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Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade

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Molecular Plant 2024年第10期17卷 1558-1572页

作者： Jordan Powers Xing Zhang Andres VReyes Raul Zavaliev Roni Ochakovski Shou-Ling Xu Xinnian Dong howard Hughes Medical institute Duke UniversityDurhamNC 27708USA University Program in Genetics and Genomics Duke UniversityDurhamNC 27708USA Carnegie institute for Science Stanford UniversityStanfordCA 94305USA

For over 60 years,salicylic acid(SA)has been known as a plant immune signal required for basal and systemic acquired *** activates these immune responses by reprogramming∼20%of the transcriptome through ***,components in the NPR1 signaling hub,which appears as nuclear condensates,and the NPR1 signaling cascade have remained elusive due to difficulties in studying this transcriptional cofactor,whose chromatin association is indirect and likely *** overcome this challenge,we applied TurboID to divulge the NPR1 proxiome,which detected almost all known NPR1 interactors as well as new components of transcription-related *** of new components showed that chromatin remodeling and histone demethylation contribute to SA-induced ***,the NPR1 proxiome has a striking similarity to the proxiome of GBPL3 that is involved in SA synthesis,except for associated transcription factors(TFs),suggesting that common regulatory modules are recruited to reprogram specific transcriptomes by transcriptional cofactors,like NPR1,through binding to unique *** green fluorescent protein-tagged factor cleavage under target and release using nuclease(greenCUT&RUN)analyses showed that,upon SA induction,NPR1 initiates the transcriptional cascade primarily through association with TGACG-binding TFs to induce expression of secondary TFs,predominantly ***,WRKY54 and WRKY70 were identified to play a major role in inducing immune-output genes without interacting with NPR1 at the ***,loss of condensate formation function of NPR1 decreases its chromatin association and transcriptional activity,indicating the importance of condensates in organizing the NPR1 signaling hub and initiating the transcriptional ***,this study demonstrates how combinatorial applications of TurboID and stepwise greenCUT&RUN transcend traditional genetic methods to globally map signaling hubs and transcriptional cascades for in

关键词： salicylic acid-induced transcription NPR1 TGA WRKY TFs greenCUT&RUN TurbolD

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra

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Signal Transduction and Targeted Therapy 2016年第1期1卷 75-80页

作者： Scott Ayton Peng Lei Catriona Mclean Ashley I Bush David I Finkelstein The florey institute for Neuroscience and Mental Health The University of MelbourneParkvilleVictoriaAustralia Department of Neurology State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduSichuanChina The Alfred Hospital Department of Anatomical PathologyMelbourneVictoriaAustralia

Iron deposition in Parkinson’s disease(PD)is a potential disease-modifying *** previously showed that supplementation of the iron-exporter,ceruloplasmin,selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)*** delivers iron to transferrin(Tf),the extracellular iron-transporting *** show that Tf protein levels are decreased in the nigra of post-mortem PD brains compared with controls(−35%;n=10 each).Because Tf traffics iron away from iron-replete tissues,we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in *** cultured neurons,Tf treatment corrected iron accumulation,and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the MPTP model of *** these data support a role for Tf in the disease mechanism for PD,and its potential use for correcting disorders of iron overload,Tf therapy also caused systemic iron depletion,which could limit its application for PD.

关键词： corrected sized deficient

iBioChina and iBiology: spreading scientific knowledge together

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Science China(Life Sciences) 2015年第11期58卷 1180-1182页

作者： DELL Karen R VALE Ronald D i Biology University of California howard Hughes Medical institute Department of Cellular and Molecular PharmacologyUniversity of California

It is becoming increasingly important for the public to un- derstand how new scientific information and technology impact their lives and how scientists obtain new knowledge. Without this understanding, how do people know if global warming is real or if it is safe to eat genetically modified crops？ Dr. Chen ZhangLiang, the Vice President of China Association of Science and Technology （CAST）, conveyed this message in his talk at the Chinese Society for Cell Bi- ology （CSCB） Biennial Conference held in Shenzhen in April, 2015.

关键词：科学知识科学技术协会传播科学信息转基因作物全球变暖联合国科学家

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Unfolding the Mysteries of Strigolactone Signaling

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Molecular Plant 2014年第6期7卷 934-936页

作者： Zuyu Zheng Alexandre de Saint Germain Joanne Chory howard Hughes Medical institute Plant Biology Laboratory The Salk Institute for Biological Studies La Jolla CA 92037 USA

Phytohormones integrate plant growth and developmental programs with extrinsic biotic and abiotic stimuli, thereby ensuring plant architecture is optimized for the local envi- ronment. Strigolactones （SLs）, newly identified carote- noid-derived plant hormones, play non-redundant and multifaceted roles throughout the plant life cycle （de Saint Germain et al.2013）, similarly to other plant hormones.

关键词：节目单内皮缩血管肽类生命周期各时期胰岛素游戏和玩具植物生长调节物

High-temperature characteristics of Al_xGa_(1-x)N/GaN Schottky diodes

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Journal of Semiconductors 2009年第3期30卷 39-45页

作者：张小玲李菲吕长志谢雪松李英 Mohammad S N Department of Electronic Information and Control Engineering Beijing University of Technology Department of Mechanical and Electrical Engineering Shougang Institute of Technology Department of Electrical & Computer Engineering Howard University

High-temperature characteristics of the metal/AlxGa1-xN/GaN M/S/S （M/S/S） diodes have been studied with current-voltage （I-V） and capacitance-voltage （C-V） measurements at high temperatures. Due to the presence of the piezoelectric polarization field and a quantum well at the AlxGa1-xN/GaN interface, the AlxGal-xN/GaN diodes show properties distinctly different from those of the AlxGa1-xN diodes. For the AlxGa1-xN/GaN diodes, an increase in temperature accompanies an increase in barrier height and a decrease in ideality factor, while the AlxGa1-xN diodes are opposite. Furthermore, at room temperature, both reverse leakage current and reverse breakdown voltage are superior for the AlxGa1-xN/GaN diodes to those for the AlxGa1-xN diodes.

关键词： Schottky diodes AlGaN/GaN high-temperature

RNA m^6A modification and its function in diseases

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Frontiers of Medicine 2018年第4期12卷 481-489页

作者： Jiyu Tong Richard A. Flavell Hua-Bing Li Shanghai institute of Immunology Department of Microbiology and Immunology Shanghai Jiao Tong University School of Medicine (SJTU- SM) Shanghai 200025 China Department of Immunobiology Yale University School of Medicine New Haven CT 06520 USA howard Hughes Medical institute Chevy Chase MD 20815-6789 USA

N^6-methyladenosine （m^6A） is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism, m^6A modification could be installed by m^6A ＂writers＂ composed of core catalytic components （METTL3/METTL14/WTAP） and newly defined regulators and removed by m^6A ＂erasers＂（FTO and ALKBH5）. The function of m^6A is executed by m^6A ＂readers＂ that bind to m^6A directly （YTH domain-containing proteins, eIF3 and IGF2BPs） or indirectly （HNRNPA2B1）. In the past few years, advances in m^6A modulators （＂writers,＂＂erasers,＂ and ＂readers＂） have remarkably renewed our understanding of the function and regulation of m^6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m^6A are still largely unknown. Moreover, investigations of the m^6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m^6A research and highlight the functional relevance and importance of m^6A modification in in vitro cell lines, in physiological contexts, and in cancers.

关键词： RNA modification m^6A immunity cancer epigenetics

运用分子遗传学来指导肥厚型心肌病的诊断与治疗

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中华心血管病杂志 2009年第12期37卷 1063-1068页

作者：王立斌 J · G· Seidman Christine E. Seidman Massachusetts 02115 Department of Genetics Harvard Medical School howard Hughes Medical institute

肥厚型心肌病(hypertrophy cardiomyopathy,HCM)是常染色体显性遗传疾病,其特征为在无明显诱因的(如高血压或瓣膜疾病)的心肌肥厚~([1]).在过去的50多年中,有关此疾病的文献报道已数以千计.最早对HCM的描述只局限于该病的病理解剖及组... 详细信息

肥厚型心肌病(hypertrophy cardiomyopathy,HCM)是常染色体显性遗传疾病,其特征为在无明显诱因的(如高血压或瓣膜疾病)的心肌肥厚~([1]).在过去的50多年中,有关此疾病的文献报道已数以千计.最早对HCM的描述只局限于该病的病理解剖及组织学特征~([2-3]).随后,因血液动力学改变而导致多种临床表现的机制得到了进一步的阐述,例如左心室流出道梗阻以及无症状患者的猝死。

关键词：分子遗传学肥厚型心肌病诊断治疗

Local HY5 Activity Mediates Hypocotyl Growth and Shoot-to-Root Communication

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Plant Communications 2020年第5期1卷 64-72页

作者： Yogev Burko Christophe Gaillochet Adam Seluzicki Joanne Chory Wolfgang Busch howard Hughes Medical institute Salk Institute for Biological StudiesLa JollaCA 92037USA Plant Biology Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Integrative Biology Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA

Plants optimize their growth in fluctuating environments using information acquired by different *** information is then transmitted through the rest of the plant using both short-and long-distance signals,including hormones and mobile *** a few of these signals have been characterized,long-distance signaling is not well understood in ***,the light-regulated transcription factor HY5 was reported to move from the shoot to the root to regulate root *** generated a cell-type specifically expressed HY5 fusion protein that could not be detected outside the tissue in which it was *** expressing this DOF-HY5 protein in specific cell types of the hypocotyl,we showed that its local activity was sufficient to regulate hypocotyl *** also found that,although DOF-HY5 was expressed specifically in the shoot and not detected in the roots,it could rescue hy5 growth defects in primary roots but not in lateral *** therefore conclude that HY5 protein mobility is not required in the hypocotyl or for shoot-to-root *** results indicate that a signal downstream of,or in parallel with,HY5 in the shoot is mobile and links shoot and root growth.

关键词： HY5 shoot-to-root communication hypocotyl root lateral root Arabidopsis

Inflammation,microbiome and colorectal cancer disparity in African-Americans:Are there bugs in the genetics?

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World Journal of Gastroenterology 2022年第25期28卷 2782-2801页

作者： Sami Ahmad Hassan Ashktorab Hassan Brim Franck Housseau Department of Oncology Johns Hopkins UniversityBaltimoreMD 21231United States Department of Medicine Howard UniversityWashingtonDC 20060United States Department of Pathology Howard UniversityWashingtonDC 20060United States

Dysregulated interactions between host inflammation and gut microbiota over the course of life increase the risk of colorectal cancer(CRC).While environmental factors and socio-economic realities of race remain predominant contributors to CRC disparities in African-Americans(AAs),this review focuses on the biological mediators of CRC disparity,namely the under-appreciated influence of inherited ancestral genetic regulation on mucosal innate immunity and its interaction with the *** remains a poor understanding of mechanisms linking immune-related genetic polymorphisms and microbiome diversity that could influence chronic inflammation and exacerbate CRC disparities in AAs.A better understanding of the relationship between host genetics,bacteria,and CRC pathogenesis will improve the prediction of cancer risk across race/ethnicity groups overall.

关键词： Inflammation African-American Population-specific genome wide association studies Minorities health Microbiome Colorectal cancer