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Probing the Bardeen-Kiselev black hole with the cosmological constant caused by Einstein equations coupled with nonlinear electrodynamics using quasinormal modes and greybody bounds

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Communications in Theoretical Physics 2024年第6期76卷 102-119页

作者： S R wu B Q Wang Z W Long College of Physics Guizhou UniversityGuiyang 550025China College Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this work,we investigate a static and spherically symmetric Bardeen-Kiselev black hole(BH)with the cosmological constant,which is a solution of the Einstein-non-linear Maxwell field *** compute the quasinormal frequencies for the Bardeen-Kiselev BH with the cosmological constant due to electromagnetic and gravitational *** varying the BH parameters,we discuss the behavior of both real and imaginary parts of the BH quasinormal frequencies and compare these frequencies with the Reissner-Nordström-de Sitter BH surrounded by quintessence(RN-dSQ).Interestingly,it is shown that the responses of the Bardeen-Kiselev BH with the cosmological constant and the RN-dSQ under electromagnetic perturbations are different when the charge parameter q,the state parameter w and the normalization factor c are varied;however,for the gravitational perturbations,the responses of the Bardeen-Kiselev BH with the cosmological constant and the RN-dSQ are different only when the charge parameter q is ***,compared with the gravitational perturbations,the electromagnetic perturbations can be used to understand nonlinear and linear electromagnetic fields in curved spacetime *** interesting observation is that,due to the presence of Kiselev quintessence,the electromagnetic perturbations around the Bardeen-Kiselev BH with the cosmological constant damps faster and oscillates slowly;for the gravitational perturbations,the quasinormal mode decays slowly and oscillates *** also study the reflection and transmission coefficients along with the absorption cross section in the Bardeen-Kiselev BH with the cosmological constant;it is shown that the transmission coefficients will increase due to the presence of Kiselev quintessence.

关键词： quasinormal modes greybody factors Bardeen-Kiselev black hole with cosmological constant

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Differences in the Origin of Philosophy between chinese medicine and Western medicine:Exploration of the Holistic Advantages of chinese medicine

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chinese Journal of Integrative medicine 2013年第9期19卷 706-711页

作者：孙大志李绍旦刘毅张印梅荣杨明会 Department of traditional chinese medicine Changzheng HospitalSecond Military Medical University institute of traditional chinese medicine Research General Hospital

To explore advantages of chinese medicine （CM） by analyzing differences in the origin of philosophy for human health between CM and Westem medicine （WM）. Methodologically, a distinctive feature of CM is its systems theory, which is also the difference between CM and WM. Since the birth of CM, it has taken the human body as a whole from the key concepts of ＂qi, blood, yin-yang, viscera （Zang-Fu）, and meridian and channel＂, rather than a single cell or a particular organ. WM evolves from the Westem philosophic way of thinking and merely uses natural sciences as the foundation. The development of WM is based on human structures, or anatomy, and therefore, research of WM is also based on the way of thinking of decomposing the whole human body into several independent parts, which is the impetus of promoting the development of WM. The core of CM includes the holistic view and the dialectical view. chinese herbal medicines contain various components and treat a disease from multiple targets and links. Therefore, chinese herbal medicines treat a diseased state by regulating and mobilizing the whole body rather than just regulating a single factor, since the diseased state is not only a problem in a local part of the body but a local reflection of imbalance of the whole body.

关键词： chinese medicine Western medicine philosophy differences integration

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Cupping therapy can improve the quality of life of healthy people in Tehran

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Journal of traditional chinese medicine 2017年第4期37卷 558-562页

作者： Gholamreza Kordafshari Mohammad Reza Shams Ardakani Mansoor Keshavarz Mohammad Mehdi Esfahani Ismaeel Nazem Maryam Moghimi Arman Zargaran Hoorieh Mohammadi Kenari Department of traditional medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Department of traditional Pharmacy School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Hadis and Teb Sciences Research Center Tehran University of Medical Sciences Tehran *** Iran Research Office for the History of Persian medicine Shiraz University of Medical Sciences Shiraz *** Iran Research institute for Islamic and Complementary medicine School of Iranian Traditional Medicine Iran University of Medi- cal SciencesTeh ran *** Iran

OBJECTIVE: To examine the influence of cupping on the quality of life of healthy people who referred to traditional Persian medicine clinics in ***: All participants were examined by traditional Persian medicine specialists and their temperaments were determined. The area between the shoulders was cleaned, and cupping was performed with a disposable cupping glass for a few minutes. The questionnaire used in this project was the Persian version of the SF-36 questionnaire which assesses people's understanding of their health status. Before cupping and then one monthafter cupping, all participants were called and the questionnaires were completed again. Finally, all given data was ***: From a total of 290 questionnaires completed in the first phase of the project, 112 patients were excluded. Ultimately, the data of 178 participants was analyzed. After one month, the quality of life score of 155 participants(88%) increased, remained unchanged for 21 participants(11.7%), and decreased for 2 participants(1.1%). Asked about possible complications from cupping, 160 participants reported no side effects(89.9%).CONCLUSION: Our findings suggest that cupping therapy can improve the scores of quality of life in the participants in Tehran.

关键词： Persian medicine Hijama Cupping therapy Quality of life

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Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet

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World Journal of Hepatology 2023年第9期15卷 1043-1059页

作者： Yun-Kai Dai Hai-Na Fan Kai Huang Xin Sun Zhi-Min Zhao Cheng-Hai Liu Shuguang Hospital Affiliated to Shanghai University of traditional chinese medicine Institute of Liver DiseasesShanghai 201203China Shanghai Key Laboratory of traditional chinese Clinical medicine Institute of Liver DiseasesShanghai 201203China Key Laboratory of Liver and Kidney Diseases Institute of Liver DiseasesShanghai 201203China

BACKGROUND After receiving entecavir or combined with FuzhengHuayu tablet(FZHY)treatment,some sufferers with hepatitis B virus(HBV)-related liver fibrosis could achieve a histological improvement while the others may fail to improve even *** metabolomics at baseline in these patients who were effective in treatment remain *** To explore baseline serum metabolites characteristics in *** A total of 132 patients with HBV-related liver fibrosis and 18 volunteers as healthy controls were ***,all subjects were divided into training set and validation ***,the included patients were subdivided into entecavir responders(E-R),entecavir no-responders(E-N),FZHY+entecavir responders(FR),and FZHY+entecavir no-responders(F-N)following the pathological histological changes after 48 wk’***,Serum samples of all subjects before treatment were tested by high performance liquid chromatographytandem mass spectrometry(LC-MS)high-performance *** processing was conducted using multivariate principal component analysis and orthogonal partial least squares discriminant *** tests of selected differential metabolites were used for Boruta analyses and logistic *** As for the intersection about differential metabolic pathways between the groups E-R vs E-N and F-R vs F-N,results showed that 4 pathways including linoleic acid metabolism,aminoacyl-tRNA biosynthesis,cyanoamino acid metabolism,alanine,aspartate and glutamate metabolism were screened *** for the differential metabolites,these 7 intersected metabolites including hydroxypropionic acid,tyrosine,citric acid,taurochenodeoxycholic acid,benzoic acid,2-Furoic acid,and propionic acid were *** Our findings showed that 4 metabolic pathways and 7 differential metabolites had potential usefulness in clinical prediction of the response of entecavir or combined with FZHY on HBV fibrotic liver.

关键词： Serum metabolomics Differential metabolites Therapeutic responders Entecavir FuzhengHuayu tablet Hepatitis B virus-related liver fibrosis

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8-O-4’ Neolignan glycosides from the aerial parts of Matteuccia struthiopteris

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chinese Chemical Letters 2016年第1期27卷 63-65页

作者： Ling-Juan Zhu Fei Yan Jin-Peng Chen Nan Zhang Xue Zhang Xin-Sheng Yao College of traditional chinese Materia Medica Shenyang Pharmaceutical University Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University State Key Laboratory of Bioactive Substance and Function of Natural medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College institute of traditional chinese medicine & Natural Products College of Pharmacy Jinan University

Two new 8-O-4＇ neolignan glycosides, named matteustruthiosides A（1） and B（2） were isolated from the aerial parts of Matteuccia struthiopteris. Their chemical structures were characterized on the basis of various spectroscopic techniques. The absolute configurations of them were determined by experimental circular dichroism（CD） spectra. Compounds 1 and 2 were inactive against influenza A（H1N1） virus in vitro.

关键词： Matteuccia struthiopteris 8-O-4' Neolignan glycosides Matteustruthioside A Matteustruthioside B

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Effect of Roucongrong(Herba Cistanches Deserticolae) on reproductive toxicity in mice induced by glycoside of Leigongteng(Radix et Rhizoma Tripterygii)

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Journal of traditional chinese medicine 2014年第3期34卷 324-328页

作者： Jie Li Di Huang Liqun He Department of traditional chinese medicine Children's Hospital of Shanghai Shanghai Jiao Tong University Department of Nephrology Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai E-institute of traditional chinese medicine Internal medicine of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine

OBJECTIVE： The purpose of this research is to study the effect of Roucongrong （Herba Cistanches Deserticolae） on reproductive toxicity in mice in- duced by a glycoside extracted from Leigongteng （Radix et Rhizoma Tripterygii）（GRT）. METHODS： Forty-eight BALB/c mice were random-ly divided into two groups in the ratio of I ： 3, 12 in one group and 36 in the other. The 12-mouse group was the control group that was intragastrical- ly administered physiological saline for 3 weeks. The 36 mice in the other group were given 30 mg- kg ·^-1 d i GRT for 3 weeks, then randomly divided into 3 subgroups： the model group, GRI group and Roucongrong （Herba Cistanches Deserticolae） group, with 12 mice in each group. In the model group, 0.25 mL physiological saline was intragastri- cally administered; in the GRT group, GRT, 0.25 mL at 30 mg · kg ^-1· d ^-1 was intragastrically adminis- tered once a day; in the Roucongrong （Herba Cis- tanches Deserticolae） group, mice were adminis- tered Roucongrong （Herba Cistanches Deserticolae） decoction equivalent to 0.25 mL at a final dose of *** 1.d.1 crude drug （calculated as per 20 times of 0.5 g· kg^-1. d ^-1 for adults）, and GRT 0.25 mL at 30 mg- kg^-1· d^- 1 daily. After another 3 weeks of exposure, expression levels of the reproduction-re- lated genes DEAD （Asp-Glu-Ala-Asp） box polypep- tide 3, Y-linked, B-cell CLL/lymphoma 6 and Signal transducer and activator of transcription 3 were evaluated. RESULTS： After 6 weeks of GRT treatment, the sper- matogenic cell population in the convoluted tu- bule of testis was in disorder and the tubule cavity expanded. Sertoli cell and Leydig cells exhibited at- rophy or disappeared. The number of sperm de- creased. The spermatogenic cell level of testis for male mice was ranked in order and sperm was pro- duced in the cavity of the spermatogenic cell. The expression levels of DDX3Y, BCL6 and STAT3 were ***： GRT affected reproduction-related genes. Roucongrong （Herba Cistanches Des

关键词： Cistanche deserticola Tripterygium wil-fordii Toxicity Reproduction-related genes Hypo-gonadal model

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Abietane diterpenoids and iridoids from Caryopteris mongolica

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chinese Journal of Natural medicines 2023年第12期21卷 927-937页

作者： ZHANG Shanshan MAO Xudong XU Hongtao WEI Xiaohui CHOU Guixin institute of chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai R&D Center for Standardization of chinese medicines Shanghai 201203China State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris *** intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic *** process was further enhanced by the application of DP4+probability analyses and electronic circular dichroism(ECD)*** isolation and structural elucidation,the cytotoxicity of these compounds was *** them,compound 3 stood out,displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83±1.28μmol·L^(−1).Additionally,compounds 1,2,4,9,and 10 manifested moderate cytotoxic effects on specific cell lines,with IC50 values ranging from 11.7 to 20.9μmol·L^(−1).

关键词： Caryopteris mongolica Abietane diterpenoids Spectroscopic analysis Cytotoxicity

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Relationship between Endogenous Hydrogen Sulfide and Blood Stasis Syndrome Based on the Qi-Blood Theory of chinese medicine

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chinese Journal of Integrative medicine 2013年第9期19卷 701-705页

作者：黎巍威郭浩王学美 Integrated Laboratory of chinese and Western medicine Peking University First Hospital institute of traditional chinese medicine Research Tianjin University of Traditional Chinese Medicine

＂Qi＂ and ＂blood＂ are two essential concepts in chinese medicine （CM）. As qi is intangible, the concept of qi is still controversial between CM and Western medicine. However, the endogenous hydrogen sulfide （H2S） and other gaseous signaling molecules provides a new approach for understanding the essence of qi in CM. Blood stasis syndrome is a common syndrome in CM. According to the CM theory, the incidence of blood stasis syndrome is closely correlated to the reckless movement of qi, as qi and blood are inseparable in regulating physiological functions. In recent years, more and more evidences suggest a close correlation between blood stasis syndrome and microcirculation dysfunction. In this paper, we discuss the relationship between endogenous H2S and blood stasis syndrome based on qi-blood theory of CM. We found that endogenous H2S maybe a material basis in concept of qi in CM, while dysfunctional microcirculation is the pathological basis of the blood stasis syndrome. As qi is closely associated with incidence and progression of blood stasis syndrome, endogenous H2S may play an important role in preventing and treating the blood stasis syndrome by improving the function of microcimulation.

关键词： endogenous hydrogen sulfide qJ-blood theory chinese medicine

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Effect of Aidi injection plus transarterial chemoembolization on primary hepatic carcinoma： a systematic review and Meta-analysis

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Journal of traditional chinese medicine 2017年第5期37卷 567-587页

作者： Shen Zhengjie Gu Wenzhe Cheng Haibo Shen Weixing Sun Dongdong Zeng Yun Tao Lihuiping wu Mianhua First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210046China Department of Medical Oncology Zhangjiagang First People's HospitalZhangjiagang 215600China Jiangsu Collaborative Innovation Center of traditional chinese medicine Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210046China Translational medicine Research Center Nanjing University of Chinese MedicineNanjing 210046China Department of Otolaryngology Zhangjiagang Hospital of Traditional Chinese MedicineZhangjiagang 215600China Nanjing University of chinese medicine Nanjing 210046China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210000China

OBJECTIVE: To assess the efficacy and safety of Aidi injection plus transarterial chemoembolization(TACE) in patients with primary hepatic ***: A comprehensive research of seven electronic databases was performed for comparative studies evaluating Aidi injection combined with TACE for primary hepatic carcinoma until September 2016. Two authors independently extracted data and assessed the methodological quality of the included trials using the Cochrane risk of bias tool from the Cochrane Handbook version 5.1.0. Data was synthesized by using Rev Man 5.3 ***: Forty-nine studies involving 3435 patients met the inclusion criteria, most of which were low methodological quality. Compared with TACE alone, Aidi injection plus TACE can significantly improve the efficiency rate [RR = 1.33, 95% CI(1.24, 1.43), P < 0.000 01], clinical beneficial rate[RR = 1.25, 95% CI(1.17, 1.33), P < 0.000 01], survival rate [6 months, RR = 1.19, 95% CI(1.09, 1.29), P <0.0001], 12 months, [RR = 1.37, 95% CI(1.24, 1.52),P < 0.000 01], 18 months, [RR = 2.00, 95% CI(1.26,3.20), P < 0.004], 24 months, [RR = 1.44, 95% CI(1.22, 1.70), P < 0.0001], 36 months, [RR = 1.50, 95%CI(1.07, 2.11), P = 0.02 < 0.05], quality of life [RR =1.84, 95% CI(1.64, 2.05), P < 0.000 01] and immune function [CD3+, MD = 11.12, 95% CI(7.93, 14.30),P < 0.000 01], CD4 +, [MD = 10.37, 95% CI(7.29,13.45), P < 0.000 01], CD4+/CD8+, [MD = 0.30, 95%CI(0.07, 0.53), P = 0.01 < 0.05], NK, [MD = 7.49, 95%CI(6.64, 8.34), P < 0.000 01]. A significant improvement was also found in improvement of symptoms[RR = 1.64, 95%CI(1.38, 1.94), P < 0.000 01], leukopenia [RR = 0.60, 95% CI(0.54, 0.66), P < 0.000 01],thrombocytopenia [RR = 0.46, 95% CI(0.34, 0.61),P < 0.000 01], nausea and vomiting incidence [RR =0.66, 95% CI(0.54, 0.81), P < 0.0001), liver damage rate [RR = 0.57, 95% CI(0.42, 0.77), P = 0.0003 <0.05), and kidney damage rate [RR = 0.18, 95% CI(0.05, 0.68), P = 0.01 < 0.05].CONCLUSION: The results suggested

关键词： Carcinoma hepatocellular Chemoembolization therapeutic Aidi injection Review Meta-analysis

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TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer’s disease

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Translational Neurodegeneration 2024年第1期13卷 300-323页

作者： Jia Lu Kexin wu Xudong Sha Jiayuan Lin Hongzhuan Chen Zhihua Yu Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai University of traditional chinese medicine Shanghai 201203China

Background Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzhei-mer’s disease(AD).APOE4,the most important genetic risk factor for sporadic AD,encodes apolipoprotein E4,which by itself is a potent modulator of immune ***,little is known about the immune hub that governs the crosstalk between the nervous and the adaptive immune *** receptor potential vanilloid type 1(TRPV1)channel is a ligand-gated,nonselective cation channel with Ca^(2+)permeability,which has been proposed as a neuroprotective target in *** Using Ca^(2+)-sensitive dyes,dynamic changes of Ca^(2+)in microglia were measured,including exogenous Ca^(2+)uptake and endoplasmic reticulum Ca^(2+)*** mRFP-GFP-tagged LC3 plasmid was expressed in microglia to characterize the role of TRPV1 in the autophagic *** analyses and flow cytometry were performed to investigate the effects of APOE4 on brain microglia and T cells from APOE-targeted replacement mice with micro-glia-specific TRPV1 gene *** Both APOE4 microglia derived from induced pluripotent stem cells of AD patients and APOE4-related tauopa-thy mouse model showed significantly increased cholesterol biosynthesis and accumulation compared to their APOE3 ***,cholesterol dysregulation was associated with persistent activation of microglia and elevation of major histocompatibility complex II-dependent antigen presentation in microglia,subsequently accompanied by T cell *** addition,TRPV1-mediated transient Ca^(2+)influx mitigated cholesterol biosynthesis in microglia by suppressing the transcriptional activation of sterol regulatory element-binding protein 2,promoted autophagic activity and reduced lysosomal cholesterol accumulation,which were sufficient to resolve excessive immune response and neurodegeneration in APOE4-related tauopathy mouse ***,microglia-specific deficiency of TRPV1 gene accelerate

关键词： APOE4 Cholesterol TRPV1 Microglia Tau

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