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Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHyang JENG PO-YU CHENG YUEH-HSIEN LIN PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

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Study on Evacuation Strategy of Commercial High-Rise Building under Fire Based on FDS and Pathfinder

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1077-1102页

作者： Zheng Yan Ying Wang Longxiao Chao Jian Guo Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education SoutheastUniversityNanjing210096China Nanjing yang Zi State-Owned Investment Group Nanjing210096China

With the development of economy and society and the growth of population,the high-rise and multi-function of commercial buildings have become an international *** it also poses huge fire *** of the existing studies’research objects are predominantly high-rise residential buildings,without considering the impact of different functional zones(Standard floor,entertainment zone,office zone,equipment room and so on)and personnel distribution of commercial buildings *** the influence of using elevators to carry evacuees on the refuge floor on personnel evacuation is rarely *** this work,the fire scenario of the yangtze River InternationalConferenceCenter,a high-rise commercial building,is simulated with the Pyrosim programto get the necessary parameters under various fire scenarios and to calculate the available evacuation time *** the same time,according to the complex functional zone of the commercial high-rise building and the distribution of people in different time periods,a reasonable evacuation strategy is developed and simulated by Pathfinder *** results indicate that unorganized evacuation will lead individuals to take the erroneous evacuation route,resulting in a vast region of congestion;comprehensive consideration of the time staggering and the reasonable distribution of evacuation routes can significantly improve evacuation efficiency,and the TRSET of night and working hours is 36.6%–55.3%and 49.9%–79.6%of unorganized evacuation,*** the night fire,60%of the people use elevator-refuge floor to evacuate is the optimal strategy;for the fire during working hours,half of the people on standard floors use the elevator to evacuate and people on multifunctional floors evacuate in four batches is the best *** results of this study can provide viable solutions and a foundation for analyzing the fire evacuation and safety of big commercial high-rise buildings.

关键词： High-rise building fire personnel evacuation refuge floor safety analysis

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Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-Hua Wang He-yang Zhou Jin-Yun Ma Gui-Qing Ding Hua Yu Yong-Sheng Jin Xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

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Multimodal imaging for the diagnosis of oligodendroglioma associated with arteriovenous malformation:A case report

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World Journal of Radiology 2024年第8期16卷 348-355页

作者： Peng Guo Wei Sun Ling-Xie Song Wen-Yu Cao Jin-Ping Li Department of Neurosurgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Pathology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND The rare co-occurrence of oligodendroglioma and arteriovenous malformation(AVM)in the same intracranial *** SUMMARY In a 61-year-old man presenting with progressive headaches,is described in this case *** multimodal imaging techniques(computed tomography,magnetic resonance imaging,magnetic resonance spectroscopy,digital subtraction angiography,and computed tomography angiography)were employed to detect hemorrhage,cystic and solid lesions,and arteriovenous shunting in the right temporal *** patient underwent right temporal craniotomy for lesion removal,and postoperative pathological analysis confirmed the presence of oligodendroglioma(World Health Organization grade II,not otherwise specified)and *** The preoperative utilization of multimodal imaging examination can help clinicians reduce the likelihood of misdiagnosis or oversight of these conditions,and provides important information for subsequent *** case supports the feasibility of craniotomy for the removal of glioma with AVM.

关键词： Oligodendroglioma Arteriovenous malformation Angioglioma Multimodal imaging Case report

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Semi-volatile organic compounds in a museum in China:A non-targeted screening approach

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Science China(Technological Sciences) 2024年第9期67卷 2693-2705页

作者： SONG ZiDong NIAN LuYing SHI Meng REN XiaoPeng TANG Ming SHI AnMei HAN Ying LIU Min WANG Luyang ZHANG YinPing XU Ying FENG XiaoMeng Department of Building Science Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Beijing 100084China National Museum of China Beijing 100006China Department of Endocrinology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Non-targeted analysis(NTA)was conducted to identify semi-volatile organic compounds(SVOCs)in a museum in China using the gas chromatography(GC)-Orbitrap-mass spectrometer(MS).Approximately 160 SVOCs were detected,of which 93 had not been reported in previous studies of museum *** of the detected SVOCs were found to be associated with the chemical agents applied in conservation treatment and the materials used in *** results of hierarchical cluster analysis(HCA)indicated a spatial variation of SVOCs in the indoor air in the museum,but there were no obvious temporal differences of SVOCs observed in indoor ***'s correlation analysis showed that several classes of SVOCs were well correlated,suggesting their common *** and plasticizers were found to be the primary sources of SVOC pollution detected in the *** with compounds in outdoor air,indoor SVOCs had a lower level of unsaturation and more portions of chemically reduced *** study is the first of its kind to comprehensively characterize SVOCs in a museum using an automated NTA approach with *** SVOCs identified in the current study are likely to be present in other similar museums;therefore,further examination of their potential impacts on cultural heritage artifacts,museum personnel,and visitors may be warranted.

关键词： non-target analysis high-resolution mass spectrometry semi-volatile organic compounds museum environment air pollutants

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Esophageal ulcer and multisystem inflammatory syndrome after COVID-19:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 483-488页

作者： Ni yang Zhen Liu Tong Jin Hai-Wei Xin Li Gu Yue Zheng Hui-Xing Zhou Ning Li Xin-Juan Liu Department of Gastroenterology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Infectious Diseases and Clinical Microbiology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Surgical Intensive Care Unit Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Hematology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China

BACKGROUND Multisystem inflammatory syndrome in adults(MIS-A)is a rare but severe disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 *** develops in adults with inflammation of different organs including the gastrointestinal tract,heart,kidneys,skin and hematopoietic *** SUMMARY We present a 58-year-old Chinese man diagnosed with *** chief complaints were fever,generalized fatigue and anorexia,accompanied with rashes on his *** examination showed cardiac,renal and liver *** had melena and gastroscopy indicated esophageal ulcer and severe *** blood and sputum culture did not show growth of bacteria or *** treatment was stopped due to unsatisfactory *** condition improved after prednisone and other supportive *** Gastrointestinal involvement in MIS-A is not *** involvement predominates,and esophageal involvement is rarely *** ulcer with bleeding could also be a manifestation of MIS-A.

关键词： Multisystem inflammatory syndrome Esophageal ulcer SARS-CoV-2 Gastrointestinal bleeding Case report

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The role of cell-free DNA in non-invasive diagnosis of urinary tract infection

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UroPrecision 2024年第2期2卷 41-50页

作者： Yu Zhao Wenhui Zhang Yina Ma Xin Zhang Department of Urology Surgery Beijing Chao-Yang Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Hepatobiliary Surgery Beijing Chao‐Yang Hospital Affiliated to Capital Medical UniversityBeijingChina

Urinary tract infection(UTI)constitutes a pervasive health *** are dichotomously classified into upper and lower strata,and further categorized as either complicated or *** UTIs predominantly afflict the renal and ureteral domains,typified by conditions exemplified in pyelonephritis,whereas lower UTIs manifest within the confines of the urethra and *** conventional diagnosis of UTIs relies upon clinical manifestations and urine *** symptoms encompass dysuria,frequent micturition,hematuria,and suprapubic *** culture serves to identify the specific pathogens instigating the infection and assess their antibiotic ***,this procedural protocol generally necessitates an approximate duration of 24 h,coupled with an additional 24-h interval for antibiotic susceptibility *** contradistinction,the detection of cell-free DNA(cfDNA)in the circulatory system presents a potential avenue for non-invasive diagnostic ***,cfDNA emanates from deteriorating cells,affording insights into the extant cellular demise within the *** scholarly inquiry has established a positive correlation between cfDNA concentration in the bloodstream and the incidence of cell death in conditions,such as severe traumas,sepsis,aseptic inflammation,myocardial infarction,and ***,limited investigative effort has been devoted to elucidating the diagnostic potential of cfDNA in the context of ***,the concentration and constitution of plasma cfDNA harbor substantial promise for non-invasively diagnosing *** summation,the utilization of cfDNA in UTI diagnosis remains an incipient area of scholarly pursuit,underscoring the imperative for further research to elucidate the prospective role of plasma cfDNA in non-intrusively discerning UTIs.

关键词： cell-free DNA diagnosis DNA methylation urinary tract infection

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Deep Learning for Covert Communication

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China Communications 2024年第9期21卷 40-59页

作者： Shen Weiguo Chen Jiepeng Zheng Shilian Zhang Luxin Pei Zhangbin Lu Weidang yang Xiaoniu Innovation Studio of Academician yang National Key Laboratory of Electromagnetic Space SecurityJiaxing 314033China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China School of Information Science and Technology Fudan UniversityShanghai 200438China

In recent years,deep learning has been gradually used in communication physical layer receivers and has achieved excellent *** this paper,we employ deep learning to establish covert communication systems,enabling the transmission of signals through high-power signals present in the prevailing environment while maintaining covertness,and propose a convolutional neural network(CNN)based model for covert communication receivers,namely Deep *** model leverages CNN to execute the signal separation and recovery tasks commonly performed by traditional *** enables the direct recovery of covert information from the received *** simulation results show that the proposed Deep CCR exhibits significant advantages in bit error rate(BER)compared to traditional receivers in the face of noise and multipath *** verify the covert performance of the covert method proposed in this paper using the maximum-minimum eigenvalue ratio-based method and the frequency domain entropy-based *** results indicate that this method has excellent covert *** also evaluate the mutual influence between covert signals and opportunity signals,indicating that using opportunity signals as cover can cause certain performance losses to covert *** the interference-tosignal power ratio(ISR)is large,the impact of covert signals on opportunity signals is minimal.

关键词： convolutional neural network covert communication deep learning

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Preoperative systemic inflammatory response index as a prognostic marker for distal cholangiocarcinoma after pancreatoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2910-2924页

作者： Wen-Hui Zhang Yu Zhao Cheng-Run Zhang Jin-Can Huang Shao-Cheng Lyu Ren Lang Department of Hepatobiliary Surgery Beijing Chao-Yang Hospital Affiliated to Capital Medical UniversityBeijing 100020China Department of Urology Surgery Beijing Chao-Yang Hospital Affiliated to Capital Medical UniversityBeijing 100020China

BACKGROUND The relationship between preoperative inflammation status and tumorigenesis as well as tumor progression is widely *** To assess the prognostic significance of preoperative inflammatory biomarkers in patients with distal cholangiocarcinoma(dCCA)who underwent pancreat-oduodenectomy(PD).METHODS This single-center study included 216 patients with dCCA after PD between January 1,2011,and December 31,*** individuals were categorized into two sets based on their systemic inflammatory response index(SIRI)levels:A low SIRI group(SIRI<1.5,n=123)and a high SIRI group(SIRI≥1.5,n=93).Inflam-matory biomarkers were evaluated for predictive accuracy using receiver operating characteristic *** univariate and multivariate Cox proportional hazards analyses were performed to estimate SIRI for overall survival(OS)and recurrence-free survival(RFS).RESULTS The study included a total of 216 patients,with 58.3%being male and a mean age of 65.6±9.6 years.123 patients were in the low SIRI group and 93 were in the high SIRI group after PD for *** had an area under the curve value of 0.674 for diagnosing dCCA,showing better performance than other inflammatory *** analysis indicated that having a SIRI greater than 1.5 independently increased the risk of dCCA following PD,leading to lower OS[hazard ratios(HR)=1.868,P=0.006]and RFS(HR=0.949,P<0.001).Additionally,survival analysis indicated a significantly better prognosis for patients in the low SIRI group(P<0.001).CONCLUSION It is determined that a high SIRI before surgery is a significant risk factor for dCCA after PD.

关键词： Distal cholangiocarcinoma Pancreatoduodenectomy Biomarker Systemic inflammatory response index Prognosis

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Translating bacteriophage-derived depolymerases into antibacterial therapeutics:Challenges and prospects

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Acta Pharmaceutica Sinica B 2024年第1期14卷 155-169页

作者： Honglan Wang Yannan Liu Changqing Bai Sharon Shui Yee Leung School of Pharmacy the Chinese University of Hong KongHong Kong SARChina Emergency Medicine Clinical Research Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory Shenzhen University General HospitalShenzhen University Clinical Medical AcademyGuangdong 518055China

Predatory bacteriophages have evolved a vast array of depolymerases for bacteria capture and *** depolymerases are enzymes responsible for degrading diverse bacterial surface *** are exploited as antibiofilm agents and antimicrobial adjuvants while rarely inducing bacterial resistance,making them an invaluable asset in the era of antibiotic *** depolymerases have been investigated preclinically,with evidence indicating that depolymerases with appropriate dose regimens can safely and effectively combat different multidrug-resistant pathogens in animal infection ***,some formulation approaches have been developed for improved stability and activity of ***,depolymerase formulation is limited to liquid dosage form and remains in its infancy,posing a significant hurdle to their clinical translation,compounded by challenges in their applicability and *** development must address these obstacles for clinical ***,after unravelling the history,diversity,and therapeutic use of depolymerases,we summarized the preclinical efficacy and existing formulation findings of recombinant ***,the challenges and perspectives of depolymerases as therapeutics for humans were assessed to provide insights for their further development.

关键词： Phage-derived polysaccharide depolymerases Bacteriophage proteins Bacterial capsules Polysaccharide capsules Antibiotic resistance Biofilms Antibacterial therapy Antimicrobial adjuvants Combination treatment

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