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Journal of Geriatric Cardiology 2015年第1期12卷 83-87页

作者： Claudia Stollberger Andreas Ulram Adam Bastovansky Josef Finsterer hospital rudolfstiftung Juehgasse 25 A-1030 Vienna Austria

One disadvantage of direct anticoagulant drug is the lack of an antidote, which may become relevant in patients with traumatic brain in- jury. A 77-years old man with atrial fibrillation and syncope received dabigatran despite recurrent falls. Due to a ground-level-fall, he suffered from subarachnoidal and intraparenchymal hemorrhages, subdural hematoma and brain edema with a midline shift. Despite osteoelast/c trepanation and hematoma-evacuation he remained comatose and died seven days later without regaining consciousness. Most probably, decreased dabigatran clearance due to increased age might have contributed to the fatal course. We suggest withholding anticoagulant therapy in patients with unexplained falls. If anticoagulant therapy is deemed necessary, vitamin-K-antagonists with their potential for laboratory monitoring and reversal of anticoagulant activity should be preferred.

关键词： Cerebral hemorrhage Anticoagulation Dabigatran Atrial fibrillation

Asymmetric parietal and temporal lobe atrophy due to the variant m.8363G>A in transfer ribonucleic acid(Lysine)

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Chinese Medical Journal 2021年第2期134卷 243-244页

作者： Josef Finsterer Department of Neurology City Hospital RudolfstiftungMesserli InstituteViennaAustria

To the Editor:With interest,we read the article by Xu et al[1]about a 54-year old man with a multisystem mitochondrial disorder(MID)affecting the brain,ears,and *** manifestations were attributed to the variant m.8363... 详细信息

关键词： attributed multisystem transfer

Beneficiality of combined levetiracetam, clonazepam for myoclonus in MERRF requires further confirmation

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Chinese Medical Journal 2019年第5期132卷 622-623页

作者： Josef Finsterer Department of Neurology City Hospital Rudolfstiftung Messerli Institute Veterinary University of Vienna Vienna 1180 Austria

To the Editor: With interest, we read the article by Su et al[1] about the antiepileptic drug (AED) treatment of 17 patients with genetically confirmed myoclonic epilepsy with ragged-red fibers (MERRF) syndrome. It wa... 详细信息

关键词： combined levetiracetam myoclonus MERRF

Recurrent abscess after primary successful endo-sponge treatment of anastomotic leakage following rectal surgery

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World Journal of Gastroenterology 2010年第36期16卷 4570-4574页

作者： Stefan Riss Anton Stift Caroline Kienbacher Bernhard Dauser Ingrid Haunold Stefan Kriwanek Wolfgang Radlsboek Michael Bergmann Division of General Surgery Department of SurgeryMedical University of ViennaA-1090 ViennaAustria Department of Surgery Floridsdorf HospitalA-1210 ViennaAustria Department of Surgery Barmherzige Brüder WienA-1020 ViennaAustria Department of Surgery Barmherzige Schwestern WienA-1060 ViennaAustria Department of Surgery Rudolfstiftung HospitalA-1030 ViennaAustria Department of Surgery G-ttlicher Heiland WienA-1170 ViennaAustria

AIM:To assess long-term efficacy of initially successful endo-sponge assisted ***:Between 2006 and 2009,consecutive patients who had undergone primary successful endo-sponge treatment of anastomotic leakage following rectal cancer surgery were enrolled in the *** were recruited from 6 surgical departments in *** and oncologic outcomes were assessed through routine endoscopic and radiologic follow-up ***:Twenty patients(7 female,13 male)were *** indications for endosponge treatment were anastomotic leakage(n=17)and insufficiency of a rectal stump after Hartmann's procedure(n=3).All patients were primarily operated for rectal *** overall mortality rate was 25%.The median followup duration was 17 mo(range 1.5-29.8 mo).Five patients(25%)developed a recurrent *** time between last day of endosponge therapy and occurrence of recurrent abscess was 255 d(range 21-733 d).One of these patients was treated by computed tomography-guided drainage and in 3 patients Hartmann's procedure had to be *** patients(10%)developed a local tumor recurrence and subsequently ***:Despite successful primary outcome,patients who receive endo-sponge therapy should be closely monitored in the first 2 years,since recurrence might occur.

关键词： Rectal surgery Anastomotic leakage Endo-sponge Endo-vacuum treatment

Helicobacter pylori and gastric cancer: current status of the Austrian-Czech-German gastric cancer prevention trial (PRISMA-Study)

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World Journal of Gastroenterology 2001年第2期7卷 243-247页

作者： S.Miehlke C.Kirsch B.Dragosics M.Gschwantler G.Oberhuber D.Antos P.Dite J.Lauter J.Labenz A.Leodolter P.Malfertheiner A.Neubauer G.Ehninger M.Stolte E.Bayerdorffer Medical Department I GastroenterologyHematologyOncologyPulmonology & Infectious DiseasesTechnical University Hospital Carl Gustav CarusDresdenGermany Gesundheitszentrum Süd ViennaAustria Medical Department 4 Krankenanstalt RudolfstiftungViennaAustria Institute for Pathology General HospitalViennaAustria Surgical Department Ludwig-Maximilians-University Hospital GroβhadernMunichGermany Univerzitni nemocnice Jihlavska Brno-BohuniceCzech Republic Institute for Medical Statistics Otto-von-Guericke-UniversityMagdeburgGermany Department of Medicine Evang. Jung-Stilling HospitalSiegenGermany Department of Gastroenterology Otto-v.-Guericke University HospitalMagdeburgGermany Department for Hematology Oncology&ImmunologyUniversity Hospital MarburgGermany Institute of Pathology Klinikum BayreuthBayreuthGermany

AIM To test the hypothesis that Helicobacter pylori eradication alone can reduce the incidence of gastric cancer in a subgroup of individuals with an increased risk for this fatal *** It is a prospective, randomized,double-blind, placebo-controlled multinational multicenter trial. Men between 55 and 65 years of age with a gastric cancer phenotype of Helicobacterpylori gastritis are randomized to receive a 7-day course of omeprazole 2 × 20 mg,clarithromycin 2 × 500 mg, and amoxicillin 2 ×lg for 7 days, or omeprazole2 × 20mg plusplacebo. Follow - up endoscopy is scheduled 3months after therapy, and thereafter in one-year intervals. Predefined study endpoints are gastric cancer, precancerous lesions (dysplasia, adenoma), other cancers, *** Since March 1998, 1524 target patients have been screened, 279 patients (18.3%) had a corpus-dominant type of *** gastritis, and 167 of those were randomized (58.8%). In the active treatment group (n -- 86), H. pylori infection infection was cured in 88.9% of patients. Currently, thecumulative follow-up time is 3046 months (253.8patient-years, median follow-up 16 months). So far, none of the patients developed gastric cancer or any precancerous lesion. Three(1.8%) patients reached study endpoints other than gastric *** Among men between 55 and 65years of age, the gastric cancer phenotype of *** gastritis appears to be more common than expected. Further follow- up and continuing recruitment are necessary to fulfil the main aim of the study.

关键词： Helicobacter pylori Helicobacter infections/complications Helicobacter infections/drug therapy stomach neoplasms /microbiology stomach neoplasms/drug therapy gastritis/microbiology gastritis/drug therapy

Mitochondrial tRNA Glutamic Acid Variant 14709T〉C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers

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Chinese Medical Journal 2018年第20期131卷 2518-2519页

作者： Josef Finsterer Fulvio A Scorza Ana C Fiorini Carla A Scorza Antonio Carlos de Almeida Department of Neurology City Hospital Rudolfstiftung Vienna Austria Department of Neuroscience University of Sao Paolo Sao Paolo Brazil Department of Audiology University of Sao Paolo Sao Paolo Brazil Department of Biosystems Engineering Laboratory of Experimental and Computational Neuroscience Sao Paolo Brazi

We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.

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Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats

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World Journal of Critical Care Medicine 2019年第7期8卷 106-119页

作者： Andreas Janata Ingrid AM Magnet Kristin L Schreiber Caleb D Wilson Jason P Stezoski Keri Janesko-Feldman Patrick M Kochanek Tomas Drabek Safar Center for Resuscitation Research University of Pittsburgh School of MedicinePittsburghPA 15224United States Department of Critical Care Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Emergency Department KA RudolfstiftungVienna 1030Austria Department of Emergency Medicine Vienna General HospitalMedical University of ViennaVienna 1090Austria Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Wyoming Otolaryngology Wyoming Medical CenterCasperWY 82604United States

BACKGROUND Prolonged cardiac arrest(CA)produces extensive neuronal death and microglial proliferation and activation resulting in neuro-cognitive *** other potential mechanisms,microglia have been implicated as triggers of neuronal death after hypoxic-ischemic *** is neuroprotective in some brain ischemia models,either by blunting the microglial response or by a direct effect on *** To improve survival,attenuate neurologic deficits,neuroinflammation,and histological damage after ventricular fibrillation(VF)CA in *** Adult male isoflurane-anesthetized rats were subjected to 6 min VF CA followed by 2 min resuscitation including chest compression,epinephrine,bicarbonate,and *** return of spontaneous circulation(ROSC),rats were randomized to two groups:(1)Minocycline 90 mg/kg intraperitoneally(i.p.)at 15 min ROSC,followed by 22.5 mg/kg *** 12 h for 72 h;and(2)Controls,receiving the same volume of vehicle(phosphate-buffered saline).The rats were kept normothermic during the postoperative *** injury was assessed daily using Overall Performance Category(OPC;1=normal,5=dead)and Neurologic Deficit Score(NDS;0%=normal,100%=dead).Rats were sacrificed at 72 *** degeneration(Fluoro-Jade C staining)and microglia proliferation(anti-Iba-1 staining)were quantified in four selectively vulnerable brain regions(hippocampus,striatum,cerebellum,cortex)by three independent reviewers masked to the group *** In the minocycline group,8 out of 14 rats survived to 72 h compared to 8 out of 19 rats in the control group(P=0.46).The degree of neurologic deficit at 72 h[median,(interquartile range)]was not different between survivors in minocycline vs controls:OPC 1.5(1-2.75)vs 2(1.25-3),P=0.442;NDS 12(2-20)vs 17(7-51),P=0.328)or between all studied *** number of degenerating neurons(minocycline vs controls,mean±SEM:Hippocampus 58±8 vs 76±8;striatum 121±43 vs 153±32;cerebellum 20±7 vs 22

关键词： Heart arrest/pathology Cardiopulmonary resuscitation Survival rate Neurons/drug effects Microglia/drug effects Minocycline/pharmacology