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A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 102-114页

作者： Cuixia Zheng Lingling Sun Hongjuan Zhao Mengya Niu Dandan Zhang Xinxin Liu Qingling Song Weijie Zhong Baojin Wang Yun Zhang Lei Wang School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Huaihe hospital of Henan university Translational medicine CenterKaifeng 475000China Pingyuan Lab Henan Normal UniversityXinxiang 453007China Gynecology the Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Weihai Municipal hospital Cheeloo College of MedicineShandong UniversityWeihai 264200China

Bacterial-based antitumor immunity has become a promising strategy to activate the immune system for fighting ***,the potential application of bacterial therapy is hindered by the presence of instability and susceptibility to infections within bacterial ***,monotherapy is ineffective in completely eliminating complex cancer with multiple contributing *** this study,based on our discovery that spore shell(SS)of Bacillus coagulans exhibits excellent tumor-targeting ability and adjuvant activity,we develop a biomimetic spore nanoplatform to boost bacteria-mediated antitumor therapy,chemodynamic therapy and antitumor immunity for synergistic cancer *** detail,SS is separated from probiotic spores and then attached to the surface of liposome(Lipo)that was loaded with hemoglobin(Hb),glucose oxidase(GOx)and JQ1to construct SS@Lipo/Hb/GOx/*** tumor tissue,highly toxic hydroxyl radicals(·OH)are generated via sequential catalytic reactions:GOx catalyzing glucose into H_(2)O_(2)and Fe^(2+)in Hb decomposing H_(2)O_(2)into·*** combination of·OH and SS adjuvant can improve tumor immunogenicity and activate immune ***,JQ1-mediated down-regulation of PD-L1 and Hb-induced hypoxia alleviation synergistically reshape immunosuppressive tumor microenvironment and potentiate immune *** this manner,SS@Lipo/Hb/GOx/JQ1 significantly suppresses tumor growth and *** summarize,the nanoplatform represents an optimum strategy to potentiate bacteria-based cancer immunotherapy.

关键词： Biomimetic spore shell Bacteria-mediated antitumor therapy Chemodynamic therapy Immunotherapy Tumor microenvironment

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Differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

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World Journal of Gastroenterology 2024年第10期30卷 1377-1392页

作者： Yuan-Peng Li Tian-Yu Lu Fu-Rong Huang Wei-Min Zhang Zhen-Qiang Chen Pei-Wen Guang Liang-Yu Deng Xin-Hao Yang College of Physical Science and Technology Guangxi Normal UniversityGuilinGuangxi 541004China Department of Gastroenterology The Affiliated Hospital of South University of Science and TechnologyShenzhen 518000Guangdong ProvinceChina Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically ***,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and *** To develop a method to identify CD and ITB with high accuracy,specificity,and *** A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or *** wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential *** The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and *** Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

关键词： Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease Differential diagnosis Inflammatory bowel disease

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Surface Topological Glycosylation-Mediated Mucoadhesion of Bacteria

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Chinese Journal of Chemistry 2024年第13期42卷 1447-1455页

作者： Xiao Kuang Xiaobing Liu Ju Chen Wenyan Lv Mengmeng Zhang Huan Chen Feng Wu Jinyao Liu School of Life Sciences Shanghai UniversityShanghai 200444China Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Institute of Molecular MedicineState Key Laboratory of Systems Medicine for CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234China

Sugar moieties present on bacterial surface serve as pivotal regulators of bacterial *** adjusting the abundance and distribution of surface sugar moieties can offer an important approach to manipulating bacterial behavior,but has been proven to be ***,surface topological glycosylation is reported to mediate the interaction of bacteria with mucous *** functionalized by sugar moieties with different branching are synthesized through iterative Michael addition and amide condensation *** a copper-catalyzed azide-alkyne cycloaddition,the resulting compounds with different branching structures can be attached onto bacterial surface that is modified with azido *** a proof-of-concept study,a set of topologically glycosylated probiotics(TGPs)is prepared using linear,two-branched,and tetra-branched compounds,*** interaction between mucin and TGPs was studied and the results demonstrate that,compared to unmodified bacteria,TGPs exhibit an enhanced adhesive capacity to mucin,which increases with the branching *** binding trend is observed in ex vivo colonic mucus adhesion experiments and bacteria glycosylated with tetra-branched compounds display the highest binding *** work proposes a chemical method to tune the abundance and distribution of sugar moieties on bacteria,providing unique significant insights into the manipulation of bacterial behavior through surface modification.

关键词： Topochemistry Bacteria Glycosylation Surface modification Mucoadhesion Click chemistry

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Photolyses of mammalian carboxy-hemoglobin studied by photoacoustic calorimetry

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Science China(Physics,Mechanics & Astronomy) 2013年第7期56卷 1301-1309页

作者： ZHAO JinYu LI JiaHuang ZHANG Zheng ZHANG ShuYi QU Min FANG JianWen HUA ZiChun Laboratory of Modern Acoustics College of PhysicsNanjing University Laboratory of Pharmaceutical Biotechnology College of Life SciencesNanjing University Nanjing First hospital attached to Nanjing Medical university Department of Physics Zhejiang Normal University

The enthalpy and conformational volume changes in the photolyses of carboxy-hemoglobin (HbCO) of human, bovine, pig, horse and rabbit are investigated by photoacoustic calorimetry. Considering the time scales of the exciting laser pulse and the receiving ultrasound transducers (PVDF films and PZT ceramics), as well as the reaction lifetimes in the photolysis processes of HbCO, the measured results are related to the geminate recombination and tertiary relaxation in photolyses of HbCO. Moreover, the quantum yields of the five mammals are also measured by laser pump-probe technique. The results show that the dynamic parameters, such as enthalpy and conformational volume changes, differ between the processes of the geminate recombination and tertiary relaxation. Also, the dynamic parameters differ among the five mammals although some of them may be consistent with each other.

关键词： photoacoustic calorimetry photolysis enthalpy change conformational volume change carboxy-hemoglobin

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Depressive symptoms and their associated factors in heart failure patients

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Frontiers of Nursing 2021年第4期8卷 389-397页

作者： Deng-Xin He Ming-Hao Pan School of Nursing Hubei University of Chinese MedicineWuhanHubei 430065China School of Medicine Xinyang Normal UniversityXinyangHenan 464000China

Objectives:Depressive symptoms are common in heart failure(HF)patients and they may exacerbate the progression of ***,identifying associations with depressive symptoms is essential to develop effective interventions to alleviate patients’depressive ***,this study aimed to explore the factors related to HF patients’depressive ***:Potential hospitalized patients were recruited from a university-affiliated hospital by convenience *** study included 321 HF patients who had completed information about depressive symptoms,functional capacity,social support,dispositional optimism,self-care confidence,and health *** statistics were used to characterize the *** group t-tests and one-way analysis of variance were used to assess the difference in depressive symptoms score in demographic and clinical characteristics,while Pearson’s correlation was used to assess the associations among continuous ***:The scores for functional capacity,social support,dispositional optimism,self-care confidence,and health literacy were negatively associated with the score for depressive *** interaction effect between the functional capacity and the dispositional optimism on depressive symptoms was ***:Interventions targeted improving the above-mentioned factors may be beneficial to reduce depressive symptoms in HF patients.

关键词： depressive symptoms dispositional optimism functional capacity heart failure social support

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Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer’s disease

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Engineered Regeneration 2023年第4期4卷 349-356页

作者： Guidan Wang Zhenshan Pan Xiaorui Zhu Ruyue Yang Rong Yang Tingting Yang Dong Hu Aihua Jing Gaofeng Liang School of Medical Technology and Engineering Henan University of Science&TechnologyLuoyang 471023China Department of Psychiatry the fifth people’s hospital of Luoyangthe Fifth Affiliated Hospital of Henan University of Science and TechnologyLuoyang 471027China Collaboration Innovative Center of Henan Province for Energy-Saving Building Materials Xinyang Normal UniversityXinyang 464000China School of Basic Medicine and Forensic Medicine Henan University of Science&TechnologyLuoyang 471023China

Exosomes are nanoscale membrane-enclosed extracellular vesicles secreted by various cells,which have enormous potential as disease biomarkers for clinical ***,the isolation and detection of exosomes remain enormous challenges,which limits their further ***,inspired by immunomagnetic beads,a magnetic nanoparticle conjugated aptamer was repurposed for the effective capture and detection of *** magnetic nanoparticles,composed of Fe 3 O 4 synthesized by the hydrothermal method as the core and coupled with gold nanoparticles(Fe 3 O 4@Au),provide a large specific surface area,making the resulting composite material an effective platform for exosome ***,the elution of captured exosomes with 1.0 M NaCl made downstream analysis of exosomes *** preliminary clinical application value of the composite in exosome analyses of serum from healthy individuals and patients with Alzheimer’s disease(AD)has also been verified,which could provide a promising platform for biomedical and clinical diagnosis.

关键词： Exosomes Capture Detection Alzheimer’s disease(AD)

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Varicella-zoster virus meningitis with hypoglycorrhachia: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7101-7106页

作者： Li-Juan Cao Yi-Ming Zheng Fan Li Hong-Jun Hao Feng Gao Department of Neurology Peking University First HospitalBeijing 100034China Department Acupuncture and Moxibustion Huguosi Traditional Chinese Medicine Hospital Attached to Beijing Traditional Chinese Medicine UniversityBeijing 100034China

BACKGROUND Varicella-zoster virus(VZV)is a common viral infection,but meningitis is a rare complication of VZV *** cerebrospinal fluid glucose of viral meningitis is usually within the normal range,which is different from bacteria,fungi,and cancerous *** paper reports a case of VZV meningitis with hypoglycorrhachia and the relevant literature was *** SUMMARY We report a case of an immunocompetent 39-year-old male,presenting with severe headache and fevers,without meningeal signs or exanthem,found to have VZV meningitis by the metagenomic next-generation sequencing of cerebrospinal *** cerebrospinal fluid analysis revealed hypoglycorrhachia(cerebrospinal fluid glucose of 2.16)and he was treated successfully with intravenous *** literature review identified only ten cases diagnosed with VZV meningitis with hypoglycorrhachia previously reported to date in the English literature whose cerebrospinal fluid glucose was from 1.6 to 2.7mmol/L,with a ratio of cerebrospinal fluid to serum glucose from 0.30 to *** Although rare,the cerebrospinal fluid of patients with VZV meningitis may have hypoglycorrhachia,which broadens the understanding of the disease.

关键词： Hypoglycorrhachia Varicella-zoster virus Meningitis Case report

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Exosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration

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World Journal of Stem Cells 2020年第8期12卷 803-813页

作者： Zhi-Lei Hu Hai-Yin Li Xian Chang Yue-Yang Li Chen-Hao Liu Xiao-Xin Gao Yu Zhai Yu-Xuan Chen Chang-Qing Li Department of Orthopedics Xinqiao HospitalArmy Military Medical UniversityChongqing 400037China Center of Traumatic Orthopedics People's Liberation Army 990 HospitalXinyang 46400Henan ProvinceChina

Intervertebral disc(IVD)degenerative diseases are a common problem in the world,and they cause substantial social and economic burdens for *** current methods for treating IVD degenerative diseases mainly include surgery and conservative treatment,which cannot fundamentally restore the normal structure of the *** continuous research on the mechanism of degeneration and the development of regenerative medicine,rapid progress has been made in the field of regenerative medicine regarding the use of stem cell-derived exosomes,which are active biological substances used in intercellular communication,because they show a strong effect in promoting tissue *** study of exosomes in the field of IVD degeneration has just begun,and many surprising achievements have been *** paper mainly reviews the biological characteristics of exosomes and highlights the current status of exosomes in the field of IVD degeneration,as well as future developments regarding exosomes.

关键词： Exosomes Intervertebral disc degeneration Stem cells MicroRNA Regenerative medicine Biological characteristic

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Portal venous arterialization resulting in increased portal inflow and portal vein wall thickness in rats

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World Journal of Gastroenterology 2008年第43期14卷 6681-6688页

作者： Wen-Gang Li Yong-Liang Chen Jing-Xi Chen Lei Qu Bin-Dang Xue Zhi-Hai Peng Zhi-Qiang Huang Department of Hepatobiliary Pancreas and Vessel Surgery Xiamen First Hospital Attached Fujian Medical University Xiamen 361003 Fujian Province China Institute of Hepatobiliary Surgery General Hospital ofPLA Beijing 100853 China Image Processing Centre Beijing University of Aeronautics and Astronautics Beijing 100083 China

AIM： To explore the influence of portal vein hemodynamic changes after portal venous arterialization （PVA） on peribiliary vascular plexus （PVP） morphological structure and hepatic pathology, and to establish a theoretical basis for the clinical application of PVA. METHODS： Sprague-Dawley rats were randomly divided into control and PVA groups. After PVA, hemodynamic changes of the portal vein and morphological structure of hepatohilar PVP were observed using Doppler ultrasound, liver function tests, ink perfusion transparency management and three-dimensional reconstruction of computer microvisualization, and pathological examination was performed on tissue from the bile duct wall and the liver. RESULTS： After PVA, the cross-sectional area and blood flow of the portal vein were increased, and the increase became more significant over time, in a certain range. If the measure to limit the flow in PVA was not adopted, the high blood flow would lead to dilatation of intrahepatic portal vein and its branches, increase in collagen and fiber degeneration in tunica intima. Except glutamic pyruvic transaminase （GPT）, other liver function tests were normal. CONCLUSION： Blood with a certain flow and oxygen content is important for filling the PVP and meeting the oxygen requirement of the bile duct wall. After PVA, It is the anatomic basis to maintain normal morphology of hepatohilar bile duct wall that the blood with high oxygen content and high flow in arterialized portal vein may fill PVP by collateral vessel reflux. A adequate measure to limit blood flow is necessary in PVA.

关键词： Peribiliary vascular plexus Portal venous arterialization Liver transplantation Bile duct neoplasms Three-dimensional reconstruction Hemodynamics

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Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

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Military Medical Research 2023年第2期10卷 162-174页

作者： Guang-Ying Cui Ben-Chen Rao Zhao-Hai Zeng Xue-Mei Wang Tong Ren Hai-Yu Wang Hong Luo Hong-Yan Ren Chao Liu Su-Ying Ding Jun-Jie Tan Zhen-Guo Liu Ya-Wen Zou Zhi-Gang Ren Zu-Jiang Yu Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene hospital of Henan Province/Precision Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Infectious Diseases Guangshan County People’s HospitalGuangshan CountyXinyang 465450HenanChina Department of Breast Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450052China Shanghai Mobio Biomedical Technology Co. LtdShanghai 201111China Health Management Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Due to the outbreak and rapid spread of coronavirus disease 2019(COVID-19),more than 160 million patients have become convalescents worldwide to *** alterations have occurred in the gut and oral microbiome and metabonomics of patients with ***,it is unknown whether their characteristics return to normal after the 1-year ***:We recruited 35 confirmed patients to provide specimens at discharge and 1 year later,as well as 160healthy controls.A total of 497 samples were prospectively collected,including 219 tongue-coating,129 stool and 149 plasma ***-coating and stool samples were subjected to 16S rRNA sequencing,and plasma samples were subjected to untargeted metabolomics ***:The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to *** the recovery process,the microbial diversity gradually *** acid-producing microbes and Bifidobacterium gradually increased,whereas lipopolysaccharideproducing microbes gradually *** addition,sphingosine-1-phosphate,which is closely related to the inflammatory factor storm of COVID-19,increased significantly during the recovery ***,the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year ***:This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of *** key microbiome and metabolites in the process of recovery were identified,and provided new treatment ideas for accelerating *** the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.

关键词： Coronavirus disease 2019(COVID-19) Gut microbiome Oral microbiome Plasma metabonomics Convalescents Individual outcomes Patient stratifcation Predictive Preventive and personalized medicine(3PM)

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