检索结果-南通市图书馆

Asian Agricultural Research 2011年第1期3卷 51-54页

作者： CHEN Hui-min School of Economics&Management Hunan Institute of EngineeringXiangtan 411104China

By using error correction model, I conduct co-integration analysis on the research of the relationship between the per capita practical consumption and per capita practical disposable income of urban residents in hunan province from 1978 to 2009. The results show that there is a co-integration relationship between the per capita practical consumption and the practical per capita disposable income of urban residents, and based on these, the corresponding error correction model is established. Finally, corresponding countermeasures and suggestions are put forward as follows: broaden the income channel of urban residents; create goods consuming environment; perfect socialist security system.

关键词： Residential income Co-integration Error correction model China

Evaluation of Ecological Environment Competitiveness of hunan province Based on Prefecture Level Cities

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Agricultural Science & Technology 2020年第3期21卷 45-52页

作者： CAO Jian LIU Wen-xiang YANG Wen-lin FU Xiao-hua Central South University of Forestry and Technology College of Environmental Science and EngineeringEcological Environment Management and Assessment CenterChangsha 410004PRC hunan Institute of Agricultural Information and Engineering Changsha 410125PRC

Based on the data of 13 eco-environmental indicators of 14 prefecture level cities in hunan province from 2014 to 2018,this paper quantitatively evaluated the eco-environmental competitiveness and its advantages and disadvantages by principal component analysis(PCA).The results showed that:(1)the overall ecoenvironmental competitiveness of hunan province was relatively high,whereas the competitiveness level of each city and prefecture was quite *** comprehensive score of eco-environmental competitiveness of Changsha City was 2.96,ranking the first,and Zhangjiajie city ranking the last with a score of-1.60,which indicated that there was an obvious difference in the level of eco-environmental competitiveness among different regions.(2)The overall eco-environmental competitiveness of cities and prefectures in Western hunan province was *** the 14 prefectures and cities in hunan province,the comprehensive scores of eco-environmental competitiveness of 6 prefectures and cities were negative,whereas the scores of Zhangjiajie,Xiangxi and Huaihua in Western hunan were all lower than the *** the face of increasingly serious environmental problems,cities and prefectures should adjust measures according to local conditions and put forward specific measures to enhance environmental *** particular,cities and prefectures in Western hunan should give full play to their advantages in ecological resources,take the path of green development,enhance the competitiveness of ecological environment,and provide support for local economic development.

关键词： hunan province Ecological environment competitiveness Index system Evaluation research

NATURAL TYPE Ib DIAMONDS IN DIAMOND PLACER IN hunan province

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Chinese Science Bulletin 1986年第4期31卷 257-261页

作者：郭九皋蔡秀成邓华兴陈丰谈逸梅邓尔森容振球 Institute of Geochemistry Academia Sinica Guiyang The 413 Geological Team Hunan The 413 Geological Team Hunant is well known that nitrogen is a major impurity in diamond because it can substitute the carbon in the diamond lattice. Hence diamonds may be classified as TypeⅠor Ⅱ based on the nitrogen content. The diamonds with higher nitrogen content are classified into Type Ⅰ. Diamonds in which nitrogen is mainly present in aggregated form are put in Type Ia whercas those in which nitrogen is mainly present in dispersed and isolated form into Type Ib. Synthetic diamonds often belong to Type Ib. However

It is well known that nitrogen is a major impurity in diamond because it can substitute the carbon in the diamond lattice. Hence diamonds may be classified as TypeⅠor Ⅱ based on the nitrogen content. The diamonds with higher nitrogen content are classified into Type Ⅰ. Diamonds in which nitrogen is mainly present in aggregated form are put in Type Ia, whercas those in which nitrogen is mainly present in dispersed and isolated form into Type Ib. Synthetic diamonds often belong to Type Ib. However,

关键词： diamond dispersed aggregated classified impurity ultraviolet orange irradiation annealed infra

Age Structure and Change Trend of Tobacco Farmers:A Case Study of Shashi Town,Liuyang City,hunan province

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Asian Agricultural Research 2023年第8期15卷 8-15页

作者： Jianwen WANG Liangjiao LIU Zhengguang ZHAI Zhiqiang DENG Tao ZHU Sihan HUANG Changsha Tobacco Company Liuyang Branch Changsha 410302China Changsha Tobacco Company Changsha 410600China PublicAdministration and Law College Hunan Agricultural UniversityChangsha 410128China Changsha Tobacco Company Ningxiang Branch Changsha 410600China

Taking the tobacco-growing area of Shashi Town,Liuyang City as the object,the number of registered,newly added and resigned tobacco farmers in each year,average age,number and proportion of tobacco farmers of different ages,number and proportion of tobacco farmers born in different eras,as well as planting scale and planting history of flue-cured tobacco in the last 10 years were analyzed *** results showed that the number of tobacco farmers in Shashi Town showed a rapid decline trend from 2012 to 2018,while the average age continuously increased,and the average planting scale rose in a wave like *** 2019 to 2021,the decline rate of the number of tobacco farmers slowed down,and the average planting scale continuously increased,while the aging of tobacco farmers ***,the birth years of tobacco farmers were further concentrated in the 1960s,and they were mainly at the age of *** tobacco industry in Shashi Town of Liuyang City is facing the crisis of aging tobacco farmers and no successor of flue-cured tobacco planting,and it is predicted that the next 5-10 years will continue the change trend from 2019 to 2021.

关键词： Tobacco farmers Number Birth year Average age Planting years Change trend Prediction

Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

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Neural Regeneration Research 2024年第2期19卷 360-368页

作者： Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan Department of Anatomy and Neurobiology Central South University Xiangya Medical SchoolChangshaHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Hunan Children’s HospitalChangshaHunan ProvinceChina Department of Neurology Brain Hospital of Hunan ProvinceChangshaHunan ProvinceChina

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug *** signaling through the excitatory neurotransmitter glutamate is intricately associated with *** glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic *** mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of *** this review,we first introduce the three groups of mGluRs and their associated signaling ***,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in *** addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also *** hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关键词： antiepileptic drugs epileptogenesis metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials

OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong Cui Wei Chen Li Du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in hunan province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury:predictors of patient prognosis

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Neural Regeneration Research 2024年第7期19卷 1553-1558页

作者： Sihong Huang Jungong Han Hairong Zheng Mengjun Li Chuxin Huang Xiaoyan Kui Jun Liu Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Computer Science Aberystwyth UniversityAberystwythCeredigionUK Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong ProvinceChina School of Computer Science and Engineering Central South UniversityChangshaHunan ProvinceChina Department of Radiology Quality Control Center of Hunan ProvinceChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging of hunan province ChangshaHunan ProvinceChina

Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly *** resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain *** approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and ***,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional *** that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is *** the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain *** this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy ***-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network *** the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention *** than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 ***,better cognitive function was associated with more efficient ***,our data indicated that small-worldness in the acute sta

关键词： cognitive function cross-section follow-up functional connectivity graph theory longitudinal study mild traumatic brain injury prediction small-worldness structural connectivity subnetworks whole brain network

Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou Xiao-Zi Lu Ren-Jiao Li Yi-Fan Xiong Xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

P-aminobenzoic acid promotes retinal regeneration through activation of Ascl1a in zebrafish

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Neural Regeneration Research 2024年第8期19卷 1849-1856页

作者： Meihui He Mingfang Xia Qian Yang Xingyi Chen Haibo Li Xiaobo Xia Eye Center of Xiangya Hospital Central South UniversityChangshaHunan ProvinceChina hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The retina of zebrafish can regenerate completely after injury.M ultiple studies have demonstrated that metabolic alte rations occur during retinal damage;however to date no study has identified a link between metabolites and retinal regeneration of ***,we performed an unbiased metabolome sequencing in the N-methyl-D-aspartic acid-damaged retinas of zebrafish to demonstrate the metabolomic mechanism of retinal *** the differentially-ex pressed metabolites,we found a significant decrease in p-aminobenzoic acid in the N-methyl-D-aspartic acid-damaged retinas of ***,we investigated the role of p-aminobenzoic acid in retinal regeneration in adult *** rtantly,p-aminobenzoic acid activated Achaetescute complex-like 1a expression,thereby promoting Müller glia reprogramming and division,as well as Müller glia-derived progenitor cell ***,we eliminated folic acid and inflammation as downstream effectors of PABA and demonstrated that PABA had little effect on Müller glia *** together,these findings show that PABA contributes to retinal regeneration through activation of Achaetescute complex-like 1a expression in the N-methyl-Daspartic acid-damaged retinas of zebrafish.

关键词： Achaetescute complex-like 1a(Ascl1a) metabolomics Müller glia p-aminobenzoic acid(PABA) retina regeneration zebrafish

p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model

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Neural Regeneration Research 2024年第10期19卷 2299-2309页

作者： Lemeng Feng Chao Wang Cheng Zhang Wulong Zhang Weiming Zhu Ye He Zhaohua Xia Weitao Song National Clinical Research Center for Geriatric Diseases Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Eye Center of Xiangya Hospital Central South UniversityChangshaHunan ProvinceChina hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogenactivated protein kinase(MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its downstream targets, such as p53, have been shown to be associated with ferroptosis. However, whether ferroptosis also occurs in retinal ganglion cells in response to glutamate excitotoxicity and whether inhibition of ferroptosis reduces the loss of retinal ganglion cells induced by glutamate excitotoxicity remain unclear. This study investigated ferroptosis in a glutamate-induced glaucoma rat model and explored the effects and molecular mechanisms of SB202190 on retinal ganglion cells. A glutamate-induced excitotoxicity model in R28 cells and an N-methyl-D-aspartate-induced glaucoma model in rats were used. In vitro experiments showed that glutamate induced the accumulation of iron and lipid peroxide and morphological changes of mitochondria in R28 cells, and SB202190 inhibited these changes. Glutamate induced the levels of p-p38 MAPK/p38 MAPK and SAT1 and decreased the expression levels of ferritin light chain, SLC7A11, and GPX4. SB202190 inhibited the expression of iron death-related proteins induced by glutamate. In vivo experiments showed that SB202190 attenuated N-methyl-D-aspartate-induced damage to rat retinal ganglion cells and improved visual function. These results suggest that SB202190 can inhibit ferroptosis and protect retinal ganglion cells by regulating ferritin light chain, SAT1, and SLC7A11/Gpx4 pathways and may represent a potential retina protectant.

关键词： ferroptosis glaucoma glutamate excitotoxicity p38 MAPK retinal ganglion cell SB202190