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Acta Mathematica Sinica,English Series 2024年第7期40卷 1697-1726页

作者： Timilehin Opeyemi Alakoya Oluwatosin Temitope Mewomo school of Mathematics Statistics and Computer ScienceUniversity of KwaZulu-NatalDurbanSouth Africa

In this paper,we study the concept of split monotone variational inclusion problem with multiple output *** propose a new relaxed inertial iterative method with self-adaptive step sizes for approximating the solution of the problem in the framework of Hilbert *** proposed algorithm does not require the co-coerciveness nor the Lipschitz continuity of the associated single-valued ***,some parameters are relaxed to accommodate a larger range of values for the step *** some mild conditions on the control parameters and without prior knowledge of the operator norms,we obtain strong convergence result for the proposed ***,we apply our result to study certain classes of optimization problems and we present several numerical experiments to demonstrate the implementability of the proposed *** of the existing results in the literature could be viewed as special cases of our result in this paper.

关键词： Split inverse problems non-Lipschitz operators inertial technique self-adaptive step sizes

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler Ga-Ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

High-performance formaldehyde prediction for indoor air quality assessment using time series deep learning

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Building Simulation 2024年第3期17卷 415-429页

作者： Liu Lu Xinyu Huang Xiaojun Zhou Junfei Guo Xiaohu Yang Jinyue Yan school of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’anChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Future Energy Profile School of BusinessSocietyand EngineeringMälardalen UniversityVästeråsSweden

Indoor air pollution resulting from volatile organic compounds(VOCs),especially formaldehyde,is a significant health concern needed to predict indoor formaldehyde concentration(Cf)in green intelligent building *** study develops a thermal and wet coupling calculation model of porous fabric to account for the migration of formaldehyde molecules in indoor air and cotton,silk,and polyester fabric with heat flux in Harbin,Beijing,Xi’an,Shanghai,Guangzhou,and Kunming,*** time-by-time indoor dry-bulb temperature(T),relative humidity(RH),and Cf,obtained from verified simulations,were collated and used as input data for the long short-term memory(LSTM)of the deep learning model that predicts indoor multivariate time series Cf from the secondary source effects of indoor fabrics(adsorption and release of formaldehyde).The trained LSTM model can be used to predict multivariate time series Cf at other emission times and *** LSTM-based model also predicted Cf with mean absolute percentage error(MAPE),symmetric mean absolute percentage error(SMAPE),mean absolute error(MAE),mean square error(MSE),and root mean square error(RMSE)that fell within 10%,10%,0.5,0.5,and 0.8,*** addition,the characteristics of the input dataset,model parameters,the prediction accuracy of different indoor fabrics,and the uncertainty of the data set are *** results show that the prediction accuracy of single data set input is higher than that of temperature and humidity input,and the prediction accuracy of LSTM is better than recurrent neural network(RNN).The method’s feasibility was established,and the study provides theoretical support for guiding indoor air pollution control measures and ensuring human health and safety.

关键词： multivariate time series formaldehyde concentration deep learning heat-humidity coupling mass transfer secondary source effect

Discovery and Asymmetric Total Synthesis of Phlegmine A as a Selective Inhibitor of ASIC1a

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CCS Chemistry 2024年第10期6卷 2529-2536页

作者： Zai-Feng Yuan Fei Liu Yu-Fei Ou Wen-Yan Li Li-Yan Peng Xiao-Nian Li Qin-Shi Zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201 school of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137 university of Chinese Academy of Sciences Beijing 10049

Phlegmine A(1),a novel type of Lycopodium alkaloid with a unique skeleton,was isolated from the rare and endangered herbal medicinal plant,Phlegmariurus *** methods and X-ray diffraction analysis were employed to unambiguously elucidate the structure of phlegmine A(1).Furthermore,we realized the asymmetric total synthesis of the natural product phlegmine A(1)in 18 linear steps from commercial ingredients,achieving a 1.3%overall *** intramolecular carbene cyclization,dimethyldioxirane(DMDO)enamine oxidation,and Stevens rearrangement were exploited to establish the sterically congested vicinal quaternary centers,and an epimerization/aldol condensation/deacetylation reaction was utilized for the rapid assembly of enone at the final *** our semisynthesis attempts,a novel transformation was developed to constructα-aminoketone from enamine ***,the synthetic sample obtained from this work enabled the successful verification of phlegmine A(1)as a new type of highly selective acidsensing ion channel 1a(ASIC1a)inhibitor,which also exerted an in vivo analgesic effect,rendering it a promising lead compound.

关键词： Lycopodium alkaloids phlegmine A total synthesis ASIC1a inhibitor analgesic

Effect of solar radiation on human thermal sensation and physiological parameters in a convection–radiation air conditioning environment

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Building Simulation 2024年第8期17卷 1359-1377页

作者： Guanyu Li Dong Liu Anjie Hu Qidong Yan Lina Ma Liu Tang Xiaozhou Wu Jun Wang Zhenyu Wang school of Civil Engineering and Architecture Southwest University of Science and TechnologyMianyang 621010China Sichuan Province Engineering Technology Research Center of Healthy Human Settlement Chengdu 610065China Sichuan university Engineering Design&Research Institute Co.Ltd Chengdu 610065China school of Civil Engineering Dalian University of TechnologyDalian 116081China College of Architecture and Environment Sichuan UniversityChengdu 610065China school of Environment and Resources Southwest University of Science and TechnologyMianyang 621010China

This study focused on the effect of glass structures of modern architecture on the indoor thermal environment during *** particular,this study examined how solar radiation significantly altered people’s thermal *** tests on convection–radiation air conditioning systems were conducted,encompassing 12 different scenarios,including diverse indoor open areas,terminal forms,and levels of solar *** tests aimed to explore the physiological and psychological responses of the human body to solar radiation penetrating through windows into the inner *** the experiments,the participants’subjective thermal sensations and thermal comfort were recorded,along with continuous monitoring of their physiological and environmental *** showed that solar radiation significantly increased local skin temperature,with a maximum rise of 2.15℃.Operative temperature is a reliable indicator of human skin temperature and thermal sensation vote(TSV).This study established two models that could predict the skin temperature of individuals indoors through operative temperature under conditions without or with solar radiation,and identified sensitive ranges of operative temperature for both models,to be specific,26.32℃to 28.43℃and 28.51℃to 34.11℃,***,this study established the relationship between skin temperature and TSV under conditions with and without solar *** results indicate that solar radiation enhances the human body’s adaptability to indoor environmental parameters;a convection–radiation system(FC+RF)could be used to optimize indoor thermal control under solar radiation,achieving more stable environmental temperatures and improved indoor comfort.

关键词： system modeling solar radiation mean skin temperature thermal comfort terminal form irradiation area

Tendency to Avoid Physical Activity and Sport:Associations with Weight Stigma,and Psychological Distress in a Two-Wave Longitudinal Study

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International Journal of Mental Health Promotion 2024年第8期26卷 633-641页

作者： Saffari Mohsen Yi-Ching Lin Po-Ching Huang Yu-Ting Huang Ru-Yi Huang Chi Hsien Huang Jung-Sheng Chen Wai Chuen Poon Mark D.Griffiths Chung-Ying Lin Health Research Center Life Style InstituteBaqiyatallah University of Medical SciencesTehran***Iran Health Education Department Faculty of HealthBaqiyatallah University of Medical SciencesTehran***Iran Department of Early Childhood and Family Education National Taipei University of EducationTaipei106TaiwanChina school of Physical Therapy Graduate Institute of Rehabilitation ScienceCollege of MedicineChang Gung UniversityTaoyuan333TaiwanChina Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Division of Family medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundationand School of MedicineTzu Chi UniversityHualienTaiwanChina Data Science Degree Program National Taiwan University and Academia SinicaTaipeiTaiwanChina Department of Family medicine and Community medicine E-Da HospitalI-Shou UniversityKaohsiung824TaiwanChina College of medicine I-Shou UniversityKaohsiung840Taiwan Department of Medical Research E-Da HospitalI-Shou UniversityKaohsiung840TaiwanChina Sunway Business school Sunway UniversitySelangor47500Malaysia International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14BUUK Department of Public Health College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan704TaiwanChina Department of Occupational Therapy College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina

Background:Physical inactivity is a major public health problem worldwide that results in physical and mental health *** major issue for physical inactivity is weight stigma(WS),especially perceived WS,which could lead to a tendency to avoid physical activity(PA).To better understand the association between perceived WS and PA,knowledge of the likely mediators in this association such as weight bias internalization(WBI)and psychological distress were investigated in the present ***:Using a two-wave longitudinal study and convenient sampling,388 Taiwan residents participants(55%females;mean age=29.7 years[SD±6.3])completed two surveys six months *** mass index(BMI),Perceived Weight Stigma Scale(PWSS),Weight Bias Internalization Scale(WBIS),Depression,Anxiety,Stress Scale(DASS-21),and Tendency to Avoid Physical Activity and Sport Scale(TAPAS)were ***:A mediation model controlling for age,gender,and BMI with 5000 bootstrapping resamples was *** WS exerted significant direct effects on WBI(β=0.25;p<0.001),psychological distress(β=0.15;p=0.003),and tendency to avoid PA(β=0.10;p=0.027);WBI exerted a significant direct effect on tendency to avoid PA(β=0.47;p<0.001).Standardized indirect effects of WBI and psychological distress on the association between perceived WS and tendency to avoid PA were 0.12 and 0.01,***:Given the direct association of perceived WS on the tendency to avoid PA and the mediating role of WBI in this association,interventions addressing perceived WS and WBI may contribute to promoting ***,health interventionists(both when planning and executing PA programs)need to consider weight stigmawhen encouraging physical activity.

关键词： Mediation model physical activity psychological distress weight stigma young adults

Increasing age and duration of sex work among female sex workers in South Africa and implications for HIV incidence estimation:Bayesian evidence synthesis and simulation exercise

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Infectious Disease Modelling 2024年第1期9卷 263-277页

作者： Nanina Anderegg Mariette Slabbert Kholi Buthelezi Leigh F.Johnson Centre for Infectious Disease Epidemiology and Research School of Public HealthUniversity of Cape TownSouth Africa Institute of Social and Preventive medicine University of BernSwitzerland Independent Consultant PretoriaSouth Africa National Sex Workers Movement in South Africa

Introduction:In sub-Saharan Africa,accurate estimates of the HIV epidemic in female sex workers are crucial for effective prevention and care *** estimates are typically derived from mathematical models that assume certain demographic and behavioural characteristics like age and duration of sex work to remain constant over *** reviewed this assumption for female sex workers in South ***:We reviewed studies that reported estimates on either the age or the duration of sex work among female sex workers in South *** used Bayesian hierarchical models to synthesize reported estimates and to study time *** a simulation exercise,we also investigated the potential impact of the"constant age and sex work duration"-assumption on estimates of HIV ***:We included 24 different studies,conducted between 1996 and 2019,contributing 42 estimates on female sex worker age and 27 estimates on sex work *** was evidence suggesting an increase in both the duration of sex work and the age of female sex workers over *** to the fitted models,over each decade the expected duration of sex work increased by 55.6%(95%-credible interval[CrI]:23.5%–93.9%)and the expected age of female sex workers increased by 14.3%(95%-CrI:9.1%–19.1%).Over the 23-year period,the predicted mean duration of sex work increased from 2.7 years in 1996 to 7.4 years in 2019,while the predicted mean age increased from 26.4 years to 32.3 *** for these time trends in the simulation exercise resulted in a notable decline in estimated HIV incidence rate among sex workers over *** decline was significantly more pronounced than when assuming a constant age and duration of sex ***:In South Africa,age and duration of sex work in female sex workers increased over *** this trend might be influenced by factors like expanding community mobilization and improved rights advocacy,the ongoing criminalisation,stigmatisation of s

关键词： Female sex workers Mathematical modelling South Africa HIV

Game-theoretic multi-agent motion planning in a mixed environment

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Control Theory and Technology 2024年第3期22卷 379-393页

作者： Xiaoxue Zhang Lihua Xie school of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore City 639798Singapore

The motion planning problem for multi-agent systems becomes particularly challenging when humans or human-controlled robots are present in a mixed *** address this challenge,this paper presents an interaction-aware motion planning approach based on game theory in a receding-horizon manner Leveraging the framework provided by dynamic potential games for handling the interactions among agents,this approach formulates the multi-agent motion planning problem as a differential potential game,highlighting the effectiveness of constrained potential games in facilitating interactive motion planning among ***,online learning techniques are incorporated to dynamically learn the unknown preferences and models of humans or human-controlled robots through the analysis of observed *** evaluate the effectiveness of the proposed approach,numerical simulations are conducted,demonstrating its capability to generate interactive trajectories for all agents,including humans and human-controlled agents,operating within the mixed *** simulation results illustrate the effectiveness of the proposed approach in handling the complexities of multi-agent motion planning in real-world scenarios.

关键词： Motion planning Differential potential game Multi-agent systems Constrained potential game

Breaking the scattering limits of water waves

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National Science Review 2024年第6期11卷 85-86页

作者： Adrià Canós Valero Thomas Weiss Yuri Kivshar Institute of Physics University of Graz 4th Physics Institute University of Stuttgart Research school of Physics Australian National University

When water, light or sound waves impinge on objects smaller than the wavelength, a scattering process takes place[1]. The scattering of waves plays an essential role in a myriad of natural phenomena. In ocean engineering, enhancing the scattering of water waves allows capturing energy from larger areas, with clear implications for energy harvesting and coastal protection.

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High-efficiently doping nitrogen in kapok fiber-derived hard carbon used as anode materials for boosting rate performance of sodium-ion batteries

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Journal of Energy Chemistry 2024年第9期96卷 472-482页

作者： Tianyun Zhang Tian Zhang Fujuan Wang Fen Ran school of Mechanical and Electronical Engineering Lanzhou University of TechnologyLanzhou 730050GansuChina State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730500GansuChina

The engineering of plant-based precursor for nitrogen doping has become one of the most promising strategies to enhance rate capability of hard carbon materials for sodium-ion batteries;however,the poor rate performance is mainly caused by lack of pyridine nitrogen,which often tends to escape because of high temperature in preparation process of hard *** this paper,a high-rate kapok fiber-derived hard carbon is fabricated by cross-linking carboxyl group in 2,6-pyridinedicarboxylic acid with the exposed hydroxyl group on alkalized kapok with assistance of zinc ***,a high nitrogen doping content of 4.24%is achieved,most of which are pyridine nitrogen;this is crucial for improving the defect sites and electronic conductivity of hard *** optimized carbon with feature of high nitrogen content,abundant functional groups,degree of disorder,and large layer spacing exhibits high capacity of 401.7 mAh g^(−1)at a current density of 0.05 A g^(−1),and more importantly,good rate performance,for example,even at the current density of 2 A g^(−1),a specific capacity of 159.5 mAh g^(−1)can be *** findings make plant-based hard carbon a promising candidate for commercial application of sodium-ion batteries,achieving high-rate performance with the enhanced pre-cross-linking interaction between plant precursors and dopants to optimize aromatization process by auxiliary pyrolysis.

关键词： Kapok fiber Hard carbon Electrode materials Rate performance Sodium-ion batteries