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Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1175-1186页

作者： Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed Pharmacognosy Department National Research Centre Hormones Department National Research Centre Chemistry of Natural Compounds Department National Research Centre Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) National Research Centre Therapeutical Chemistry Department National Research Centre Laboratory of Immune and Biomarkers for Infection the Center of Excellence for Advanced SciencesNational Research Centre

Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical ***:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,*** polysaccharide extracts(20 mg/kg *** 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were ***:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,*** polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC ***,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),*** bioactive polysaccharides in HCC induced rats improved the humoral immune *** photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological ***,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/***,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic ***:The pronounced antitumor activi

关键词： Jania rubens Pterocladia capillacea Enteromorpha intestinalis Polysaccharide-protein complexes Anti-tumor activity Anti-angiogenesis

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Overexpression of the phytochrome B gene from Arabidopsis thaliana increases plant growth and yield of cotton (Gossypium hirsutum)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 326-334页

作者： Abdul Qayyum RAO Muhammad IRFAN Zafar SALEEM Idrees Ahmad NASIR Sheikh RIAZUDDIN Tayyab HUSNAIN National centre of Excellence in Molecular Biology

The phytochrome B (PHYB) gene of Arabidopsis thaliana was introduced into cotton through Agrobacterium *** and expression of PHYB gene in cotton plants were confirmed by molecular *** RNA (mRNA) expression in one of the transgenic lines,QCC11,was much higher than those of control and other transgenic *** cotton plants showed more than a two-fold increase in photosynthetic rate and more than a four-fold increase in transpiration rate and stomatal *** increase in photosynthetic rate led to a 46% increase in relative growth rate and an 18% increase in net assimilation *** recorded up to two generations,both in the greenhouse and in the field,revealed that overexpression of Arabidopsis thaliana PHYB gene in transgenic cotton plants resulted in an increase in the production of cotton by improving the cotton plant growth,with 35% more ***,the presence of the Arabidopsis thaliana PHYB gene caused pleiotropic effects like semi-dwarfism,decrease in apical dominance,and increase in boll size.

关键词： Transformation Gossypium hirsutum Phytochrome B Overexpression Plant growth Yield

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Phytochemical screening, antioxidant and antibacterial properties of daphne mucronata

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Journal of Traditional Chinese Medicine 2019年第6期39卷 764-771页

作者： Ghosia Lutfullah Asma Shah Kafeel Ahmad Jamila Haider centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE:To aim at preliminary phytochemical screening of Daphne mucronata and evaluate its antioxidant and antibacterial ***:Preliminary phytochemical screening was conducted for the crude extracts using standard *** properties of crude methanolic extracts,n-hexane,chloroform,ethyl acetate and aqueous fractions of leaves,roots and bark were evaluated following standard *** antibacterial activities were checked against Acinetobacter baumannii(***),Escherichia coli(***),Pseudomonas aeruginosa(***),Staphylococcus aureus(***),Morganella morganii(***)and vancomycin resistant ***(VRSA).RESULTS:Carbohydrates,saponins,steroids,phenols/tannins,flavonoids and glycosides were present in different parts of Daphne *** extracts showed good antioxidant activity with EC50 values of 157.82-361.61μg/m *** extracts of roots showed good activity against ***(86.95%),***(85.18%)and ***(84.61%).Methanolic extracts of bark were active against ***(65.21%),***(65.21%)and ***(62.96%).Methanolic extracts of leaves showed good activity against ***(78.26%),***(77.78%),***(74.07%),***(73.07%),***(69.56%),VRSA(68%)and Proteus vulgaris(60%).The n-hexane fraction of roots was effective against ***(78.26%).Chlorofom fraction of roots showed moderate activity against ***(60.86%)and ***(61.53%).Ethyl acetate fraction of roots showed moderate activity against ***(69.56%),***(62.96%)and ***(69.23%).CONCLUSION:This study illustrates that Daphne mucronata possesses good antioxidant and antibacterial *** plant could be further exploited as potential natural antioxidant and as a new source of antimicrobials for treatment of various infections.

关键词： Antioxidants Anti-bacterial agents Phytochemicals Daphne mucronata

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Optimal placement of magnets in Indus-2 storage ring

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Chinese Physics C 2015年第3期39卷 58-65页

作者： Riyasat Husain A D Ghodke Gurnam Singh Raja Ramanna centre for Advanced Technology

In Indus-2, by optimizing the position of the magnetic elements, using the simulated annealing algorithm, at different locations in the ring with their field errors, the effects on beam parameters have been minimized. Closed orbit distortion and beta beat are considerably reduced by optimizing the dipole and quadrupole magnets positions in the ring. For the Indus-2 storage ring, sextupole optimization gives insignificant improvement in dynamic aperture with chromaticity-correcting sextupoles. The magnets have been placed in the ring with the optimized sequence and storage of the beam has been achieved at injection energy without energizing any corrector magnets. Magnet sorting has led to the easy beam current accumulation and the measurement of parameters such as closed orbit distortion, beta function, dispersion, dynamic aperture etc.

关键词： sorting magnet-to-magnet errors beta beat closed orbit distortion dynamic aperture simulatedannealing

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Molecular predictors of gemcitabine response in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2011年第11期3卷 153-164页

作者： Ioannis A Voutsadakis centre Pluridisciplinaire d'Oncologie Centre Hospitalier Universitaire Vaudois

Gemcitabine is one of the most used anti-neoplastic drugs with documented activity in almost all major localizations of *** pancreatic cancer treatment,gemcitabine occupies a prominent place as a first line chemotherapy,partly because of the paucity of other efficacious chemotherapy *** fact,only a minority of pancreatic cancer patients display a response or even stability of disease with the *** are currently no clinically applicable means of predicting which patient will derive a clinical benefit from gemcitabine although several proposed markers have been studied. These markers are proteins involved in drug up-take,activation and catabolism or proteins that define the ability of the cell to undergo apoptosis in response to the *** of these markers are reviewed in this *** also briefly discuss the possible role of stem cells in drug resistance to gemcitabine.

关键词： Pancreatic cancer Gemcitabine Chemotherapy Drug resistance Metabolism Akt kinase Nuclear factor-κB

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Phytoplankton abundance and community structure in the Antarctic polar frontal region during austral summer of 2009

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Chinese Journal of Oceanology and Limnology 2013年第1期31卷 21-30页

作者： SHRAMIK Patil RAHUL Mohan SUHAS Shetye SAHINA Gazi National centre for Antarctic and Ocean Research

The Antarctic polar front region in the Southern Ocean is known to be most productive. We studied the phytoplankton community structure in the Indian sector at this frontal location during late austral summer (February, 2009) onboard R/V Akademic Boris Petrov. We used the phytoplankton and microheterotrophs abundance, as also the associated physico-chemical parameters to explain the low phytoplankton abundance in the study region. This study emphasizes the shift of phytoplankton, from large (>10 μm) to small (10 μm) phytoplankton abundance during the late austral summer. This study highlights the highly productive polar front nevertheless becomes a region of low phytoplankton abundance, due to community shifts towards pico-phytoplankton (<10 μm) during late austral summer.

关键词： Southern Ocean polar front diatom ciliate dinoflagellate

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Exploratory analysis of structural diversity indicators at stand level in three Italian beech sites and implications for sustainable forest management

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Journal of Forestry Research 2019年第1期30卷 121-127页

作者： Giada Bertini Claudia Becagli Ugo Chiavetta Fabrizio Ferretti Gianfranco Fabbio Luca Salvati CREA Research Centre for Forestry and Wood

The present study introduces an exploratory data analysis based on structural indicators with the aim to assess the effect of silvicultural practices on tree stand structure. The study was carried out in three Italian beech forests of different ages with stand structures that originated from dissimilar regeneration and cultivation techniques(Cansiglio, northern Italy, Chiarano, central Italy,and Mongiana, southern Italy). Ten structural indicators were considered when investigating the latent multivariate relationship between stand structure attributes before and after thinning operations by using a multiway factor analysis(MFA). The MFA results identified the older stand at Cansiglio as more homogeneous for cultivation regimes,and more stable to practices when compared with the younger sites(Chiarano and Mongiana). Heterogeneous stands were sensitive to silvicultural practice thus suggesting their possible impact on forest attributes. The proposed approach proved to be an operational tool to evaluate comprehensively the response of forest structure to planned interventions.

关键词： Forest diversity Multiway factor analysis Silviculture Structural diversity indicators Tree stand structure

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Combat utility prediction

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Defence Technology（防务技术） 2016年第6期12卷 446-463页

作者： Stanislas GABROVSEK Ian COLWILL Elias STIPIDIS Vetronics Research centre University of Brighton

The majority of allied casualties from recent conflicts were caused by blast wave and fragments perforation damage from Improvised Explosive Devices. Survivability to this type of threat is a critical factor to consider for land platform design. This paper proposes an original approach to platform survivability assessment using a combination of Agent-Based(AB) simulation and Fault Tree Analysis(FTA) to predict the consequences of IED fragment impacts on the platform operational status. As a demonstration, this approach is applied to the comparison of different platform architectures to gain insight into the optimisation of the platform component topology.

关键词： Mission Survivability Simulation Agent-based Fault-tree analysis Platform architecture

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Guided mode resonance in planar metamaterials consisting of two ring resonators with different sizes

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Chinese Physics B 2017年第7期26卷 408-412页

作者：俞禛陈航刘建军井绪峰李向军洪治 centre for THz Research China Jiliang University

We proposed and experimentally investigated a two-ring-resonator composed planar hybrid metamaterial（MM）, in which the spectra of guided mode resonance（GMR） and Fano resonance or EIT-like response induced by coherent interaction between MM resonance and GMR can be easily controlled by the size of the two rings in the terahertz ***, a four-ring-resonator composed MM for polarization-insensitive GMRs was demonstrated, where GMRs of both TE and TM modes are physically attributed to the diffraction coupling by two ±45° tilting gratings. Such kind of device has great potential in ultra-sensitive label-free sensors, filters, or slow light based devices.

关键词： metamaterials terahertz guided mode resonance

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Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 403-410页

作者： Farouk K.El-Baz Gehad A.Abdel Jaleel Dalia O.Saleh Rehab A.Hussein Plant Biochemistry Department National Research Centre (NRC) Pharmacology Department National Research Centre (NRC) Pharmacognosy Department National Research Centre (NRC)

Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina(D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose(D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL(200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass(250 mg/kg), its carotenoid(250 μg/kg) and polar(250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31%. salina carotenoid fraction as well as the total biomass amelior β-carotene. Conclusions: Date D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β-carotene.

关键词： Aging Cardiac dysfunction Dunaliella salina Rats

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