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Furin Enzyme-Responsive siRNA Delivery System for Efficient Anti-Hypoxia-Assisted Cancer Photodynamic Therapy

CCS Chemistry 2024年第4期6卷 999-1010页

作者： Shuyue Ye Yali Feng Yuqi Zhang Jing Fang Anna Wang Chaoxiang Cui Jinfeng Zhu Liangsheng Guo Guohua Fan Haibin Shi State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123 Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004 Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004

RNA interfering therapy has emerged as a promising therapeutic modality to treat *** specific and efficient delivery of RNA into a tumor is crucial for achieving effective cancer gene therapy but remains a huge ***,we report a novel furin-responsive small interfering RNA(siRNA)delivery vehicle with multiple functions for colorectal tumor treatment.A peptide-based siRNA delivery vehicle RVRR-P18-Gd,consisting of furin enzyme-specific peptide substrate Arg-Val-Arg-Arg(RVRR)with positive charge for siRNA binding,a Gd(III)chelated 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid(DOTA)(DOTA-Gd)for magnetic resonance imaging,and purpurin 18 as photosensitizer for photodynamic therapy(PDT),was rationally designed and *** advantage of the cationic amphiphilic feature,RVRR-P18-Gd molecules spontaneously self-assembled with negatively charged Hif-1αsiRNA into stable nanoparticles via attractive electrostatic interaction,which effectively prevented siRNA degradation by nucleases,prolonged the circulation half-life,and enhanced tumor ***,the specific release of Hif-1αsiRNA mediated by endogenous furin significantly downregulated Hif-1αexpression in colorectal cancer cells,resulting in enhanced therapeutic susceptibility,and with the PDT effect,effectively suppressed HCT116 tumor growth in living *** work highlights a powerful and universal approach to precisely deliver siRNA to targeted tumors for efficient synergistic therapy.

关键词： self-assembly RNA interfering enzymeresponsive delivery anti-hypoxia photodynamic therapy

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A case of Rickettsia felis infection-induced encephalitis in a pregnant woman

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World Journal of Emergency Medicine 2024年第2期15卷 150-152页

作者： Jinghua Qiu Hui Feng Lijun Liu Jianjun Zhu Department of Emergency and Critical Care Medicine the Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

Rickettsia felis is an exclusively cytozoic Gram-negative prokaryote with cat fleas as the major vectors.[1]As early as 1918,Rickettsia felis was detected in cat fleas in Europe and named Rickettsia ctenocephali.[2]Symptoms of fever,malaise,headache,maculopapular rash and eschar are observed in patients with Rickettsia felis infection.

关键词： encephalitis headache infection

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Incidence of surgical site infection in minimally invasive colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1121-1129页

作者： Lu-Ting Ni Ru Zhao Yi-Ru Ye Yi-Ming Ouyang Xin Chen Department of Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Surgical site infection(SSI)is a common complication of colorectal *** invasive surgery notably reduces the incidence of *** study aimed to compare the incidences of SSI after robot-assisted colorectal surgery(RACS)vs that after laparoscopic assisted colorectal surgery(LACS)and to analyze associated risk factors for SSI in minimally invasive colorectal *** To compare the incidences of SSI after RACS and LACS,and to analyze the risk factors associated with SSI after minimally invasive colorectal *** Clinical data derived from patients who underwent minimally invasive colorectal surgery between October 2020 and October 2022 at the First Affiliated Hospital of soochow university were *** in clinical characteristics and surgeryrelated information associated with RACS and LACS were compared,and possible risk factors for SSI were *** A total of 246 patients(112 LACS and 134 RACS)were included in the ***(17.5%)developed *** proportions of patients who developed SSI were similar in the two groups(17.9%vs 17.2%,P=0.887).Diabetes mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for *** additional risk factors included neoadjuvant therapy,lesion site,and operation *** There was no difference in SSI incidence in the RACS and LACS *** mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for postoperative SSI.

关键词： Colorectal surgery Minimally invasive surgery Surgical site infection

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Wideband chaos generation using a VCSEL with intensity modulation optical injection for random number generation

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Science China(Information Sciences) 2024年第6期67卷 457-458页

作者： Yu HUANG Shuangquan GU Yuhang FENG Yigong YANG Shuiying XIANG Pei ZHOU Nianqiang LI School of Optoelectronic Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University State Key Laboratory of Integrated Service Networks Xidian University Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province & Key Lab of Modern Optical Technologies of Education Ministry of China Soochow University

Physical random numbers have been widely used in modern network society,such as the generation of cryptographic keys for classical and quantum cryptography systems[1].Among the many sources of physical entropy,chaotic semiconductor lasers have attracted wide attention due to their desired characteristics including larger bandwidth,low cost,and monolithic integration[2].

关键词： Optical signal processing

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Gelfand-Kirillov Dimension and Reducibility of Scalar Generalized Verma Modules for Classical Lie Algebras

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Acta Mathematica Sinica,English Series 2024年第3期40卷 658-706页

作者： Zhan Qiang BAI Jing JIANG School of Mathematical Sciences Soochow UniversitySuzhou 215006P.R.China E-mail:zqbai@*** jjsd6514@***

Let g be a classical complex simple Lie algebra and q be a parabolic *** M be a generalized Verma module induced from a one dimensional representation of *** M is called a scalar generalized Verma *** this paper,we will determine the reducibility of scalar generalized Verma modules associated to maximal parabolic subalgebras by computing explicitly the Gelfand-Kirillov dimension of the corresponding highest weight modules.

关键词： Generalized Verma module Gelfand-Kirillov dimension Young tableau

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Semitransparent organic solar cells with high light utilization efficiency and color rendering index

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Science China Chemistry 2024年第7期67卷 2248-2256页

作者： Ni Gao Haijun Bin Shangrong Wu RenéA.J.Janssen Yongfang Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China Molecular Materials and Nanosystems&Institute for Complex Molecular Systems Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands

Semitransparent organic solar cells(ST-OSCs)have garnered considerable attention as promising renewable energy technology for integrating photovoltaics into ***,there is a trade-off between power conversion efficiency(PCE)and average visible transmittance(AVT),which hinders the achievement of a high light utilization efficiency(LUE).In this study,we propose a valuable method to address this challenge by replacing the transparent top electrode,Ag,with a 20 nm layer of *** ST-OSCs based on the 20 nm Au electrode demonstrate superior exciton extraction,more efficient charge collection,and higher color-rendering index(CRI)due to their smoother surface,higher conductivity,and enhanced visible light transmittance,resulting in a significantly higher PCE of 13.67%and an enhanced AVT of 30.17%,contributing to a high LUE of 4.15%.Additionally,optically transparent dielectric layers,applied on the front and back sides of the ST-OSCs to further boost performance,delivered an impressive LUE of 4.93%,with PCE and AVT values reaching 14.44%and 34.12%,***,the champion ST-OSCs also exhibited a favorable CRI value of *** achievements represent the bestperforming ST-OSCs to date with both high LUE and CRI and hold significant implications for the prospective commercialization of ST-OSCs.

关键词： semitransparent organic solar cells power conversion efficiency average visible transmittance light utilization efficiency color-rendering index

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Multi-scenario Simulation of the Impact of Land Use Change on the Ecosystem Service Value in the Suzhou-Wuxi-Changzhou Metropolitan Area,China

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Chinese Geographical Science 2024年第1期34卷 79-92页

作者： WANG Bin HU Chunguang ZHANG Yushuo Department of Tourism Management Soochow UniversitySuzhou215123China Academy of Culture and Tourism Research Soochow UniversitySuzhou215123China School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhan430074China Hubei Engineering and Technology Research Center of Urbanization Wuhan430074China Faculty of Culture Tourism Shanxi University of Finance and EconomicsTaiyuan030006China

As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem service value(ESV).Based on the patterns of land use change and the ESV change in Su-Xi-Chang metropolitan area from 2000 to 2020,we set up four scenarios:natural development scenario,urban development scenario,arable land protection scenario and ecological protection scenario,and simulated the impact of land use changes on the ESV in these *** results showed that:1) the area of built-up land in the Su-XiChang metropolitan area increased significantly from 2000 to 2020,and the area of other types of land *** land underwent the highest transfer-out area,and was primarily converted into built-up *** total ESV of Su-Xi-Chang metropolitan area increased initially then declined from 2000–2020,and the value of almost all individual ecosystem services decreased.2) Population density,GDP per area,night lighting intensity,and road network density can negatively impact the ESV.3) The total ESV loss under the natural development and urban development scenarios was high,and the expansion of the built-up land and the drastic shrinkage of the arable land contributed to the ESV decline under both *** total ESV under arable land protection and ecological protection scenarios increases,and therefore these scenarios are suitable for future land use optimization in *** study could provide a certain reference for land use planning and allocation,and offer guidance for the rational allocation of land resources.

关键词： multiple scenarios land use simulation ecosystem service value(ESV) Patch-Generating Land Use Simulation(PLUS)model Suzhou-Wuxi-Changzhou(Su-Xi-Chang)metropolitan area

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Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

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Oncology Research 2024年第2期32卷 353-360页

作者： ZHI ZHANG XIAOSONG LI YING ZHANG HAO ZHU ZHENGUO QIAO YANG LU XIUWEI MI HUIHUA CAO GENHAI SHEN SONGBING HE Department of General Surgery Suzhou Ninth People’s HospitalSuzhou Ninth Hospital Affiliated to Soochow UniversitySuzhouChina Medical College of Nantong university NantongChina Department of Gastroenterology Suzhou Ninth People’s HospitalSuzhou Ninth Hospital Affiliated to Soochow UniversitySuzhouChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncological Surgery Kunshan Traditional Hospital Affiliated to Nanjing University of Chinese MedicineKunshanChina

Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality *** in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome *** this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain ***,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in *** findings showed a reduced AIM2 expression in most CRC cell *** of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell *** research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and ***,our achievements distinctly underscored AIM2’s antitumor role in ***2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC.

关键词： Absent in melanoma 2 Proliferation Migration Apoptosis P38MAPK Colorectal cancer

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Exploring Tourists’Low-carbon Cognition and Influencing Factors from the Dimension of Education Level

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Journal of Resources and Ecology 2024年第4期15卷 1083-1093页

作者： CHENG Jinhong College of history and Tourism Culture Shanxi Normal UniversityTaiyuan 030031China

The cognition of low-carbon tourism among tourists is closely related to education *** this study,the degree of coordination of low-carbon cognition with different educational levels is assessed by the coupling model in Wutai Mountain,and the effect of each factor on low-carbon cognition is analyzed by the geographical *** results show that:(1)The six cognition aspects of low-carbon tourism gradually transition from the level of intermediate coordination to good coordination with the advancement of the education *** the low-level and lower-level tourists belong to the lag type of low-carbon visiting cognition,and the higher-level tourists belong to the lag type of low-carbon shopping cognition,while the high-level tourists show the lag type of low-carbon food cognition.(2)According to the individual factors and interactive effects in the geographical detector,each impacting factor has a decisive effect on tourists’cognition of low-carbon tourism,and the effect of any two factors after interaction shows either a double-factor or nonlinear *** findings of this study provide valuable practical implications for helping tourism destinations to educate tourists and improve their low-carbon tourism *** the same time,this study will provide theoretical standards for measuring tourists’cognition of low-carbon tourism,so as to enrich and improve the theoretical research related to low-carbon tourism.

关键词： low-carbon tourism cognitive differences education level model of coupling coordination degree Geo-detector

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A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

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Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun‑sing Lee Shengliang Li Xiao‑Hong Zhang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

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