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hepatobiliary & pancreatic Diseases International 2021年第2期20卷 182-189页

作者： Yu-Ling Sun Jian-Jun Gou Kai-Ming Zhang Wen-Qi Li Xiu-Xian Ma Lin Zhou Rong-Tao Zhu Jian Li Institute of hepatobiliary and pancreatic Diseases Department of Hepatobiliary and Pancreatic Surgerythe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Digestive the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Delayed gastric emptying(DGE)is the main complication after pancreaticoduodenectomy(PD),but the mechanism is still *** aim of this study was to elucidate the role of complete resection of the gastric antrum in decreasing incidence and severity of DGE after ***:Sprague-Dawley rats were divided into three groups:expanded resection(ER group),complete resection(CR group),and incomplete resection(IR group)of the gastric *** tension(g)of remnant stomach contraction was *** analyzed the histological morphology of the gastric wall by different excisional methods after distal ***,patients underwent PD at our department between January 2012 and May 2016 were included in the *** cases were divided into IR group and CR group of the gastric antrum,and the clinical data were retrospectively ***:The ex vivo remnant stomachs of CR group exhibited much greater contraction tension than others(Pdisorders caused by damage to gastric smooth muscles might be the mechanism underlying DGE.

关键词： Delayed gastric emptying Gastric antrum Gastric electrophysiology Histological morphology pancreaticoduodenectomy

Postoperative outcomes after open splenectomy versus laparoscopic splenectomy in cirrhotic patients:a meta-analysis

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hepatobiliary & pancreatic Diseases International 2016年第1期15卷 14-20页

作者： Khaled Al-raimi Shu-Sen Zheng Division of hepatobiliary pancreatic Surgery First Affiliated HospitalZhejiang University School of Medicine

BACKGROUND： Laparoscopic splenectomy is considered the gold standard for resecting normal-to-moderately bigger spleens in benign conditions, and in addition could be tried for patients with malignant splenic disorders. However, the safety of laparoscopic splenectomy in patients with hyper- splenism is not well-known. This study aimed to investigate the efficacy and safety of laparoscopic splenectomy for pa- tients with hypersplenism secondary to liver cirrhosis by com- paring with the open splenectomy.

关键词： open splenectomy laparoscopic splenectomy cirrhosis

Endoscopic therapy in acute recurrent pancreatitis

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World Journal of Gastroenterology 2008年第7期14卷 1034-1037页

作者： John Baillie hepatobiliary and pancreatic disorders service Wake Forest University Health SciencesWinston-SalemNorth Carolina 27157United States

Endoscopic retrograde cholangiopancreatography (ERCP) has evolved from a largely diagnostic to a largely therapeutic modality. Cross-sectional imaging, such as computed tomography (CT) and magnetic resonance imaging (MRI), and less invasive endoscopy, especially endoscopic ultrasound (EUS), have largely taken over from ERCP for diagnosis. However, ERCP remains the "first line" therapeutic tool in the management of mechanical causes of acute recurrent pancreatitis, including bile duct stones (choledocholithiasis), ampullary masses (benign and malignant), congenital variants of biliary and pancreatic anatomy (e.g. pancreas divisum, choledochoceles), sphincter of Oddi dysfunction (SOD), pancreatic stones and strictures, and parasitic disorders involving the biliary tree and/or pancreatic duct (e.g Ascariasis, Clonorchiasis).

关键词： Acute pancreatitis Endoscopic retrograde cholangiopancreatography Endoscopic Ultrasound Choledocholithiasis Ampullary lesions Cystic tumors of the pancreas Sphincter of Oddi dysfunction Pancreas divisum Choledochal cyst pancreatic stones

Utility of routine blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones

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World Journal of Gastrointestinal Surgery 2017年第6期9卷 149-152页

作者： Offir Ben-Ishay Marina Zeltser Yoram Kluger Surgical Oncology Pancreatic and Hepatobiliary Surgery ServiceDepartment of General SurgeryDivision of SurgeryRambam Health Care CampusHaifa 35254Israel

AIM To evaluate the value of blood testing after elective laparoscopic cholecystectomy and its association with procedure related *** Charts of all patients undergoing elective laparoscopic cholecystectomy from January 2013 through December2014 were reviewed retrospectively for demographics,indication for surgery,operative course and *** our institution the decision to perform postoperative blood analysis is left for the discretion of the surgeon,therefore we had the possibility to compare the results of those who had blood analyses results to those who did *** was performed to identify variables associated with the decision to perform postoperative blood *** a univariate and multivariate analyses was performed comparing the two *** subgroup analysis was performed to identify factors associated with procedure related *** Five hundred and thirty-two elective laparoscopic cholecystectomies for symptomatic gallstones were performed during the study ***-four percent of the patients(n=340)had blood tests taken post *** that had laboratory tests taken were older(P=0.006,OR=1.01),had longer surgery(P<0.001,OR=3.22)had more drains placed(P<0.001,OR=3.2)and stayed longer in the hospital(P<0.001,OR=1.2).A subgroup analysis of the patients who experienced complications revealed longer stay in the hospital(P<0.001),higher body mass index(BMI)(P=0.04,OR=1.08),increased rates of drain placement(P=0.006,OR=3.1)and higher conversion rates(P=0.01,OR=14.6).Postoperative blood tests withdrawals were not associated with complications(P=0.44).On Multivariate analysis BMI and drain placement were independently associated with *** The current study indicate that routine postoperative blood tests after elective laparoscopic cholecystectomy for symptomatic gallstones does not predict complications and may have an added benefit in diagnosis and management of cases w

关键词： Cholecystectomy Blood tests Laparoscopy Complications Post-operative Gallstones symptomatic

Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice

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World Journal of Diabetes 2023年第12期14卷 1824-1838页

作者： Qi-Yan Sun Xu-Ye Wang Zu-Pin Huang Jing Song En-Dong Zheng Fang-Hua Gong Xiao-Wang Huang School of Pharmacy Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Zhejiang Medical Products service Center Hangzhou 310012Zhejiang ProvinceChina Department of hepatobiliary and pancreatic Surgery The Affiliated Cangnan Hospital of Wenzhou Medical UniversityWenzhou 325800Zhejiang ProvinceChina

BACKGROUND Fibroblast growth factor 21(FGF21),primarily secreted by the pancreas,liver,and adipose tissues,plays a pivotal role in regulating glucose and lipid *** pancreatitis(AP)is a common inflammatory disease with specific clinical *** patients with diabetes present with concurrent inflammatory *** exacerbates intestinal permeability and intestinal inflammation,thus leading to the progression to *** previous study indicated that FGF21 significantly attenuated susceptibility to AP in *** To investigate the potential protective role of FGF21 against AP in diabetic *** In the present study,a mouse model of AP was established in diabetic(db)/db diabetic mice through ceruletide ***,the protective effects of recombinant FGF21 protein against AP were evaluated,with an emphasis on examining serum amylase(AMS)levels and pancreatic and intestinal inflammatory cytokines[interleukin(IL)-6,tumor necrosis factor-alpha(TNF-),and intestinal IL-1β].Additionally,the impact of this treatment on the histopathologic changes of the pancreas and small intestinal was examined to elucidate the role of FGF21 in diabetic mice with *** antibiotic(Abx)cocktail was administered in combination with FGF21 therapy to investigate whether the effect of FGF21 on AP in diabetic mice with AP was mediated through the modulation of the gut microbiota. Subsequently, thePhylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt), a bioinformaticssoftware package, was used to predict different pathways between the groups and to explore the potentialmechanisms by which the gut microbiota influenced the protective effect of *** results indicated that FGF21 notably diminished the levels of serum AMS (944.5 ± 15.9 vs 1732 ± 83.9, P < 0.01)and inflammatory factors including IL-6 (0.2400 ± 0.55 vs 1.233 ± 0.053, P < 0.01), TNF- (0.7067 ± 0.22 vs 1.433 ±0.051, P < 0.01), and IL-1β (1.377 ±

关键词： Acute pancreatitis Fibroblast growth factor 21 Gut microbiota Diabetes PICRUSt2 Cocktail of antibiotics

Amino acid metabolism in health and disease

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4597-4628页

作者： Zhe-Nan Ling Yi-Fan Jiang Jun-Nan Ru Jia-Hua Lu Bo Ding Jian Wu Division of hepatobiliary and pancreatic Surgery Department of SurgeryThe First Affliated HospitalZhejiang University School of Medicine79 Qingchun RoadHangzhouZhejang Province 310o03P.R.China NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiang ProvincePR.China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment For Hepatobiliary and Pancreatic CancerChinese Academy of Medical Sciences(2019RU019)HangzhouZhejiang ProvinceP.R.China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhouZhejiang ProvinceP.R.China

Amino acids are the building blocks of protein *** are structural elements and energy sources of cells necessary for normal cell growth,differentiation and *** acid metabolism disorders have been linked with a number of pathological conditions,including metabolic diseases,cardiovascular diseases,immune diseases,and *** the case of tumors,alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies.

关键词： synthesis. function. metabolism

A mixed blessing for liver transplantation patients—Rapamycin

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hepatobiliary & pancreatic Diseases International 2023年第1期22卷 14-21页

作者： Guang-Han Fan Chen-Zhi Zhang Feng-Qiang Gao Xu-Yong Wei Sun-Bin Ling Kai Wang Jian-Guo Wang Shu-Sen Zheng Mehrdad Nikfarjam Xiao Xu Department of hepatobiliary and pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University CancerGuangzhou 510060China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou 310024China Department of hepatobiliary and pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of hepatobiliary and pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China NHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Department of Surgery University of MelbourneAustin HealthHeidelbergVIC 3084Australia

Background:Liver transplantation(LT)is an effective treatment option for end-stage liver *** target of rapamycin(m TOR)inhibitors,such as rapamycin,are widely used post *** sources:In this review,we focused on the anti-cancer activities and metabolic side effects of rapamycin after *** literature available on Pub Med for the period of January 1999-September 2022 was *** key words were rapamycin,sirolimus,liver transplantation,hepatocellular carcinoma,diabetes,and lipid metabolism ***:Rapamycin has shown excellent effects and is safer than other immunosuppressive *** has exhibited excellent anti-cancer activity and has the potential in preventing hepatocellular carcinoma(HCC)recurrence post *** is closely related to two long-term complications after LT,diabetes and lipid metabolism ***:Rapamycin prevents HCC recurrence post LT in some patients,but it also induces metabolic *** use of rapamycin benefits the liver recipients.

关键词： Liver transplantation Rapamycin Metabolic disease Hepatocellular carcinoma Tumor recurrence

Relationship between Prognosis and Time Interval from Cholecystectomy to Reoperation in Postoperative Incidental Gallbladder Carcinoma

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Chinese Medical Journal 2018年第20期131卷 2503-2505页

作者： Jing Du Xin-Wei Yang Zhi-Jian Wen Chen Xue Yao-Min Wu Meng-Chao Wu Lu-Lu Zhang Department of Military Health service Management College of Health Service Second Military Medical University Shanghai 200433 China Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital Shanghai 200438 China Department of hepatobiliary pancreatic Vascular Surgery No. 174 Hospital of People's Liberation Army Xiamen University Xiamen Fujian 361000 China

To the Editor： Gallbladder cancer （GBC）, a rare entity with poor prognosis, is often discovered incidentally during or after *** tends to disseminate early through lymphatic, peritoneal, endobiliary, and hematogenous pathways. Patients usually present with metastatic diseases. If GBC is suspected during cholecystectomy, conversion to open surgery to perform radical resection after confirmation of cancer by intraoperative frozen biopsy is considered. When GBC is diagnosed after cholecystectomy, reoperation for radical resection according to depth of invasion of cancer （T stage） is inevitable. However, reoperation with radical surgery is not performed in all patients for several reasons including refusal to undergo radical surgery, poor medical condition, or cancer progression suggesting unresectability.

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Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM

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World Journal of Gastroenterology 2008年第8期14卷 1231-1236页

作者： Sufi HZ Rahman M Golam Azam M Anisur Rahman MS Arfin M Mahbub Alam Tareq M Bhuiyan Nasim Ahmed Motiur Rahman Shamsun Nahar MS Hassan Department of Immunology Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Gastrointestinal hepatobiliary and pancreatic Diseases Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Pathology Ibrahim MedicalCollege Dhaka Bangladesh Laboratory Sciences Division International Centre for Diarrhoeal Diseases Research Bangladesh Dhaka Bangladesh

AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.

关键词： H pylori ELISA Immunochromatographic test Immunoblot Current infection marker

Research progress on the immune microenvironment of the gallbladder in patients with cholesterol gallstones

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 887-895页

作者： Jing-Yi Jiao Xiao-Jun Zhu Chun Zhou Peng Wang Department of hepatobiliary and pancreatic Surgery Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of hepatobiliary Surgery Nantong First People's HospitalNantong 226001Jiangsu ProvinceChina Department of General Practitioner Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

Cholesterol gallstones are very common in hepatobiliary surgery and have been studied to a certain extent by doctors worldwide for ***,the mechanism of cholesterol gallstone formation is not fully understood,so there is currently no completely effective drug for the treatment and prevention of cholesterol *** formation and development of cholesterol gallstones are caused by a variety of genetic and environmental factors,among which genetic susceptibility,intestinal microflora disorders,impaired gallbladder motility,and immune disorders are important in the pathogenesis of cholesterol *** review focuses on recent advances in these *** also discuss some new targets that may be effective in the treatment and prevention of cholesterol gallstones,which may be hot areas in the future.

关键词： Microflora Cholesterol gallstones Gallbladder Pathogenesis Immune disorders