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Intratumoural microbiota:a new frontier in cancer development and therapy

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Signal Transduction and Targeted Therapy 2024年第2期9卷 597-620页

作者： Yaqi Cao Hui Xia Xueyun Tan Chunwei Shi Yanling Ma Daquan Meng Mengmeng Zhou Zhilei Lv Sufei Wang Yang Jin department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesKey Laboratory of Respiratory Diseases of National Health CommissionState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Engineering Research Center for Tumour-Targeted Biochemotherapy MOE Key Laboratory of Biological Targeted TherapyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological *** studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to *** concept of intratumoural microbiota was subsequently *** could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour *** studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and *** more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under *** addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable ***,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field.

关键词： tumour invasion metabolism

Predictive value of neutrophil-to-lymphocyte ratio in in-hospital mortality in sepsis patients:A cross-sectional study

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Journal of Acute Disease 2024年第3期13卷 106-110页

作者： Pankaj Kumar Jain Manoj Seval Vikas Meena Dinesh Kumar Meena department of Internal Medicine Government Medical CollegeKotaIndia

Objective:To explore the predictive value of neutrophil-to-lymphocyte ratio(NLR)in in-hospital mortality in sepsis ***:A prospective observational cross-sectional study was conducted on 100 patients with *** data about the patient’s demography,medical history,general examination including pulse rate,blood pressure,etc,use of vasopressor support,need for renal replacement therapy,mechanical ventilation,outcome,and lab parameters including total lymphocyte count with neutrophil-to-lymphocyte ratio were *** parameters between survivals and non-survivals were ***:Out of 100 patients,80%were from rural *** patients were 50 to 59 years old.26 Patients were *** patients in the nonsurvivor group were older and more had a history of diabetes mellitus when compared with the survivor *** non-survivor group had a higher NLR,APACHE栻,and SOFA ***:NLR is a readily available parameter and can be used as a good prognostic indicator for mortality in sepsis patients.

关键词： Neutrophil-to-lymphocyte ratio Sepsis Intensive Care Unit Mortality APACHE score SOFA score

Application of geophysical well logs in solving geologic issues:Past,present and future prospect

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Geoscience Frontiers 2024年第3期15卷 85-118页

作者： Jin Lai Yang Su Lu Xiao Fei Zhao Tianyu Bai Yuhang Li Hongbin Li Yuyue Huang Guiwen Wang Ziqiang Qin National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China college of Geosciences China University of Petroleum(Beijing)Beijing 102249China department of Petroleum Engineering University of WyomingLaramieWY 82071USA

Geophysical well logs are widely used in geological fields,however,there are considerable incompatibilities existing in solving geological issues using well log *** review critically fills the gaps between geology and geophysical well logs,as assessed from peer reviewed papers and from the authors’personal experiences,in the particular goal of solving geological issues using geophysical well *** origin and history of geophysical logging are *** follows a review of the state of knowledge for geophysical well logs in terms of type of specifications,vertical resolution,depth of investigations and demonstrated *** the current status and advances in applications of geophysical well logs in fields of structural geology,sedimentary geology and petroleum geology are *** logs are used in structural and sedimentary geology in terms of structure detection,in situ stress evaluation,sedimentary characterization,sequence stratigraphy division and fracture *** logs can also be applied in petroleum geology fields of optimizing sweet spots for hydraulic fracturing in unconventional oil and gas *** well logs are extending their application in other fields of geosciences,and geological issues will be efficiently solved via well logs with the improvements of advanced well log *** work is required in order to improve accuracy and diminish uncertainties by introducing artificial *** review provides a systematic and clear descriptions of the applications of geophysical well log data along with examples of how the data is displayed and processed for solving geologic problems.

关键词： Geophysical well logs Sequence stratigraphy Source rock Unconventional oil and gas resources Artificial intelligence

Neuroimaging features in a patient with non-ketotic hyperglycaemic seizures: A case report

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World Journal of Clinical Cases 2024年第5期12卷 1004-1009页

作者： Jing Wu Huijie Feng Yaxiong Zhao Junfeng Li Ting Li Kefeng Li department of Radiology Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Changzhi Key Lab of Functional Imaging for Brain Diseases Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China

BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic *** clinical characteristics of NKH seizures are atypical and lack unified diagnostic criteria,leading to potential misdiagnoses in the early stages of the *** SUMMARY This report presents a rare case of NKH seizures in a 52-year-old male patient with a history of type 2 diabetes *** performed comprehensive magnetic resonance imaging(MRI)studies at admission,12 d post-admission,and 20 d *** imaging techniques included contrast-enhanced head MRI,T2-weighted imaging(T2WI),fluid-attenuated inversion recovery(FLAIR),diffusion-weighted imaging,susceptibility-weighted imaging,magnetic reso-nance spectroscopy(MRS),and magnetic resonance *** the time of admission,T2WI and FLAIR of the cranial MRI showed that the left parieto-occipital cortex had gyrus-like swelling and high signal,and subcortical stripes had low *** showed a reduced N-acetylaspartate peak and increased creatine and choline peaks in the affected areas.A follow-up MRI 20 d later showed that the swelling and high signal of the left parieto-occipital cortex had disappeared,and the low signal of the subcortex had *** This case study provides valuable insights into the potential pathogenesis,diagnosis,and treatment of NKH *** comprehensive MRI findings highlight the potential utility of various MRI sequences in diagnosing and characterizing NKH seizures.

关键词： Non-ketotic hyperglycaemia seizures Magnetic resonance imaging Magnetic resonance spectroscopy Diabetes Case report

Analysis of the history and Current Situation of the Development of General Practice Teaching Clinics in China

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Open Journal of Preventive Medicine 2024年第2期14卷 29-38页

作者： Xiaotong Huo Yajun Lian Graduate School Changzhi Medical College Changzhi China department of Family Medicine Peace Hospital Changzhi Medical College Changzhi China

A summary of the exploration of the teaching mode of the general practice teaching clinic, a summary of the deficiencies of the teaching clinic and a summary of the significance of the establishment of the general practice teaching clinic are presented with a view to promoting the development of general practice and cultivating more excellent successors in general practice.

关键词： General Practice Teaching Clinic Teaching Models Teaching Deficiencies in the Clinic Significance of the Teaching Clinic

Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

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World Journal of Gastroenterology 2024年第9期30卷 1108-1120页

作者： Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-Wei Wang Jing-Nan Li department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China department of Gastroenterology Nanjing Drum Tower HospitalNanjing 21000Jiangsu ProvinceChina department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina department of Gastroenterology Renji HospitalShanghai 200127China department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina department of Gastroenterology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina department of Gastroenterology and Hepatology The People’s Hospital of Zhengzhou UniversityThe Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai Jiao Tong UnivesrityRuijin HospitalSchool MedicineShanghai 200025China department of Gastroenterology and Hepatology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina department of Gastroenterology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina department of Gastroenterology Nanfang HospitalGuangzhou 510080Guangdong ProvinceChina department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of Gastroenterology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina department of Gastroenterology Peking University Third HospitalBeijing 100191China department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei Pr

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully *** lack of consensus regarding its treatment has resulted in varied treatment *** To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in *** We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and *** and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of *** Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were *** pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting *** was classified as chronic non-atrophic in 69.9%of *** those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat *** patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more *** those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more *** CEG is a multifactorial disease which is common in Asian patients and has non-specific *** may play a major role in its detection and *** should be individualized based on symptom profile.

关键词： Chronic erosive gastritis Symptom Endoscopic findings Treatment pattern Real-world

Patterns of Infertility and Abortion in Saudi Arabia: A Cross-Sectional Study

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 911-922页

作者： Majed Saeed Alshahrani department of Obstetrics and Gynaecology College of Medicine Najran University Najran Saudi Arabia

Background: Infertility and abortion are significant reproductive health concerns globally, impacting individuals' well-being and healthcare systems. In Saudi Arabia, cultural, social, and religious factors influence perceptions and management of these issues, necessitating research to understand the patterns and associated factors. Study Aim: This cross-sectional study aimed to investigate the patterns of infertility and abortion among 458 women in Saudi Arabia, focusing on demographic profiles, reproductive histories, medical conditions, and lifestyle factors. Methodology: Participants were recruited from healthcare facilities, and data on age, BMI, reproductive history, medical conditions, assisted reproduction methods, and lifestyle behaviors were collected. Statistical analyses, including chi-square tests, were conducted to examine associations between variables. Results: The majority of participants were aged 30 - 39 years (47.4%), with 76.9% experiencing secondary infertility. Among those with offspring (76.9%), 31% reported using assisted reproduction methods, primarily ovarian stimulators (54.2%). Abortion history was reported by 39.5% of participants. Significant associations were found between age and infertility type (X2 = 5.8, p = 0.054), having offspring and infertility type (X2 = 458.0, p = 0.001), menstrual irregularity and infertility type (X2 = 11.4, p = 0.001), and abortion history and delayed fertility (X2 = 10.4, p = 0.001). Conclusion: Our study reveals significant associations between demographic, medical, and lifestyle factors with infertility patterns and abortion history among Saudi women. These findings emphasize the need for tailored interventions addressing medical conditions, age-related factors, and access to reproductive healthcare services.

关键词： Infertility Abortion Saudi Arabia Reproductive Health Assisted Reproduction Cross-Sectional Study

Physical separation from the mate diminishes male＇s attentiveness towards other females： a study in monogamous prairie voles Microtus ochrogaster

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Current Zoology 2017年第5期63卷 537-544页

作者： Christine J. DELEVAN Natalia A. RODRIGUEZ Karine M. LEGZIM Fayeza ALIOU Jamie T. PARKER Maryam BAMSHAD department of Biological Sciences Lehman College--The City University of New York Bronx NY 10468 USA

We tested whether continuous cohabitation in monogamous voles affects the mated male＇s atten-tiveness to his breeding partner versus another female. Each male was housed in a 3-chamber ap-paratus with a Focal female （FF） and a Control female （CF） for 13 days then placed in a T-maze toassess his attentiveness to and memory of those females. The Distal male remained physically sep-arated from both females, but received their distal cues. The Separate male cohabited with the FFfor 3 days then remained physically separated from both females. The Disrupt male＇s continuouscohabitation with the FF was disrupted by having him physically separated from her after 10 daysand placed with the CF for the last 3 days. The Continuous male cohabited continuously with the FFfor 13 days. With females in the T-maze, the Separate and Disrupt males spent more time near theFF＇s box and the Disrupt males spent more time manipulating the FF＇s box than the CF＇s box. TheSeparate males groomed themselves more when near the FF＇s box than the CF＇s box. The Distaland Continuous males＇ attentiveness to the two females did not differ. Results suggest that phys-ical distance from the partner may reduce male＇s attentiveness toward other potential *** voles might be similar to socially monogamous primates in using tactile cues as a signal formaintaining their social bonds.

关键词： attachment, monogamy, partner preference, partner separation, social cognition.

The Channel Branches & Network Vessels on the Tianhui Lacquered Meridian Figurine——Taking the Heart-Regulated Channel as an Example

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Chinese Medicine and Culture 2024年第3期7卷 222-232页

作者： ZHOU Qi Lena Springer Institute for the history of Chinese Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China department for Theology and Religious Studies King’s College LondonLondon WC2B 6NRUnited Kingdom Institute of Chinese Su Folk Culture Studies Sichuan UniversityChengdu 610065China

Along with the surge of unearthed medical literature and cultural relics in recent years,a network of channels in the system of medical conduit vessels(meridians) during the early Western Han dynasty has become much clearer *** it,the increasing number of channel branches,network vessels and needle insertion holes(acupoints) is an important feature of the development of channel medicine during the Western Han *** is not only a reflection of the expanding requirements of the theoretical system of the main trunk channels and other vessels,but also an inevitable result of the continuous enrichment and accumulation of clinical *** article integrates the information about channel branches,network vessels,inscriptions,dots and further relics on the Tianhui(天回) Lacquered Meridian Figurine to compare the unearthed literature of the channel genre with the transmitted classical literature about *** “Heart-Regulated Channel” in Medical Manuscripts on Bamboo Slips from Tianhui(《天回医简》) serves as an example to explain the occurrence,development and changes of the channel branches and network vessels in the early system of medical channels.

关键词： Tianhui Lacquered Meridian Figurine(天回髹漆经脉人像) Tianhui Medicine Slips Heart-Regulated Channel(心主之脉) Channel branches Network channels