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HACD1,a regulator of membrane composition and fluidity,promotes myoblast fusion and skeletal muscle growth

分子细胞生物学报:英文版 2015年第5期7卷 429-440页

作者： Jordan Blondelle Yusuke Ohno Vincent Gache Stephane Guyot Sebastien Storck Nicolas Blanchard-Gutton Ines Barthelemy Gemma Walmsley Anaelle Rahier Stephanie Gadin Marie Maurer Laurent Guillaud Alexandre Prola Arnaud Ferry Genevieve Aubin-Houzelstein Jean Demarquoy Frederic Relaix Richard JPiercy Stephane Blot Akio Kihara Laurent Tiret Fanny Pilot-Storck Inserm IMRB U955-E1094000 CreteilFrance Universite Paris-Est Ecole nationale veterinaire d’Alfort(EnvA)94700 Maisons-AlfortFrance Universite Paris-Est Creteil Faculte de medecine94000 CreteilFrance Laboratory of Biochemistry Faculty of Pharmaceutical SciencesHokkaido UniversitySapporo 060-0812Japan Universite de Bourgogne UMR A 02.102 PAM-EPMBAgroSup Dijon21000 DijonFrance Institut Necker-Enfants Malades INSERM U1151-CNRS UMR 8253Sorbonne Paris CiteUniversite Paris DescartesFaculte de Medecine-Site Broussais75015 ParisFrance Comparative Neuromuscular Disease Laboratory Department of Clinical Sciences and ServicesRoyal Veterinary CollegeLondon NW10TUUK Therapie des maladies du muscle strie INSERM U974-CNRS UMR7215-UPMC UM76-Institut de Myologie Universite Pierre et Marie Curie-Universite Paris Descartes75000 ParisFrance Universite de Bourgogne Faculte des Sciences GabrielBio-PeroxIL21000 DijonFrance

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies,yet the underlying cellular and molecular mechanisms remain *** this study,we investigate the role of HACD1/PTPLA,which is involved in the elongation of the very long chain fatty acids,in muscle fibre *** humans and dogs,HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized *** of HACD1-deficient Labradors,Hacd1-knockout mice,and Hacd1-deficient myoblasts,we provide evidence that HACD1 promotes myoblast fusion during muscle development and *** further demonstrate that in normal differentiating myoblasts,expression of the catalytically active HACD1 isoform,which is encoded by a muscle-enriched splice variant,yields decreased lysophosphatidylcholine content,a potent inhibitor of myoblast fusion,and increased concentrations of≥C18 and monounsaturated fatty acids of *** lipid modifications correlate with a reduction in plasma membrane *** conclusion,we propose that fusion impairment constitutes a novel,non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism.

关键词： centronuclear myopathy LPC MUFA PTPLA VLCFA

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Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018

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Burns & Trauma 2019年第1期7卷 356-395页

作者： Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi Department of Plastic Reconstructive and Aesthetic SurgeryNippon Medical School1-1-5 Sendagi Bunkyo-kuTokyo 113-8603Japan Department of Plastic Surgery Wound Repair and RegenerationFukuoka UniversityFukuoka 814-0180Japan Department of Plastic Surgery Nippon Medical School Musashikosugi Hospital1-396 KosugichoNakahara-kuKawasaki-shiKanagawa 211-8533Japan Department of Plastic and Reconstructive Surgery Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Department of Plastic and Reconstructive Surgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-8638Japan Department of Plastic Surgery Tokai University School of Medicine4-1-1 KitakanameHiratsukaKanagawa 259-1292Japan Department of Plastic and Reconstructive Surgery Tokyo Medical University6-7-1 NishishinjukuShinjuku-kuTokyo 160-0023Japan Department of Plastic and Reconstructive Surgery Osaka Saiseikai Nakatsu Hospital2-10-39 ShibataKita-kuOsaka 530-0012Japan Department of Plastic Reconstructive and Aesthetic SurgeryIwate Medical University School of Medicine19-1 UchimaruMoriokaIwate 020-8505Japan Department of Plastic Surgery Oita University Hospital1-1 IdaigaokaHasamamachiYufu-shiOita 879-5503Japan Department of Plastic Surgery Showa University Fujigaoka Hospital1-30 FujigaokaAoba-kuYokohamaKanagawaJapan Department of Plastic and Reconstructive Surgery Japanese Red Cross Fukui Hospital2-4-1 TsukimiFukui 918-8501Japan Division of Dermatology and Dermatopathology Nippon Medical School Musashikosugi Hospital1-396KosugichoNakahara-kuKawasaki-shiKanagawa 211-8533Japan Faculty of Pharmaceutical Sciences Teikyo Heisei University4-21-2 NakanoNakano-kuTokyo 164-8530Japan Wakamatsu-cho Mental and Skin Clinic 9-4 Wakamatsu-choShinjyuku-kuTokyo 162-0056Japan Department of Radiation Oncology Nippon Medical School HospitalTokyo 113-8603Japan

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic *** is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these *** contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be *** ethnic disparity also means that countries vary in terms of their differential diagnostic *** lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven *** overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature *** tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected *** tool is simple and easy to *** a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their *** JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment *** guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment *** Consensus Document is provided in this *** describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these *** believe that t

关键词： Keloid Hypertrophic scars Pathological scars Guideline Pathology Surgery Radiotherapy Steroid Laser

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Evaluation of an oral moisture-checking device for screening dry mouth

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Open Journal of Stomatology 2013年第8期3卷 440-446页

作者： Yosuke Fukushima Tetsuya Yoda Shoichiro Kokabu Ryuichiro Araki Tsubasa Murata Yoshimasa Kitagawa Ken Omura Shuji Toya Kayoko Ito Saori Funayama Hiroshi Iwabuchi Kazuhiro Asano Yutaka Imai Akihide Negishi Satoshi Yokoo Goichi Matsumoto Eiro Kubota Hideki Watanabe Mikio Kusama Kojiro Onizawa Takuya Goto Seiji Nakamura Ryuichi Nakazawa Kiyoshi Harada Takashi Fujibayashi Community Health Science Center Saitama Medical University Saitama Japan Department of Dentistry and Oral Surgery Tochigi National Hospital Tochigi Japan Department of Oral and Maxillofacial Surgery Division of Medicine Interdisciplinary Graduate School of Medicine and Engi- neering Univer-sity of Yamanashi Kofu and Tamaho Japan Department of Oral and Maxillofacial Surgery Dokkyo Medical University School of Medicine Tochigi Japan Department of Oral and Maxillofacial Surgery Faculty of Medicine Sai-tama Medical University Saitama Japan Department of Oral and Maxillofacial Surgery Institute of Clinical Medicine University of Tsukuba Tsukuba Japan Department of Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan Department of Oral and Maxillofacial Surgery Kanagawa Dental College Yokosuka Japan Department of Stomatology and Oral Surgery Gunma University Graduate School of Medicine Maebashi Japan Division of Gereatric Dentistry Niigata University Medical & Dental Hospital Niigata Japan Oral and Maxillofacial Surgery Dry Mouth Clinic The Nippon Dental University Niigata Hospital Niigata Japan Oral Diagnosis and Medicine Department of Oral Pathobiological Science Graduate School of Dental Medicine Hokkaido University Sapporo Japan Oral Surgery Department of Oral Restitution Division of Oral Health Sciences Graduate School Tokyo Medical and Dental University Tokyo Japan Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

关键词： Dry Mouth Oral Moisture-Checking Device ROC Analysis

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我国羊泰勒虫病快速诊断方法成环恒温扩增法的研制

我国羊泰勒虫病快速诊断方法成环恒温扩增法的研制

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中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十次学术研讨会

作者：刘志杰侯俊玲 Mohammed A.Bakheit Diaeldin A.salih 罗建勋殷宏 Jabbar S.Ahmed Ulrike Seitzer 中国农业科学院兰州兽医研究所国家兽医病原生物学重点实验室甘肃省兽医寄生虫病重点实验室 Division of Veterinary Infection Biology and Immunology Research Center BorstelGermany National Research Center for Protozoan Disease Obihiro University for Agriculture and Veterinary MedicineInada-choObihiroHokkaidoJapan 中国农业科学院兰州兽医研究所国家兽医病原生物学重点实验室甘肃省兽医寄生虫病重点实验室

成环恒温扩增方法(LAMP)是一个新型的核酸检测方法,该方法需要两对或三对引物与目标DNA模板结合,在恒温条件下反应,这一方法具有高效,敏感和特异等特点。本研究中,我们以引起我国羊泰勒虫病的病原尤氏泰勒虫(Theileria uilenbergi)和吕...

成环恒温扩增方法(LAMP)是一个新型的核酸检测方法,该方法需要两对或三对引物与目标DNA模板结合,在恒温条件下反应,这一方法具有高效,敏感和特异等特点。本研究中,我们以引起我国羊泰勒虫病的病原尤氏泰勒虫(Theileria uilenbergi)和吕氏泰勒虫(***)同源基因(UTRu6,UTRlu8)的保守区为模板,设计了LAMP引物。这组引物能同时扩增这两种病原,反应条件为63摄氏度,反应时间为15分钟。反应产物经EcoRⅠ酶切消化和序列测定证明了反应的特异性,另外,通过测定10倍稀释的DNA样品,证明了该方法具有从0.1皮克DNA样品中扩增到目标基因的敏感性。最后,通过比较LAMP和反向线性应迹法(RLB)测定86份野外样品的结果,确定了LAMP的敏感性和特异性分别为66.0%和97.4%。由于该方法快速,简便,廉价,敏感且特异,所以它将具有对我国羊泰勒虫病的诊断和流行病学调查的潜在应用价值。

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Contribution of Sumalindo Company:In Managing Forest Resources with Local Communities:Mahakam Ulu-East Kalimantan

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Journal of Environmental Science and Engineering(B) 2022年第4期11卷 111-124页

作者： Herman Hidayat Massa Jafar David A.Sonnenfeld Stephen Wyatt Masatoshi Sasaoka Ndan Imang Martinus Nanang Research Center for Society and Culture National Research and Innovation Agency(BRIN)Gatot Subroto Street number 10South Jakarta 12710Indonesia Graduate School of Social and Political Sciences Universitas Nasional-JakartaHarsono Street number 1-RagunanSouth Jakarta 12550Indonesia College of Environmental Science of Forestry State University of New YorkSyracuse 262 W 38 th St 506NY 10018USA School of Forestry Universite’de MonctonCampus d’EdmunstonNew Brunswick 506Canada Faculty of Human Science Hokkaido UniversityKita 8Nishi 5Kita-Ku 060-0808SapporoJapan Faculty of Agriculture Mulawarman UniversityCampus Gunung KeluaPenajam StreetSamarinda75119East Kalimantan Faculty of Social and Political Science Mulawarman UniversityCampus Gunung KeluaPenajam StreetSamarinda75119East

The role of HPH(Forest Logging Concession)in developing rural communities is very ***(Sumalindo Lestari Jaya)as HPH company has an important contribution in empowering local communities,especially in opening land transportation in the interior and helping to build agriculture and *** existence of Sumalindo company participates in developing forest resource management with local communities,among others,increasing livelihoods,maintaining and developing biodiversity conservation and maintaining climate *** efforts are in accordance with the regulations of the KLHK(Ministry of Environment and Forestry),that every HPH holder is required(mandatory)to obtain a certificate of“PHAPL”(Sustainable Production Natural Forest Management)and an“eco label”from the Indonesian Eco Label ***,it is recommended that the holders of HPH concessions and HTI(Industrial Timber Plantations)have an FSC(Forest Stewardship Council)certificate from the EU(European Union),and must meet three indicator elements,namely economic,social and ecological in SFM(Sustainable Forest Management).This article examines three critical questions that show the role of Sumalindo Company in economic,ecological and social development and managing forest resources with the community as follows:(1)The role of Sumalindo company contributes to the development of road infrastructure in the interior;(2)The role of Sumalindo in improving livelihoods and economic and social empowerment of local communities;(3)The role of Sumalindo with local communities in managing forest resources,including maintaining and developing biodiversity conservation and maintaining climate change.

关键词： SLJ economic ecological and social forest resource management PHAPL management FSC local communities

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Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods

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Plant Phenomics 2021年第1期3卷 277-285页

作者： Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du Végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Hiphen SAS 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Wheat Genetics Resource Center Dep.of Plant PathologyKansas State Univ.4024 Throckmorton Plant Sciences CenterManhattanKansasUSA Global Wheat Program International Maize and Wheat Improvement Centre(CIMMYT)MexicoD.F.Mexico Faculty of Biosciences Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway Agricultural Research Corporation Wheat Research ProgramP.O.Box 126Wad MedaniSudan Arid Land Research Center Tottori UniversityTottori 680-0001Japan Laboratories of Plant Genetics and Plant Breeding Graduate School of AgricultureKyoto UniversityJapan CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Crop Science National Agriculture and Food Research OrganizationJapan hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Biosystems Dynamics and Exchanges TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant Sciences TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada College of Agriculture and Life Sciences University of ArizonaTucsonArizona

The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/*** an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science *** this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label *** address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat *** now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version.

关键词： Wheat adding release

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期105卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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