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Kelulut honey ameliorates glucocorticoid induced osteoporosis via its antioxidant activity in rats

Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 493-500页

作者： Mohd Amir Kamaruzzaman Amardev Thanu Mohd Rafizul Yusof Ima Nirwana Soelaiman Elvy Suhana Ramli Department of Anatomy Faculty of MedicineUKM Medical CentreCanselor Tuanku Mukhriz HospitalJalan Yaacob Latiff56000CherasKuala LumpurMalaysia Department of Pharmacology Faculty of MedicineUKM Medical CentreCanselor Tuanku Mukhriz HospitalJalan Yaacob Latiff56000CherasKuala LumpurMalaysia

Objective:To explore the effects of kelulut honey on bone structure and histomorphometry against glucocorticoid-induced ***:Thirty-five male rats were used(n=7).Twenty-eight adrenalectomized rats were divided into four groups;each group was given normal saline 0.9%(negative control),calcium water(positive control),kelulut honey(200 mg/kg/day and 400 mg/kg/day,respectively)treatment,*** of them were administered with intramuscular injection of dexamethasone(120μg/kg/day)to induce *** sham operated rats were given vehicle palm olein 0.05 mL/100 g/day by intramuscular injection and 0.1 mL/kg/day *** the treatments were given daily for 2 *** peroxidation and oxidative stress enzymes were *** addition,bone structural and histomorphometry analyses were also ***:Two-month glucocorticoid treatment increased the level of malondialdehyde and decreased superoxide dismutase *** significant changes were found in the activities of catalase and glutathion *** volume/tissue volume and trabecular number were significantly reduced while trabecular separation of the femoral bones was increased which corresponded to the decreased number of osteoblast surface after two months of receiving glucocorticoid *** honey treatment restored the level of superoxide dismutase and reduced malondialdehyde significantly(P<0.05).Moreover,kelulut honey increased bone volume/tissue volume,trabecular number and decreased trabecular separation significantly(P<0.05),which were further confirmed by increased osteoblast surface and decreased osteoclast surface number(P<0.05).Conclusions:Kelulut honey may have potential bone protective effect,and may be a prophylaxis against glucocorticoid-induced osteoporosis.

关键词： Kelulut honey Glucocorticoid-induced osteoporosis Oxidative stress Antioxidant Bone structure Histomorphometry Male rats

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Baerveldt glaucoma implant with Supramid© ripcord stent in neovascular glaucoma: a case series

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 265-271页

作者： Yuen Keat Gan Shiivaa Manjare Birapadian Muhammad Irfan Abdul Jalal Norshamsiah Md Din Department of Ophthalmology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia UKM Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia hospital canselor tuanku muhriz Jalan Yaacob LatifBandar Tun RazakKuala Lumpur 56000Malaysia

AIM:To report the outcome of Baerveldt glaucoma implant(BGI)with Supramid©ripcord use in neovascular glaucoma(NVG).METHODS:We retrospectively evaluated the surgical outcome of the BGI with Supramid©3/0 ripcord stent in patients with *** tube ligation or venting slits were *** was removed after 3mo if the target intraocular pressure(IOP)was not *** success was defined as IOP≤21 mm Hg with(qualified success)or without IOP-lowering medications(complete success).RESULTS:Twenty-six eyes from 24 patients were included in the *** median duration of follow-up was 4[interquartile range(IQR)=1-5]y,ranging from 0.5 to *** decreased by a mean of 24.2 mm Hg(59.7%);from a mean of 40.5±12.6 mm Hg at baseline to 16.3±11.9 mm Hg,P≤*** number of glaucoma medications reduced from a median of 5(IQR=5-6)to 1(IQR=0-2,P≤0.001)at the final *** success rates were 88.0%at 1y,34.8%at 3y,66.7%at 4y,and 50%at *** phase(HP)in the first 3mo occurred in 15/26 eyes(57.7%)with a mean IOP of 31.1 mm ***:BGI with Supramid©ripcord stent gives close to 90%of the overall survival rate at the final follow-up without significant early ***,early HP is still a challenge.

关键词： neovascular glaucoma Supramid ripcord stent Baerveldt glaucoma implant

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Fatal case of amoebic liver abscess in a child

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Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 858-860页

作者： Khuen Foong Ng Kah Kee Tan Romano Ngui Yvonne AL Lim Amirah Amir Yamuna Rajoo Hamimah Hassan Rohela Mahmud Department of Pediatric Tuanku Jaafar Hospital Department of Parasitology Faculty of MedicineUniversity of Malaya Department of Medical Microbiology Faculty of MedicineUniversity of Malaya

We reported a case of amoebic liver abscess(ALA) in a 6-year-old Malaysian boy who presented with fever,lethargy,diarrhea and right hypochondriac *** admission he was diagnosed with perforated acute appendicitis and a laparotomy was *** surgery he developed acute respiratory ***,chest X-Ray and CT scan revealed two ALAs in the posterior segment of right lobe of liver,pleural effusion and collapsed consolidation of lungs *** liver abscesses drainage was done and intravenous Metronidazole was *** carried out on the pus from the abscess was positive for Entamoeba *** however succumbed to the infection one week after admission.

关键词： Amoebic liver abscess Entamoeba histolytica Childr

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The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1685-1690页

作者： Yong Zheng Wai Fiona Lee Min Chew Mohamad Aziz Salowi Chai Liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh Department of Ophthalmology Hospital Tuanku Jaafar Seremban Department of Ophthalmology Hospital Selayang Department of Ophthalmology Faculty of Medicine University Sultan Zainal Abidin Department of Emergency Medicine Hospital Teluk Intan Faculty of Medicine MAHSA University Clinical Research Centre Hospital Kuala Lumpur

AIM：To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis（POE）based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry（MOH CSR）.METHODS：Data was collected from the web-based MOH *** consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were *** criteria were traumatic cataract or previous ocular *** data,ocular co-morbidities,intraoperative details and postoperative visual acuity（VA）at final ophthalmological follow-up were *** eyes were taken for *** with POE were compared against subjects with no POE for risk factor assessment using multiple logistic ***：A total of 163 503 subjects were *** incidence of POE was 0.08%（131/163 503）.Demographic POE risk factors included male gender（OR：2.121,95%CI：1.464-3.015）and renal disease（OR：2.867,95%CI：1.503-5.467）.POE risk increased with secondary causes of cataract（OR：3.562,95%CI：1.740-7.288）,uveitis（OR：11.663,95%CI：4.292-31.693）and diabetic retinopathy（OR：1.720,95%CI：1.078-2.744）.Intraoperative factors reducing POE were shorter surgical time（OR：2.114,95%CI：1.473-3.032）,topical or intracameral anaesthesia（OR：1.823,95%CI：1.278-2.602）,posterior chamber intraocular lens（PCIOL;OR：4.992,95%CI：2.689-9.266）and foldable IOL（OR：2.276,95%CI：1.498-3.457）.POE risk increased with posterior capsule rupture（OR：3.773,95%CI：1.915-7.432）and vitreous loss（OR：3.907,95%CI：1.720-8.873）.Postoperative VA of 6/12 or better was achieved in 15.27%（20/131）subjects with ***：This study concurs with other studies regarding POE risk *** strengthening of MOH CSR data collection process will enable deeper analysis and optimization of POE treatment.

关键词： cataract endophthalmitis eye infection surgery

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Fundus changes in pregnancy induced hypertension

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 694-697页

作者： Sagili Chandrasekhara Reddy Sivalingam Nalliah Sheila Rani a/pKovil George Tham Seng Who Department of Ophthalmology Faculty of MedicineInternational Medical University Department of Obstetrics and Gynaecology Faculty of Medicine International Medical University Department of Obstetrics and Gynaecology Hospital Tuanku Jaafar

AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH.

关键词： pregnancy induced hypertension retinal changes preeclampsia eclampsia cortical blindness

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Irreducible Posterior Hip Dislocation with Associated Isolated Comminuted Greater Trochanter Avulsion Fracture Treated with Universal Locking Trochanteric Stabilization Plate: A Rare Combination of Hip Injury

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Open Journal of Orthopedics 2022年第2期12卷 41-49页

作者： Mohamad Hafiz Mohmad Hassim Norhaslinda Bahaudin Zamri Abdul Rahman Abdul Rauf Ahmad Department of Orthopaedic Hospital Tuanku Ja’afar Seremban Negeri Sembilan Malaysia

Posterior hip dislocation with greater trochanter fracture is an uncommon injury pattern in the acute trauma patient. Frequently associated injury includes a combination of hip dislocation with posterior wall of acetabulum, head of femur fracture, intertrochanteric fracture and even the most severe type of combined acetabular fracture. We report a 42-year-old man post traumatic bilateral hip injuries with irreducible posterior hip dislocation and associated isolated greater trochanteric fracture successfully managed with open reduction and fixation of greater trochanter with universal locking trochanteric stabilization plate.

关键词： Irreducible Posterior Hip Dislocation Greater Trochanter Avulsion Universal Locking Trochanteric Stabilization Plate

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Fibroscan-AST(FAST)score and other non-invasive tests for the diagnosis of fibrotic non-alcoholic steatohepatitis

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 763-767页

作者： Wah Loong Chan C.Vikneshwaran Chandra Kumar Wah Kheong Chan Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Gastroenterology and Hepatology Unit Department of MedicineHospital Tuanku Ja’afarSerembanNegeri Sembilan

The Fibroscan-AST(FAST)score was developed based on the data of patients who had a liver biopsy for non-alcoholic fatty liver disease(NAFLD)at several liver centres in England,and it was validated using data from seven clinical studies from North America,Europe and Asia(1).The FAST score requires only controlled attenuation parameter(CAP)and liver stiffness measurement(LSM)from a vibration-controlled transient elastography(VCTE)examination and serum aspartate aminotransferase(AST)level in its calculation.

关键词： Non-alcoholic steatohepatitis(NASH) metabolic dysfunction associated fatty liver disease(MAFLD) metabolic dysfunction-associated steatotic liver disease(MASLD) metabolic-associated steatohepatitis(MASH) metabolic dysfunction-associated steatohepatitis

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Arthroscopic Assessment of Intra-Articular Injury in Patients with Acute Unstable Malleolar Fracture

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Open Journal of Orthopedics 2020年第8期10卷 179-192页

作者： Noor Mahazrinna Hayadin Yi Hui Foo Vijay Babu Subramaniam Mohd Izani Ibrahim Mohd Asni Alias hospital tuanku Fauziah Perlis Malaysia hospital Raja Permaisuri Bainun Perak Malaysia Pantai hospital Manjung Perak Malaysia

Introduction: Purpose to study prevalence of the intraarticular chondral lesion in the malleolar fracture by using ankle arthroscopy to fully understand the severity and complexity of the injury. Methods: Cross sectional study of 32 patients diagnosed with ankle fracture and undergone open reduction and internal fixation with arthroscopic assessment performed stimultaneously. The mechanism of injury, patterns of injury and intraarticular chondral injury were documented. Results: Mean age was 38 years (SD = 14.1, range 18 - 68 years). Eighteen were female and 14 were male. Fifteen involved syndesmostic distruption, 22 had Danis-Weber B injury and 16 had supination external rotation (SER). Ten (31.2%) had positive intraoperative cartilage injury. Significant correlation between the Lauge-Hansen classifications with positive findings with 6 had SER, 2 had pronation adduction and 2 had pronation external rotation. Conclusion: The prevalence of chondral injury in ankle fracture was quite high and may leads to poor outcome. Arthroscopy procedure allow surgeon to assess intraarticular surface and reduction of the ankle fracture which prompt further intervention that may improve the clinical outcomes and prognosis of the patients.

关键词： Ankle Fracture Malleolar Fracture Ankle Arthroscopy Arthroscopy Assessment Chondral Injury Articular Injury Cartilage Injury Intraarticular Injury

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Coincident Bilateral Atraumatic Hip Fracture in a Young Patient with Renal Osteodystrophy

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Open Journal of Orthopedics 2020年第11期10卷 313-320页

作者： Shukriah Aqilah Zakaria Mohd Shafiee Johan Chin Max Yong Guang Yi Mohd Atiq Che Roselam Mohamad Hafiz Mohmad Hassim Department of Orthopaedic Hospital Bintulu Bintulu Malaysia Department of Orthopaedic Hospital Kuala Lumpur Kuala Lumpur Malaysia Department of Orthopaedic Hospital Tuanku Jaafar Seremban Malaysia

Bilateral, coincident, atraumatic hip fracture is extremely uncommon and usually occurs secondary to seizures, trauma and metabolic disease including renal osteodystrophy. One of the major types, secondary hyperparathyroidism is associated with high bone turnover due to excess parathyroid hormone and usually seen in a chronic dialysis patient. We reported a 20-year-old woman with end stage renal failure and renal osteodystrophy. She sustained atraumatic right subtrochanteric fracture and left neck of femur fracture (Garden 1), then underwent bilateral long proximal femoral nail. Renal osteodystrophy causes pathological fracture by affecting calcium metabolism that stimulates bone resorptions and leads to osteoporotic bone. The aim of this case report is to discuss the approach and management done to the patient presented to our center. Bilateral long proximal femoral nail (PFN) was chosen, taking into account the patient’s premorbid, age, fracture pattern and potential complications. Careful multidisciplinary team approach led by the orthopaedic surgeon, nephrologist and physical therapist is vital for the patient to achieve good outcome postoperatively, thus reducing morbidity and mortality.

关键词： Pathological Fracture Hip Fracture Secondary Hyperparathyroidism Renal Osteodystrophy

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Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1782-1790页

作者： Aimy Mastura Zurairah Yusof Othmaliza Othman Seng Fai Tang Mohd Rohaizat Hassan Norshamsiah Md Din Department of Ophthalmology Tuanku Mizan Armed Forces HospitalKuala Lumpur 53300Malaysia Department of Ophthalmology UKM Medical CenterJalan Yaacob LatifCheras 56000Kuala LumpurMalaysia Department of Community Health UKM Medical CenterJalan Yaacob LatifCheras 56000Kuala LumpurMalaysia

AIM: To compare the diagnostic ability of glaucoma parameters measured by the optical coherence tomography(OCT) in normal, preperimetric glaucoma(PPG) and perimetric glaucoma(PG) patients. METHODS: This cross-sectional observational study includes 127 eyes of 127 subjects. Patients were divided into PPG(51 eyes), PG(46 eyes), and normal controls(30 eyes) based on clinical optic disc assessment and Humphrey visual field changes. The Heidelberg Spectralis OCT machine using Glaucoma Module Premium Edition software was used to measure the retinal nerve fiber layer(RNFL) and Bruch’s membrane opening-minimum rim width(BMO-MRW) to assess the optic nerve head and ganglion cell layer(GCL) thickness in the macula. RESULTS: RNFL, MRW, and GCL thickness were all significantly thinner in PG compared to PPG and the normal group. The BMO-MRW parameters showed better specificity(>70%) at 90% specificity compared to both RNFL and GCL parameters to discriminate normal, PPG, and PG patients. All BMO-MRW parameters showed higher area under curves(AUC) compared to RNFL and GCL parameters with the highest AUC observed in the superotemporal sector of the BMO-MRW(AUC=0.819 and and 0.897 between normal and PPG and PG groups respectively).CONCLUSION: While the BMO-MRW best discriminates PPG and PG against normal eyes, GCL parameters poorly differentiate the three groups.

关键词： glaucoma preperimetric ganglion cell layer Bruch’s membrane opening minimum rim width retinal nerve fibre layer

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