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A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection

Protein & Cell 2023年第1期14卷 64-68页

作者： Fei Feng Yunkai Zhu Yanlong Ma Yuyan Wang Yin Yu Xinran Sun Yuanlin Song Zhugui Shao Xinxin Huang Ying Liao Jingyun Ma Yuping He Mingyuan Wang Longhai Tang Yaowei Huang Jincun Zhao Qiang Ding Youhua Xie Qiliang Cai Hui Xiao Chun Li Zhenghong Yuan Rong Zhang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalShanghai Key Laboratory of Lung Inflammation and InjuryFudan UniversityShanghai 200032China The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyInstitute Pasteur of ShanghaiCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Technical Center for Animal Plant and Food Inspection and Quarantine of Shanghai CustomsShanghai 200032China Shanghai Veterinary Research Institute CAASShanghai 200241China College of Animal Science South China Agricultural UniversityGuangzhou 510642China Shanghai International Travel Healthcare Center Shanghai 200335China Suzhou Blood Center Suzhou 215006China Key Laboratory of Animal Virology of Ministry of Agriculture College of Animal SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510182China Center for Infectious Disease Research School of MedicineTsinghua UniversityBeijing 100086China

Dear Editor,Identifying the host factors that are utilized for virus infection and mapping their cell-type expression profile can help to understand the viral tissue/organ tropism and *** effort has been devoted to th... 详细信息

关键词： infection al. activation

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Epidemiological and etiological characteristics of hand,foot,and mouth disease before and after introducing enterovirus 71 vaccines in Sichuan,China:a 6-year retrospective study

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Chinese Medical Journal 2021年第24期134卷 3017-3019页

作者： Wen-Bin Tong Xue-Qi Wu Miao He Feng-Jiao Yang Ye Jiang Gang Zhang Pei-Bin Zeng Institute of Microbiological Detection Sichuan Center for Disease Control and PreventionChengduSichuan 610041China Department of Health inspection and quarantine West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base ChengduSichuan 610052China Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Sichuan Provincial Hospital for Women and Children(Affiliated Women and Children’s Hospital of Chengdu Medical College) ChengduSichuan 610045China

To the Editor:Hand,foot,and mouth disease(HFMD)is well recognized as a pediatric infectious disease caused by a group of enteroviruses(EVs)with global ***,the HFMD is still one among the major threats to the health of children in China,with estimated 20,537,199 cases,resulting in 3667 deaths in 2018.[1]Available data indicated that most of HFMD cases were caused by serotypes of enterovirus 71(EV-71)and coxsackievirus A16(CV-A16).EV-71 was found to be predominant among severe and fatal *** from 2015,three inactivated monovalent EV-71 vaccines were licensed in China and proved with high protective efficacy against HFMD caused by EV-71 but no cross-protection for non-EV-71 serotypes,[2]and the EVs exhibit highly geographical diversity and serotype ***,concerns have raised for the outbreaks of CV-A6 and CV-A10 with severe cases,as well as emerging of rare serotypes such as echo virus 11 and echo virus *** inadequate coverage of vaccine protection,the geographical diversity,and changing spectrum of HFMD etiology still challenge the comprehensive HFMD prevention and control in *** regarding the broad feature of HFMD epidemiology,and the shifting of viral genetic diversity and evolution dynamic as EV-71 vaccination progressing,are still ***,we conducted a comprehensive retrospective analysis on the epidemiological and etiological characteristics of HFMD in Sichuan Province from 2014 to 2019 before and after the introduction of EV-71 vaccines,which was expected to help better HFMD prevention and control in this area.

关键词： enterovirus prevention epidemiology

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Single-atom sites on perovskite chips for record-high sensitivity and quantification in SERS

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Science China Materials 2022年第6期65卷 1601-1614页

作者： Ran Feng Qing Miao Xiang Zhang Peixin Cui Cong Wang Yibo Feng Liyong Gan Jiaxing Fu Shibo Wang Ziyi Dai Liming Hu Yunjing Luo Weihai Sun Xiaoxian Zhang Jiawen Xiao Jinbo Wu Bingpu Zhou Mingqiang Zou Dawei He Xiaoyuan Zhou Xiaodong Han Beijing Key Laboratory of Microstructure and Properties of Solids Institute of Microstructure and Property of Advanced MaterialsFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Luminescence and Optical Information Ministry of EducationInstitute of Optoelectronic TechnologyBeijing Jiaotong UniversityBeijing 100044China College of Physics and Center for Quantum Materials and Devices Analytical and Testing CenterChongqing UniversityChongqing 401331China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Faculty of Environment and Life Beijing Key Laboratory of Environmental and OncologyBeijing University of TechnologyBeijing 100124China Materials Genome Institute Shanghai UniversityShanghai 200444China College of Materials science and Engineering Huaqiao UniversityXiamen 361021China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078China Chinese Academy of inspection and quarantine(CAIQ) Beijing 100123China

Surface enhanced Raman scattering(SERS)is a rapid and nondestructive technique that is capable of detecting and identifying chemical or biological *** SERS quantification is vital for practical applications,particularly for portable detection of biomolecules such as amino acids and ***,few approaches can achieve sensitive and quantitative Raman detection of these most fundamental components in ***,a noblemetal-free single-atom site on a chip strategy was applied to modify single tungsten atom oxide on a lead halide perovskite,which provides sensitive SERS quantification for various analytes,including rhodamine,tyrosine and *** single-atom site on a chip can enable quantitative linear SERS responses of rhodamine(10^(−6)-1 mmol L^(−1)),tyrosine(0.06-1 mmol L^(−1))and cytosine(0.2-45 mmol L^(−1)),respectively,which all achieve record-high enhancement factors among plasmonic-free *** experimental test and theoretical simulation both reveal that the enhanced mechanism can be ascribed to the controllable single-atom site,which can not only trap photoinduced electrons from the perovskite substrate but also enhance the highly efficient and quantitative charge transfer to ***,the label-free strategy of single-atom sites on a chip can be applied in a portable Raman platform to obtain a sensitivity similar to that on a benchtop instrument,which can be readily extended to various biomolecules for low-cost,widely demanded and more precise point-of-care testing or in-vitro detection.

关键词： SERS single-atom site point-of-care testing in-vitro diagnosis charge-transfer mechanism lead halide perovskite

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A Simple and Reliable Assay for Detecting Specifi c Nucleotide Sequences in Plants Using Optical Thin-fi lm Biosensor Chips

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分子植物育种 2007年第2期5卷 241-241页

作者： S. Bai　 X. Zhong　 L. Ma 　W. Zheng　 L. Fan N. Wei　 X.W. Deng Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology and The National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing100871 China Dopartment of Pharmacology Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS 66160 USA Tianjin Custom inspection and quarantine bureau of the People＇s Republic of China Tianjin 300201 China Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06520-8104 USA

Here we report the adaptation and optimization of an effi cient, accurate and inexpensive assay that employs custom-designed silicon-based optical thin-fi lm biosensor chips to detect unique transgenes in genetically ... 详细信息

关键词：核苷酸生物传感器植物实验研究

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钙钛矿上单原子位点实现高灵敏定量化表面拉曼增强（英文）

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Science China Materials 2022年

作者：冯冉苗清张翔崔培昕王聪冯奕博甘立勇傅加兴王仕博戴子忆胡利明罗云敬孙伟海张小娴肖家文巫金波周冰朴邹明强何大伟周小元韩晓东 Beijing Key Laboratory of Microstructure and Properties of Solids Institute of Microstructure and Property of Advanced Materials Faculty of Materials and Manufacturing Beijing University of Technology Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University College of Physics and Center for Quantum Materials and Devices Analytical and Testing Center Chongqing University Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Science Chinese Academy of Sciences Materials Genome Institute Shanghai University College of Materials science and Engineering Huaqiao University Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of Macau Faculty of Environment and Life Beijing Key Laboratory of Environmental and Oncology Beijing University of Technology Chinese Academy of inspection and quarantine (CAIQ)

表面增强拉曼散射（SERS）是一种快速且无损的化学和生物分子检测技术.高灵敏且定量化的SERS检测技术对其在实际中的应用至关重要,尤其是对生物分子如氨基酸和碱基的便携化检测.但是鲜有技术手段能够实现对这些最基本的生物分子进行高...

表面增强拉曼散射（SERS）是一种快速且无损的化学和生物分子检测技术.高灵敏且定量化的SERS检测技术对其在实际中的应用至关重要,尤其是对生物分子如氨基酸和碱基的便携化检测.但是鲜有技术手段能够实现对这些最基本的生物分子进行高灵敏且定量化的拉曼检测.我们提出了一种无需贵金属的单原子位点修饰芯片策略,用钨单原子氧化物修饰铅卤钙钛矿芯片,实现了多种检测物的高灵敏定量化识别,包括罗丹明、酪氨酸和胞嘧啶.芯片上单原子位点技术能够实现对罗丹明、酪氨酸和胞嘧啶的线性检测,相应的定量化区间分别为:10;–1 mmol L;, 0.06–1 mmol L;和0.2–45 mmol L;,同时我们的拉曼增强芯片对这三种分子的增强因子在非等离子激元半导体中是最高的.我们通过实验测试结合理论模拟揭示了由可控单原子位点实现拉曼增强的机理:束缚由钙钛矿基底产生的光生电子,同时高效且定量地将这些电子转移到待测分子上.不仅如此,芯片上单原子位点技术可以在便携式拉曼设备下得到与台式拉曼设备类似的增强效果,这意味着这项技术有机会应用于多种生物分子的低成本、广谱、即时检测和体外检测.

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Impact of Oriental Fruit Fly Postharvest Treatments on Avocado

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American Journal of Plant Sciences 2017年第3期8卷 549-560页

作者： Daniel Carrillo Amy Roda Clara Sarmiento Armando Monterroso Xiqui Wei Teresa I. Narvaez Jeff Crawford William Guyton Alan Flinn Don Pybas Woodard D. Bailey Department of Entomology and Nematology Tropical Research and Education Center University of Florida-Institute of Food and Agricultural Sciences Homestead FL USA United States Department of Agriculture-Animal and Plant Health inspection Service Center for Plant Health Science and Technology Miami FL USA Brooks Tropicals LLC. Homestead FL USA Avocado Administrative Committee Homestead FL USA

The detection in August 2015 of the Oriental Fruit Fly (Bactrocera dorsalis Hendel, Diptera: Tephritidae) in the Redland area in Miami-Dade County, Florida triggered a quarantine that restricted the movement of fruit fly host material in an approximately 99-square mile (256-square kilometer) area. The quarantine affected 4000 acres of fruit bearing commercial avocado groves. Approved post-harvest treatments for B. dorsalis and avocado included in the USDA Treatment Manual were acceptable for immediate certification and movement of fresh avocados from the quarantine area. However, it was unknown if Florida avocados would meet quality standards (US combination grade) after the treatments. Three post-harvest treatments that combine methyl bromide fumigation and cold storage periods were tested on six avocado varieties from Florida. The treatments differed in the durations of the fumigation and cold treatment periods. A seven day transit period at 8.3°C (47°F) was added to account for the time when the fruit leaves the packing house until it is sold by retailers. None of the six varieties had met the US combination grade after the treatments and transit period. Treated fruit exhibited both internal (pulp) and external (skin) damage. Damage was attributed to the fumigation component of the treatment, but the six varieties tolerated the cold portion of the treatment. Damage by fumigation ranged from 26% - 100%. In general, the longer the fumigation period the worse the effect. The need for alternative post-harvest treatments for Florida avocados is discussed.

关键词： Bactrocera dorsalis Persea americana Postharvest quarantine Fumigation

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Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2022年第6期117卷 1-272页

作者： Ruvishika S.Jayawardena Kevin D.Hyde Song Wang Ya‑Ru Sun Nakarin Suwannarach Phongeun Sysouphanthong Mohamed A.Abdel‑Wahab Faten A.Abdel‑Aziz Pranami D.Abeywickrama Vanessa P.Abreu Alireza Armand AndréAptroot Dan‑Feng Bao Dominik Begerow Jean‑Michel Bellanger Jadson D.P.Bezerra Digvijayini Bundhun Mark S.Calabon Ting Cao Taimy Cantillo João LVRCarvalho Napalai Chaiwan Che‑Chih Chen Régis Courtecuisse Bao‑Kai Cui Ulrike Damm Cvetomir M.Denchev Teodor T.Denchev Chun Y.Deng Bandarupalli Devadatha Nimali Ide Silva Lidiane Ados Santos Nawal K.Dubey Sylvain Dumez Himashi SFerdinandez André L.Firmino Yusufon Gaforov Achala J.Gajanayake Deecksha Gomdola Sugantha Gunaseelan Shucheng‑He Zin H.Htet Malarvizhi Kaliyaperumal Martin Kemler Kezhocuyi Kezo Nuwan DKularathnage Marco Leonardi Ji‑Peng Li Chunfang Liao Shun Liu Michael Loizides Thatsanee Luangharn Jian Ma Hugo Madrid S.Mahadevakumar Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda María P.Martín Niranjan Mekala Pierre‑Arthur Moreau Yan‑Hong Mu Pasouvang Pahoua Dhandevi Pem Olinto L.Pereira Wiphawanee Phonrob Chayanard Phukhamsakda Mubashar Raza Guang‑Cong Ren Andrea C.Rinaldi Walter Rossi Binu C.Samarakoon Milan CSamarakoon Vemuri V.Sarma Indunil C.Senanayake Archana Singh Maria F.Souza Cristina M.Souza‑Motta Adriano A.Spielmann Wenxin Su Xia Tang XingGuo Tian Kasun M.Thambugala Naritsada Thongklang Danushka S.Tennakoon Nopparat Wannathes DingPeng Wei Stéphane Welti Subodini N.Wijesinghe Hongde Yang Yunhui Yang Hai‑Sheng Yuan Huang Zhang Jingyi Zhang Abhaya Balasuriya Chitrabhanu SBhunjun Timur S.Bulgakov Lei Cai Erio Camporesi Putarak Chomnunti Y.S.Deepika Mingkwan Doilom Wei‑Jun Duan Shi‑Ling Han Naruemon Huanraluek EBGareth Jones NLakshmidevi Yu Li Saisamorn Lumyong Zong‑Long Luo Surapong Khuna Jaturong Kumla Ishara S.Manawasinghe Ausana Mapook Wilawan Punyaboon Saowaluck Tibpromma Yong‑Zhong Lu JiYe Yan Yong Wang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouChina Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Biotechnology and Ecology Institute Ministry of Agriculture and ForestryP.O.Box:811Vientiane CapitalLao PDR Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Beijing Key Laboratory of Environment-Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Departamento de Fitopatologia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMato Grosso do Sul CEP 79070-900Brazil College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanChina Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Institute of Plant Science and Microbiology Universität HamburgOrganismic Botany and MycologyOhnhorststr.1822609 HamburgGermany CEFE CNRSUniv.MontpellierEPHEIRDINSERM1919Route de Mende34293 Montpellier Cedex 5France Setor de Micologia Departamento de Biociências e TecnologiaInstituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásRua 235S/NSetor UniversitárioGoiâniaGO CEP:74605-050Brazil Division of Biological Sciences College of Arts and SciencesUniversity of the Philippines Visayas5023 MiagaoIloiloPhilippines CA

This article is the 14th in the Fungal Diversity Notes series,wherein we report 98 taxa distributed in two phyla,seven classes,26 orders and 50 families which are described and *** in this study were collected from Australia,Brazil,Burkina Faso,Chile,China,Cyprus,Egypt,France,French Guiana,India,Indonesia,Italy,Laos,Mexico,Russia,Sri Lanka,Thailand,and *** are 59 new taxa,39 new hosts and new geographical distributions with one new *** 59 new species comprise Angustimassarina kunmingense,Asterina lopi,Asterina brigadeirensis,Bartalinia bidenticola,Bartalinia caryotae,Buellia pruinocalcarea,Coltricia insularis,Colletotrichum fexuosum,Colletotrichum thasutense,Coniochaeta caraganae,Coniothyrium yuccicola,Dematipyriforma aquatic,Dematipyriforma globispora,Dematipyriforma nilotica,Distoseptispora bambusicola,Fulvifomes jawadhuvensis,Fulvifomes malaiyanurensis,Fulvifomes thiruvannamalaiensis,Fusarium purpurea,Gerronema atrovirens,Gerronema favum,Gerronema keralense,Gerronema kuruvense,Grammothele taiwanensis,Hongkongmyces changchunensis,Hypoxylon inaequale,Kirschsteiniothelia acutisporum,Kirschsteiniothelia crustaceum,Kirschsteiniothelia extensum,Kirschsteiniothelia septemseptatum,Kirschsteiniothelia spatiosum,Lecanora immersocalcarea,Lepiota subthailandica,Lindgomyces guizhouensis,Marthe asmius pallidoaurantiacus,Marasmius tangerinus,Neovaginatispora mangiferae,Pararamichloridium aquisubtropicum,Pestalotiopsis piraubensis,Phacidium chinaum,Phaeoisaria goiasensis,Phaeoseptum thailandicum,Pleurothecium aquisubtropicum,Pseudocercospora vernoniae,Pyrenophora verruculosa,Rhachomyces cruralis,Rhachomyces hyperommae,Rhachomyces magrinii,Rhachomyces platyprosophi,Rhizomarasmius cunninghamietorum,Skeletocutis cangshanensis,Skeletocutis subchrysella,Sporisorium anadelphiae-leptocomae,Tetraploa dashaoensis,Tomentella exiguelata,Tomentella fuscoaraneosa,Tricholomopsis lechatii,Vaginatispora favispora and Wetmoreana *** new combin

关键词： 59 New taxa 39 New records Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Sordariomycetes Ustilaginomycotina

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