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Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy

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World Journal of Psychiatry 2024年第7期14卷 1017-1026页

作者： Xiu-Qiao Hao Xiang-Dan Yang Yue Qi Department of hematology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat *** advancements of science and technology have resulted in more and more patients being able to receive effective treatment,they still face side effects such as fatigue and *** is important to thoroughly investigate the factors that contribute to cancer-related fatigue(CRF)during *** To explore the factors related to CRF,anxiety,depression,and mindfulness levels in patients with DLBCL during *** General information was collected from the electronic medical records of eligible *** quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short *** Piper Fatigue Scale was used to evaluate the CRF *** Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression *** analysis and multivariate regression analysis were used to investigate the factors related to *** The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74±*** 25 patients,the highest rate of mild fatigue was in the cognitive dimension(40.32%),and in 35 patients the highest moderate fatigue rate in the behavioral dimension(56.45%).In the emotional dimension,severe fatigue had the highest rate of occurrence,34 cases or 29.03%.The CRF score was positively correlated with cancer experience(all P<0.01)and negatively correlated with cancer treatment efficacy(all P<0.01).Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with DLBCL during *** There was a significant correlation between CRF and perceptual control level in *** staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level

关键词： Diffuse large B-cell lymphoma Chemotherapy Cancer-related fatigue Anxiety Depression Mindfulness

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Adult rhabdomyosarcoma combined with acute myeloid leukemia: A case report

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World Journal of Clinical Cases 2024年第3期12卷 582-586页

作者： Lu Zheng Fen-Juan Zhang Department of hematology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma is a tumor of mesenchymal *** leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to cytotoxic chemotherapy or radiation therapy for other *** SUMMARY We present the case of a 36-year-old female patient who was diagnosed with rhabdomyosarcoma and acute myeloid *** disease progression was observed after multiline ***,the patient suffered cerebral hemorrhage,which resulted in *** The incidence of rhabdomyosarcoma in adults is extremely low,and secondary leukemia caused by rhabdomyosarcoma is even *** leukemia has a very poor prognosis and a low overall survival rate.

关键词： Rhabdomyosarcoma Secondary acute myeloid leukocytes Chemotherapeutics Secondary leukemia Case report

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STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses

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National Science Review 2024年第7期11卷 189-204页

作者： Taokun Luo Xiaomin Jiang Yingjie Fan Eric Yuan Jinhong Li Langston Tillman Wenbin Lin Department of Chemistry University of Chicago Department of Radiation and Cellular oncology and the Ludwig Center for Metastasis Research University of Chicago

Radiotherapy is widely used for cancer treatment, but its clinical utility is limited by radioresistance and its inability to target metastases. Nanoscale metal-organic frameworks(MOFs) have shown promise as high-Z nanoradiosensitizers to enhance radiotherapy and induce immunostimulatory regulation of the tumor microenvironment. We hypothesized that MOFs could deliver small-molecule therapeutics to synergize with radiotherapy for enhanced antitumor efficacy. Herein, we develop a robust nanoradiosensitizer,GA-MOF, by conjugating a STING agonist, 2,3-cyclic guanosine monophosphate–adenosine monophosphate(GA), on MOFs for synergistic radiosensitization and STING activation. GA-MOF demonstrated strong anticancer efficacy by forming immune-cell-rich nodules(artificial leukocytoid structures) and transforming them into immunostimulatory hotspots with radiotherapy. Further combination with an immune checkpoint blockade suppressed distant tumors through systemic immune activation. Our work not only demonstrates the potent radiosensitization of GA-MOF, but also provides detailed mechanisms regarding MOF distribution, immune regulatory pathways and long-term immune effects.

关键词： metal-organic framework radiosensitization STING agonist artificial leukocytoid structures immune hotspots immunotherapy nanomedicine

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Designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer

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Nano Research 2024年第8期17卷 7504-7512页

作者： Meijin Yang Zhiying Tang Xiaoying Li Yanzi Yu Lizhen He Tianfeng Chen College of Chemistry and Materials Science Department of Oncology of The First Affiliated HospitalJinan UniversityGuangzhou 510632China

Bone metastasis along with osteolysis is a common complication of advanced breast cancer,which directly destroys bone function and becomes one of the major causes of cancer-related *** is crucial to develop a new strategy to achieve effective cancer therapy and inhibition of osteolytic bone *** ruthenium(Ru)complexes exhibit therapeutic potential in cancer ***,the clinical applications of Ru complexes were limited by poor bioavailability,lacking targeting,nonspecific ***,in this study,engineering of cell membrane biomimetic modification was used to construct a highly biocompatible nanoplatform with carrying Ru metal complex of RuPOP and Se nanoparticles(SeNPs).Strikingly,the obtained RPSR nanoparticles can efficiently inhibit the proliferation,invasion and migration of breast cancer cells(MDA-MB-231 cells)in *** importantly,RPSR nanoparticles can induce cycle arrest,apoptosis by generating excessive intracellular(reactive oxygen species,ROS)to disrupt the normal redox balance and induce DNA damage in tumor ***,RPSR nanoparticles can also reshape bone microenvironment by regulating selenoproteins to inhibit osteoclasts and avoid osteolytic bone metastasis induced by tumor *** together,this study not only provides an effective cell membrane biomimetic strategy to enhance the shortcomings of metal complexes,but also demonstrates potential clinical significance for the combined treatment of anti-cancer and bone metastasis inhibition.

关键词： cell membrane nanoparticles biomimetic modification ruthenium complexes selenium nanoparticles tumor bone metastasis

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Assessing the efficacy and safety of gemcitabine-induced thrombocytopenia/neutropenia and thrombocytopenia interventions in zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 970-973页

作者： Jialong Deng Ziyuan Zhou Wangjun Liao Qing Lin Yiyue Zhang Innovation Centre of Ministry of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of hematology The Sixth Affiliated HospitalSchool of MedicineSouth China University of TechnologyFoshanGuangdong 528200China Department of oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Cancer is a major global health issue;in 2020,there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide(Siegel et al.,2023).Despite ongoing research,chemotherapy remains the primary treatment due to its broad anti-cancer effects(Marra and Curigliano,2021).However,intravenous chemotherapeutic drugs commonly induce hematotoxicity,necessitating dose adjustments or treatment ***-induced thrombocytopenia(CIT)and neutropenia(CIN)are the primary manifestations of chemotherapy-induced hematotoxicity,which requires intervention due to the heightened risk of bleeding and infection(Blayney and Schwartzberg,2022).Currently,there are no FDA-approved treatments for CIT(Song and Al-Samkari,2023).While a CIT mouse model using 5-FU has been developed for drug evaluation(Shin et al.,2023),it lacks a comprehensive hematotoxicity assessment and the benefits of high throughput,cost-effectiveness,and ***,it is urgent to develop a high-throughput CIT model for risk assessment and safer chemotherapy strategies with clinical potential.

关键词： chemotherapy treatment visibility

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Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： Yu-Qi Zhou Jun-Fei Yuan Hong-Shi Shen Ya-Ping Wang Han-Fei Shi De-Jian Pan Min Ye Department of hematology and oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

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Genetic predisposition to childhood cancer

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World Journal of Clinical Pediatrics 2024年第3期13卷 4-10页

作者： Jelena Roganovic Department for Pediatric oncology and hematology Children's Hospital ZagrebZagreb 10000Croatia Faculty of Biotechnology and Drug Development University of RijekaRijeka 51000Croatia

The etiology of childhood cancer remains largely *** evidence suggests that genetic factors play a substantial role in pediatric *** adult cancers,pediatric cancers typically have a higher prevalence of germline pathogenic variants in cancer predisposition *** cancer predisposition syndromes account for approximately 10%of all childhood *** the years,the diagnosis of cancer predisposition syndromes was based on clinical suspicion prompting referral to a specialized ***,advances in molecular technologies have led to a shift toward a“genotypefirst”*** of genetic variants related to cancer predisposition enables tailored treatment,improves clinical outcome,optimizes surveillance,and facilitates genetic counseling of the affected child and the family.

关键词： Cancer Children Etiology Genetics Cancer predisposition syndromes

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Mixed neuroendocrine non-neuroendocrine neoplasms in gastroenteropancreatic tract

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World Journal of Gastrointestinal oncology 2024年第4期16卷 1166-1179页

作者： Sebastián Díaz-López Jerónimo Jiménez-Castro Carlos Enrique Robles-Barraza Carlos Ayala-de Miguel Manuel Chaves-Conde Medical oncology Department Hospital Universitario ValmeSeville 41014AndalucíaSpain

Mixed neuroendocrine non-neuroendocrine neoplasms(MiNENs)are a hetero-geneous group of malignant neoplasms that can settle in the gastroenteropan-creatic *** are composed of a neuroendocrine(NE)and a non-NE compo-nent in at least 30%of each *** non-NE component can include different histological combinations of glandular,squamous,mucinous and sarcomatoid phenotypes,and one or both of the components can be low-or high grade *** changes in the nomenclature of these neoplasms might lead to great deal of confusion,and the lack of specific clinical trials is the main reason why their management is *** review aims to clarify the definition of MiNEN and analyze available evidence about their diagnosis and treatment options according to their location and extension through careful analysis of the available *** would be important to reach a general consensus on their diagnosis in order to construct a classification that remains stable over time and facilitates the design of clinical trials that,due to their low incidence,will require long recruitment periods.

关键词： Mixed neuroendocrine non-neuroendocrine neoplasms Mixed adenoneuroendocrine carcinomas Mixed tumours Gastroenteropancreatic Treatment Etiology Diagnosis

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Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： Zhi-Yun Weng Wen-Ye Huang Bin-Kan Shi Jian-Jia Pan Department of hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intracranial lesions shrank *** BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

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Pharmacological methods for ovarian function and fertility preservation in women with cancer:A literature review

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oncology Research 2024年第8期32卷 1309-1322页

作者： ANA S.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA D.ZIVKOVIC MAJA J.POPOVIC MARIJANA M.MILOVIC KOVACEVIC LAZAR S.POPOVIC Department for oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of oncology University Clinical Centre NisNis18000Serbia Department of Internal Medicine and Medical Sciences(DiMI) School of MedicineUniversity of GenovaGenova16100Italy Department of Medical oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy Department of General Medical oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium Department of Medical oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia Department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Medicine University of Novi SadNovi Sad21000Serbia Department of Medical oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and *** ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufﬁciency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian ***,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological ***,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor *** addition,studies on hematological malignancies have yielded negative results;nevertheless,theﬁndings must be interpreted with caution owing to numerous *** guidelines from the American Society of Clinical oncology and ESMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisﬁeld

关键词： Gonadotropin-releasing hormone agonists(GnRHa) Fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

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