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Signal Transduction and Targeted Therapy 2021年第3期6卷 602-604页

作者： Yao Yao Fei Ye Kailong Li Peng Xu Wenjie Tan Quansheng Feng Shuquan Rao School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengduChina Division of Hematology/Oncology Boston Children's HospitalDepartment of Pediatric OncologyDana-Farber Cancer InstituteHarvard Medical SchoolBostonMAUSA NHC Key Laboratory of Biosafety National Institute for Viral Disease Control&PreventionChinese Center for Disease Control and PreventionChina CDCBeijingChina Children's medical center Research Institute University of Texas Southwestern Medical CenterDallasTXUSA Hematology center of Cyrus Tang medical Institute Soochow UniversitySuzhouChina

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a major global health *** is predominantly caused by severe respiratory failure related to interstitial pneumonia in both lungs and acute respiratory distress ***,genome-wide association studies(GWASs)have identified chromosome 3p21.31(sentinel variant:rsl 1385942)to be associated with both severe and general affected COVID-19 cases.

关键词： acute respiratory distress

COVID-19 vaccination and diabetic ketoacidosis

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World Journal of Diabetes 2023年第5期14卷 560-564页

作者： Beuy Joob Viroj Wiwanitkit Academic center Sanitation1 Medical Academic CenterBangkok 1033300Thailand Community Medicine DY Patil VidhyapeethPune 233230India

An efficient coronavirus disease 2019(COVID-19)vaccine is urgently required to fight the pandemic due to its high transmission rate and quick *** have been numerous reports on the side effects of the COVID-19 immunization,with a focus on its negative *** endocrinology is extremely interested in the endocrine issue that arises after receiving the COVID-19 *** was already mentioned,after receiving the COVID-19 vaccine,many clinical problems could ***,there are some compelling reports on *** receiving the COVID-19 vaccine,a patient experienced hyperosmolar hyperglycemia state,a case of newly-onset type 2 *** has also been information on a potential connection between the COVID-19 vaccine and diabetic *** symptoms include thirst,polydipsia,polyuria,palpitations,a lack of appetite,and *** extremely rare clinical circumstances,a COVID-19 vaccine recipient may develop diabetes complications such as hyperglycemia and *** these circumstances,routine clinical care has a successful track *** is advised to give vaccine recipients who are vulnerable to problems,such as those with type 1 diabetes as an underlying illness,extra attention.

关键词： Diabetes COVID-19 Vaccine Ketoacidosis Effect

Early versus delayed laparoscopic cholecystectomy in uncomplicated biliary colic: An observational study

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第2期6卷 69-72页

作者： Krishnendu Vidyadharan Rajkumar KembaiShanmugam Ganesan Ayyasamy Satheshkumar Thandayuthapani Department of General Surgery Kovai Medical Center and HospitalCoimbatore641014India

Objective:Biliary colic is a condition treated with laparoscopic ***,the outcomes of surgery depend on early or delayed time *** research findings reported no benefits of early over delayed,on contra,other reported *** study aims to compare the benefits associated with early and delayed laparoscopic cholecystectomy among uncomplicated biliary colic ***:This observational study included patients with right upper abdominal pain and abdominal ultrasound showing *** who were admitted at the first and second visits(within 6 weeks of the first visit)were assigned to the early and delayed groups,*** participants were followed up for one-week *** diagnosis of the patient,postoperative hospital stay,duration of surgery and complications were noted and compared ***:A total of 80 patients were included,40 each in the early group and delayed *** patients in the two groups had comparable mean ages(40.55±13.12 y vs.40.45±12.06 y,p=0.972).The early group had more female patients(72.5%vs.45.0%,p=0.012).The duration of hospital stay(2.18±0.38 d vs.2.68±1.04 d,p=0.009)and duration of surgery(61.63±3.64 min vs.71.13±16.19 min,p=0.001)were found to be significantly different between the early and delayed *** 1(2.5%)patient in both groups was converted to open *** biliary colic requiring hospital admission was seen in 1(2.5%)patient and 6(15.0%)patients,acute cholecystitis in 2(5.0%)and 6(15.0%),biliary pancreatitis in 1(2.5%)and 2(5.0%),and obstructive jaundice in 1(2.5%)and 1(2.5%)in the early and delayed groups,respectively,with insignificant differences(p>0.05).Conclusion:Early laparoscopic cholecystectomy decreases the operating time and duration of hospital *** terms of postoperative complications,our study did not find any significant difference between the groups.

关键词： Laparoscopic cholecystectomy Uncomplicated biliary colic Acute cholecystitis Obstructive jaundice Biliary pancreatitis

Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma:A single-center experience

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World Journal of Gastroenterology 2014年第35期20卷 12595-12601页

作者： Fu-Bo Zhang Ai-Min Zhang Zhi-Bin Zhang Xin Huang Xi-Tao Wang Jia-Hong Dong Department of Hepatobiliary Surgery Chinese PLA General Hospital medical School Nankai University Department of Tuberculosis Binzhou Center Hospital

AIM: To investigate preoperative differential diagnoses made between intrahepatic biliary cystadenoma and intrahepatic biliary cystadenocarcinoma. METHODS: A retrospective analysis of patient data was performed, which included 21 cases of intrahepatic biliary cystadenoma and 25 cases of intrahepatic biliary cystadenocarcinoma diagnosed between April 2003 and April 2013 at the General Hospital of PLA. Potential patients were excluded whose diagnoses were not confirmed pathologically. Basic information (including patient age and gender), clinical manifestation, duration of symptoms, serum assay results (including tumor markers and the results of liver function tests), radiological features and pathological results were collected. All patients were followed up. RESULTS: Preoperative levels of cancer antigen 125 (12.51 +/- 9.31 vs 23.20 +/- 21.86, P < 0.05) and carbohydrate antigen 19-9 (22.56 +/- 26.30 vs 72.55 +/- 115.99, P < 0.05) were higher in the cystadenocarcinoma subgroup than in the cystadenoma subgroup. There were no statistically significant differences in age or gender between the two groups, or in pre- or post-operative levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin (TBIL), and direct bilirubin (DBIL) between the two groups. However, eight of the 21 patients with cystadenoma and six of the 25 patients with cystadenocarcinoma had elevated levels of TBIL and DBIL. There were three cases in the cystadenoma subgroup and six cases in the cystadenocarcinoma subgroup with postoperative complications. CONCLUSION: Preoperative differential diagnosis relies on the integration of information, including clinical symptoms, laboratory findings and imaging results. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Intrahepatic biliary cystadenoma Intrahepatic biliary cystadenocarcinoma Preoperative differential diagnosis

Flexible electronics for cardiovascular healthcare monitoring

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The Innovation 2023年第5期4卷 124-138页

作者： Tianqi Zhang Ning Liu Jing Xu Zeye Liu Yunlei Zhou Yicheng Yang Shoujun Li Yuan Huang Shan Jiang Hangzhou Ins itute of Technology Xidian UniversityHangzhou 311200China Department of Gastrointestinal Surgery Hainan General HospitalHainan ffliated Hospital of Hainan Medical UniversityHaikou 570311China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Structural Heart Disease National Center for Cardiovascular DiseaseChina&Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100037China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPediatric Cardiac Surgery CenterFuwai HospitalChinese Academy ofMedical Sciencesand Peking Union Medical CollegeBejing 100037China

Cardiovascular diseases(CVDs)are one of the most urgent threats to humans worldwide,which are responsible for almost one-third of global *** the last decade,research on flexible electronics for monitoring and treatment of CVDs has attracted tremendous *** contrast to conventional medical instruments in hospitals that are usually bulky,hard to move,monofunctional,and time-consuming,flexible electronics are capable of continuous,noninvasive,real-time,and portable *** progress has been made in this emerging field,and thus a number of significant achievements and concomitant research prospects deserve attention for practical ***,we comprehensively review the latest progress of flexible electronics for CVDs,focusing on new functions provided by flexible ***,the characteristics of CVDs and flexible electronics and the foundation of their combination are briefly ***,four representative applications of flexible electronics for CVDs are elaborated:blood pressure(BP)monitoring,electrocardiogram(ECG)monitoring,echocardiogram monitoring,and direct epicardium *** operational principles,progress,merits and demerits,and future efforts are ***,the remaining challenges and opportunities for flexible electronics for cardiovascular healthcare are outlined.

关键词： electronics monitoring consuming

Retinal laser photocoagulation and intravitreal injection of anti-VEGF for hemorrhagic retinal arterial microaneurysm

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2041-2048页

作者： Ying Huang Wei-Wei Zheng Ying-Zi Li Zu-Hua Sun Bing Lin National Clinical Research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the efficacy of retinal laser photocoagulation and intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF)for hemorrhagic retinal arterial macroaneurysm(RAM).METHODS:This was a retrospective clinical *** with hemorrhagic RAM were divided into 4 groups defined by different treatments:a retinal laser photocoagulation therapy monotherapy group,an anti-VEGF intravitreal injection monotherapy group,a laser and anti-VEGF combination therapy group,and an observation *** acuity(VA),central macular thickness(CMT),and retinal hemorrhage area(RHA)were ***:Forty-seven eyes of 47 patients were *** improved and had a significant difference between baseline and final in each treatment group(logMAR;laser group:1.90±0.53 vs 1.05±0.63,P<0.001;anti-VEGF group:1.75±0.63 vs 1.12±0.54,P=0.009;combination group:1.76±0.38 vs 1.01±0.52,P<0.001);however,VA decreased and had no significant difference in observation group(1.63±0.51 vs 1.76±0.61,P=0.660).CMT decreased and had a significant difference between baseline and final in each group(laser group:815.16±310.83 vs 252.05±83.90μm,P<0.001;anti-VEGF group:725.00±290.79 vs 203.56±69.89μm,P=0.001;combination group:595.50±186.51 vs 253.13±55.06μm,P=0.001;observation group:758.88±195.65 vs 267.00±120.90μm,P=0.001).RHA were 28.99±28.15,25.94±11.58,19.64±8.97,and 27.45±13.76 mm^(2) in laser group,anti-VEGF group,combination group and observation group,*** was statistically correlated with final VA(P=0.032)in the observation ***:Both laser and anti-VEGF treatments are effective for hemorrhagic *** therapy reduces the number of injections of *** is a visual prognosis predictor in the natural history of hemorrhagic RAM.

关键词： retinal laser photocoagulation anti-vascular endothelial growth factor retinal arterial macroaneurysm

Association between Life’s Essential 8 and Cerebral Small Vessel Disease

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Stroke & Vascular Neurology 2024年第5期9卷 481-489页

作者： Dandan Liu Xueli Cai Yingying Yang Suying Wang Lerong Mei Jing Jing Shan Li Mengxing Wang Yun Chen Xia Meng Tiemin Wei Yongjun Wang Yilong Wang Yuesong Pan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijingPeople's Republic of China Department of Neurology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Lishui Clinical Research center for Neurological Diseases The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Cerebrovascular Research Lab The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiZhejiangChina Department of Cardiology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishuiChina Advanced Innovation center for Human Brain Protection Capital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina

Background Given that associations of Life’s Essential 8(LE8)and cerebral small vessel disease(CSVD)or its imaging markers were unclear,we examined relationship between *** The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events *** calculated the total LE8 score,medical LE8 score and behavioural score,and categorised them into low(10)was allocated one *** on modified total CSVD score(0–6 points),WMH or CMB was modified to three grades,and BG-EPVS(N>20)was allocated one *** Among 3061 participants in this study,1424(46.5%)were *** LE8 score was associated with lower total CSVD score(moderate vs low:cOR 0.78,95%CI 0.63 to 0.96;high vs low:cOR 0.44,95%CI 0.33 to 0.59),and the medical score was inversely related to the total CSVD ***,the medical score was inversely related to odds of WMH(p<0.05),modified WMH(p<0.05),lacunes(p<0.05)or BG-EPVS(p<0.05),and the behavioural score were inversely related to the odds of lacunes and *** Higher LE8 score which indicates better cardiovascular status was associated with lower burden of CSVD and its MRI *** studies are needed to examine the causality.

关键词： cerebral behaviour Essential

Impact of sarcopenia on mortality in patients undergoing liver retransplantation

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World Journal of Hepatology 2020年第10期12卷 807-815页

作者： Amaninder Dhaliwal Diana Larson Molly Hiat Lyudmila M Muinov William L Harrison Harlan Sayles Tomoki Sempokuya Marco A Olivera Fedja A Rochling Timothy M McCashland Department of Gastroenterology and Hepatology University of South Florida and Moffitt Cancer CenterTampaFL 33612United States Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198United States Department of Radiology University of Nebraska Medical CenterOmahaNE 68198United States Division of Abdominal Imaging Department of RadiologyUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Biostatistics College of Public HealthUniversity of Nebraska Medical CenterOmahaNE 68198United States

BACKGROUND Sarcopenia,which is a loss of skeletal muscle mass,has been reported to increase post-transplant mortality and morbidity in patients undergoing the first liver ***-sectional imaging modalities typically determine sarcopenia in patients with cirrhosis by measuring core abdominal ***,there is limited evidence for sarcopenia related outcomes in patients undergoing liver re-transplantation(re-OLT).AIM To evaluate the risk of mortality in patients with pre-existing sarcopenia following liver *** This is a retrospective study of all adult patients who had undergone a liver re-OLT at the University of Nebraska medical center from January 1,2007 to January 1,*** divided patients into sarcopenia and no sarcopenia groups.“TeraRecon AquariusNet 4.***.12.194”software was used to evaluate computed tomography or magnetic resonance imaging of the patients done within one year prior to their re-OLT,to calculate the Psoas muscle area at L3-L4 intervertebral *** defined cutoffs for sarcopenia as<1561 mm2 for males and<1464 mm2 for *** primary outcome was to compare 90 d,one,and 5-year survival *** also compared complications after re-OLT,length of stay,and readmission within 30 *** analysis was performed with Kaplan-Meier survival *** variables were evaluated with Wilcoxon rank-sum *** variables were evaluated with Fisher’s exact *** Fifty-seven patients were included,32 males:25 females,median age 50 *** patients were excluded due to incomplete ***,47%(26)of patients who underwent re-OLT had *** were found to have significantly more sarcopenia than males(73%vs 17%,P<0.001).Median model for end stage liver disease at re-OLT was 28 in both sarcopenia and no sarcopenia *** in the no sarcopenia group had a trend of longer median time between the first and second transplant(36.5 mo vs 16.7 mo).Biological markers,outcome par

关键词： Sarcopenia Liver transplantation Mortality Re-transplantation Psoas muscle index

Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： Hang Zhang Ling-Zi Wu Zhen-Yu Liu Zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

Update on the management of sigmoid diverticulitis

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World Journal of Gastroenterology 2021年第9期27卷 760-781页

作者： Mark H Hanna Andreas M Kaiser Division of Colorectal Surgery Department of SurgeryCity of Hope National Medical CenterDuarteCA 91010-3000United States

Diverticular disease and diverticulitis are the most common non-cancerous pathology of the *** has traditionally been considered a disease of the elderly and associated with cultural and dietary *** has been a growing evolution in our understanding and the treatment guidelines for this *** provide an updated review of the epidemiology,pathogenesis,classification and highlight changes in the medical and surgical management of *** is increasingly being seen in young patients(medical and surgical management of this common ***-surgical management remains the appropriate treatment for greater than 70%of *** individuals with non-relenting,persistent,or recurrent symptoms and those with complicated disease and sequelae,a segmental colectomy remains the most effec

关键词： Diverticulitis Epidemiology Antibiotics Surgical resection Laparoscopic lavage Classification