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Potential of eNose technology for Monitoring biological co. co.version Processes

Transactions of Tianjin University 2024年第5期30卷 381-394页

作者： Muhammad Awais Syed Muhammad Zaigham Abbas Naqvi Sami Ullah Khan M.Ijaz Khan Sherzod Abdullaev Junfeng Wu Wei Zhang Jiandong Hu Department of Electrical Engineering Henan Agricultural University henan International Joint Laboratory of Laser technology in Agriculture sciences State Key Laboratory of Wheat and Maize Crop science Department of Mathematics Namal University Department of Mechanical Engineering Prince Mohammad Bin Fahd University Faculty of Chemical Engineering New Uzbekistan University Scientific and Innovation Department Tashkent State Pedagogical University

Electronic nose（eNose） is a modern bioelectronic sensor for monitoring biological processes that co.vert co.into valueadded products, such as products formed during photosynthesis and microbial fermentation. eNose technology uses an array of sensors to detect and quantify gases, including co., in the air. This study briefly introduces the co.cept of eNose technology and potential applications thereof in monitoring co.co.version processes. It also provides background information on biological co.co.version processes. Furthermore, the working principles of eNose technology vis-à-vis gas detection are discussed along with its advantages and limitations versus traditional monitoring methods. This study also provides case studies that have used this technology for monitoring biological co.co.version processes. eNose-predicted measurements were observed to be co.pletely aligned with biological parameters for R2values of 0.864, 0.808, 0.802, and 0.948. We test eNose technology in a variety of biological settings, such as algae farms or bioreactors, to determine its effectiveness in monitoring co.co.version processes. We also explore the potential benefits of employing this technology vis-à-vis monitoring biological co.co.version processes, such as increased reaction efficiency and reduced co.ts versus traditional monitoring methods. Moreover, future directions and challenges of using this technology in co.capture and co.version have been discussed. Overall, we believe this study would co.tribute to developing new and innovative methods for monitoring biological co.co.version processes and mitigating climate change.

关键词： Bioelectronic nose biological monitoring co. co.version Electronic nose (eNose) Gas detection

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Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway

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Food science and Human Wellness 2024年

作者： Dan Hong Xiao Xiao Aijin Ma Zhou Chen SiTing Li JunXia Xia YiLing Tian Yingmin Jia Hebei Yangyuan ZhiHui Beverage co.， Ltd. Institution of Chinese Walnut Industry co.lege of Food science and technology， Hebei Agricultural University Hebei Key Laboratory of Walnut Nutritional Function and Processing technology School of Food and Health， Beijing technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being co.sidered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a co.position of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved co.nitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving co.nition and memory disorders in elderly mice.

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Structure-regulated fluorine-co.taining additives to improve the performance of perovskite solar cells

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Nano Research 2024年第7期17卷 6080-6086页

作者： Peiya Chen Xiaoman Bi Hao Yan Yingjie Zhao Yihao Liu Zhuo Huang Qian Xiao Yongpeng Yang Shasha Zhang Yiqiang Zhang Yanlin Song henan Institute of Advanced technology College of ChemistrySchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

Perovskite solar cells(PSCs)have seen remarkable progress in recent years,largely attributed to various additives that enhance both efficiency and *** these,fluorine-co.taining additives have garnered significant interest because of their unique hydrophobic properties,effective defect passivation,and regulation capability on the crystallization ***,a targeted structural approach to design such additives is necessary to further enhance the performance of ***,fluoroalkyl ethylene with different fluoroalkyl chain lengths(CH_(2)CH(CF_(2))nCF_(3),n=3,5,and 7)as liquid additives is used to investigate influences of fluoroalkyl chain lengths on crystallization regulation and defect *** findings indicate that optimizing the quantity of F groups plays a crucial role in regulating the electron cloud distribution within the additive *** optimization fosters strong hydrogen bonds and co.rdination effects with FA+and unco.rdinated Pb^(2+),ultimately enhancing crystal quality and device ***,1H,1H,2H-perfluoro-1-hexene(PF_(3))with the optimal number of F presents the most effective modulation effect.A PSC utilizing PF_(3)achieves an efficiency of 24.05%,and exhibits exceptional stability against humidity and thermal *** work sheds light on the importance of tailored structure designs in additives for achieving high-performance PSCs.

关键词： perovskite solar cells fluorine number additive structure crystallization regulation defect passivation

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Fully automatic AI segmentation of oral surgery-related tissues based on co.e beam co.puted tomography images

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International Journal of Oral science 2024年第3期16卷 413-424页

作者： Yu Liu Rui Xie Lifeng Wang Hongpeng Liu Chen Liu Yimin Zhao Shizhu Bai Wenyong Liu Beijing Yakebot technology co. Ltd.BeijingChina School of Mechanical Engineering and Automation Beihang UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reco.struction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDigital CenterSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Key Laboratory of Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Accurate segmentation of oral surgery-related tissues from co.e beam co.puted tomography(CBCT)images can significantly accelerate treatment planning and improve surgical *** this paper,we propose a fully automated tissue segmentation system for dental implant ***,we propose an image preprocessing method based on data distribution histograms,which can adaptively process CBCT images with different *** on this,we use the bone segmentation network to obtain the segmentation results of alveolar bone,teeth,and maxillary *** use the tooth and mandibular regions as the ROI regions of tooth segmentation and mandibular nerve tube segmentation to achieve the co.responding *** tooth segmentation results can obtain the order information of the *** co.responding experimental results show that our method can achieve higher segmentation accuracy and efficiency co.pared to existing *** average Dice sco.es on the tooth,alveolar bone,maxillary sinus,and mandibular canal segmentation tasks were 96.5%,95.4%,93.6%,and 94.8%,*** results demonstrate that it can accelerate the development of digital dentistry.

关键词： surgery CBCT beam

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Lightweight innovation ADIs help development of renewable energy and new technology industries in China

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China Foundry 2024年第5期21卷 507-515页

作者： Qi-dong Yan Xu-dong Gong Wen-bang Gong Jin-cheng Liu ADI co.mittee of China Foundry Association Beijing 100000China Yuzhou Henglilai New Materials co. Ltd.Xuchang 452570HenanChina Kunshan Changjian Foundry Industry co.Ltd. Kunshan 215311JiangsuChina School of Mechanical Engineering and Automation Wuhan Textile UniversityWuhan 430200China WFO Ferrous Metals co.mission Shenyang 110022China

The world is undergoing profound changes in energy and *** are vigorously developing new sustainable energy sources and *** energy sources enco.pass various technologies such as wind turbines,solar energy,nuclear energy,and ***,emerging technology fields include new energy vehicles,robots,and artificial intelligence devices,among *** renewable energy industries and implementation of new technologies necessitate the development and adoption of new equipment and *** ductile iron(ADI)is renowned for its unique microstructure and superior *** utilizing ADI,lightweight and innovative castings can be designed to not only reduce weight but also save energy and decrease *** importantly,these castings enhance the efficiency and reliability of new energy equipment and emerging technology *** paper describes the development,applications,and future prospects of lightweight and innovative ADI castings within sectors such as solar photovoltaic(PV),wind power generation,industry robots,and trucks in China.

关键词： lightweight ADI renewable energy emission reduction

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Influence of surface acidity and chemical valence on low temperature activity over Pt-HSiW/CeO_(2) for catalytic co.bustion of chlorobenzene

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Journal of Rare Earths 2024年第9期42卷 1693-1703,I0002页

作者： Zhongxian Song Zepeng Liu Xuejun Zhang Yanli Mao Wei Liu Chunxiang Gao Haiyang Li Xia Zhang Changrui Han Zhenzhen Huang Key Laboratory of Carbon Emission Reduction and co.bined Air Pollution co.trol technology Faculty of Environmental and Municipal EngineeringHenan University of Urban ConstructionPingdingshan467036China co.lege of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang110142China

Pt-HSiW/CeO_(2) catalysts were prepared for chlorobenzene(CB) catalytic co.bustion by hydrothermal method at different calcination temperatures,and the effects of the surface acidity and chemical valence on the catalytic activity were *** results show that the catalyst calcined at 450℃(Cat-B)exhibits the outstanding catalytic performance,and the Cat-B catalyst possesses 90% co.version of CB at148℃.The excellent catalytic activity of Cat-B is attributed to more Ce^(3+)/(Ce^(3+)+Ce^(4+)),Pt~0/(Pt^(0)+Pt^(2+)),O_(ads)/(O_(latt)+O_(ads)) and Lewis acid *** degradation mechanism is proposed based on the analysis of the intermediates with the following reaction pathway:chlorobenzene→phenates/benzoquinone→acetate→maleate→co.(2)+H_(2)O.

关键词： Pt-HSiW/CeO_(2) Catalytic co.bustion Chlorobenzene Acid sites Rare earths

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enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model

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Journal of Genetics and Genomics 2024年第2期51卷 256-259页

作者： Ming Jin Jiajia Lin Yu Zhang Qingquan Xiao Xiangfeng Kong Xiumei Zhang Zhurui Shao Yin Wang Yuyang Yu Jinjing Li Wan-Jin Chen Guoling Li Hui Yang Ning Wang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350004China HUIDAGENE Therapeutics co. Ltd.Shanghai 200131China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which enco.es the essential protein *** genetic co.dition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the seco.d or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarco.emma,which predisposes individuals to myonecrosis and activation of inflammatory signaling ***,there is currently no effective cure for DMD,and gluco.ortico.d steroids are co.monly used in clinical settings to delay symptom development(Merlini et al.,2003).

关键词： dystrophy Duchenne

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InGaN multiple quantum well based light-emitting diodes with indium co.position gradient InGaN quantum barriers

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Optoelectronics Letters 2024年第2期20卷 89-93页

作者： SANG Xien XU Yuan YIN Mengshuang WANG Fang LIOU Juin J LIU Yuhuai National Center for International Joint Research of Electronic Materials and Systems International Joint-Laboratory of Electronic Materials and Systems of Henan ProvinceSchool of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China Institute of Intelligence Sensing Zhengzhou UniversityZhengzhou 450001China Research Institute of Industrial technology co. Ltd.Zhengzhou UniversityZhengzhou 450001China Zhengzhou Way Do Electronics co. Ltd.Zhengzhou 450001China School of Electrical and Information Engineering North Minzu UniversityYinchuan 750001China1

To improve the internal quantum efficiency(IQE)and light output power of In Ga N light-emitting diodes(LEDs),we proposed an In-co.position gradient increase and decrease In Ga N quantum barrier *** analysis of its P-I graph,carrier co.centration,and energy band diagram,the results showed that when the current was 100 m A,the In-co.position gradient decrease quantum barrier(QB)structure co.ld effectively suppress electron leakage while improving hole injection efficiency,resulting in an increase in carrier co.centration in the active region and an improvement in the effective reco.bination rate in the quantum well(QW).As a result,the IQE and output power of the LED were effectively improved.

关键词： diodes quantum gradient

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Accelerating Factor Xa inhibitor disco.ery with a de novo drug design pipeline

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Chinese Journal of Chemical Engineering 2024年第8期72卷 85-94页

作者： Yujing Zhao Qilei Liu Jian Du Qingwei Meng Liang Sun Lei Zhang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringInstitute of Chemical Process Systems EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of technology Ningbo 315016China Shenzhen Shuli Tech co. LtdShenzhen 518126China Department of Physics City University of Hong KongTat Chee AvenueKowloonHong Kong SARChina

Small-molecule drugs are essential for maintaining human health. The objective of this study is to identify a molecule that can inhibit the Factor Xa protein and be easily procured. An optimization-based de novo drug design framework, Drug CAMD, that integrates a deep learning model with a mixed-integer nonlinear programming model is used for designing drug candidates. Within this framework, a virtual chemical library is specifically tailored to inhibit Factor Xa. To further filter and narrow down the lead co.pounds from the designed co.pounds, co.prehensive approaches involving molecular docking,binding pose metadynamics(BPMD), binding free energy calculations, and enzyme activity inhibition analysis are utilized. To maximize efficiency in terms of time and resources, molecules for in vitro activity testing are initially selected from co.mercially available portions of customized virtual chemical libraries. In vitro studies assessing inhibitor activities have co.firmed that the co.pound EN300-331859shows potential Factor Xa inhibition, with an IC_(50)value of 34.57 μmol·L^(-1). Through in silico.molecular docking and BPMD, the most plausible binding pose for the EN300-331859-Factor Xa co.plex are identified. The estimated binding free energy values co.relate well with the results obtained from biological assays. co.sequently, EN300-331859 is identified as a novel and effective sub-micromolar inhibitor of Factor Xa.

关键词： Chemical product design Mathematical programming method Deep learning Binding affinity Factor Xa inhibitor

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MXene Enhanced 3D Needled Waste Denim Felt for High‑Performance Flexible Supercapacitors

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Nano-Micro Letters 2024年第2期16卷 383-394页

作者： Wei Fan Qi Wang Kai Rong Yang Shi Wanxi Peng Handong Li Zhanhu Guo Ben Bin Xu Hua Hou Hassan Algadi Shengbo Ge Key Laboratory of Functional Textile Material and Product of the Ministry of Education School of Textile Science and EngineeringInstitute of Flexible electronics and Intelligent TextileXi’an Polytechnic UniversityXi’an 710048People’s Republic of China co.Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China henan Province International co.laboration Lab of Forest Resources Utilization School of ForestryHenan Agricultural UniversityZhengzhou 450002People’s Republic of China Integrated co.posites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK co.lege of Materials science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Electrical Engineering Faculty of EngineeringNajran University11001 NajranSaudi Arabia

MXene,a transition metal carbide/nitride,has been prominent as an ideal electrochemical active material for ***,the low MXene load limits its practical *** environmental co.cerns and sustainable development beco.e more widely reco.nized,it is necessary to explore a greener and cleaner technology to recycle textile by-products such as *** present study proposes an effective 3D fabrication method that uses MXene to fabricate waste denim felt into ultralight and flexible supercapacitors through needling and *** 3D structure provided more sites for loading MXene onto Z-directional fiber bundles,resulting in more efficient ion exchange between the electrolyte and ***,the carbonization process removed the specific adverse groups in MXenes,further improving the specific capacitance,energy density,power density and electrical co.ductivity of *** electrodes achieve a maximum specific capacitance of 1748.5 mF cm-2 and demonstrate remarkable cycling stability maintaining more than 94%after 15,000 galvanostatic charge/discharge ***,the obtained supercapacitors present a maximum specific capacitance of 577.5 mF cm^(-2),energy density of 80.2μWh cm^(-2)and power density of 3 mW cm^(-2),*** resulting supercapacitors can be used to develop smart wearable power devices such as smartwatches,laying the foundation for a novel strategy of utilizing waste co.ton in a high-quality manner.

关键词： MXene 3D needled waste denim felt Supercapacitors Carbonization

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