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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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Joint Spectrum Partition and Performance Analysis of Full-Duplex D2D Communications in Multi-Tier Wireless Networks

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Computers, Materials & Continua 2019年第7期61卷 171-184页

作者： Yueping Wang Xuan Zhang Yixuan Zhang Nanjing University of Aeronautics and Astronautics NanjingChina huawei Corporation NanjingChina huawei research center Singapore

Full-duplex(FD)has been recognized as a promising technology for future 5G networks to improve the spectrum ***,the biggest practical impediments of realizing full-duplex communications are the presence of self-interference,especially in complex cellular *** the current development of self-interference cancellation techniques,full-duplex has been considered to be more suitable for device-to-device(D2D)and small cell communications which have small transmission range and low transmit *** this paper,we consider the full-duplex D2D communications in multi-tier wireless networks and present an analytical model which jointly considers mode selection,resource allocation,and power ***,we consider a distance based mode selection *** performance analysis of different D2D communications modes are performed based on stochastic geometry,and tractable analytical solutions are *** we investigate the optimal resource partitions between dedicated D2D mode and cellular *** results validate the theoretical anlaysis and indicate that with appropriate proportions of users operated in different transmission modes and optimal partitioning of spectrum,the performance gain of FD-D2D communication can be achieved.

关键词： Full-duplex device-to-device communications HetNets power control spectrum partition

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Privacy-Aware Service Subscription in People-Centric Sensing:A Combinatorial Auction Approach

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Computers, Materials & Continua 2019年第7期61卷 129-139页

作者： Yuanyuan Xu Shan Li Yixuan Zhang Hohai University Nanjing211100China Nanjing University of Aeronautics and Astronautics Nanjing211106China huawei research center singapore Metropolis Tower 2Singapore

With the emergence of ambient sensing technologies which combine mobile crowdsensing and Internet of Things,large amount of people-centric data can be obtained and utilized to build people-centric *** that the service quality is highly related to the privacy level of the *** this paper,we investigate the problem of privacy-aware service subscription in people-centric *** efficient resource allocation framework using a combinatorial auction(CA)model is ***,the resource allocation problem that maximizes the social welfare in view of varying requirements of multiple users is formulated,and it is solved by a proposed computationally tractable solution ***,the prices of allocated resources that winners need to pay are figured out by a designed *** results demonstrate the effectiveness of the proposed scheme.

关键词： Privacy-aware service subscription combinatorial auction winner determination

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Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China research center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

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Space efficient revocable IBE for mobile devices in cloud computing

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Science China(Information Sciences) 2020年第3期63卷 282-284页

作者： Baodong QIN Ximeng LIU Zhuo WEI Dong ZHENG National Engineering Laboratory for Wireless Security Xi'an University of Posts and Telecommunications State Key Laboratory of Cryptology School of Information Systems Singapore Management University huawei singapore research center

Dear editor,Revocation capacity is one of the main properties for an identity-based encryption(IBE), as in practice users’ private keys are possibly leaked or expired. However, existing revocable IBE schemes [1–3] usually lack of short keys. Recently, Lin et al. [4] proposed a method to design space efficient revocable IBE scheme from

关键词： IBE Space efficient revocable IBE for mobile devices in cloud computing

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Double-authentication-preventing signatures revisited:new definition and construction from chameleon hash

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 176-186页

作者： Fei LI Wei GAO Gui-lin WANG Ke-fei CHEN Chun-ming TANG School of Mathematics and Statistics Ludong University Key Laboratory of Information Security Guangzhou University China-USA Computer Science research center Nanjing University of Information Science and Technology Shield Lab Singapore Research Center of Huawei Department of Mathematics Hangzhou Normal University

Double-authentication-preventing signature(DAPS) is a novel signature notion proposed at ESORICS2014. The double-authentication-preventing property means that any pair of signatures on two different messages with the same subject will result in an immediate collapse of the signature system. A few potential applications of DAPS have been discussed by its inventors, such as providing a kind of self-enforcement to discourage certificate authority(CA) from misbehaving in public key infrastructure and offering CA some cryptographic arguments to resist legal coercion. In this study, we focus on some fundamental issues on DAPS. We propose a new definition,which is slightly weakened but still reasonable and strong enough to capture the DAPS concept. We develop the new notion of invertible chameleon hash functions with key exposure. Then we propose a generic DAPS scheme, which is provably secure if the underlying invertible chameleon hash function with key exposure is secure. We instantiate this general construction to obtain the DAPS schemes respectively based on the well-known assumptions of integer factorization, Rivest-Shamir-Adleman(RSA), and computational Diffie-Hellman(CDH). They are more efficient than previous DAPS schemes. Furthermore, unlike previous constructions, the trusted setup condition is not needed by our DAPS schemes based on RSA and CDH.

关键词： Double-authentication-preventing signatures Chameleon hash function Digital signature Provable security Authority trust level

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Flow field generated by a dielectric barrier discharge plasma actuator in quiescent air at initiation stage

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Chinese Journal of Aeronautics 2021年第3期34卷 13-24页

作者： Xin ZHANG Y.D.CUI Chien Ming Jonathan TAY B.C.KHOO State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000China National University of singapore Singapore 119260Singapore

A single Dielectric Barrier Discharge(DBD) plasma actuator driven by Alternating Current(AC) power, capable of inducing a starting vortex and a wall jet in quiescent air, is suited for low-Reynolds-number flow control. However, the starting vortex and the wall jet are usually observed after the plasma actuator has been operated for dozens of and hundreds of cycles of the voltage, respectively. The detail of the induced flow field at the initiation stage of the plasma actuator has rarely been addressed. At the initiation stage, a thin jet that provides the impetus for the entrainment of the induced flow at the beginning of the plasma actuation is first observed by using a high-accuracy phase-lock Schlieren technique and a high-speed Particle Image Velocimetry(PIV) system. This is the initial form of the momentum transfer from the plasma to the ***, an arched type jet is created by the plasma actuator. In addition, the whole development process of the induced flow field from the starting point of the thin jet to the quasi-steady stage of wall jet is presented for providing a comprehensive understanding of the plasma actuator and proposing a relevant enhancement of the numerical simulation model.

关键词： Dielectric barrier discharge Particle image velocimetry Plasma actuator Schlieren technique Wall jet

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Application of proteomics in environmental science

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Frontiers of Environmental Science & Engineering 2009年第4期3卷 393-403页

作者： Xiaona CHU Jiangyong HU Say Leong ONG center for Water research Division of Environmental Science and Engineering National University of Singapore10 Kent Ridge CrescentSingapore 119260Singapore

Proteomics involves the separation of proteins,identification of the amino acid sequence of the interested or target proteins,study of the function of the proteins,modification,structure and ultimate assignments to functional pathways in the *** proteomic investigations have contributed greatly to human diseases studies,new drugs discovery researches,and environmental science in recent *** article provides a review on the development of the main proteomic technologies,including both the gel based and non-gel based technologies,and their applications in environmental *** technologies have been utilized in the environmental stresses studies to analyze the induction or reduction of proteins at expression level and identify the target proteins to investigate their function in response to environmental stresses,such as high or low pH,oxidation stress,and toxic *** protein responses are also helpful to understand the mechanisms of some cellular activities and the functions of some proteins.

关键词： proteomics environmental stress two dimensional(2D)gel electrophoresis mass spectrometry

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