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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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chinese Journal of Integrative medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-rong LI Shuo-fu MEI Wen-ya LIU Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Relative exchangeable copper, a high-quality biomarker for differentiation of traditional chinese medicine syndrome in Wilson's disease

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Journal of traditional chinese medicine 2024年第05期44卷 1017-1023页

作者： DING Yufeng YANG Wenming CHENG Yuan YANG Yulong ZHU Jun LU Yachun FANG Xiang ZHANG Jing Department of Neurology the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Department of clinical laboratory the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

OBJECTIVE: To investigate the value of relative exchangeable copper(REC) in diagnosing Wilson's disease(WD) and to determine its significance in the differentiation of traditional chinese medicine(TCM) ***: A total of 78 patients with WD were recruited on the same day of the medical visit, and among them,32 were suffering from non-WD(N-WD) and 37 were heterozygous ATP7B carriers(HC) enrolled as *** genetic testing was performed for diagnosing WD and HC. Additionally, REC levels in different TCM syndromes were investigated. The correlation between REC and serum ceruloplasmin(Cp), serum copper oxidase(CO), and 24-h urinary copper was analyzed using the Global Assessment Scale and Unified Wilson's Disease Rating Scale and the significance of REC in WD diagnosis was investigated. Resting-state functional magnetic resonance imaging was used to assess the clinical symptoms of WD and analyze its severity in different TCM ***: REC determination helped in significantly distinguishing patients with N-WD or HC from those with WD with a cut-off of 21.15%. Furthermore, the comparative analysis of REC ratios among different TCM syndromes showed markedly high REC levels in the dampness-heat internal accumulation syndrome ***, the seed-based functional connectivity value from the putamen to the cerebellum was significantly correlated with TCM ***: REC level is a high-quality biomarker for diagnosing WD that effectively reflects disease severity and plays an essential role in deciding on treatment strategies and prognosis. Furthermore, REC levels are closely related to TCM syndromes in WD; thus, it is a potential objective quantitative indicator for distinguishing TCM syndromes in WD.

关键词： Global Assessment Scale traditional chinese medicine syndrome Wilson’s disease relative exchangeable copper the Unified Wilson’s Disease Rating Scale

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Efficacy and safety of Tianqi Pingchan Granule, a compound chinese herbal medicine, for levodopa-induced dyskinesia in Parkinson's disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative medicine 2024年第5期22卷 545-551页

作者： Yu Zhang Xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao Li Can-xing Yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao Yan Liang Chuan-ying Xu Mei-juan Liu Chen Gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Parkinson's Disease Center the Affiliated Hospital of Xuzhou Medical University Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Department of Neurology Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Neurology Wenzhou Central Hospital

Background: Patients with Parkinson's disease(PD) undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID). Amantadine is the main drug recommended for the treatment of LID by current guidelines, but it is far from meeting clinical needs. Tianqi Pingchan Granule(TPG), a compound chinese herbal medicine, has been developed to relieve symptom of ***: This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***, setting, participants and interventions: This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu, Zhejiang and Shanghai, China. One hundred PD patients with ≥ 0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group) or the placebo plus amantadine group(placebo group), and treated for a period of12 weeks. To ensure unbiased results, all study participants, investigators and sponsors were unaware of group allocations. Additionally, the data analysts remained blinded until the analysis was *** outcome measures: The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104). The key secondary end point was improvement of motor and non-motor symptoms. Safety analyses included all enrolled ***: One hundred patients were enrolled and randomized into the two treatment groups. The changes in UDysRS at week 12 were –11.02 for the TPG group and –4.19 for the placebo group(treatment difference –6.83 [–10.53 to –3.12]; P = 0.0004). Adverse events were reported for 2 of 50 patients(4.0%) in each of the ***: This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated, demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Levodopa-induced dyskinesia Parkinson’s disease Tianqi Pingchan Granule

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Antibacterial Activity of Plants in Cirsium:A Comprehensive Review

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chinese Journal of Integrative medicine 2024年第9期30卷 835-841页

作者： TANG Xiao-meng XIE Ming-xia GOU Jun-li CHEN Liang TIAN Jin-long ZHANG Xia LU You-yuan WANG Han-qing College of Pharmacy Ningxia Medical UniversityYinchuanNingxia750004China College of traditional chinese medicine Hunan University of Chinese MedicineChangsha410007China General Hospital of Ningxia Medical University YinchuanNingxia750004China Ningxia Regional Characteristic traditional chinese medicine Collaborative Innovation Center Co-constructed by the Province and Ministry Ningxia Engineering and Technology Research Center for Modernization of Regional Characteristic Traditional Chinese MedicineNingxia Medical UniversityYinchuan750004China Key Laboratory of Ningxia Minority medicine Modernization Ministry of EducationYinchuan750004China

As ethnic medicine,the whole grass of plants in Cirsium was used as *** review focuses on the antimicrobial activity of plants in Cirsium,including antimicrobial components,against different types of microbes and bacteriostatic *** results showed that the main antimicrobial activity components in Cirsium plants were flavonoids,triterpenoids and phenolic acids,and the antimicrobial ability varied according to the species and the content of *** them,phenolic acids showed a strong antibacterial ability against Acinetobacter baumannii,Pseudomonas aeruginosa,and Enterococcus *** antibacterial mechanisms include:(1)damaging the cell membrane,cell walls,mitochondria and nucleus of bacteria;(2)inhibiting the synthesis of proteins and nucleic acids;(3)suppressing the synthesis of enzymes for tricarboxylic acid cycle pathways and glycolysis,and then killing the bacteria via inhibition of energy ***,most research results on antimicrobial activity of Cirsium plants are reported based on in vitro *** evidence from clinical data and comprehensive evaluation are needed.

关键词： Cirsium traditional use antibacterial active components bacteriostatic activity bacteriostatic mechanism chinese medicine

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Treatment of bilateral developmental dysplasia of the hip joint with an improved technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1320-1325页

作者： Xing-Xing Yu Jian-Ye Chen Hong-Sheng Zhan Ming-Da Liu Yun-Fei Li Yu-Yan Jia College of traditional chinese medicine Changchun University of Traditional Chinese MedicineChangchun 130117Jilin ProvinceChina Shi's Traumatology Medical Center Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China College of traditional chinese medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina

BACKGROUND Developmental dysplasia of the hip(DDH)is a common osteoarticular deformity in pediatric orthopedics.A patient with bilateral DDH was diagnosed and treated using our improved technique"(powerful overturning acetabuloplasty)"combined with femoral rotational shortening *** SUMMARY A 4-year-old girl who was diagnosed with bilateral DDH could not stand normally,and sought surgical treatment to solve the problem of double hip extension and *** this child had high dislocation of the hip joint and the acetabular index was high,we changed the traditional acetabuloplasty to"powerful turnover acetabuloplasty"combined with femoral rotation shortening *** the short-term postoperative follow-up(1,3,6,9,12,and 15 months),the child had no discomfort in her lower *** the braces and internal fixation plates were removed,formal rehabilitation training was actively carried *** Our"powerful overturning acetabuloplasty"combined with femoral rotational shortening osteotomy is feasible in the treatment of DDH in *** technology may be widely used in the clinic.

关键词： Developmental dysplasia of the hip Improved technique Case report

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Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-Jun Yu Jun-Jun Li Yao Xiao Guang-Sen Li Fang Yang Liang Dong Chengdu University of traditional chinese medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Vesicular drug delivery systems for oral absorption enhancement

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chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui Zou Meng Cheng Kaili Hu Jianfang Feng Liangxing Tu Jiangxi University of chinese medicine Nanchang 330006China Guangxi University of chinese medicine Nanning 530200China Shanghai University of traditional chinese medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

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Effects of anterior sciatic nerve acupuncture on lower limb paralysis after cerebral infarction:study protocol for a randomized controlled trial

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Journal of traditional chinese medicine 2024年第1期44卷 205-211页

作者： LI Menghan WANG Yu RAN Dawei YANG Xinming DENG Shizhe SHI Lei MENG Zhihong Department of Acupuncture First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for chinese medicine Acupuncture and Moxibustion Tianjin 300193China Graduate department Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Massage and Rehabilitation Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Stroke is the main cause of disability in the middle and old ***,especially lower limb paralysis,often leads to the loss of self-care ability and a series of secondary *** main method to improve hemiplegic limb movement is exercise therapy,but there are still many patients with disabilities after rehabilitation *** one of the non-pharmacological therapies for stroke,acupuncture has been recognized to improve motor function in ***,we propose a new method,anterior sciatic nerve acupuncture,which can stimulate both the femoral nerve and the sciatic *** designed this study to determine the effect of this method on lower limb motor *** participants recruited with hemiplegia after cerebral infarction will be randomly assigned to the test group or control group in a 1:1 *** control group will receive Xingnao Kaiqiao acupuncture,and the test group will receive anterior sciatic nerve acupuncture on this *** participants will get acupuncture treatment once a day,6 times a week for 2 *** primary outcome is Fugl-Meyer Assessment of Lower Extremity and the secondary outcomes are Modified Ashworth Scale and Modified Barthel *** will be collected before treatment,1week after treatment,and 2 weeks after treatment,and then statistical analysis will be *** study can preliminarily verify the effect of anterior sciatic nerve acupuncture on improving lower limb motor function in patients with cerebral infarction,which may provide an alternative approach for clinical treatment of hemiplegia.

关键词： anterior sciatic nerve acupuncture paralysis cerebral infarction Xingnao Kaiqiao clinical protocols

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Bazi Bushen alleviates reproductive aging in aged male mice

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chinese Journal of Natural medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG Yaping JIANG Yuning JI Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WEI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of traditional chinese medicine·College of Integrated traditional chinese and Western medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： traditional chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

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Yemazhui(Herba Eupatorii Lindleyani)ameliorates lipopolysaccharide-induced acute lung injury via modulation of the toll-like receptor 4/nuclear factor kappa-B/nod-like receptor family pyrin domain-containing 3 protein signaling pathway and intestinal flor

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Journal of traditional chinese medicine 2024年第2期44卷 303-314页

作者： REN Li HAI Yang YANG Xue LUO Xianqin Chongqing Key Laboratory of traditional chinese medicine for Prevention and Cure of Metabolic Diseases College of Traditional Chinese MedicineChongqing Medical UniversityChongqing 400016China College of Basic medicine Chongqing Medical UniversityChongqing 400016China

OBJECTIVE:To investigate the impact of Yemazhui(Herba Eupatorii Lindleyani,HEL)against lipopolysaccharide(LPS)-induced acute lung injury(ALI)and explore its underlying mechanism in ***:The chemical constituents of HEL were analyzed by ultra-high performance liquid chromatographyquadrupole time-of-flight mass spectrometry ***,HEL was found to suppress LPS-induced ALI in ***-week-old male Sprague-Dawley rats were randomly divided into 6 groups:control,LPS,Dexamethasone(Dex),HEL low dose 6 g/kg(HEL-L),HEL medium dose 18 g/kg(HEL-M)and HEL high dose 54 g/kg(HEL-H)*** model rats were intratracheally injected with 3 mg/kg LPS to establish an ALI *** counts,lung wet/dry weight ratio,as well as myeloperoxidase(MPO)activity were determined followed by the detection with hematoxylin and eosin staining,enzyme linked immunosorbent assay,quantitative real time polymerase chain reaction,western blotting,immunohistochemistry,and ***,to explore the effect of HEL on ALI-mediated intestinal flora,we performed 16s rRNA sequencing analysis of intestinal ***:HEL attenuated LPS-induced inflammation in lung tissue and intestinal flora *** study indicated that HEL suppressed the lung coefficient and wet/dry weight ratio of LPS-induced ALI in rats,inhibited leukocytes exudation and MPO activity,and improved the pathological injury of lung *** addition,HEL reduced the expression of tumor necrosis factoralpha,interleukin-1beta(IL-1β)and interleukin-6(IL-6)in bronchoalveolar lavage fluid and serum,and inhibited nuclear displacement of nuclear factor kappa-B p65(NF-κBp65).And 18 g/kg HEL also reduced the expression levels of toll-like receptor 4(TLR4),myeloid differentiation factor 88,NF-κBp65,phosphorylated inhibitor kappa B alpha(phospho-IκBα),nod-like receptor family pyrin domain-containing 3 protein(NLRP3),IL-1β,and interleukin-18(IL-18)in lung tissue,and regulated intestinal flora disturban

关键词： Yemazhui(Herba Eupatorii Lindleyani) acute lung injury anti-inflammation toll-like receptor 4 nuclear factor kappa-B nod-like receptor family pyrin domain-containing 3 protein signal transduction gastrointestinal microbiome

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