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SUPERCONVERGENCES OF THE ADINI'S ELEMENT FORSECOND ORDER EQUATION

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Journal of Computational Mathematics 1999年第6期17卷 569-574页

作者： Ping Luo(Department of Computer sci.nce and Technology, Qinghua university, Beijing 100084,China)Qun Lin(Institute of syst.ms sci.nce, Academia Sinica, Beijing, 100080, China) Tsing hua Univ Dept Comp Sci & Technol Beijing 100084 Peoples R China Acad Sinica Inst Syst Sci Beijing 100080 Peoples R China

n this papers the asymptotic error expansions of Adini's element for the secondorder imhomogeneous Neumann problem are given and the superconvergence estimations are obtained. Moreover, a numerical example to support ... 详细信息

关键词： Adini's element Superconvergence estimation Asymptotic expansion.

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Comparison of walking quality variables between incomplete spinal cord injury patients and healthy subjects by using a footscan plantar pressure syst.m

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Neural Regeneration Research 2019年第2期14卷 354-360页

作者： Xiang-Nan Yuan Wei-Di Liang Feng-hua Zhou Han-Ting Li Li-Xin Zhang Zhi-Qiang Zhang Jian-Jun Li Rehabilitation Department Shengjing Hospital of China Medical University Department of Orthopedics Shengjing Hospital of China Medical University

The main goal of spinal cord rehabilitation is to restore walking ability and improve walking quality after spinal cord injury(sci.. The spatiotemporal parameters of walking and the parameters of plantar pressure can be obtained using a plantar pressure analysis syst.m. Previous studies have reported step asymmetry in patients with bilateral sci. However, the asymmetry of other parameters in patients with sci.has not been reported. This was a prospective, cross-sectional study, which included 23 patients with sci. aged 48.1 ± 14.5 years, and 28 healthy subjects, aged 47.1 ± 9.8 years. All subjects underwent bare foot walking on a plantar pressure measurement device to measure walking speed and spatiotemporal parameters. Compared with healthy subjects, sci.patients had slower walking speed, longer stride time and stance time, larger stance phase percentage, and shorter stride length. The peak pressures under the metatarsal heads and toe were lower in sci.patients than in healthy subjects. In the heel, regional impulse and the contact area percentage in sci.patients were higher than those in healthy subjects. The symmetry indexes of stance time, step length, maximum force, impulse and contact area were increased in sci.patients, indicating a decline in symmetry. The results confirm that the gait quality, including spatiotemporal variables and plantar pressure parameters, and symmetry index were lower in sci.patients compared with healthy subjects. Plantar pressure parameters and symmetry index could be sensitive quantitative parameters to improve gait quality of sci.patients. The protocols were approved by the Clinical Research Ethics Committee of Shengjing Hospital of China Medical university(approval No. 2015 PS54 J) on August 13, 2015. This trial was registered in the ISRCTN Registry(ISRCTN42544587) on August 22, 2018. Protocol version: 1.0.

关键词： nerve regeneration spinal cord injury walking gait quality plantar pressure syst.m plantar pressure distribution speed plantar pressure impulse contact area symmetry index neural regeneration

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear sci.nce and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China university of sci.nce and Technology ShanghaiChina university of sci.nce and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth sci.nce University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and university of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly university of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan university WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United university Miao-Li Dongguan university of Technology DongguanChina Tsinghua university BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power university BeijingChina Sun Yat-Sen university GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid sci.tillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst.±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid sci.tillator detector

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AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 281页

作者： Dai, Dan-Ling Xie, Chu Zhong, Lan-Yi Liu, Shang-Xin Zhang, Le-Le Zhang, hua Wu, Xing-Ping Wu, Zhou-Ming Kang, Kexin Li, Yan Sun, Ya-Meng Xia, Tian-Liang Zhang, Chen-Song Zhang, Ao Shi, Ming Sun, Cong Chen, Mei-Ling Zhao, Ge-Xin Bu, Guo-Long Liu, Yuan-Tao huang, Kui-Yuan Zhao, Zheng Li, Shu-Xin Zhang, Xiao-Yong Yuan, Yun-Fei Wen, Shi-Jun Zhang, Lingqiang Li, Bin-Kui Zhong, Qian Zeng, Mu-Sheng Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Expt Res State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat sen Univ Sch Med Shenzhen Key Lab Syst Med inflammatory Dis Shenzhen Campus Shenzhen Guangdong Peoples R China Sun Yat sen Univ Collaborat Innovat Ctr Canc Med Dept Clin Lab State Key Lab Oncol South ChinaCanc CtrGuangdong Guangzhou Peoples R China Tsinghua Univ Tsinghua Peking Ctr Life Sci Sch Life Sci State Key Lab Membrane Biol Beijing Peoples R China Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Pathol State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Xiamen Univ Sch Life Sci State Key Lab Cellular Stress Biol Xiamen Fujian Peoples R China Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Liver Surg State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Nucl Med State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Southern Med Univ Guangdong Prov Key Lab Viral Hepatitis Res State Key Lab Organ Failure Res Dept Infect DisNanfang Hosp Guangzhou Peoples R China Sun Yat sen Univ Med Synthet Chem Ctr Guangdong Prov Clin Res Ctr Canc Dept Expt ResCanc Ctr Guangzhou Peoples R China Beijing Inst Lifeom Natl Ctr Prot Sci Beijing State Key Lab Med Prote Beijing Peoples R China

Axis inhibition protein 1 (AXIN1), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify that AXIN1 acts as an effective regulator of antiviral innate immunity against both DNA and RNA virus infections. In the resting state, AXIN1 maintains the stability of the transcription factor interferon regulatory factor 3 (IRF3) by preventing p62-mediated autophagic degradation of IRF3. This is achieved by recruiting ubiquitin-specific peptidase 35 (USP35), which removes lysine (K) 48-linked ubiquitination at IRF3 K366. Upon virus infection, AXIN1 undergoes a phase separation triggered by phosphorylated TANK-binding kinase 1 (TBK1). This leads to increased phosphorylation of IRF3 and a boost in IFN-I production. Moreover, KYA1797K, a small molecule that binds to the AXIN1 RGS domain, enhances the AXIN1-IRF3 interaction and promotes the elimination of various highly pathogenic viruses. Clinically, patients with HBV-associated hepatocellular carcinoma (HCC) who show reduced AXIN1 expression in pericarcinoma tissues have low overall and disease-free survival rates, as well as higher HBV levels in their blood. Overall, our findings reveal how AXIN1 regulates IRF3 signaling and phase separation-mediated antiviral immune responses, underscoring the potential of the AXIN1 agonist KYA1797K as an effective antiviral agent.

关键词： IRF3 immunity separation