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CD300a inhibits CD16-mediated NK cell effector functions in HiV-1-infected patients

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Cellular & Molecular immunology 2019年第12期16卷 940-942页

作者： joana Vitallé iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.iribarren Carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain hospital universitari de tarragona joan xxiii IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain hospital universitario de Canarias Santa Cruz de TenerifeSpain department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HiV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 in addition,CD300a expression on B and CD4+T lymphocytes is altered during HiV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HiV-1 infection is still unknown.We have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HiV-1 infected individuals.

关键词： CD16 CD30 ADCC

Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology

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World Journal of Gastroenterology 2015年第24期21卷 7529-7544页

作者： Nahum Calvo Raúl Beltrán-debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven Unitat de Recerca Biomèdica Hospital Universitari de Sant JoanInstitut d’Investigacio Sanitària Pere VirgiliUniversitat Rovira i VirgiliCampus of International Excellence Southern Catalonia Servei de Cirurgia General i de l’Aparell Digestiu Hospital Universitari de Sant Joan de ReusUniversitat Rovira i Virgili Metabolomics Platform Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas AsociadasIISPVUniversitat Rovira i Virgili Research and Collaborations General Electric Healthcare Metabolism and Cancer Group Transla-tional Research LaboratoryCatalan Institute of OncologyGirona Biomedical Research Institute

AiM: To explore the usefulness of magnetic resonance imaging(MRi) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRi and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FiESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRi data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRi was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRi using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. improvement was also observed in the serum concentrations of selected variables. The most relevant findings using met

关键词： Fatty liver disease Magnetic resonanceimaging Lipids Magnetic resonance spectroscopy Metabolomics Mitochondrial function Morbid obesity Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

Chronic total occlusion:To treat or not to treat

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World Journal of Cardiology 2014年第7期6卷 621-629页

作者： Alfredo Bardají Judit Rodriguez-López Mauricio Torres-Sánchez Servicio de Cardiología Hospital Universitario de Tarragona Joan XXⅢUniversitat Rovira Virgili3007 TarragonaEspa■a

Over the last two decades,there has been increasing interest in new techniques for the percutaneous treatment of coronary chronic total occlusions(CTO),which have a success rate that is much higher than that of a few years ago.The rise in percutaneous treatment for these lesions is due to its ability to improve the symptoms and prognosis of patients in the chronic and stable phase of coronary disease.Current data suggest that successful percutaneous coronary intervention for CTO is associated with improvement in patient symptoms,quality of life,left ventricular function,and survival,compared with those with unsuccessful CTO PCi.However,all the scientific evidence supporting this treatment comes from observational studies,and no randomized study comparing percutaneous treatment with medical treatment has yet been published.A major limitation of these studies is their observational design,with limited information with regard to potential baseline differences between the successful vs unsuccessful cohorts.Pending randomized studies,patients should be selected very carefully,especially if they are asymptomatic or very few symptoms,and the benefits obtained in terms of complications during the procedure,the quality of life obtained and further ischemic events avoided should be evaluated systematically.in this review,we will consider the available information supporting percutaneous treatment for chronic occlusions,as well as the areas of uncertainty where more research projects are required.

关键词： Chronic total occlusion Percutaneous coronary intervention

Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease:The search for alternative causative factors

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World Journal of Gastroenterology 2015年第10期21卷 2875-2882页

作者： Jordi Camps Jorge Joven Unitat de Recerca Biomèdica Hospital Universitari de Sant Joan Institut d’Investigació Sanitària Pere Virgili Universitat Rovira i Virgili

The incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is constantly increasing.despite this is apparently associated with the growing increase in obesity,insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fatin the liver.Conversely,NAFLD is a predictor of other metabolic risks.NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and endstage liver disease.Consequently,the search for alternative molecular mechanisms with therapeutic implications in NAFLD and associated disorders deserves a careful consideration.Mitochondria are possible targets as these organelles generate energy from nutrient oxidation.Some findings,generated in patients with extreme obesity and in murine models,support the notion that NAFLD could be a mitochondrial disease.This is plausible because mitochondrial dysfunction affects the accumulation of lipids in hepatocytes and promotes lipid peroxidation,the production of reactive oxygen species,the release of cytokines causing inflammation and cell death.Here we discuss basic research and mechanistic studies targeting the role of chemokine ligand 2 in liver inflammation and that of the paraoxonases in the oxidative stress.Their combination and association with mitochondrial dysfunction may uncover mechanisms underlying the progression of NAFLD and may help to identify novel therapeutic targets.

关键词： Biomarkers Cytokines inflammation Metabolism Mitoc

Long-Term Prognostic Factors in Patients with Significant Left Main Coronary Artery Disease

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international Journal of Clinical Medicine 2014年第5期5卷 188-196页

作者： Mercedes Camprubí Ramón de Castro Mohsen Mohandes Jordi Guarinos Miriam Garcia-Bermúdez Alfredo Bardají Servicio de Cardiología Hospital Universitario de Tar-ragona Joan XXIII Pere Virgili Institute for Health Re-search Universitat Rovira Virgili Tarragona Spain

introduction and Objectives: The natural history of patients with left main coronary artery disease (LMCAD) is largely unknown. Our objective was to analyse the predictors of long-term mortality in these patients, both those that have had surgery and those that have not undergone surgery for various reasons, in a cohort treated at a university hospital. Methods: The study included patients with significant LMCAD diagnosed through consecutive coronary angiograms from 2001 to 2009. Clinical variables, the reasons for cardiac catheterisation, therapeutic decisions and clinical evolution in long-term follow-up were analysed. Results: Of the 163 patients included in the analysis, a total of 109 (66.9%) underwent revascularisation, while the remaining 54 (33.1%) received other medical treatment. We analysed the clinical events that took place with a mean follow-up period of 54 months (iQR: 25-95). The non-revascularised group had a lower survival rate than the revascularised group in unadjusted analysis (logrank test 0.005). Age (OR 1.04, Ci 1.02-1.07, p = 0.001), ventricular dysfunction (OR 2.87, Ci95% 1.71-4.81, p 0.0001), clinical instability (OR 2.11, Ci95% 1.08 to 4.13, p = 0.028) and above 70% severity of LMCAD (OR 1.78, Ci 1.09 to 2.91, p = 0.021) were independent predictors of mortality for the entire cohort, but revascularisation was not. Conclusions: Revascularisation is associated with improved survival in patients with LMCAD, but only age, ventricular dysfunction, clinical instability and the severity of the lesion are independent predictors of long-term mortality in the unselected population.

关键词： Left Main Coronary Artery Disease Surgical Revascularisation Percutaneous Coronary intervention

A Feature Selection Strategy to Optimize Retinal Vasculature Segmentation

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Computers, Materials & Continua 2022年第2期70卷 2971-2989页

作者： Jose Escorcia-Gutierrez Jordina Torrents-Barrena Margarita Gamarra Natasha Madera Pedro Romero-Aroca Aida Valls Domenec Puig Electronic and Telecommunications Engineering Program Universidad Autónoma del CaribeBarranquilla080001Colombia department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla080001Colombia Ophthalmology Service Universitari Hospital Sant JoanInstitut de Investigacio Sanitaria Pere VirgiliReus43201Spain departament d’Enginyeria informàtica i Matemàtiques Escola Tècnica Superior d’EnginyeriaUniversitat Rovira i VirgiliTarragona43007Spain

Diabetic retinopathy (DR) is a complication of diabetesmellitus thatappears in the retina. Clinitians use retina images to detect DR pathologicalsigns related to the occlusion of tiny blood vessels. Such occlusion brings adegenerative cycle between the breaking off and the new generation of thinnerand weaker blood vessels. This research aims to develop a suitable retinalvasculature segmentation method for improving retinal screening proceduresby means of computer-aided diagnosis systems. The blood vessel segmentationmethodology relies on an effective feature selection based on SequentialForward Selection, using the error rate of a decision tree classifier in theevaluation function. Subsequently, the classification process is performed bythree alternative approaches: artificial neural networks, decision trees andsupport vector machines. The proposed methodology is validated on threepublicly accessible datasets and a private one provided by hospital Sant joanof Reus. in all cases we obtain an average accuracy above 96% with a sensitivityof 72% in the blood vessel segmentation process. Compared with the state-ofthe-art, our approach achieves the same performance as other methods thatneed more computational power.Our method significantly reduces the numberof features used in the segmentation process from 20 to 5 dimensions. Theimplementation of the three classifiers confirmed that the five selected featureshave a good effectiveness, independently of the classification algorithm.

关键词： Diabetic retinopathy artificial neural networks decision trees support vector machines feature selection retinal vasculature segmentation

心血管MRi评估静力运动对主动脉反流病人的急性效应:左心室重构的作用

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国际医学放射学杂志 2017年第3期 362-363页

作者： J.M.Alegret N.Martinez-Micaelo A.L.Gerche L.Franco-Bonafonte F.Rubio-Pérez N.Calvo 郭小琴 departments of Cardiology and Sports Medicine Hospital Universitari de Sant Joan Institut d ’Investigació Sanitària Pere Virgili Universitat Rovira i Virgili

摘要目的对于主动脉反流(AR)的病人,静力运动(SE)对其全心室功能和反流程度的影响尚未见报道。方法前瞻性地对23例无症状的AR病人行静息及SE状态下的心血管MR(CMR)成像。结果 SE过程中,两心室的舒张末期(EDV)和收缩末期(ESV)容量均存在... 详细信息

摘要目的对于主动脉反流(AR)的病人,静力运动(SE)对其全心室功能和反流程度的影响尚未见报道。方法前瞻性地对23例无症状的AR病人行静息及SE状态下的心血管MR(CMR)成像。结果 SE过程中,两心室的舒张末期(EDV)和收缩末期(ESV)容量均存在反流量的下降,同时LV射血分数(EF)轻度下降,且上述变化的幅度取决于LV重构的程度。对于有较大程度LV重构的病人,由于LV ESV的下降幅度较小(相对于LV EDV)导致LV EF有所下降(静息时

关键词：心血管主动脉大动脉静力运动 MRi