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Reporting of longitudinal pancreatojejunostomy with partial pancreatic head resection(the Frey procedure) for chronic pancreatitis: A systematic review

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hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 110-116页

作者： Minas Baltatzis Santhalingam Jegatheeswaran Ajith K Siriwardena Regional hepato-Pancreato-biliary surgery unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK

Background:Longitudinal pancreatojejunostomy with partial pancreatic head resection(the Frey procedure)is accepted for surgical treatment of painful chronic ***,conduct and reporting are not standardized and thus,making comparisons *** study assesses the reporting standards of this *** sources:A systematic literature review was performed between January 1987 and January *** keyword and Medical Subject Heading"chronic pancreatitis"was used together with the individual operation term"Frey pancreatojejunostomy".Reports were included if they provided original information on conduct and ***-three papers providing information on 1205 patients constituted the study *** of bias in included reports was ***:Etiology of chronic pancreatitis(alcohol)was reported in 26 of 28(93%)studies,duration of symptoms prior to surgery in 19(58%)studies and pre-operative opiate use in 12(36%)*** terms of morphology,pancreatic duct diameter was reported in 17(52%)studies and diameter of the pancreatic head in 13(39%)*** terms of technique,three(9%)studies reported weight of excised *** were 9(0.7%)procedure-related ***-operative follow-up ranged from 6 to 82.5 *** studies reported post-operative portal ***:There is substantial heterogeneity between studies in reporting of clinical baseline,morphology of the diseased pancreas,operative detail and outcome after longitudinal pancreatojejunostomy with partial pancreatic head *** critically compromises the comparison between centers and between *** reporting is necessary for clinicians to assess choice of procedure and for patients to make informed choices when seeking treatment for painful chronic pancreatitis.

关键词： Chronic pancreatitis Frey procedure Reporting Longitudinal pancreatojejunostomy

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Added value of indocyanine green fluorescence imaging in liver surgery

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hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 310-317页

作者： Nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo Department of surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)*** clinical relevance of this method has been increasing gradually,as new procedures develop in this *** important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

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Validation of a surgical model for posthepatectomy liver failure in rats

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Animal Models and Experimental Medicine 2023年第3期6卷 266-273页

作者： Andrea Lund Michelle Meier Kasper Jarlhelt Andersen Marie Ingemann Pedersen Anders Riegels Knudsen Jakob Kirkegård Frank Viborg Mortensen Aarhus University Hospital Department of Upper Gastrointestinal and Hepato-Pancreato-Biliary SurgeryAarhus NDenmark

Background:The upper limit for liver resections in rats is approximately 90%.In the early postoperative phase,mortality *** aim of the present study was to validate the rat model of 90%partial hepatectomy(PH)as a model of post-hepatectomy liver failure(PHLF).Further,we wanted to test a quantitative scoring system as a detector of lethal outcomes caused by PHLF in ***:Sixty-eight rats were randomized to 90%PH,sham operation,or no ***,block randomization was performed based on time of euthanization:12,24,or 48 h after surgery.A general distress score(GDS)≥10 during the day or≥6 at midnight prompted early euthanization and classification as *** euthanized as planned were classified as *** euthanization,blood and liver tissue were collected,and liver-specific biochemistry was ***:Based on the biochemical results,all animals subjected to 90%PH expe-rienced *** rats were euthanized due to irreversible *** GDS increased for nonsurvivors within 12–18 h after *** mean time for euthaniza-tion was 27 h after ***:Based on the GDS and liver-specific biochemistry,we concluded that the model of 90%PH seems to be a proper model for investigating PHLF in *** a high GDS is associated with increased mortality,the GDS appears to be valuable in detect-ing lethal outcomes caused by PHLF in rats.

关键词： 90%liver resection general distress score liver failure post-hepatectomy liver failure rats

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Gastrointestinal tract injuries after thermal ablative therapies for hepatocellular carcinoma:A case report and review of the literature

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World Journal of Gastroenterology 2020年第35期26卷 5375-5386页

作者： Teresa Marzia Rogger Andrea Michielan Sandro Sferrazza Cecilia Pravadelli Luisa Moser Flora Agugiaro Giovanni Vettori Sonia Seligmann Elettra Merola Marcello Maida Francesco Antonio Ciarleglio Alberto Brolese Giovanni de Pretis Department of surgery Gastroenterology and Digestive Endoscopy UnitSanta Chiara HospitalTrento 38122Italy Gastroenterology and Endoscopy unit S.Elia-Raimondi HospitalCaltanissettaCaltanissetta 93100Italy Department of surgery Hepato-biliary Surgery UnitSanta Chiara HospitalTrento 38122Italy

BACKGROUND Radiofrequency ablation(RFA)and microwave ablation(MWA)represent the standard of care for patients with early hepatocellular carcinoma(HCC)who are unfit for *** incidence of reported adverse events is low,ranging from 2.4%to 13.1%for RFA and from 2.6%to 7.5%for *** tract(GIT)injury is even more infrequent(0.11%),but usually requires surgery with an unfavourable *** to its low incidence and the retrospective nature of the studies,the literature reporting this feared complication is heterogeneous and in many cases lacks information on tumour characteristics,comorbidities and treatment *** SUMMARY A 77-year-old man who had undergone extended right hepatectomy for HCC was diagnosed with early disease recurrence with a small nodule compatible with HCC in the Sg4b segment of the liver with a subcapsular *** was treated with percutaneous RFA and a few week later he was urgently admitted to the surgery ward for abdominal pain and fever.A subcutaneous abscess was diagnosed and treated by percutaneous drainage.A fistulous tract was then documented by the passage of contrast material from the gastric antrum to the abdominal *** oesophagogastroduodenoscopy confirmed a circular wall defect at the lesser curvature of gastric antrum, leading directly to the purulentabdominal collection. An over-the-scope clip (OTSC) was used to successfullyclose the defectCONCLUSIONThis is the first reported case of RFA-related GIT injury to have been successfullytreated with an OTSC, which highlights the role of this endoscopic treatment forthe management of this complication.

关键词： Gastrointestinal tract Radiofrequency ablation hepatocellular carcinoma Complications Endoscopy Over-the-scope clip Case report

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Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus

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World Journal of Gastroenterology 2006年第47期12卷 7561-7567页

作者： Masami Minagawa Masatoshi Makuuchi Department of hepato-biliary-Pancreatic surgery Department of Artificial Organ and Transplantation Graduate School of Medicine University of Tokyo Tokyo Japan

The prognosis of patients with hepatocellular cardnorna （HCC） accompanied by portal vein tumor thrombus （PVTT） is generally poor if leo untreated： a median survival time of 2.7-4.0 mo has been reported. Furthermore, while transcatheter arterial chemoembolization （TACE） has been shown to be safe in selected patients, the median survival time with this treatment is still only 3.8-9.5 mo. Systemic single-agent chemotherapy for HCC with PVTT has failed to improve the prognosis, and the response rates have been less than 20%. While regional chemotherapy with low-dose cisplatin and 5-fluorouracil or interferon and 5-fluorouracil via hepatic arterial infusion has increased the response rate, the median survival time has not exceeded 12 （range 4.5-11.8） mo. Combined treatment consisting of radiation for PVTT and TACE for liver tumor has achieved a high response rate, but the median survival rates have still been only 3.8-10.7 mo. With hepatic resection as monotherapy, the 5-year survival rate and median survival time were reportedly 4%-28.5% and 6-14 mo. The most promising results were reported for combined treatments consisting of hepatectomy and TACE, chemotherapy, or internal radiation. The reported 5-year survival rates and median survival times were 42% and 31 mo for TACE followed by hepatectomy; 36.3% and 22.1 mo for hepatectomy followed by hepatic arterial infusion chemotherapy; and 56% for chemotherapy or internal radiation followed by hepatectomy.

关键词： hepatocellular carcinoma Portal vein tumor Thrombus Hepatic resection Transcatheter arterial chemoembolization Chemotherapy Radiation

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Significance of preoperative sarcopenia to liver surgery

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hepatobiliary surgery and Nutrition 2019年第1期8卷 59-62页

作者： Toshimi Kaido Yuhei Hamaguchi Shinji Uemoto Division of hepato-biliary-Pancreatic and Transplant surgery Department of SurgeryGraduate School of MedicineKyoto UniversityKyotoJapan

Sarcopenia,characterized by a decline in skeletal muscle mass and muscle strength or physical activity,is now accepted worldwide as a new geriatric *** studies have identified significant associations between sarcopenia and poor outcomes of various diseases including liver diseases(1-3).This article reviews the significance of preoperative sarcopenia to liver surgery,particularly liver transplantation(LT).

关键词： surgery diseases liver

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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Division of hepato-biliary-Pancreatic surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

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Experience with the surgical treatment of hepatic hydatidosis: Case series with follow-up

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World Journal of Gastroenterology 2010年第26期16卷 3305-3309页

作者： Hector Losada Morales Luis Burgos San Juan Jorge Silva Abarca Cesar Muoz Castro Department of surgery Universidad de La Frontera hepato Pancreatic and biliary surgery Hospital Hernán Henríquez Aravena Department of surgery Clínica Alemana de Temuco

AIM: To describe patient characteristics and the results of surgical treatment for hepatic hydatidosis (HH) in the Hospital Hernán Henríquez Aravena from December 2001 to March 2005. METHODS: Subjects older than 16 years with suspected HH were included based on the clinical picture and radiological studies. Variables examined included clinical and laboratory aspects, outcome, features of the parasite and surgical aspects. Descriptive statistics were used, calculating central tendency, dispersion and extreme tendency. RESULTS: The series was comprised of 122 patients, with an average age of 44 ± 16.9 years. The most frequently used surgical technique was subtotal cys-tectomy in 90% of the patients, followed by hepatic resection (hepatectomy, segmentectomy and subsegmentectomy) in 5%. In 2%, a combination of subtotal cystectomy and segmentectomy was performed. In addition, 28% of the series presented complications in the postoperative period and mortality was 2%. CONCLUSION: The most frequently used surgical technique for HH was subtotal cystectomy and the morbidity and mortality rates in this Chilean series are comparable to other national and international series.

关键词： Echinococcosis of liver surgery Cases series Mortality Morbidity

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Treatment for superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2014年第35期20卷 12501-12508页

作者： Naomi Kakushima Hideyuki Kanemoto Masaki Tanaka Kohei Takizawa Hiroyuki Ono Division of Endoscopy Shizuoka Cancer Center Division of hepato-biliary-Pancreatic surgery Shizuoka Cancer CenterShizuoka Cancer Center

Because of the low prevalence of non-ampullary duodenal epithelial tumors(NADETs),standardized clinical management of sporadic superficial NADETs,including diagnosis,treatment,and follow-up,has not yet been *** studies have revealed certain endoscopic findings suggestive of *** adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive *** use of endoscopic treatment including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),for the treatment for superficial NADETs is *** requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after *** provides an excellent complete resection rate,however it remains a challenging method,considering the high risk of intraoperative or delayed *** invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic *** remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion,which presents a risk of lymph node *** or surgical treatment outcomes of superficial NADETs without submucosal invasion are *** an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment.

关键词： Duodenal neoplasms Duodenal cancer Pancreaticoduodenectomy Endoscopic surgery Esophagogastroduodenoscopy

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Hepatitis B virus recurrence after liver transplantation: An old tale or a clear and present danger?

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World Journal of Gastroenterology 2020年第18期26卷 2166-2176页

作者： Ilaria Lenci Martina Milana Giuseppe Grassi Tommaso M Manzia Carlo Gazia Giuseppe Tisone Roberta Angelico Leonardo Baiocchi hepatology and Liver Transplant unit University of Tor VergataRome 00133Italy hepato-Pancreato-biliary and Transplant Department of SurgeryUniversity of Rome Tor VergataRome 00133Italy

Hepatitis B virus(HBV) recurrence after liver transplantation(LT) has been described more than 50 years ago. Similarly, to other clinical conditions, in which impairment of host immune defense favors viral replication, early reports described in details recurrence and reactivation of HBV in liver transplant recipients. The evidence of a possible, severe, clinical evolution of HBV reappearance in a significant percentage of these patients, allowed to consider,for some years, HBV positivity a contraindication for LT. Moving from the old to the new millennium this picture has changed dramatically. Several studies contributed to establish efficient prophylactic protocols for HBV recurrence and with the advent of more potent anti-viral drugs an increased control of infection was achieved in transplanted patients as well as in the general immunecompetent HBV population. Success obtained in the last decade led some authors to the conclusion that HBV is now to consider just as a "mere nuisance".However, with regard to HBV and LT, outstanding issues are still on the table:(1)A standard HBV prophylaxis protocol after transplant has not yet been clearly defined;(2) The evidence of HBV resistant strains to the most potent antiviral agents is claiming for a new generation of drugs;and(3) The possibility of prophylaxis withdrawal in some patients has been demonstrated, but reliable methods for their selection are still lacking. The evolution of LT for HBV is examined in detail in this review together with the description of the strategies adopted to prevent HBV recurrence and their pros and cons.

关键词： Liver transplant Hepatitis B virus Viral recurrence Prophylaxis Minimization Antiviral drug

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