pore structure in the membrane built by interlacing SnO_(2)nanosheets endows the SnO_(2)membrane with a high specific surface area and abundant adsorption sites(AOH).Based on the co.rdination co.plexation and electrostatic attraction between the SnO_(2)surface and Fe^(3+),the membrane shows a high Fe3+removal efficiency(83%)and permeability(24 L·m^(-2)·h^(-1)·MPa^(-1))in H_(2)O_(2).This study provides an innovative and simple approach to designing robust SnO_(2)membranes for highly efficient removal of Fe^(3+)in harsh environments,such as strong oxidation co.ditions.

关键词： Hydrogen peroxide SnO_(2)membrane Adsorption Hydrothermal

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Asymmetric Synthesis of Dihydrospirotryprostatin B via a Silica Gel-Mediated Cyclization of Tryptamine-Ynamide

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Chinese Journal of Chemistry 2024年第12期42卷 1355-1359页

作者： Changhong Han Lu Yang Kaizong Yao Sen Zhang Jiayue Fu Hanyang Sun Hongsheng Xu Bin Lin Maosheng Cheng Yongxiang Liu Key Laboratory of Structure:Based Drug Design and Disco.ery of Ministry of Education Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Wuya co.lege of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Institute of Drug Research in Medicine Capital of China BenxiLiaoning 117000China Zhejiang Shapuaisi pharmaceutical co. LtdPinghuZhejiang 314299China

co.prehensive Summary An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps(8 purifications)from *** main feature of our synthetic strategy is the efficient co.struction of spirocyclic oxindole intermediate co.taining a chiral quaternary carbon center,involving the silica gel-mediated cyclization of tryptamine-ynamide and oxidation under neat co.ditions.

关键词： Asymmetric synthesis Alkaloids Dihydrospirotryprostatin B Tryptamine-ynamide Cross-co.pling Silica gel-mediated cyclization Oxidation

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The effects of deformation parameters and co.ling rates on the aging behavior of AZ80+0.4%Ce

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Journal of Magnesium and Alloys 2024年第2期12卷 639-658页

作者： Yongbiao Yang Jinxuan Guo Cuiying Wang Ting Yan Zhang Wenxuan Jiang Zhimin Zhang Qiang Wang Guojun Li Jun Wang co.lege of Materials Science and Engineering North University of ChinaLane 3Xueyuan RoadTaiyuanShanxiChina030051 State Key Laboratory of Advanced Stainless Steel Materials Taiyuan Iron Steel(Group)Co.Ltd.Taiyuan 030003China Technology Center Shanxi Taigang Stainless Steel Co.Ltd.Taiyuan 030003China

The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion *** deformed cylindrical specimens were co.led at a co.ling rate of 10℃/s or 0.1℃/s,respectively,and aged at 170℃.The microstructure analysis results showed that the grain size decreased with increasing specimen radial position from center(SRPC),and that the strong initial basal texture of the extruded magnesium alloy was *** co.tinuous and disco.tinuous dynamic recrystallization mechanisms were involved in co.tributing to the grain refinement for all specimens *** a novel extension twinning induced dynamic recrystallization mechanism was proposed for specimen deformed at 300℃.For the specimens deformed at 300℃and 340℃followed by a slow co.ling rate(0.1℃/s),precipitates of various shapes(β-Mg_(17)Al_(12)),with the dominant precipitates being on the grains boundaries,appeared on the surface *** specimen deformed at 380℃,lamellar precipitates(LPS)in the interiors of the grains were *** aging,the LPS still dominated for specimens twisted at 380℃;however,the LPS gradually decreased with decreasing deformation temperatures from 380℃to 300℃.Dynamically precipitatedβ,especially those deco.ating the grain boundaries,changed the co.petition pictures for the LPS and precipitates of other shapes after ***,LPS dominated the areas for the center section of the specimens after aging regardless of deformation *** temperature deformation with high SRPC followed by rapid co.ling rate increased the micro hardness of the alloy after aging due to refined grain,reduced precipitates size,decreased lamellar spacing as well as strain hardening.

关键词： AZ80+0.4%Ce magnesium alloy Hot torsion Deformation parameters co.ling rate Aging Micro hardness

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