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human factors for Clinical Engineering – The Realization of a Guidance Text

中国医疗设备 2016年第3期31卷 1-4页

作者： A.C.Easty A.L.Cassano-Piché M.Griffin Y-L.Lin P.Trbovich human Era University Health Network Institute of Biomaterials & Biomedical Engineering University of Toronto Institute for Health Policy Management and Evaluation University of Toronto

Industries such as aviation and nuclear power have greatly improved their safety performance through the application of human factors methods to the design, development, selection and deployment of a range of technologies and work processes. Health care safety performance generally lags behind these industries and would benefit from a similar application of human factors methods. Clinical engineers are in an ideal position to acquire and apply this human factors knowledge, and lead its adoption in health care. This paper describes a text that has been written specifically for clinical engineers and others who design, develop, select and support the use of health care technologies, to enable them to learn the key methods of human factors and adopt them as part of their ongoing work. Early indications are that these approaches help to ensure that health care technologies are used more safely and effectively, and it is hoped that large-scale adoption will result in a noticeable and worthwhile improvement in overall health care safety. The described text is now ready and has been published in English on the IFMBE website. It is available as a free download in PDF format. Clinical engineers and others working around the world in the area of health technology are encouraged to learn and adopt these methods, and use them as appropriate in their local setting. At time of writing, plans are underway for a translation of this book into Spanish. Once completed, this version will also be made available online at no charge. The authors encourage readers to contact them with their experiences, and the aim is to build a worldwide community that gradually adopts these methods and helps to drive safety improvements in health care.

关键词：人为因素可用性安全性教科书教育

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hTFtarget:A Comprehensive Database for Regulations of human Transcription factors and Their Targets

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 120-128页

作者： Qiong Zhang Wei Liu Hong-Mei Zhang Gui-Yan Xie Ya-Ru Miao Mengxuan Xia An-Yuan Guo Department of Bioinformatics and Systems Biology Key Laboratory of Molecular Biophysics of the Ministry of EducationHubei Bioinformatics and Molecular Imaging Key LaboratoryCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Clinical Center of human Genomic Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Transcription factors(TFs)as key regulators play crucial roles in biological *** identification of TF-target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene *** accumulated data of chromatin immunoprecipitation sequencing(ChIP-seq)provide great opportunities to discover the TF-target regulations across different *** this study,we constructed a database named hTFtarget,which integrated huge human TF target resources(7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs)and epigenetic modification information to predict accurate TF-target *** offers the following functions for users to explore TF-target regulations:(1)browse or search general targets of a query TF across datasets;(2)browse TF-target regulations for a query TF in a specific dataset or tissue;(3)search potential TFs for a given target gene or noncoding RNA;(4)investigate co-association between TFs in cell lines;(5)explore potential coregulations for given target genes or TFs;(6)predict candidate TF binding sites on given DNA sequences;(7)visualize ChIP-seq peaks for different TFs and conditions in a genome *** provides a comprehensive,reliable and user-friendly resource for exploring human TF-target regulations,which will be very useful for a wide range of users in the TF and gene expression regulatiol *** is available at bttp://***/hTFtarget.

关键词： Transcription factor ChIP-seq Transcriptional regulation human Database

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AstroPose:Astronaut pose estimation using a monocular camera during extravehicular activities

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Science China(Technological Sciences) 2024年第6期67卷 1933-1945页

作者： LIU ZiBin LI You WANG ChunHui LIU Liang GUAN BangLei SHANG Yang YU QiFeng College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China Key Laboratory of human factors Engineering China Astronaut Research and Training CenterBeijing100094China

With the completion of the Chinese space station,an increasing number of extravehicular activities will be executed by astronauts,which is regarded as one of the most dangerous activities in human space *** guarantee the safety of astronauts and the successful accomplishment of missions,it is vital to determine the pose of astronauts during extravehicular *** article presents a monocular vision-based pose estimation method of astronauts during extravehicular activities,making full use of the available observation ***,the camera is calibrated using objects of known structures,such as the spacesuit backpack or the circular handrail outside the space ***,the pose estimation is performed utilizing the feature points on the *** proposed methods are validated both on synthetic and semi-physical simulation experiments,demonstrating the high precision of the camera calibration and pose *** further evaluate the performance of the methods in real-world scenarios,we utilize image sequences of Shenzhou-13 astronauts during extravehicular *** experiments validate that camera calibration and pose estimation can be accomplished solely with the existing observation resources,without requiring additional complicated *** motion parameters of astronauts lay the technological foundation for subsequent applications such as mechanical analysis,task planning,and ground training of astronauts.

关键词： monocular camera astronaut pose estimation camera calibration

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Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-Hsien CHEN Kam K.H.NG Xin YUAN Cho Yin YIU human factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye tracker Electroencephalogram

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Lipocoacervate,a tunable vesicle for protein delivery

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Nano Research 2024年第10期17卷 9135-9140页

作者： Chia-Wei Yeh Nathaniel Wright Chelsea Loh Nabeen Chu Yadong Wang Nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityKimball Hall 290Ithaca 14853USA human Biology Healthand Society.College of Human EcologyCornell UniversityIthaca 14853USA

Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously *** we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and *** made of heparin and a biocompatible polycation,PEAD,forms the core of the vesicle;lipids form the membrane of the *** call this vesicle lipocoacervate(LipCo),which has a high affinity for growth factors and cytokines due to *** is a tunable protein delivery *** vesicle size is controlled through polymer and salt *** functionalization enables potential for targeting capabilities with long-term storage through ***,the controlled delivery of therapeutics also avoids high toxicity to treated cells in *** we report on these key principles of LipCo assembly and design.

关键词： complex coacervate drug delivery protein delivery heparin lipid particle

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A plasmonic S-scheme Au/MIL-101(Fe)/BiOBr photocatalyst for efficient synchronous decontamination of Cr(VI) and norfloxacin antibiotic

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eScience 2024年第2期4卷 80-91页

作者： Shijie Li Kexin Dong Mingjie Cai Xinyu Li Xiaobo Chen Zhejiang Key Laboratory of Health Risk factors for Seafood National Engineering Research Center for Marine AquacultureZhejiang Ocean UniversityZhoushan 316022China Department of Chemistry University of MissouriKansas City 64110USA

Present photocatalysts for the synchronous cleanup of pharmaceuticals and heavy metals have several drawbacks,including inadequate reactive sites,inefficient electron–hole disassociation,and insufficient oxidation and reduction *** this research,we sought to address these issues by using a facile solvothermal-photoreduction route to develop an innovative plasmonic S-scheme heterojunction,Au/MIL-101(Fe)/*** screened-out Au/MIL-101(Fe)/BiOBr(AMB-2)works in a durable and high-performance manner for both Cr(VI)and norfloxacin(NOR)eradication under visible light,manifesting up to 53.3 and 2 times greater Cr(VI)and NOR abatement rates,respectively,than ***,AMB-2's ability to remove Cr(VI)in a Cr(VI)-NOR coexistence system is appreciably better than in a sole-Cr(VI)environment;the synergy among Cr(VI),NOR,and AMB-2 results in the better utilization of photo-induced carriers,yielding a desirable capacity for decontaminating Cr(VI)and NOR *** integration of MOF-based S-scheme heterojunctions and a plasmonic effect contributes to markedly reinforced photocatalytic ability by increasing the number of active sites,augmenting the visible-light absorbance,boosting the efficient disassociation and redistribution of powerful photo-carriers,and elevating the generation of reactive *** provide details of the photocatalytic mechanism,NOR decomposition process,and bio-toxicity of the *** synergistic strategy of modifying S-scheme heterojunctions with a noble metal opens new horizons for devising excellent MOF-based photosystems with a plasmonic effect for environment purification.

关键词： Au/MIL-101(Fe)/BiOBr Metal-organic framework(MOF) Plasmonic effect S-scheme Cr(VI)removal Antibiotic degradation Synchronous removal

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Welding depth measurement for different mode lasers using optical coherence tomography

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Chinese Optics Letters 2024年第1期22卷 41-46页

作者：谢冠明王三宏张跃强李由胡彪傅愉于起峰 Institute of Intelligent Optical Measurement and Detection Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Sincevision Technology Co. Ltd.Shenzhen 518055China National Key Laboratory of human factors Engineering China Astronaut Research and Training CenterBeijing 100094China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Optical coherence tomography(OCT)allows a direct and precise measurement of laser welding depth by coaxially measuring the keyhole depth and can be used for process monitoring and *** OCT measurement was taken during single-beam laser welding,the keyhole instability of aluminum welding resulted in highly scattered OCT data and complicated the welding depth extraction *** a combination of an inner core beam and an outer ring beam,a novel adjustable ring mode(ARM)laser for producing a stable keyhole was applied to the OCT *** ARM laser power arrangements were conducted on aluminum and *** results indicated that the ring beam greatly improved the stability of the core beam-induced keyhole,and smooth welding depth can be extracted from the concentrated OCT data.

关键词： optical coherence tomography adjustable ring mode laser laser welding welding depth

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生成式人工智能使小企业也能平等竞争

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国际贸易译丛 2024年第4期 46-48页

作者：格雷厄姆·肯尼田博宇(译) Strategic factors公司不详

通常而言,资源匮乏的中小型企业很难全力以赴地举办年度战略研讨会,也无法暂停所有在办业务来应对威胁到盈利底线的突发事件。这让它们在与大型企业的竞争中处于劣势。然而,人工智能(AI)拥有实现公平竞争的潜力。

关键词：战略研讨会中小型企业资源匮乏小企业公平竞争平等竞争突发事件生成式

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Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration

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Neural Regeneration Research 2024年第7期19卷 1411-1413页

作者： Caleb A.Wood Nicholas M.Tran Department of Neuroscience Baylor College of MedicineHoustonTXUSA Department of Molecular and human Genetics Baylor College of MedicineHoustonTXUSA

A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may possess unique features that support their survival.U nderstanding the basis of neuronal resilience or vulnerability would provide a logical strategy to identify factors that could be targeted therapeutically.

关键词： selective targeted

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The effects of selenium on the translation efficiency of selenoproteins Gpx1， Gpx4， and Txnrd1 in oxLDL-induced ***926 cells

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Food Science and human Wellness 2024年

作者： Jiaqi Lu Jing Meng Yanzhi Lang Abdul Rehman Yamei Yan Linwu Ran School of Public Health， Ningxia Medical University Key Laboratory of Environmental factors and Chronic Disease Control Yinchuan School of Clinical Medicine， Ningxia Medical University Goji Berry Research Institute， Ningxia Academy of Agriculture and Forestry Sciences

Selenium is a crucial trace element that contributes to physiological processes in the body as selenoproteins. Selenoproteins serve as an integral role in the body in controlling the redox state of cells and protecting against damage induced by oxidative stress. This study aimed to investigate the effects and possible mechanism of selenium on selenoproteins expression in ***926 cells induced by oxLDL. The impact of selenium on the viability of ***926 cells was detected by the MTT method， and intracellular ROS level and mitochondrial membrane potential were assessed by fluorescent probe DCFH-DA and JC-1， respectively. RNA-seq， quantitative real-time PCR (RT-qPCR)， and western blot were used to investigate the selenoprotein expression. Selenoprotein mRNA translation efficiency was analyzed by ribosome profiling (Ribo-Seq) coupled with transcriptomics. Our data showed that selenium supplementation (0.5 μmol/L) significantly decreased ROS production， reduced mitochondrial inner membrane potential and increased the proliferative activity of ***926 cells induced by oxLDL. Moreover， The protective effects of selenium against oxLDL-induced ***926 cell injury were associated with the upregulation of the expressions of selenoproteins GPX1， GPX4， and TXNRD1. Furthermore， the expressions of selenoproteins GPX1 and GPX4 were hierarchically controlled， but the expressions of selenoproteins TXNRD1 were mainly regulated by oxLDL. Finally， Ribo-Seq coupled with transcriptomics results demonstrated that the expressions of selenoproteins GPX1， GPX4， and TXNRD1 were regulated at the translation process level. These findings suggested that selenium could have preventive effects in oxLDL induced ***926 cell injury by regulating the selenoprotein expression， and the selenoproteins expressions at the translation level in vascular endothelial cells need further study.

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