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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische universität berlin and Charité-universitätsmedizin berlin Berlin 10115Germany Charité-universitätsmedizin berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Insights into the kinetics–morphology relationship of 1-, 2-, and 3D TiNb_(2)O_(7) anodes for Li-ion storage

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Nano Research 2024年第4期17卷 2770-2780页

作者： Wenlei Xu Yaolin Xu Veronika Grzimek Andrea Martin Thorsten Schultz Patrícia ARusso Yan Lu Norbert Koch Nicola Pinna Department of Chemistry IRIS Adlershof and the Center for the Science of Materials BerlinHumboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Department of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner-Platz 114109 BerlinGermany Institut für Physik and IRIS Adlershof Humboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Joint Research Group of Molecular Systems Helmholtz-Zentrum Berlin für Materialien und Energie12489 BerlinGermany

Understanding the influence of electrode material’s morphology on electrochemical behavior is of great significance for the development of rechargeable batteries,however,such studies are often limited by the inability to precisely control the morphology of electrode ***,nanostructured titanium niobium oxides(TiNb_(2)O_(7))with three different morphologies(one-dimensional(1D),two-dimensional(2D),and three-dimensional(3D))were synthesized via a facile microwave-assisted solvothermal *** influence of the morphological dimension of TiNb_(2)O_(7) as electrode material on the electrochemical performance in Li-ion batteries(LIBs)and the underlying correlation with the electrochemical kinetics were studied in detail.2D TiNb_(2)O_(7)(TNO-2D)shows a superior rate capability and cycling stability,associated with improved kinetics for charge transfer and Li-ion diffusion,compared to the 1D and 3D *** X-ray diffraction measurements reveal the structural stability and crystallographic evolution of TNO-2D upon lithiation and delithiation and correlate the Li-ion diffusion kinetics with the lattice evolution during battery charge and ***,carbon-coated TNO-2D achieves enhanced rate capability(205 mAh·g^(-1) at 50 C)and long-term cycling stability(87%after 1000 cycles at 5 C).This work provides insights into the rational morphology design of electrode materials for accelerated charge transfer and enhanced fast-charging capability,pushing forward the development of electrode materials for high-power rechargeable batteries in future energy storage.

关键词： morphological dimension electrochemical kinetics lithium-ion batteries TiNb_(2)O_(7) structural evolution

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Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss

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Signal Transduction and Targeted Therapy 2024年第2期9卷 751-765页

作者： Xudong Xie Peng Cheng Liangcong Hu Wu Zhou Detai Zhang Samuel Knoedler Guodong Liu Yuan Xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana CPanayi Lang Chen Chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Plastic Surgery and Hand Surgery Klinikum Rechts der IsarTechnical University of MunichMunichGermany Medical Center of Trauma and War Injuries Daping HospitalArmy Medical UniversityChonqing 400042China Department of Plastic Surgery Campus CharitéMitte|Campus Virchow-KlinikumCharité-Universitätsmedizin Berlincorporate member of Freie Universität BerlinHumboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany berlin Institute of Health Charité-Universitätsmedizin BerlinBerlinGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/RhineGermany Pingshan District People’s Hospital of Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityNO.139 Ziqiang RoadShijiazhuang 050051China

The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain ***,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in both patients and *** effect was attributed to VPA-induced elevation in osteoclast formation and *** RNA-sequencing,we observed a significant rise in precursor miR-6359 expression in VPA-treated osteoclast precursors in vitro,and further,a marked upregulation of mature miR-6359(miR-6359)in vivo was demonstrated using quantitative real-time PCR(qRT-PCR)and miR-6359 fluorescent in situ hybridization(miR-6359-FISH).Specifically,the miR-6359 was predominantly increased in osteoclast precursors and macrophages but not in neutrophils,T lymphocytes,monocytes and bone marrow-derived mesenchymal stem cells(BMSCs)following VPA stimulation,which influenced osteoclast differentiation and bone-resorptive ***,VPA-induced miR-6359 enrichment in osteoclast precursors enhanced reactive oxygen species(ROS)production by silencing the SIRT3 protein expression,followed by activation of the MAPK signaling pathway,which enhanced osteoclast formation and activity,thereby accelerating bone ***,there are no medications that can effectively treat VPA-induced bone ***,we constructed engineered small extracellular vesicles(E-sEVs)targeting osteoclast precursors in bone and naturally carrying anti-miR-6359 by introducing of EXOmotif(CGGGAGC)in the 3’-end of the anti-miR-6359 *** confirmed that the E-sEVs exhibited decent bone/osteoclast precursor targeting and exerted protective therapeutic effects on VPA-induced bone loss,but not on ovariectomy(OVX)and glucocorticoid-induced osteoporotic models,deepening our understanding of the underlying mechanism and treatment strategies for VPA-induced bone loss.

关键词： miR protective stimulation

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Linkage Between European and East Asian Heatwaves on Synoptic Scales

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Journal of Tropical Meteorology 2024年第2期30卷 97-105页

作者：蔡奋颖刘彩红杨崧邓开强 KURTHS Jürgen School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519082 China Department of Complexity Science Potsdam Institute for Climate Impact Research(PIK)Member of the Leibniz AssociationPotsdam 14473 Germany Department of Water and Climate Risk Institute for Environmental StudiesVrije Universiteit AmsterdamAmsterdam 1087HV Netherlands Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen UniversityZhuhaiGuangdong 519082 China Department of Physics Humboldt-Universität zu BerlinBerlin 12489 Germany

Concurrent extreme weather events in geographically distant areas potentially cause high-end risks for *** using network analysis,the present study managed to identify significant nearly-simultaneous occurrences of heatwaves between the grid cells in East Asia and Eastern Europe,even though they are geographically far away from each *** further composite analysis,this study revealed that hot events first occurred in Eastern Europe,typically with a time lag of3-4 days before the East Asian heatwave *** eastward propagating atmospheric wave train,known as the circumglobal teleconnection(CGT)pattern,bridged the sequent occurrences of extreme events in these two remote *** blockings,amplified by surface warming over Eastern Europe,not only enhanced local heat extremes but also excited a CGT-like pattern characterized by alternative anomalies of high and low *** downstream anticyclones in the middle and upper troposphere reduced local cloud cover and increased downward solar radiation,thereby facilitating the formation of heatwaves over East *** half of East Asian heatwave events were preceded by Eastern European heatwave events in the 10-day time range before East Asian heatwave *** investigation of heatwave teleconnection in the two distant regions exhibits strong potential to improve the prediction accuracy of East Asian heatwaves.

关键词： concurrent heatwaves Eastern Europe East Asia circum-global teleconnection pattern

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农地禀赋对农户土地流转福利的影响路径研究

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中国农业资源与区划 2024年

作者：柳建玲彭开丽李胜鹏刘楠楠华中农业大学公共管理学院 Department of Agricultural Economics humboldt-universit?t zu berlin 中国地质大学(北京)土地科学技术学院

[目的]农地禀赋差异是影响区域农地流转的农户福利效应不平衡的关键因素，与流转价格和政府参与行为共同影响农户福利，本研究揭示农地禀赋对农户土地流转福利的影响路径，以期为乡村振兴与共同富裕提供决策参考。[方法]研究构建有调节... 详细信息

[目的]农地禀赋差异是影响区域农地流转的农户福利效应不平衡的关键因素，与流转价格和政府参与行为共同影响农户福利，本研究揭示农地禀赋对农户土地流转福利的影响路径，以期为乡村振兴与共同富裕提供决策参考。[方法]研究构建有调节的中介模型，运用piecewiseSEM实证检验农地禀赋影响农户福利的路径。[结果]（1）农地禀赋越高，流转价格越高，且非自发流转模式下流转价格高于自发流转模式，但流转模式在农地禀赋与流转价格间的调节效应不显著。（2）农地禀赋通过流转价格的中介作用间接影响农户福利，并通过流转模式的直接调节效应影响农户福利，非自发流转模式下农地禀赋越高、农户福利越高。[结论]研究认为不同农地禀赋条件下农地流转的农户福利效应差异明显，流转模式与流转价格在农地禀赋与农户福利间有调节的中介效应扩大了这一差距，建议适当调控流转价格，并制定差别化政策，激励禀赋较差地区的农地发生流转，同时关注禀赋较差区域农地流转后农户福利的保障与提升。

关键词：农地流转农地禀赋农户福利效应有调节的中介模型 piecewiseSEM

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Imposing temporal consistency on deep monocular body shape and pose estimation

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Computational Visual Media 2023年第1期9卷 123-139页

作者： Alexandra Zimmer Anna Hilsmann Wieland Morgenstern Peter Eisert Fraunhofer Heinrich-Hertz-Institut 10587 BerlinGermany Technische universit¨at berlin 10623 BerlinGermany humboldt universit¨at zu berlin 10117 BerlinGermany

Accurate and temporally consistent modeling of human bodies is essential for a wide range of applications,including character animation,understanding human social behavior,and AR/VR *** human motion accurately from a monocular image sequence remains challenging;modeling quality is strongly influenced by temporal consistency of the captured body *** work presents an elegant solution to integrating temporal constraints during *** increases both temporal consistency and robustness during *** detail,we derive parameters of a sequence of body models,representing shape and motion of a *** optimize these parameters over the complete image sequence,fitting a single consistent body shape while imposing temporal consistency on the body motion,assuming body joint trajectories to be linear over short *** approach enables the derivation of realistic 3D body models from image sequences,including jaw pose,facial expression,and articulated *** experiments show that our approach accurately estimates body shape and motion,even for challenging movements and ***,we apply it to the particular application of sign language analysis,where accurate and temporally consistent motion modelling is essential,and show that the approach is well-suited to this kind of application.

关键词： motion capture surface reconstruction face modeling body model estimation

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Accelerating materials-space exploration for thermal insulators by mapping materials properties via artificial intelligence

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npj Computational Materials 2023年第1期9卷 1204-1215页

作者： Thomas A.R.Purcel Matthias Scheffler Luca M.Ghiringhelli Christian Carbogno The NOMAD Laboratory at Fritz-Haber-Institut der Max-Planck-Gesellschaft and IRIS-Adlershof of the humboldt-universität zu berlin Faradayweg 4-6D-14195 BerlinGermany Physics Department and IRIS Adlershof humboldt universität zu berlin BerlinGermany

Reliable artificial-intelligence models have the potential to accelerate the discovery of materials with optimal properties for various applications,including superconductivity,catalysis,and *** in this field are often hindered by the scarcity and quality of available data and the significant effort required to acquire new *** such applications,reliable surrogate models that help guide materials space exploration using easily accessible materials properties are urgently ***,we present a general,data-driven framework that provides quantitative predictions as well as qualitative rules for steering data creation for all datasets via a combination of symbolic regression and sensitivity *** demonstrate the power of the framework by generating an accurate analytic model for the lattice thermal conductivity using only 75 experimentally measured *** extracting the most influential material properties from this model,we are then able to hierarchically screen 732 materials and find 80 ultra-insulating materials.

关键词： artificial thermal properties

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A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors

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Cellular & Molecular Immunology 2022年第2期19卷 145-146页

作者： Timo Gaber Frank Buttgereit Department of Rheumatology and Clinical Immunology Charité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt Universität zu BerlinBerlinGermany.

In a recent issue of Nature Immunology,Chen et *** differential expression signatures of metabolic programs within the germinal center(GC)compartment to distinguish GC B cells from different zones[1].Furthermore,they identified an important role of oxidative phosphorylation(OXPHOS)in the process of positive selection of B cells with higher-affinity B cell receptors(BCRs)in *** are inducible secondary lymphoid microanatomical structures that provide niches for B cells to capture and present antigens in the light zone(LZ)and to undergo clonal expansion and BCR somatic hypermutation(SHM)in the dark zone(DZ)*** migration of activated GC B cells between the LZ and DZ is assumed to result in positive selection of clones with higher-affinity B cell antigen *** clones are characterized by accelerated cell division,suggesting a genomic program activated by BCR and CD40 signaling[2].

关键词： center positive signature

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Estimating the Effects of the COVID-19 Outbreak on the Decreasing Number of Acquired Immune Deficiency Syndrome Cases and Epidemiological Trends in China

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Biomedical and Environmental Sciences 2022年第2期35卷 141-145页

作者： LI Yan Yan DING Wen Hao BAI Yi Chun WANG Lei WANG Yong Bin Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiangHenanChina Center for Musculoskeletal Surgery Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität Zu Berlin and Berlin Institute of HealthBerlinGermany

Since the first case of acquired immune deficiency syndrome(AIDS)was detected in the United States in 1981,this disease has spread to every corner of the *** the annual incidence of AIDS showing a slight decline since 1997,it remains a major cause of infectious disease-related death *** global epidemiological trends,the number of notified AIDS cases has increased in recent years in China[1].Moreover,among the class B notifiable infectious diseases,AIDS was responsible for the highest mortality rate from 2008 to 2019,still failing to be identified as a vaccine-preventable disease[1].Thus,to provide more unambiguous and quantitative direction for the effective formulation of preventive planning strategies and for the reasonable allocation of limited resources,a forecasting model with high precision and accuracy to understand the future epidemic behaviors of AIDS is *** the model-building process,accurate statistics are vital to ensure the forecasting accuracy of the model.

关键词： forecasting spite formulation

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Automatic identification of crystal structures and interfaces via artificial-intelligence-based electron microscopy

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npj Computational Materials 2023年第1期9卷 489-499页

作者： Andreas Leitherer Byung Chul Yeo Christian H.Liebscher Luca M.Ghiringhelli The NOMAD Laboratory at the Fritz-Haber-Institut of the Max-Planck-Gesellschaft and IRIS-Adlershof of the humboldt-universität zu berlin BerlinGermany Department of Energy Resources Engineering Pukyong National UniversityBusan 48513Republic of Korea Max-Planck-Institut für Eisenforschung 40237 DüsseldorfGermany Physics Department and IRIS Adlershof Humboldt-Universität zu BerlinBerlinGermany Present address:Department of Materials Science and Engineering Friedrich-Alexander Universität Erlangen-NürnbergErlangenGermany

Characterizing crystal structures and interfaces down to the atomic level is an important step for designing advanced *** electron microscopy routinely achieves atomic resolution and is capable to resolve complex arrangements of atoms with picometer ***,we present AI-STEM,an automatic,artificial-intelligence based method,for accurately identifying key characteristics from atomic-resolution scanning transmission electron microscopy(STEM)images of polycrystalline *** method is based on a Bayesian convolutional neural network(BNN)that is trained only on simulated ***-STEM automatically and accurately identifies crystal structure,lattice orientation,and location of interface regions in synthetic and experimental *** model is trained on cubic and hexagonal crystal structures,yielding classifications and uncertainty estimates,while no explicit information on structural patterns at the interfaces is included during *** work combines principles from probabilistic modeling,deep learning,and information theory,enabling automatic analysis of experimental,atomic-resolution images.

关键词： materials crystal estimates

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