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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： Chang-Sheng Zuo Kang Wang Li-Zhen Sun Ting-Ting Sun department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li Zhen Gu department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and department of Cell Biology Zhejiang University School of Medicine department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of zhejiang university MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Inorganic ionic polymerization:From biomineralization to materials manufacturing

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Nano Research 2024年第2期17卷 550-569页

作者： Yanhua Sang Kexin Qin Ruikang Tang Zhaoming Liu department of Chemistry Zhejiang UniversityHangzhou 310058China

Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent *** intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic *** methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and ***,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization ***,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization *** on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic ***,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials *** inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials.

关键词： biomineralization inorganic ionic polymerization biomimetic materials crystal growth synthetic methodology

Synthesis and characterization of three new solid polyoxometalates based on Wells-Dawson-derived sandwich-type polyanions [Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56))_(2)]^(16-)

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Journal of zhejiang university-Science A(Applied Physics & Engineering) 2024年第3期25卷 268-274页

作者： Jjijie YE Xuan XU Chuande WU department of Chemistry Zhejiang UniversityHangzhou 310058China

Three polyoxometalate-based hybrid coordination materials,[Co_(8)(H_(2)O)_(34)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·16H_(2)O(compound 1),[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22)(pz)_(2){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·21H_(2)(compound 2),and[H_(3)O]_(4)[Co_(6)(H_(2)O)_(22){Co_(4)(H_(2)O)_(2)P_(4)W_(30)O_(112)}]·29H_(2)O(compound 3)(pz-pyrazine),were built from the linkage of[Co_(4)(H_(2)O)_(2)(P_(2)W_(15)O_(56)_(2)]^(16-)-(abbreviated as{Co_(4)P_(4)W_(30})polyanions and pz and/or cobalt(II)*** compounds 1 and 2 consisted of the same components,their lamellar networks were quite *** inorganic lamellar network in compound 3 was constructed by connecting{Co_(4)P_(4)W_(30)}units with cobalt(I)*** work demonstrates that the coordination modes of{Co_(4)P_(4)W_(30)}are very sensitive to synthesis conditions,while the ring-belt tetrametals are easily substituted by different transition metal cations under mild reaction conditions.

关键词： Cobalt Crystal structure Cyclic voltammetry Hybrid Polyoxometalate

Two Applications of the ■■-Hodge Theory

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 137-150页

作者： Dingchang WEI Shengmao ZHU Center of Mathematical Sciences Zhejiang UniversityHangzhou 310027China department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

Using Hodge theory and Banach fixed point theorem,Liu and Zhu developed a global method to deal with various problems in deformation *** this note,the authors generalize Liu-Zhu's method to treat two deformation problems for non-Kahler *** apply the ■■-Hodge theory to construct a deformation formula for(p,q)-forms of compact complex manifold under deformations,which can be used to study the Hodge number of complex manifold under *** the second part of this note,by using the ■■-Hodge theory,they provide a simple proof of the unobstructed deformation theorem for the non-Kahler Calabi-Yau ■■-manifolds.

关键词： Complex structures Deformations (p,q)-Forms Non-Kahler Calabi-Yaumanifolds

Dynamical nonlinear excitations induced by interaction quench in a two-dimensional box-trapped Bose-Einstein condensate

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Chinese Physics B 2024年第2期33卷 209-215页

作者：牛真霞高超 department of Physics Zhejiang Normal UniversityJinhua 321004China Key Laboratory of Optical Information Detection and Display Technology of zhejiang Zhejiang Normal UniversityJinhua 321004China

Manipulating nonlinear excitations,including solitons and vortices,is an essential topic in quantum many-body physics.A new progress in this direction is a protocol proposed in[***.2043256(2020)]to produce dark solitons in a one-dimensional atomic Bose–Einstein condensate(BEC)by quenching inter-atomic *** by this work,we generalize the protocol to a two-dimensional BEC and investigate the generic scenario of its post-quench *** an isotropic disk trap with a hard-wall boundary,we find that successive inward-moving ring dark solitons(RDSs)can be induced from the edge,and the number of RDSs can be controlled by tuning the ratio of the after-and before-quench interaction strength across different critical *** role of the quench played on the profiles of the density,phase,and sound velocity is also *** to the snake instability,the RDSs then become vortex–antivortex pairs with peculiar dynamics managed by the initial density and the after-quench *** tuning the geometry of the box traps,demonstrated as polygonal ones,more subtle dynamics of solitons and vortices are *** proposed protocol and the discovered rich dynamical effects on nonlinear excitations can be realized in near future cold-atom experiments.

关键词： Bose-Einstein condensate quench interaction soliton vortex

Ligand-controlled electrochemiluminescence generation from CdSe/CdS/ZnS core/shell/shell quantum dots

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Nano Research 2024年第8期17卷 7776-7785页

作者： Hui Sun Zhiyuan Cao Haiyan Qin Xiaogang Peng Bin Su Key Laboratory of Excited-State Materials of zhejiang Province Department of ChemistryZhejiang UniversityHangzhou 310058China

The CdSe/CdS/ZnS core/shell/shell quantum dots(QDs)with strong exciton confinement have manifested themselves as competitive light-emitting materials in electrochemiluminescence(ECL).However,cathodic ECL generation by these QDs requires the injection of electron and hole from solid electrode and electrogenerated radicals(for example SO_(4)•^(−)),which is inevitably influenced by not only the inorganic structure of QDs but also the organic ligands on the *** this work we aimed at studying the impact of surface organic ligands on ECL performance of CdSe/CdS/ZnS *** changing the surface ligand from oleate to acetate,we phenomenologically observed the positive shift of ECL onset potential by ca.200 mV and the increase of ECL intensity by~100 times,suggesting that a short ligand is more favorable for ECL *** further comprehend the ligand effect,we measured the charge injection kinetics using potential-modulated,time-resolved photoluminescence,and thinlayer spectroelectrochemistry *** electron and hole injection into QDs were found to be accelerated by 2–20 times if shortening the ligand from oleate to acetate,confirming the significant impact of surface ligands on ECL performance of *** study is expected to provide guidance on how to design surface functionalized QDs for specific applications such as ECL immunodiagnosis,photocatalysis,and photovoltaics.

关键词： electrochemiluminescence quantum dots spectroelectrochemistry surface ligands charge injection charge transfer

The Peach Blossom Fan and the Late Ming Historical Imagination of the Qing People

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China Book International 2024年第1期 88-91页

作者： You Shujun history department at zhejiang university

This book aims to offer a comprehensive view through long-term research,using straightforward and lively *** introduces various aspects of the Qing era,including the extent of imperial power,the Banner System,the relationship between the Inner Cabinet and the Grand Council,local social management,the imperial examination system,local gentry,judicial examination and justice,imperial finances,military expenditures,women's rights,social status,and the changes in privileges and social status of the Banner people.

关键词： language. Banner finance

Nondegenerate Soliton Solutions of(2+1)-Dimensional Multi-Component Maccari System

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Chinese Physics Letters 2024年第6期41卷 11-17页

作者：孟勇方乒乒林机 department of Physics Zhejiang Normal UniversityJinhua 321004China

For a multi-component Maccari system with two spatial dimensions,nondegenerate one-soliton and two-soliton solutions are obtained with the bilinear *** can be seen by drawing the spatial graphs of nondegenerate solitons that the real component of the system shows a cross-shaped structure,while the two solitons of the complex component show a multi-solitoff *** the same time,the asymptotic analysis of the interaction behavior of the two solitons is conducted,and it is found that under partially nondegenerate conditions,the real and complex components of the system experience elastic collision and inelastic collision,respectively.

关键词： structure. degenerate soliton

Exact Box-Constrained Economic Operating Region for Power Grids Considering Renewable Energy Sources

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 514-523页

作者： Huating Xu Bin Feng Chutong Wang Chuangxin Guo Jian Qiu Mingyang Sun College of Electrical Engineering Zhejiang UniversityHangzhou 310027China department of Control Science and Engineering Zhejiang UniversityHangzhou 310027China

The growing integration of renewable energy sources manifests as an effective strategy for reducing carbon emissions. This paper strives to efficiently approximate the set of optimal scheduling plans(OSPs) to enhance the performance of the steady-state adaptive cruise method(SACM) of power grid, improving the ability of dealing with operational uncertainties. Initially, we provide a mathematical definition of the exact boxconstrained economic operating region(EBC-EOR) for the power grid and its dispatchable components. Following this, we introduce an EBC-EOR formulation algorithm and the corresponding bi-level optimization models designed to explore the economic operating boundaries. In addition, we propose an enhanced big-M method to expedite the computation of the EBCEOR. Finally, the effectiveness of the EBC-EOR formulation, its economic attributes, correlation with the scheduling plan underpinned by model predictive control, and the significant improvement in computational efficiency(over twelvefold) are verified through case studies conducted on two test systems..

关键词： Exact box-constrained economic operating region(EBC-EOR) big-M method intelligent scheduling steady-state adaptive cruise uncertainty renewable energy source