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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State key laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State key laboratory of Applied Organic chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China key laboratory of Electromagnetic materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State key laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Antioxidant activity of polyaniline nanofibers

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Chinese Chemical Letters 2007年第8期18卷 1005-1008页

作者： Jia Wang Li Hua Zhu Jing Li He Qing Tang Department of chemistry and Chemical Engineering Hubei Key laboratory of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology Wuhan 430074 China

Well-confined uniform polyaniline （PANI） nanofibers were synthesized by using photo-assisted chemical oxidative polymer- ization of aniline in the presence of different dopant acids, and the radical scavenging ability of the produced PANI nanofibers was determined by the DPPH assay. It was found that the antioxidant activity of PANI nanofibers was higher than conventional PANI, and increased with decreasing of averaged diameter of the nanofibers. The enhanced antioxidant activity was concerned with increased surface area of PANI nanofibers.

关键词： Polyaniline nanofibers Dopant acids Antioxidant activity DPPH radical

An interlocked coordination cage based on aromatic amide ligands

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Chinese Chemical Letters 2021年第4期32卷 1397-1399页

作者： Dan Luo Bo Pan Jiajia Zhang Chunmiao Ma Yuyang Su Quan Gan hubei key laboratory of bioinorganic chemistry & materia medica School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An interlocked M_(4) L_(8) coordination cage was synthesized by coordination-driven self-assembly of palladium(Ⅱ)ions with aromatic amide bidentate *** reaction of the ligand and the metal at 2:1 ratio led to the monomeric M_(2) L_(4) cage as the kinetic product,while the thermodynamic product M_(4) L_(8) cage was obtained by prolongating the *** conve rsion and the interlocked structure was clearly revealed by using~1 H NMR,mass spectrometry and X-ray *** driving force of interlocking was mainly attributed to the interactions(hydrogen bonding,aromatic stacking and electrostatic interaction)arising from the aptitude of flexibility of the amide ligand.

关键词： Coordination cage Interlocked structure Self-assembly ingle-crystal structure Supramolecular chemistry

A novel Fe(OH)3/TiO2 nanoparticles and its high photocatalytic activity

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Chinese Chemical Letters 2007年第10期18卷 1261-1264页

作者： Nan Wang Li Hua Zhu Jing Li He Qing Tang Department of chemistry and Chemical Engineering Hubei Key Lab of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology Wuhan 430074 China

A very simple and controllable approach was proposed to synthesize novel Fe（OH）3/TiO2 nanoparticles. Compared with neat TiO2, the Fe（OH）3/TiO2 increased the rate of the photocatalytic degradation of methyl orange at pH 6.0 by more than five times, showing photocatalytic activity as excellent as P25. This enhancing effect is mainly attributed to the ferric hydroxide deposits as the electron scavenger and the enriched surface hydroxyl groups.

关键词： Titanium dioxide Surface modification Ferric hydroxide Photocatalysis

A smart photodynamic therapy strategy: depletion of glutathione in cancer cells

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Science Bulletin 2017年第5期62卷 312-313页

作者： Fujian Huang Fan Xia Faculty of material Science and chemistry China University of Geosciences hubei key laboratory of bioinorganic chemistry & materia medica School of Chemistry and Chemical EngineeringHuazhong University of Science and Technology

Photodynamic therapy(PDT)is a promising cancer treatment method with fewer side effects,minimal invasion and low toxicity compared with other traditional cancer therapy methods,such as radiotherapy,chemotherapy and su... 详细信息

关键词： PDT depletion of glutathione in cancer cells A smart photodynamic therapy strategy

Mechanism of water oxidation catalyzed by vitamin B_(12):Redox non-innocent nature of corrin ligand and crucial role of phosphate

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Chinese Chemical Letters 2022年第1期33卷 358-361页

作者： Ying-Ying Li Rong-Zhen Liao key laboratory of material chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Bioinorganic Chemistry and Materia MedicaHubei Key Laboratory of Materials Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Vitamin B_(12)(macrocyclic cobalamin)has been recently reported to be capable of electrochemically catalyzing water oxidation in a neutral phosphate buffer *** this work,density functional calculations were employed to elucidate the water oxidation mechanism catalyzed by vitamin B_(12).The calculations showed that the catalytic cycle starts from the L·-Co^(Ⅱ)-OH_(2)complex 1.A proton-coupled electron transfer process then leads to the formation of a L^(·)-Co^(Ⅲ)-OH complex 2,followed by another proton-coupled electron transfer event to afford a corrin ligand radical cation intermediate 3(L^(·)-Co^(Ⅲ)-O^(·)).The redox non-innocent nature of the corrin ligand plays an essential role in the oxidation process.3 is capable of triggering the O-O bond formation via a water nucleophilic attack mechanism,in which a hydrophosphate dianion functions as a base to accept a proton from the water nucleophile.A dioxygen molecule is released after the oxidation of the Co^(Ⅲ)-OOH *** rate-determining step was calculated to be the O-O bond formation with a total barrier of 16.5 kcal/*** the use of water molecules as the proton acceptor was found to be less feasible for the O-O bond formation,with a barrier of 31.2 kcal/mol,further highlighting the crucial of phosphate in water oxidation.

关键词： Water oxidation DFT calculations Mechanism Vitamin B_(12) Cobalt

A highly sensitive DNA-AIEgen-based ＂turn-on＂ fluorescence chemosensor for amplification analysis of Hg^2+ ions in real samples and living cells

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Science China chemistry 2017年第5期60卷 663-669页

作者： Xiaowen OU Xiaoding Lou Fan Xia hubei key laboratory of bioinorganic chemistry & materia medica School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China Shenzhen Institute of Huazhong University of Science and Technology Shenzhen 518000 China

Functional nucleic acids(FNAs)-based biosensors have shown great potential in heavy metal ions detection due to their low-cost and easy to operate merits. However, in most FNAs based fluorescence probes, the ingenious designs of double-labeled(fluorophore and quencher group) DNA sequence, not only bring the annoyance of organic synthesis, but also restrict its use as a robust biosensor in practical duties. In this paper, we design a simple AIEgens functional nucleic acids(AFNAs) probe which consists of only fluorogen but no quencher group. With the help of duplex-specific nuclease(DSN) enzyme based target recycling, high fluorescence signal and superior sensitivity towards Hg^(2+) are achieved. This robust assay allows for sensitive and selective detection of Hg^(2+) in real water samples and mapping of intracellular Hg^(2+), without double-labeling of oligonucleotide with a dye-quencher pair, nor the multiple assay steps.

关键词： functional nucleic acids AIEgen Hg2+ detection real samples living cells

Recent progress in metal-organic frameworks(Part II—material application)

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Science China chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of chemistry and Chemical Engineering Yangzhou University School of materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE key laboratory of bioinorganic and Synthetic chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of chemistry and Chemical Engineering Shanghai Jiao Tong University State key laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of materials Science & Engineering Beijing University of Technology State key laboratory of Silicon and Advanced Semiconductor materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Two-Dimensional Organometallic TM3–C12S12 Monolayers for Electrocatalytic Reduction of CO2

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Energy & Environmental materials 2019年第3期2卷 193-200页

作者： Jin-Hang Liu Li-Ming Yang Eric Ganz hubei key laboratory of bioinorganic chemistry and materia medica Key Laboratory of Material Chemistry for Energy Conversion and StorageMinistry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan China School of Physics and Astronomy University of MinnesotaMinneapolis MN USA

Organometallic nanosheets are a versatile platform for design of efficient electrocatalyst materials due to their high surface area and uniform dispersion of metal active *** this paper,we systematically investigate the electrocatalytic performance of the first transition metal series TM3–C12S12 monolayers on CO2 using spin-polarized density functional *** calculations show that M3–C12S12 exhibits excellent catalytic activity and selectivity in the catalytic reduction in *** main reduction products of Sc,Ti,and Cr are CH4.V,Mn,Fe and Zn mainly produce HCOOH,and Co produces HCHO,while CO is the main product for Ni and *** Sc,Ti,and Cr,the overpotentials are>0.7 V,while for V,Mn,Fe,Co,Ni,Cu,Zn,the overpotentials are very low and range from 0.27 to 0.47 ***,our results indicate that many of the M3–C12S12 monolayers are expected to be excellent and efficient CO2 reduction catalysts.

关键词： density functional theory electrocatalytic reduction of CO2 organometallic TM3-C12S12 Monolayers single atom catalyst two-dimensional materials