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Repurposing disulfiram with CuET nanocrystals:Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2698-2715页

作者： Xueming Xu Yuanfeng Han Jiali Deng Shengfeng Wang Shijie Zhuo Kai Zhao Wenhu Zhou Hematology and Department of Critical Care Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China hunan Chidren's Hospital Changsha 410007China Department of Pharmacy The Third Xiangya HospitalCentral South UniversityChangsha 410013China key laboratory of biological nanotechnology of National Health Commission Changsha 410008China

Drug repurposing offers a valuable strategy for identifying new therapeutic applications for existing ***,disulfiram(DSF),a drug primarily used for alcohol addiction treatment,has emerged as a potential treatment for inflammatory diseases by inhibiting pyroptosis,a form of programmed cell *** therapeutic activity of DSF can be further enhanced by the presence of Cu^(2+),although the underlying mechanism of this enhancement remains *** this study,we investigated the mechanistic basis of Cu^(2+)-induced enhancement and discovered that it is attributed to the formation of a novel copper ethylthiocarbamate(CuET)*** exhibited significantly stronger anti-pyroptotic activity compared to DSF and employed a distinct mechanism of ***,despite its potent activity,CuET suffered from poor solubility and limited permeability,as revealed by our druggability *** overcome these intrinsic limitations,we developed a scalable method to prepare CuET nanocrystals(CuET NCs)using a metal coordination-driven self-assembly *** studies demonstrated that CuET NCs exhibited a 6-fold improvement in ***,CuET NCs exhibited high biodistribution in the intestine,suggesting their potential application for the treatment of inflammatory bowel diseases(IBDs).To evaluate their therapeutic efficacy in vivo,we employed a murine model of DSS-induced colitis and observed that CuET NCs effectively attenuated inflammation and ameliorated colitis *** findings highlight the discovery of CuET as a potent anti-pyroptotic agent,and the development of CuET NCs represents a novel approach to enhance the druggability of CuET.

关键词： Drug repurposing Pyroptosis Nanoparticles Bioavailability Disulfiram DSS-induced colitis NLRP3 inflammasome CuET

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Bifunctional noble-metal-free cocatalyst coating enabling better coupling of photocatalytic CO_(2)reduction and H_(2)O oxidation on direct Z-scheme heterojunction

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Nano Research 2024年第6期17卷 5022-5030页

作者： Wei Zhao Weihao Mo Yan Zhang Lingxuan Hu Yiyi Zheng Zhulei Chen Xiangyue Niu Yuling Zhao Lichun Liu Shuxian Zhong Song Bai key laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China College of biological Chemical Sciences and Engineering and Nanotechnology Research InstituteJiaxing UniversityJiaxing 314001China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Chemical and biological Engineering Zhejiang UniversityHangzhou 310058China School of biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China

Selective loading of spatially separated redox cocatalysts on direct Z-scheme heterojunctions holds great promise for advancing the efficiency of artificial photosynthesis,which however is limited to the photodeposition of noble metal cocatalysts and the fabrication of hollow double-shelled semiconductor ***,the co-exposure of discrete cocatalyst and semiconductor increases the product diversity when both the exposed sites of which participate in CO_(2)***,we present a facile and versatile protocol to overcome these limitations via surface coating of Z-scheme heterojunctions with bifunctional noble-metal-free *** Cu_(2)O/Fe_(2)O_(3)(CF)as a model heterojunction and layered Ni(OH)_(2)as a model cocatalyst,it is found that Ni(OH)_(2)lying on the surfaces of Cu_(2)O and Fe_(2)O_(3)separately co-catalyzes the CO_(2)reduction and H_(2)O *** experimental and theoretical investigation reveals that the Ni(OH)_(2)outer layer:(i)mitigates the charge recombination in CF and balances their transfer and consumption;(ii)reduces the rate-determining barriers for CO_(2)-to-CO and H_(2)O-to-O_(2)conversion,(iii)suppresses the side proton reduction occurring on CF,and(iv)protects the CF from component *** expected,the redox reactions stoichiometrically proceed,and significantly enhanced photocatalytic activity,selectivity,and stability in CO generation are achieved by the stacked Cu_(2)O/Fe_(2)O_(3)@Ni(OH)_(2)in contrast to *** study demonstrates the significance of the synergy between bifunctional cocatalysts and Z-scheme heterojunctions for improving the efficacy of overall redox reactions,opening a fresh avenue for the rational design of artificial photosynthetic systems.

关键词： Z-scheme heterojunction bifunctional cocatalyst CO_(2)reduction H_(2)O oxidation stoichiometric redox reaction

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Plant-derived nanovesicles as an emerging platform for cancer therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 133-154页

作者： Hanzhe Liu Guo-Feng Luo Zhengjun Shang The State key laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&key laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhan 430079China

Plant-derived nanovesicles(PDNVs)derived from natural green products have emerged as an attractive nanoplatform in biomedical *** are usually characterized by unique structural and biological functions,such as the bioactive lipids/proteins/nucleic acids as therapeutics and targeting groups,immune-modulation,and long-term *** the rapid development of nanotechnology,materials,and synthetic chemistry,PDNVs can be engineered with multiple functions for efficient drug delivery and specific killing of diseased cells,which represent an innovative biomaterial with high biocompatibility for fighting against *** this review,we provide an overview of the state-of-theart studies concerning the development of PDNVs for cancer *** original sources,methods for obtaining PDNVs,composition and structure are introduced *** an emphasis on the featured application,the inherent anticancer properties of PDNVs as well as the strategies in constructing multifunctional PDNVs-based nanomaterials will be discussed in ***,some scientific issues and technical challenges of PDNVs as promising options in improving anticancer therapy will be discussed,which are expected to promote the further development of PDNVs in clinical translation.

关键词： Naturally occurring nanovesicles Plant nanotechnology Drug delivery Cancer therapy

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A novel cartridge for nucleic acid extraction,amplification and detection of infectious disease pathogens with the help of magnetic nanoparticles

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中国化学快报:英文版 2023年第8期34卷 236-240页

作者： Yile Fang Yue Wang Liangxi Zhu Haoran Liu Xiangyi Su Yuan Liu Zhu Chen Hui Chen Nongyue He State key laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in hunan Province Hunan Key Laboratory of Green Chemistry and Application of Biological NanotechnologyHunan University of TechnologyZhuzhou 412007China

Nucleic acid detection(NAD)based on real-time polymerase chain reaction(real-time PCR)is gold standard for infectious disease *** nanoparticles(MNPs)are widely used for nucleic acid extraction(NAE)because of their excellent *** technology makes automated NAD ***,most of the NAD microfluidic chips are too complex to be applied to point-of-care(POC)*** this paper,a simple-structure cartridge was developed for POC detection of infectious *** self-contained cartridge can be divided into a magnetic-controlled NAE part,a valve-piston combined fluidic control part and a PCR chip,which is able to extract nucleic acid from up to 500μL of liquid samples by MNPs and finish the detection process from“sample in”to“answer out”*** tests of the cartridges show that it met the demands of automated *** of on-cartridge detection of hepatitis B virus(HBV)demonstrated that this system has good uniformity and no cross-contamination between different cartridges,and the limit of detection(LOD)of this system for HBV in serum is 50 IU/*** detections of severe acute respiratory syndrome coronaviruses 2(SARS-CoV-2)with a concentration of 500 copies/mL were carried out on the system and 100%positive detection rate was achieved.

关键词： Nucleic acid detection Cartridge Magnetic nanoparticles Fluidic control Point-of-care testing

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Syntheses and cofluorescence of complexes of Eu(Ⅲ)/Y(Ⅲ) with terephthalic acid, 2-thenoyltrifluoroacetone and trioctylphosphine oxide

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中国有色金属学会会刊：英文版 2007年第3期17卷 638-643页

作者：赵学辉黄可龙刘素琴焦飞鹏刘志国胡舜钦李朝建 School of Chemistry and Chemical Engineering Central South University key laboratory of green packaging and application biological nanotechnology of hunan Province Hunan University of Technology

A series of Eu( Ⅲ )/Y( Ⅲ ) complexes of terephthalic acid(TPA) with 2-thenoyltrifluoroacetone(HTTA) and trioctylphosphine oxide(TPPO) were synthesized. Compositions of these complexes are revealed to be Eu2(1-x)Y2x(TPA)(TTA)4- (TPPO)4 or Eu1-xYx(TPA)(TTA)(TPPO)2. Their IR spectra, fluorescent spectra and the thermal and optical stability were studied. The fluorescent excitation spectra of these complexes show more broad excitation bands than those of Eu2(TPA)3(TPPO)4 and Eu(TTA)3(TPPO)2 corresponding to their formations. In addition, both the binuclear complex EuY(TPA)(TTA)4(TPPO)4 and the chain complex Eu0.4Y0.6(TPA)(TTA)(TPPO)2 present higher thermal stability and better optical stability than the mononuclear complex Eu(TTA)3(TPPO)2 does. And their thermal and optical stabilities are preferably interpreted from the binuclear structure together with the chain polynuclear structure of the complexes. The fluorescence enhancement of cofluorescence Y3+ ions to the Eu(Ⅲ) complexes is clear. The optimum content of Y3+ is 0.6 (molar fraction) for the chain complexes Eu1-xYx(TPA)(TTA)- (TPPO)2 and 0.5 for the binuclear complexes Eu2(1-x)Y2x(TPA)(TTA)4(TPPO)4. The formation of polynuclear structure of the complex Eu1-xYx(TPA)(TTA)(TPPO)2 appears to be responsible for the good cofluorescence effect of Y3+ ions.

关键词：铕元素对酞酸 2-噻吩甲酰基三氟丙酮合成方法

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Syntheses and applications of Eu(Ⅲ) complexes of 2-thienyltrifluoroacetonate, terephthalic acid and phenanthroline as light conversion agents

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Journal of Central South University of Technology 2007年第1期14卷 62-67页

作者：赵学辉黄可龙焦飞鹏杨幼平李朝建刘志国胡舜钦 School of Chemistry and Chemical Engineering Central South University key laboratory of green packaging and application biological nanotechnology of hunan Province Hunan University of Technology

A series of europium(Ⅲ) complexes of 2-thienyltrifluoroacetonate (HTTA), terephthalic acid (TPA) and phenanthroline (Phen) were synthesized. The new complexes Eu(TPA)(TTA)Phen and Eu2(TPA)(TTA)4Phen2 were characterized by elemental analysis, IR spectrum, scanning electron microscope and thermal stability analysis. The results show that the thermal stability of the Eu( Ⅲ ) complexes increases in the following order: the mononuclear complex Eu(TTA)3Phen, the binuclear complex Eu2(TPA)(TTA)4Phen2, the chain polynuclear complex Eu(TPA)(TTA)Phen. And the formation of the binuclear/polynuclear structure of the new complexes appears to be responsible for the enhancement of their thermal and optical stability. In addition, The fluorescence excitation spectra of these new complexes show more broad excitation bands than that of the complex Eu(TTA)3Phen corresponding to their formation. The enhancement of Eu3+ fluorescence in the new complexes can be observed by the addition of Gd3+. The bright red luminescent plastics can be obtained when the complex EuGd(TPA)(TTA)4Phen2 is added above 0.5% (mass fraction).

关键词：铕荧光材料对苯二酸 2-噻吩基

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Size-tunable synthesis of gold nanorods using pyrogallol as a reducing agent

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Science China Chemistry 2015年第11期58卷 1759-1765页

作者： Yuanfu Huang Kai Xia Nongyue He Zhuoxuan Lu Liming Zhang Yan Deng Libo Nie Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in hunan Province hunan key laboratory of green packaging and application of biological nanotechnology hunan University of Technology State key laboratory of Bioelectronics School of biological Science and Medical Engineering Southeast University

A novel and facile seed-mediated method for the preparation of monodispersed gold nanorods(GNRs) is presented by introducing pyrogallol as a reductant. Fast Fourier transformation of high-resolution transmission electron microscopy reveals that the synthesized GNRs are single crystalline. The longitudinal surface plasmon resonance of GNRs can be finely tuned by varying silver ion concentrations or seed amounts. Also, both thick(diameter >30 nm) and thin(diameter <10 nm) GNRs with exceptional monodispersity can be well prepared by this method. These findings indicate that this method has a greater performance in controlling the morphology of GNRs than that of traditional approach with ascorbic acid as a reductant.

关键词：邻苯三酚还原剂纳米棒合成高分辨透射电子显微镜表面等离子体共振快速傅里叶变换金

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Isolation,characterization and extraction of mer gene of Hg^(2+) resisting strain D_2

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Transactions of Nonferrous Metals Society of China 2010年第3期20卷 507-512页

作者：曾晓希汤建新蒋佩刘宏伟戴志敏刘学端 School of Mineral Processing and Bioengineering Central South University hunan key laboratory of green packaging and biological nanotechnology Hunan University of Technology

Mercury-resistant strain D2 was isolated from mercury-contaminated soil and investigations on its 16S rDNA sequence,growth,minimal inhibitory concentrations(MICs) of metals,antibiotic susceptibility and mer gene were *** strain D2 can grow in the medium containing 60 mg/L mercury *** presents more than 99% identity of 16S rRNA gene with Pseudomonas aeruginosa,and exhibits high MIC values for heavy metals and a large spectrum antibiotics *** mer RT gene sequence was amplified from *** D2 is identified as Pseudomonas aeruginosa and the resistance to mercuric ion is related to chromosome.

关键词：基因分离汞污染 Mer 基因提取鉴定 rDNA序列抗生素敏感性 rRNA基因

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In situ synthesis of DNA micro-arrays using typography technique

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Science China Chemistry 2007年第1期50卷 75-83页

作者： TANG JianXin 1,2 ,HE NongYue 1,2,3 &LI Song 1 1State key laboratory of Bioelectronics,Southeast University,Nanjing 210096,China 2key laboratory of green packaging and application of biological nanotechnology of hunan Province,hunan University of Tech- nology,Zhuzhou 412008,China 3Zhongshan Huoju Polytechnic,Zhongshan 528436,China State key laboratory of Bioelectronics Southeast University Nanjing China key laboratory of green packaging and application of biological nanotechnology of hunan Province Hunan University of Technology Zhuzhou China Zhongshan Huoju Polytechnic Zhongshan China

A novel typography technique was developed to in situ synthesize oligonucleotide arrays on glass slide,which has the celerity,high spatial resolution,lower cost,reliable operation,and high synthetic *** principle and process of the typography technique for fabricating gene-chips have been described in detail.A suit of poly(terafluoroethylene)devices for synthesizing oligonucleotide arrays were designed and prepared,and the fiber tubes with a number of nano-or micron-channels were em- *** oligonucleotide arrays of 16 and 160 features with four different probes were synthesized using the typography *** four specific oligonucleotide probes including the matched and the mismatched by the fluorescent target sequence gave obviously different hybridization fluorescent *** was indicated that the gene-chip fabricated by the typography method could be used to rapidly screen single-nucleotide polymorphisms(SNP)and to detect mutations.

关键词： typography oligonucleotide in situ synthesis DNA microarrays

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Isolation of Mucor circinelloides Z4 and Mucor racemosus Z8 from heavy metal-contaminated soil and their potential in promoting phytoextraction with Guizhou oilseed rap

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Journal of Central South University 2015年第1期22卷 88-94页

作者：朱生翠汤建新曾晓希魏本杰杨少迪黄斌 hunan key laboratory of green packaging and biological nanotechnology Hunan University of Technology Meteorological Institute of Qinghai Province School of Metallurgy and Environment Central South University

Fungi Z4 and Z8, isolated from the heavy metal polluted soil, have strong resistance to Cd and Pb. The strains were identified on the base of their morphology and internal transcribed spacers(ITS) region. Pot experiments were conducted to study the effect of two strains(Z4 and Z8) on the growth and accumulation of Cd and Pb of Guizhou oilseed rape. The results show that strains Z4 and Z8 belong to Mucor circinelloides and Mucor racemosus, respectively. The heights of Guizhou oilseed rape inoculated with strain Z8 increase by 47.90% than the control. The highest fresh mass is found in the plant with Z4/Z8, which is enhanced by160.81%. Pot experiments show that Z4/Z8 inoculums can accelerate accumulation of heavy metals in the plant. The contents of Cd and Pb are increased by 117.60% and 63.48%, respectively. Meanwhile, the heavy metal concentrations in potting soil with the two strains are found to be lower than those of the control, and the concentrations of Cd and Pb are decreased by 60.57% and 27.12%,respectively.

关键词：重金属污染土壤总状毛霉植物提取卷枝毛霉贵州重金属积累油籽盆栽试验

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