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Experience and practice of the Emergency Operations centerz Chinese center for disease control and prevention:a case study of response to the H7N9 outbreak

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Infectious diseases of Poverty 2021年第1期10卷 87-94页

作者： Fan Ding Qun Li Lian-Mei Jin Public Health Emergency center Chinese Center for Disease Control and PreventionBeijingChina

Background:Emergency Operations center(EOC)is a place to provide response to public health *** center for disease control and prevention(China CDC)'s EOC was officially established in 2016,which has been the core department for the public health emergencies and risk *** recent years,we have been continuously improving the function of EOC through many *** the study,we hope to share the construction status,operation management experience of China CDC's EOC and the response process in the human avian influenza A(H7N9)*** text:The China CDC's EOC mainly focus on building the five core elements including sites/places and facilities,information and data,plans and procedures,training and exercises,and *** on summarizing previous emergency respons巳the China CDC's EOC established its own incident management and the standardized response *** event-specific data,context-specific data and event management data could be obtained through various *** logistics department of the EOC also provides comprehensive *** well-trained staff is another necessary conditions for its *** sharing the response process of H7N9 outbreak,it further explains the EOC's functions in the five phases of outbreak response,such as the formulation of the incident response framework,monitoring,personnel dispatch and resource ***:The EOC con tributes to faster and more efficient responses during emergencies which en able a greater reduction in morbidity and *** with the traditional incident response process,under the command and coordination of China CDC's EOC,each group involved in the response has a clearer goal,responsibilities and tasks at each ***,each group also gave full play to its own expertise and *** a whole,incident response tended to be more specialized and precise,which generally improves the efficiency of incident ***,different co

关键词： Emergency Operations center Practice Response Plan Human avian influenza A(H7N9)

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China Stroke Statistics 2019:A Report From the National center for Healthcare Quality Management in Neurological diseases,China National Clinical Research center for Neurological diseases,the Chinese Stroke Association,National center for Chronic and Non-communicable disease control and prevention,Chinese center for disease control and prevention and Institute for Global Neuroscience and Stroke Collaborations

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Stroke & Vascular Neurology 2020年第3期5卷 211-239页

作者： Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee China National Clinical Research center for Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National center for Healthcare Quality Management in Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National center for Chronic and Non-communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Neurology and Stroke center The First Affiliated HospitalJinan UniversityGuangzhouGuangdongChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA 不详

China faces the greatest challenge from stroke in the *** death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in *** ranked third among the leading causes of death behind malignant tumours and heart *** age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,*** to the Global Burden of disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in *** absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in *** main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over *** on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco *** those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during *** those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age

关键词： admitted smoke insurance

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou center for disease control and prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation center for prevention and control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Seventy years’ achievements of international cooperation by the National Institute of Parasitic diseases at the Chinese center for disease control and prevention

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Infectious diseases of Poverty 2020年第6期9卷 1-4页

作者： Ru-Bo Wang Yi-Ting Hong Xiao-Nong Zhou National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention Chinese center for Tropical diseases Research WHO Collaborating Centre for Tropical diseases National center for International Research on Tropical diseases Ministry of Science and Technology Key Laboratory of Parasite and Vector Biology Ministry of HealthShanghaiChina

Background: With the promotion of national control programs on parasitic and tropical diseases in China,the National Institute of Parasitic diseases(NIPD),Chinese center for disease control and prevention has gained significant experience in the global health arena through international cooperation over the last seven decades allowing a multilateral impact in the elimination of major endemic ***:: The achievements of NIPD since 1950 has been analyzed with emphasis on the various stages that started with research and control of the endemic parasitic and other tropical diseases at the national level and progressed via international cooperation into a global ***: The major achievements contributed by NIPD consist of(i)improving technical capability;(ii)promoting control and elimination of parasitic and tropical diseases;(iii)participating in global health governance and cooperation;and(iv)developing a cooperation model for technical assistance and global public health *** is expected that NIPD’s experience of international cooperation will be essential for the dissemination of China's successful experience in global health governance,emergency response and development,with focus on malaria and neglected tropical diseases such as schistosomiasis,soil-borne and food-borne helminthiases and ***: NIPD’s new tasks will not only continue to promote national control of endemic parasitic infections and disease elimination programs in China,but also play a leading role in global health and disease elimination programs in the future.

关键词： Seventy years International cooperation The National Institute of Parasitic diseases

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第01期 303-305页

作者： Ziqian Xu Lianpan Dai Jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan center for disease control and prevention Chengdu CitySichuan ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Suqian center for disease control and prevention Suqian CityJiangsu ProvinceChina Jiangsu center for disease control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Shandong center for disease control and prevention Jinan CityShandong ProvinceChina Anhui center for disease control and prevention Hefei CityAnhui ProvinceChina hubei center for disease control and prevention Wuhan CityHubei ProvinceChina Hunan center for disease control and prevention Changsha CityHunan ProvinceChina Guizhou center for disease control and prevention Guiyang CityGuizhou ProvinceChina Gansu center for disease control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

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Pollution of HCHs,DDTs and PCBs in tidal flat of Hangzhou Bay 2009–2013

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Chinese Journal of Oceanology and Limnology 2016年第3期34卷 539-548页

作者：赵鹏龚文杰毛国华李继革徐奋奋施家威 Jiangbei center for disease control and prevention Ningbo Cixi center for disease control and prevention Ningbo Ningbo Municipal center for disease control and prevention Ningbo

The concentration and distribution of three persistent organic pollutants （hexachlorocyclohexanes （HCHs）, dichlorodiphenyltrichloroethanes （DDTs） and polyehlorinated biphenyls （PCBs）） was assessed in tidal fiat sediments collected from the south bank of Hangzhou Bay, China from 2009 to 2013. Gas chromatography coupled to triple quadrupole mass spectrometry （GC-MS/MS） was used for analysis, based on United States Environmental Protection Agency methods EPAS080A, EPA8081B, and EPA3550B. The results showed that the levels of HCHs, DDTs and PCBs decreased in the order of DDTs 〉 HCHs 〉 PCBs, and their mass fractions ranged from 0.29-32.91, 0.09-13.19 and 0.16-4.10 ktg/kg （dry mass）, respectively. The levels of HCHs, DDTs and PCBs decreased slowly from 2009 to 2013, with considerably greater concentrations in winter than in spring and summer. In this study area, the concentrations of DDTs and HCHs decreased gradually towards the mouth of Hangzhou Bay, while the concentrations of PCBs were related to changes in the local economy. In addition, the sources of HCHs and DDTs were identified as atmospheric precipitation and historical residues, Finally, we predicted that PCBs pollution primarily originated from Aroclor 1254（Lot A4）, which might root in the illegal demolition and stacking of abandoned paint, transformer or electronic equipment in the south bank of Hangzhou Bay.

关键词： South Bank of Hangzhou Bay sediment hexachlorocyclohexanes (HCHs) dichlorodiphenyltrichloroethanes (DDTs) polychlorinated biphenyls (PCBs)

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An Outbreak of NCIP (2019-nCoV) Infection in China --Wuhan, hubei Province, 2019−2020

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China CDC weekly 2020年第5期2卷 79-80页

作者： The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team Qun Li Chinese center for disease control and prevention BeijingChina hubei Provincial center for disease control and prevention WuhanHubeiChina Wuhan Municipal center for disease control and prevention WuhanHubeiChina.

Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of cases of viral pneumonia of unknown etiology(VPUE),now known as novel coronavirus-infected pneumonia(NCIP),occurred in Wuhan,hubei Province and was reported to health authorities on December 29,2019(2).A national,provincial,and municipal joint investigation team has been assembled to conduct field investigations and implement disease control and prevention *** report shows interim results of the investigation and makes recommendations for response measures.

关键词： prevention Wuhan hubei

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Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng Sun Ying Bao Leijin Mao Lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Gansu center for disease control and prevention Lanzhou CityGansu ProvinceChina hubei center for disease control and prevention Wuhan CityHubei ProvinceChina Shandong center for disease control and prevention Jinan CityShandong ProvinceChina Sichuan center for disease control and prevention Chengdu CitySichuan ProvinceChina Anhui center for disease control and prevention Hefei CityAnhui ProvinceChina Guizhou center for disease control and prevention Guiyang CityGuizhou ProvinceChina Hunan center for disease control and prevention Changsha CityHunan ProvinceChina Jiangsu center for disease control and prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

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