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Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission

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CCS Chemistry 2022年第6期4卷 1961-1976页

作者： Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang Key Laboratory of Pesticide and Chemical Biology(Ministry of Education) Hubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079 Fluorescence research Group Singapore University of Technology and DesignSingapore 487372 Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 120-750

Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic *** efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic *** this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene *** dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 *** long wavelength emission prompted a superior bioimaging resolution in *** particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of *** significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence *** work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission.

关键词： fluorescent probe heptamethine cyanine second near-infrared emission molecular design biological application

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CNTNAP2 intracellular domain(CICD)generated byγ-secretase cleavage improves autism-related behaviors

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3415-3426页

作者： Jing Zhang Fang Cai Renbin Lu Xiaoliang Xing Lu Xu Kunyang Wu Zishan Gong Qing Zhang Yun Zhang Mengen Xing Weihong Song Jia-Da Li Furong Laboratory Center for Medical GeneticsHunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and Kangning HospitalThe Second Affiliated Hospital and Yuying Children’s HospitalWenzhou Medical UniversityWenzhouZhejiang 325035China Advanced Innovation Center for Human brain Protection The National Clinical Research Center for Geriatric DiseaseXuanwu HospitalCapital Medical UniversityBeijing 100053China

As the most prevalent neurodevelopmental disorders in children,autism spectrum disorders(ASD)are characterized by deficits in language development,social interaction,and repetitive behaviors or inflexible *** associated protein like 2(CNTNAP2),encoding a single transmembrane protein(CNTNAP2)with 1331 amino acid residues,is a widely validated ASD-susceptible gene.

关键词： behaviors cleavage residues

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Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing Zhang Mengen Xing Zhengkai Bao Lu Xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing Zhang Zhe Wang Yili Wu Yun Zhang Jia-Da Li Weihong Song Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational Medical research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

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Association of variants in the KIF1A gene with amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 235-247页

作者： Panlin Liao Yanchun Yuan Zhen Liu Xiaorong Hou Wanzhen Li Jin Wen Kexuan Zhang Bin Jiao Lu Shen Hong Jiang Jifeng Guo Beisha Tang Zhuohua Zhang Zhonghua Hu Junling Wang hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Engineering research Center of hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha 410008China hunan international scientific and technological cooperation base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China hunan Provincial Clinical research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangsha 410008China hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangsha 410008China.

Background:Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal *** in many other neurodegenerative disorders,the genetic risk factors and pathogenesis of ALS involve dysregulation of cytoskeleton and neuronal ***,sen-sory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2(HSAN2)and spastic paraplegia 30(SPG30)share several causative genes with ALS,as well as having common clinical ***1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors(SVPs)and dense core vesicles and has been reported as a causative gene for HSAN2 and ***:Here,we analyzed whole-exome sequencing data from 941 patients with ALS to investigate the genetic association of KIF1A with ***:We identified rare damage variants(RDVs)in the KIF1A gene associated with ALS and delineated the clini-cal characteristics of ALS patients with KIF1A ***,these patients tended to exhibit sensory ***,the majority of these variants are located at the C-terminal cargo-binding region of the KIF1A *** examination revealed that the ALS-associated KIF1A variants located in the C-terminal region preferentially enhanced the binding of SVPs containing RAB3A,VAMP2,and *** of several disease-related KIF1A mutants in cultured mouse cortical neurons led to enhanced colocalization of RAB3A or VAMP2 with the KIF1A ***:Our study highlighted the importance of KIF1A motor-mediated transport in the pathogenesis of ALS,indicating KIF1A as an important player in the oligogenic scenario of ALS.

关键词： Amyotrophic lateral sclerosis KIF1A Axonal transport Presynaptic vesicle precursors

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Controllable synthesis of layered black bismuth oxidechloride nanosheets and their applications in internal tumor ablation

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Regenerative Biomaterials 2022年第1期9卷 501-510页

作者： Qianlan Fang Yu Xu Lijia Luo Chuang Liu Zihou Li Jie Lin Tianxiang Chen Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000P.R.China

The recently emerging bismuth oxyhalide(BiOX)nanomaterials are promising indirect band gap photosensitizer for ultraviolet(UV)light-triggered phototherapy due to their unique layered nanosheet ***,the low absorption and poor photothermal conversion efficiency have always impeded their further applications in cancer clinical ***,BiOCl rich in oxygen vacancies has been reported to have fullspectrum absorption properties,making it possible to achieve photothermal property under near-infrared *** 808nm irradiation,the photothermal conversion efficiency of black BiOCl nanosheets(BBNs)is up to 40%.BBNs@PEG can effectively clear primary subcutaneous tumors and prevent recurrence,achieving good synergistic treatment *** results not only broke the limitation of UV on the BiOCl material and provided a good template for other semiconductor materials,but also represent a promising approach to fabricate BBN@PEG a novel,potent and multifunctional theranostic platform for precise photothermal therapy and prognostic evaluation.

关键词： black bismuth oxidechloride nanosheet photothemal therapy tumor photothermal conversion efficiency

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Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment

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Chinese Chemical Letters 2024年第10期35卷 63-72页

作者： Hajing Cui Weihao Zhu Chuning Yue Ming Yang Wenzhi Ren Aiguo Wu Cixi Biomedical research Institute Wenzhou Medical UniversityNingbo 315300China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Ningbo315201China C Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue *** dioxide(TiO_(2))nanomaterials,recognized as excellent sonosensitizers,have been extensively studied in cancer *** review first outlines the mechanism of TiO_(2)-based SDT,then systematically discusses the regulation of TiO_(2) sonosensitivity,covering aspects such as morphology,particle size,element doping,defect engineering,heterojunction structure,and interactions with the tumor ***-more,the review generalizes ultrasound-responsive TiO_(2)-based therapeutic modalities for tumor treat-ment,including SDT,SDT combined with chemotherapy,chemodynamic therapy,photothermal therapy,immunotherapy,and treatment ***,the review navigates the ongoing challenges and prospects in TiO_(2)-based cancer SDT.

关键词： Titanium dioxide Sonodynamic therapy Reactive oxygen species Cavitation effects Combined therapy

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miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第2期14卷 635-652页

作者： Man Luo Yayan Pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong Pediatric research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Anatomy Basic Medical CollegeChongqing Medical UniversityChongqing 400016China Townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouver BC V6T 1Z3Canada Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceZhejiang Clinical Research Center for Mental DisordersSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhou 325000China Institute for brain Science and Disease of Chongqing Medical University Chongqing 400016China

Alzheimer ’s disease(AD) is a leading cause of dementia in the ***-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in ***,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively ***(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA ***,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model *** further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ *** importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment.

关键词： Alzheimer's disease MKP-1 miR-429-3p AMPAreceptor Learning and memory Long-term potentiation

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Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer

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Bioactive Materials 2023年第9期27卷 72-81页

作者： Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640GuangdongPR China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCAS1219 ZhongGuan West RoadNingbo315201PR China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000PR China Department of Radiology Ningbo No.2 HospitalNingbo315010PR China

Currently,precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver ***,we synthesized Mn-doped Ti MOFs(Mn-Ti MOFs)nanosheets by in-situ doping method and applied them for microwave *** thermal imaging results indicate Mn-Ti MOFs can rapidly increase the temperature of normal saline,attributing to the porous structure improving microwave-induced ion collision ***,Mn-Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn *** the same time,Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging(r2/r1=2.315).Further,results on HepG2 tumor-bearing mice prove that microwave-triggered Mn-Ti MOFs nearly eradicate the tumors after 14 days of *** study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer.

关键词： Metal-organic framework Titanium-based nanomaterials Microwave dynamic therapy Microwave thermal therapy MR image

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Author Correction:GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3547-3548页

作者： Yao Long Jiaxing Guo Jielin Chen Jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao Xiangya Hospital Central South University Department of Pathology Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education) Changsha China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615) School of Basic Medicine Central South University NHC Key Laboratory of Carcinogenesis of Ministry of Health (Central South University) Cancer Research Institute Changsha China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164) Xiangya Hospital Central South University Department of Pathology Changsha China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615) Second Xiangya Hospital Central South University Hunan Key Laboratory of Tumor Models and Individualized Medicine Department of Thoracic Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Xiangya Hospital Central South University Department of Pathology Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education) Changsha China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615) School of Basic Medicine Central South University NHC Key Laboratory of Carcinogenesis of Ministry of Health (Central South University) Cancer Research Institute Changsha China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164) Xiangya Hospital Central South University Department of Pathology Changsha China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615) Second Xiangya Hospital Central South University Hunan Key Laboratory of Tumor Models and Individualized Medicine Department of Thoracic Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Xiangya Hospital Central South University Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research Changsha China (GRID:grid.452223.0) (ISNI:0000 0004 1757 7615)

Since the publication of this article,we noticed a minor mistake in the article that needs to be *** have checked the original data;the correct data are provided in this Corrigendum as *** key findings of the article ... 详细信息

关键词： damage suppressor checked

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Serum Concentrations of Angiotensin, C-Reactive Protein, Interleukin-8, and tumor Necrosis Factor-α in Train Driver Population

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Open Journal of Immunology 2016年第1期6卷 7-13页

作者： Ziwei Zhu Linxiong Wu Aihua Liu Mei Zhou Fukai Bao Cuiping Xu Jiaru Yang Hua Zhao Yunnan Key Laboratory for Tropical Infectious Diseases Kunming China Department of Microbiology and Immunology School of Basic Medical Science Kunming Medical University Kunming China Yunnan Collaborative Innovation Center for Public Health and Disease Control Kunming China The Institute for Tropical Medicine Kunming Medical University Kunming China Department of Biochemistry and Molecular Biology School of Basic Medical Science Kunming Medical University Kunming China Yunnan Province base for international scientific and technological cooperation in Tropical Diseases Kunming China

Train drivers are engaged in high-stress job. It may induce sleep, fatigue, and alertness loss at work, and endanger public safety. It’s unclear that cytokines of train driver would be influenced by their job. The research considers the hypothesis that stressful professions, such as train driver, influence the body’s immune system through the long-time and high-pressure working, and change production of neuro-immune factors. Using enzyme linked immunosorbent assay (ELISA), several neuro-immune factors were assayed among train drivers (N = 82) and health blood donors (N = 80) enrolled in the Yunnan Collaborative Innovation Center for Public Health and Disease Control. The concentrations of angiotensin, C-reactive protein (CRP), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) were determined. Kruskal-Wallis test and Dunn’s multiple comparisons test were performed for overall comparison between groups and for pairwise comparison, respectively. Statistical significance level was set at P < 0.05. The profession of train driving was not associated with significant increases or decreases in the systemic levels of inflammatory (CRP, IL-8, and TNF-α), but it was associated with the high expression of angiotensin in vivo. These findings suggest that the job of train driving may not be associated with significant alterations in systemic immune condition, but arouse the level of angiotensin.

关键词： Train Driver Occupational Stress Angiotensin C-Reactive Protein Interleukin-8 tumor Necrosis Factor-Alpha

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