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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 50-51页

作者：李榕 hepatol unit&dept infect dis Nanfang HospSouth Med UnivGuangzhou 510515

Objective To compare the postoperative liver function injury condition in patients with intermediateand advanced-stage hepatocellular carcinoma (HCC)treated with hepatic artery infusion chemotherapy(HAIC) and hepatic artery chemoembolization (TACE)combined with immune checkpoint inhibitors (ICIs) and multi-target tyrosine kinase inhibitors (TKIs).

关键词： hepatic chemotherapy postoperative

Clinical efficacy and prognosis analysis of different treatment regimens in patients with uncomplicated brucellosis

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 24-25页

作者：袁关敏 dept infect dis Natl Infect Dis Med CenterShanghai Key Lab Infect Dis&Biosafety Emerg ResponseHuashan HospFudan UnivShanghai 200040

Objective To analyze the efficacy and prognosis of different treatment regimens in patients with uncomplicated brucellosis,and to provide guidance for clinical *** The patients diagnosed with brucellosis in the Sixth ... 详细信息

关键词： regimen patients prognosis

Clinical features and prognostic analysis of transarterial chemoembolization combined with targeted immunotherapy in the treatment of patients with hepatitis B virus-related intermediate- and advanced-stage hepatocellular carcinoma with secondary cholestas

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 51-52页

作者：王柠柠 dept infect dis Affil HospXuzhou Med UnivXuzhou 221000

Objective To study the clinical features and prognostic impact of transarterial chemoembolization(TACE),immune checkpoint inhibitors (ICIs),and tyrosine kinase inhibitors (TKIs) combination therapy regimens in the treatment of patients with hepatitis B virus-related intermediate-and advanced-stage hepatocellular carcinoma with secondary cholestasis.

关键词： patients hepatocellular arterial

A comparative study of gastrointestinal gas volume in patients with functional dyspepsia based on abdominal computed tomography and gas volume score

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 48-49页

作者：王彬 dept Gastroenterol&hepatol Tianjin Med Univ General HospTianjin Instit Dig DisTianjin Dig Dis Key LabTianjin 300052

Objective To compare the difference between gas volume score (GVS) method and combination of computed tomography (CT) image and calculation formula method (hereinafter referred to as CT method)in the detection of gast... 详细信息

关键词： patients dyspepsia gastrointestinal

Reaction Mechanism of Actin ATP Hydrolysis Studied by QM/MM Calculations

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 849-855页

作者： Wang, Yiwen Lin, Lirui Xu, Li-Yan Li, En-Min Dong, Geng Shantou Univ Med Coll Dept Biochem & Mol Biol Shantou 515041 Peoples R China Shantou Univ Med Coll Guangdong Higher Educ Inst Key Lab Mol Biol High Canc Incidence Coastal Area Shantou 515041 Peoples R China Shantou Univ Med Coll Med Informat Res Ctr Shantou 515041 Peoples R China Shantou Univ Med Coll Guangdong Prov Key Lab Infect Dis & Mol Immunopath Shantou 515041 Peoples R China Shantou Univ Med Coll Dept Bioinformat Shantou 515041 Peoples R China Shantou Univ Med Coll Canc Res Ctr Shantou 515041 Peoples R China

Actin fibers are an important part of the cytoskeleton, providing vital support for the plasma membrane. This function is driven by its ATPase (ATP: adenosine triphosphate) activity, i.e., ATP+H2O -> ADP+Pi. This seemingly simple reaction has attracted much attention because the hydrolysis of ATP provides energy to support life processes. However, the reaction mechanism of ATP hydrolysis in actin is not clear. In order to gain deep insights into the functions of actin, it is essential to elucidate the reaction mechanism of the actin ATP hydrolysis. In this paper, we have studied the reaction mechanism of the ATP hydrolysis in actin by the combined quantum mechanical and molecular mechanics (QM/MM) calculations. Our results show that 1) bond cleavage of the P gamma-OS of ATP and bond formation between oxygen of the lytic water and P gamma atoms take place simultaneously, and this is the rate-limiting step of the hydrolysis; 2) the proton on the lytic water transfers to the phosphate to form H2P gamma O4-via one bridge water. The energy barrier of the complete reaction is 17.6 kcal/mol (1 kcal=4.184 kJ), which is in high agreement with the experimental value.

关键词： Actin Adenosine triphosphate (ATP) hydrolysis Quantum mechanical and molecular mechanics (QM/MM) Reaction mechanism MOLECULAR-DYNAMICS SIMULATIONS APPROXIMATION QUANTUM

A multi-center performance evaluation of different hepatitis C virus core antigen assays for clinical infection screening

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 23-23页

作者：杨瑞锋 Peking Univ People's Hosp Peking Univ Hepatol InstitNatl Clin Res Infect Dis CenterBeijing Key LabLiver Dis Hepatitis C&ImmunotherapBeijing 100044

Objective To evaluate the performance for three commercial hepatitis C virus(HCV) core antigen assays in HCV infection screening,and to provide clues for further improving the sensitivity and specificity of the *** Ke... 详细信息

关键词： infection specificity assays

Multi-omics combined test performance effectiveness on opportunistic screening of high-risk liver cancer population

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 110-110页

作者：谢婵 dept infect dis 3rd Affil HospSun Yat-Sen UnivGuangzhou 510630

Objective To validate the performance of a multiomics combined test for early screening of high-risk liver cancer *** 173 high-risk patients with liver cancer were prospectively screened in a real-world setting,and 164 cases were finally enrolled.B-ultrasound,alpha-fetoprotein(AFP),and HCC screens were conducted in all the patients.A multi-omics early screeninggtestwas performed for liver cancer in combination with multi-gene methylation,TP53/TERT/CTNNB1 mutations,AFP,and abnormal prothrombin(PIVKA-II).Differences in rates were compared using the chi-square test,adjusted chi-square test,or Fisher's exact probabilityymethod forcount data.

关键词： cancer liver performance

Cloning and expression of core gene cDNA of Chinese hepatitis C virus in cosmid pTM3

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World Journal of Gastroenterology 2000年第2期6卷 220-222页

作者： Jiang RL Lu QS Luo KX Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China

AIM To clone core gene cDNA of Chinesehepatitis C virus(HCV)into eukaryoticexpression vector cosmid pTM3 and to expressHCV core antigen in HepG2 *** Core gene cDNA of HCV wasintroduced into eukaryotic expression vectorcosmid *** vaccinia virus/bacteriophage T7 hybrid expression system,HepG2 cells were transfected with therecombinant plasmid pTM3-Q534 by *** From the transfected bacteriaTop10F’,2 pTM3-Q534 clones containing therecombinant plasmid were identified fromrandomly selected 10 *** reverse transcription PCR andindirect immunofluorescence technique,HCVRNA and core protein was identified in HepG2cells transfected with the recombinant *** The construction of arecombinant plasmid and the expression of coregene cDNA of HCV in HepG2 was successful.

关键词： hepatitis C virus gene viral cDNA cosmid vector gene expression

Pathogenic characteristics of elderly patients with urinary tract infection

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 83-83页

作者：张晓玉 1st infect dis dept 1st Affil HospChina Med UnivShenyang 110001

Objective To analyze the pathogenic distribution characteristics of elderly inpatients with urinary tract infection(UTI).Methods Retrospective analysis of the clinical data and pathogen detection of 809 patients with UTI aged≥60 years admitted to The First Affiliated Hospital of China Medical University from January 2019 to January 2023 was *** differences in the pathogen distribution of patients with UTI were compared between groups of 60 to 79 years old and≥80 years *** chi-square test was used for statistical *** logistic regression analysis was used to analyze the risk factors for bacterial production of extended spectrumβlactamase(ESBL).Results A total of 914 strains of pathogens were isolated from 809 patients,including 584 strains isolated from 60 to 79 years old patients,330 strains isolated from≥80 years old patients,and 62 patients had mixed infections with bacteria and *** the group of patients≥80 years old,there were 144(43.64%)Gram-negative *** coli(16.67%(55/330)).

关键词： patients urinary admitted

Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats

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World Journal of Gastroenterology 2010年第21期16卷 2657-2663页

作者： Wang, Yu-Ping Cheng, Ming-Liang Zhang, Bao-Fang Mu, Mao Wu, Jun Guiyang Med Coll Dept Infect Dis Guiyang 550004 Guizhou Prov Peoples R China

AIM:To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2(Nrf2) transcription factor in ***:Forty-five male Sprague-Dawley rats were randomly divided into control group(A);CCl4-induced hepatic fibrosis group(B);blueberry prevention group(C);Dan-shao-hua-xian capsule(DSHX) prevention group(D);and blueberry + DSHX prevention group(E).Liver fibrosis was induced in rats by subcutaneous injection of CCl4 and a high-lipid/low-protein diet for 8 wk(except the control group).The level of hyaluronic acid(HA) and alanine aminotransferase(ALT) in serum was *** activity of superoxide dismutase(SOD),glutathione-S-transferase(GST) and malondialdehyde(MDA) in liver homogenates was *** degree of hepatic fibrosis was evaluated by hematoxylin and eosin and Masson *** of Nrf2 and NADPH quinone oxidoreductase 1(Nqo1) was detected by real-time reversed transcribed-polymerase chain reaction,immunohistochemical techniques,and western ***:Compared with group B,liver indices,levels of serum HA and ALT of groups C,D and E were reduced(liver indices:0.038 ± 0.008,0.036 ± 0.007,0.036 ± 0.005 vs 0.054 ± 0.009,P<0.05;HA:502.33 ± 110.57 ng/mL,524.25 ± 255.42 ng/mL,499.25 ± 198.10 ng/mL vs 828.50 ± 237.83 ng/mL,P<0.05;ALT:149.44 ± 16.51 U/L,136.88 ± 10.07 U/L,127.38 ± 11.03 U/L vs 203.25 ± 31.62 U/L,P<0.05),and SOD level was significantly higher,but MDA level was lower,in liver homogenates(SOD:1.36 ± 0.09 U/mg,1.42 ± 0.13 U/mg,1.50 ± 0.15 U/mg vs 1.08 ± 0.19 U/mg,P<0.05;MDA:0.294 ± 0.026 nmol/mg,0.285 ± 0.025 nmol/mg,0.284 ± 0.028 nmol/mg vs 0.335 ± 0.056 nmol/mg,P<0.05).Meanwhile,the stage of hepatic fibrosis was significantly weakened(P<0.05).Compared with group A,the activity of GST liver homogenates and expression levels of Nrf2 and Nqo1 in group B were elevated(P<0.05).The expression level of Nrf2 and Nqo1 in groups C,D,and E were increased as compared with group B,but the difference was not significant

关键词： Blueberry Hepatic fibrosis NF-E2-related factor 2 NADPH quinone oxidoreductase 1 GlutathioneS-transferase