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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National&Local Joint Engineering Research Centre for High-efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004HenanChina

Solution-processed Cu(In,Ga)Se_(2)(CIGS) solar cells suffer from serious carrier recombination and power conversion efficiency(PCE) loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage(VOC) of 662 m V and fill factor(FF) of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solarcells Solution-processedmethod Ag doping Crystal growth Defects engineering

Immunotherapy and liver transplantation for hepatocellular carcinoma:Current and future challenges

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World Journal of transplantation 2025年第2期15卷 8-29页

作者： Theodoros Pettas Sofia Lachanoudi Filippos F Karageorgos Ioannis A Ziogas Asimina Fylaktou Vassilios Papalois Georgios Katsanos Nikolaos Antoniadis Georgios Tsoulfas Department of transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University School of MedicineThessaloniki 54642Greece Department of Surgery University of Colorado Anschutz Medical CampusAuroraCO 80045United States Department of Immunology National Peripheral Histocompatibility CenterHippokration General HospitalThessaloniki 54642Greece Department of Transplant Surgery Imperial College Renal and Transplant CentreLondon W120HSUnited Kingdom Department of transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece

Despite existing curative options like surgical removal,tissue destruction techniques,and liver transplantation for early-stage hepatocellular carcinoma(HCC),the rising incidence and mortality rates of this global health burden necessitate continuous exploration of novel therapeutic *** review critically assesses the dynamic treatment panorama for HCC,focusing specifically on the burgeoning role of immunotherapy in two key contexts:early-stage HCC and downstaging advanced HCC to facilitate liver transplant *** delves into the unique immunobiology of the liver and HCC,highlighting tumor-mediated immune evasion *** the diverse immunothera-peutic approaches including checkpoint inhibitors,cytokine modulators,vaccines,oncolytic viruses,antigen-targeting antibodies,and adoptive cell therapy,this review acknowledges the limitations of current diagnostic markers alpha-fetoprotein and glypican-3 and emphasizes the need for novel biomarkers for patient selection and treatment *** the rationale for neoadjuvant and adjuvant immunotherapy in early-stage HCC,current research is actively exploring the safety and effectiveness of diverse immunothera-peutic approaches through ongoing clinical *** review further explores the potential benefits and challenges of combining immunotherapy and liver transplant,highlighting the need for careful patient selection,meticulous monitoring,and novel strategies to mitigate post-transplant ***,this review delves into the latest findings from the clinical research landscape and future directions in HCC management,paving the way for optimizing treatment strategies and improving long-term survival rates for patients with this challenging malignancy.

关键词： Hepatocellular carcinoma Immunotherapy Liver transplantation Neoadjuvant and adjuvant immunotherapy Immune checkpoint inhibitors Vaccine therapies Oncolytic viruses Adoptive cell therapy Antigen-targeting antibodies Diagnostic biomarkers

Metal-free construction of diverse 1,2,4-triazolo[1,5-a]pyridines on water

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Chinese Chemical Letters 2025年第1期36卷 244-247页

作者： Chunhua Ma Mengjiao Liu Siyu Ouyang Zhenwei Cui Jingjing Bi Yuqin Jiang Zhiguo Zhang Collaborative Innovation centre of henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Engineering Research Centre of Chiral Hydroxyl PharmaceuticalHenan Engineering Laboratory of Chemical Pharmaceutical and Biomedical MaterialsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China Chongqing Aoshe Bio-chemical Co.Ltd. Chongqing 400000China

A transition-metal-and oxidant-free amination/cyclization reaction to access 1,2,4-triazolo[1,5-a]pyridines was realized in water by using amino diphenylphosphinate as amino source.A broad array of readily accessible N-(pyridyl)amides could be converted into the products featuring a diverse set of functional *** sustainable methodology was successfully applied to the late-stage functionalization of natural products and drugs.

关键词： 1,2,4-Triazolo[1,5-a]pyridines On water N-(Pyridyl)amides Cyclization Metal-free

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British research centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Basiliximab is superior to low dose rabbit anti-thymocyte globulin in pediatric kidney transplant recipients: The younger, the better

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中华医学杂志(英文版) 2025年第2期138卷 225-227页

作者： Zhu Lan Zhang Lei Shang Wenjun Liu Wenhua Sa Rula Guo Zhiliang Liu Longshan Tan Jinghong Zhang Hengxi Feng Yonghua Zhao Wenyu Cong Wenqi Wu Jianyong Wang Changxi Chen Gang Institute of organ transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Organ Transplantation Ministry of Education NHC Key Laboratory of Organ Transplantation Key Laboratory of Organ Transplantation Chinese Academy of Medical Sciences Wuhan Hubei China Department of organ transplantation First Affiliated Hospital Naval Medical University Shanghai China Department of Renal transplantation First Affiliated Hospital Zhengzhou University Zhengzhou Henan China Clinical research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China organ Transplant Center The First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong China Center of Nephrology First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China

Merging polymers of intrinsic microporosity and porous carbon-based zinc oxide composites in novel mixed matrix membranes for efficient gas separation

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Green Energy & Environment 2025年第1期10卷 203-213页

作者： Muning Chen Jiemei Zhou Jing Ma Weigang Zheng Guanying Dong Xin Li Zhihong Tian Yatao Zhang Jing Wang Yong Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou450001HenanChina State Key Laboratory of Materials-Oriented Chemical Engineering and College of Chemical Engineering Nanjing Tech UniversityNanjing211816JiangsuChina Singapore Membrane Technology centre Nanyang Environment and Water Research InstituteNanyang Technological UniversitySingapore637141Singapore Engineering research Center for Nanomaterials Henan UniversityKaifeng475004HenanChina State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Energy and Environment Southeast UniversityNanjing210096JiangsuChina

Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of ***,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and *** this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate *** dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting ***,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in *** a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH_(4) selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper ***,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@*** summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.

关键词： Mixed matrix membranes Polymers of intrinsic microporosity CO_(2)separation Porous carbon materials

Global transplantation:Lessons from organ transplantation organizations worldwide

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World Journal of transplantation 2025年第1期15卷 44-56页

作者： Solonas Symeou Eleni Avramidou Vassilios Papalois Georgios Tsoulfas Medical School University of IoanninaIoannina 45110Greece Department of transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Imperial College Renal and Transplant centre Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and Cancer Imperial College LondonLondon SW72AZUnited Kingdom

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains *** in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity *** with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant *** technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations *** review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the *** differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different *** a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

关键词： organ transplantation National transplant organizations organ donation Global transplantation Transplant systems

Development and characterization of bacterial wilt-resistant synthetic polyploid peanuts

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The Crop Journal 2025年第1期13卷 125-134页

作者： Pei Du Fanpei Zeng Qian Wang Lijuan Miao Feiyan Qi Meili Yang Xiao Wang Hua Liu Guoquan Chen Liuyang Fu Suoyi Han Ziqi Sun Li Qin Wenzhao Dong Xinyou Zhang The Shennong Laboratory/Nation Industrial Innovation centre for Bio-Breeding/Key Laboratory of Oil Crops in Huang-Huai-Hai Plains Ministry of Agriculture/Henan Provincial Key Laboratory for Oil Crops Improvement/Institute of Crop Molecular BreedingHenan Academy of Agricultural SciencesPostgraduate T&R Base of Zhengzhou UniversityZhengzhou 450002HenanChina School of Agricultural Sciences Zhengzhou UniversityZhengzhou 450001HenanChina School of Life Science Zhengzhou UniversityZhengzhou 450001HenanChina Hebi Academy of Agricultural Sciences Hebei 458031HenanChina

Wild peanut(Arachis)species are promising sources of disease resistance for improving peanut *** objective of this study was to assess cross-compatibility among cultivated and wild peanuts in crosses between eight peanut cultivars and 27 wild species carrying the A,B,E,Ex,F,K,P,and H *** culture and chromosome doubling led to polyploids representing hybrids between cultivated peanut and ***,***,***,***,and *** first two showed greater resistance to bacterial wilt than their cultivated *** markers were developed for verifying the hybrids and for identifying translocation or introgression lines with alien chromosome fragments.

关键词： Peanut Wild species Cross compatibility Polyploids Bacterial wilt

In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la Cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe Ying Hao Jiang Yan Wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries